Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[(2R)-4-[4-[2-[2-(dimethylamino)ethoxy]pyrimidin-5-yl]-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-imidazo[4,5-b]pyridin-3-ylethanone
    Show/Hide
 PubChem ID
CID: 168296640
Canonical SMILES
C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1sc(nc1-c1cnc(OCCN(C)C)nc1)C(F)(F)F
    Show/Hide
Compound Formula C25H28F3N9O2S
Compound Structure
Protein Name
 Protein Info 
C-X-C chemokine receptor type 3
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CXC chemokine receptor
Uniprot ID
P49682
Gene Name
CXCR3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 6.7 nM
   TI
   LI
   LO
   TS
CL000043 U2OS
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS