| Compound ID |
Compound Name |
Compound Formula |
|
CP0572651
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-imidazo[4,5-b]pyridin-3-ylethanone
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|
C23H23F3N8O2S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0546732
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-pyrrolo[3,2-c]pyridin-1-ylethanone
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|
C24H24F3N7O2S
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0572652
|
1-[2-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-oxoethyl]-3H-indol-2-one
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|
C25H25F3N6O3S
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0546731
|
US9266876, 51
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|
C24H21F3N8OS
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0572644
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-2-methyl-4-[4-(2-propylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
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|
C24H25F3N8OS
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0551916
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-pyrrolo[2,3-b]pyridin-1-ylethanone
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|
C24H24F3N7O2S
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0543476
|
2-(benzimidazol-1-yl)-1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
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|
C24H24F3N7O2S
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0550339
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-pyrazolo[3,4-b]pyridin-1-ylethanone
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|
C23H23F3N8O2S
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0546734
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-(3-methylpyrazol-1-yl)ethanone
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|
C21H24F3N7O2S
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0578313
|
1-[(2R)-4-[4-(2-cyclobutyloxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-(3,5-dimethyl-1,2,4-triazol-1-yl)ethanone
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|
C23H27F3N8O2S
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0567946
|
2-(3,5-dimethylpyrazol-1-yl)-1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
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|
C22H26F3N7O2S
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0571705
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-[3-(trifluoromethyl)pyrazol-1-yl]ethanone
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|
C21H21F6N7O2S
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0569956
|
3-[2-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-oxoethyl]-1,3-benzoxazol-2-one
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|
C24H23F3N6O4S
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0543586
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-4-[4-(6-methoxypyridin-3-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C23H22F3N7O2S
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0567919
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-[3-(trifluoromethyl)-1,2,4-triazol-1-yl]ethanone
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|
C20H20F6N8O2S
|
1
|
| 1 |
IC50 = 118 nM
|
|
|
|
CP0400471
|
US9266876, 80
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|
C23H21BrN8OS
|
1
|
| 1 |
IC50 = 126 nM
|
|
|
|
CP0572643
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-4-[4-(4-methoxyphenyl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
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|
C24H23F3N6O2S
|
1
|
| 1 |
IC50 = 131 nM
|
|
|
|
CP0571706
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[4-(2-propan-2-yloxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
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|
C22H27F3N8O2S
|
1
|
| 1 |
IC50 = 138 nM
|
|
|
|
CP0550338
|
1-[(2R)-4-[4-[2-[2-(dimethylamino)ethoxy]pyrimidin-5-yl]-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-imidazo[4,5-b]pyridin-3-ylethanone
Show/Hide
|
C25H28F3N9O2S
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0550340
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-(5-methylpyrazol-1-yl)ethanone
Show/Hide
|
C21H24F3N7O2S
|
1
|
| 1 |
IC50 = 162 nM
|
|
|
|
CP0543561
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-2-methyl-4-[4-(2-methylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C22H21F3N8OS
|
1
|
| 1 |
IC50 = 168 nM
|
|
|
|
CP0575647
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C21H25F3N8O2S
|
1
|
| 1 |
IC50 = 173 nM
|
|
|
|
CP0567922
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-4-[4-(2-methoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C22H21F3N8O2S
|
1
|
| 1 |
IC50 = 177 nM
|
|
|
|
CP0569010
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[2-(trifluoromethyl)-4-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C20H20F6N8OS
|
1
|
| 1 |
IC50 = 222 nM
|
|
|
|
CP0569001
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[4-(2-propylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C22H27F3N8OS
|
1
|
| 1 |
IC50 = 258 nM
|
|
|
|
CP0543592
|
2-(4-chloropyrazol-1-yl)-1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C20H21ClF3N7O2S
|
1
|
| 1 |
IC50 = 272 nM
|
|
|
|
CP0546729
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-4-[4-[2-(2-methoxyethoxy)pyrimidin-5-yl]-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C24H25F3N8O3S
|
1
|
| 1 |
IC50 = 324 nM
|
|
|
|
CP0550342
|
1-[(2R)-4-[4-(2-cyclopropylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-(3,5-dimethyl-1,2,4-triazol-1-yl)ethanone
Show/Hide
|
C22H25F3N8OS
|
1
|
| 1 |
IC50 = 349 nM
|
|
|
|
CP0573965
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-4-[4-(6-ethoxypyridin-3-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C22H26F3N7O2S
|
1
|
| 1 |
IC50 = 505 nM
|
|
|
|
CP0573963
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[4-(2-pyrrolidin-1-ylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C23H28F3N9OS
|
1
|
| 1 |
IC50 = 523 nM
|
|
|
|
CP0546733
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-4-[4-(2-methoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C20H23F3N8O2S
|
1
|
| 1 |
IC50 = 558 nM
|
|
|
|
CP0550341
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[4-(2-methylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C20H23F3N8OS
|
1
|
| 1 |
IC50 = 578 nM
|
|
|
|
CP0526110
|
US9266876, 50
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|
C26H28N8OS
|
1
|
| 1 |
IC50 = 599 nM
|
|
|
|
CP0477961
|
US9266876, 49
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|
C24H24N8OS
|
1
|
| 1 |
IC50 = 604 nM
|
|
|
|
CP0577506
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[2-(trifluoromethyl)-4-[6-(trifluoromethyl)pyridin-3-yl]-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C21H21F6N7OS
|
1
|
| 1 |
IC50 = 608 nM
|
|
|
|
CP0565786
|
US9266876, 73
Show/Hide
|
C26H26N8OS
|
1
|
| 1 |
IC50 = 745 nM
|
|
|
|
CP0551814
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-pyrazol-1-ylethanone
Show/Hide
|
C20H22F3N7O2S
|
1
|
| 1 |
IC50 = 811 nM
|
|
|
|
CP0517372
|
US9266876, 17
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|
C23H22N8OS
|
1
|
| 1 |
IC50 = 830 nM
|
|
|
|
CP0526126
|
US9266876, 146
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|
C25H26N8OS
|
1
|
| 1 |
IC50 = 862 nM
|
|
|
|
CP0546735
|
1-[(2R)-4-[4-(2-tert-butylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-(3,5-dimethyl-1,2,4-triazol-1-yl)ethanone
Show/Hide
|
C23H29F3N8OS
|
1
|
| 1 |
IC50 = 1030 nM
|
|
|
|
CP0490947
|
US9266876, 144
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|
C24H24N8OS
|
1
|
| 1 |
IC50 = 1050 nM
|
|
|
|
CP0570252
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-4-[4-(6-methoxypyridin-3-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C21H24F3N7O2S
|
1
|
| 1 |
IC50 = 1170 nM
|
|
|
|
CP0543593
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-4-[4-(2-ethylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C21H25F3N8OS
|
1
|
| 1 |
IC50 = 1430 nM
|
|
|
|
CP0413582
|
US9266876, 223
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|
C26H29N9OS
|
1
|
| 1 |
IC50 = 2360 nM
|
|
|
|
CP0519216
|
US9266876, 113
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|
C26H26N8O2S
|
1
|
| 1 |
IC50 = 6220 nM
|
|
|
|
CP0526109
|
US9266876, 47
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|
C23H22N8OS
|
1
|
| 1 |
IC50 = 8030 nM
|
|
|
|
CP0550334
|
US9266876, 225
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|
C24H24N8O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
