| Compound ID |
Compound Name |
Compound Formula |
|
CP0486368
|
US9266876, 239
Show/Hide
|
C24H28F3N9OS
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0526130
|
US9266876, 175
Show/Hide
|
C21H19ClF3N7OS
|
2
|
| 1 |
IC50 = 0.1 nM
|
|
|
| 2 |
IC50 = 1.7 nM
|
|
|
|
CP0565453
|
US9266876, 176
Show/Hide
|
C22H22F3N7OS
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0490126
|
US9266876, 174
Show/Hide
|
C22H22F3N7OS
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0537474
|
US9266876, 23
Show/Hide
|
C24H22ClN7OS
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0566363
|
US9266876, 141
Show/Hide
|
C24H23N7OS
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0493170
|
US9266876, 187
Show/Hide
|
C25H22F2N6O2S
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0545938
|
US9266876, 169
Show/Hide
|
C23H20F3N9OS
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0515276
|
US9266876, 91
Show/Hide
|
C23H20F2N8OS
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0559787
|
US9266876, 199
Show/Hide
|
C24H23F3N6OS
|
2
|
| 1 |
IC50 = 0.4 nM
|
|
|
| 2 |
IC50 = 6.1 nM
|
|
|
|
CP0384800
|
US9266876, 96
Show/Hide
|
C23H21FN8OS
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0546363
|
US9266876, 173
Show/Hide
|
C21H20F3N7OS
|
2
|
| 1 |
IC50 = 0.5 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0576436
|
US9266876, 94
Show/Hide
|
C24H23ClN8OS
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0400471
|
US9266876, 80
Show/Hide
|
C23H21BrN8OS
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 2.8 nM
|
|
|
|
CP0413520
|
US9266876, 166
Show/Hide
|
C26H25F3N8O2S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0413521
|
US9266876, 167
Show/Hide
|
C26H23F3N8O3S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0413522
|
US9266876, 191
Show/Hide
|
C22H22F3N7OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0413583
|
US9266876, 230
Show/Hide
|
C22H22F4N8OS
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 3.1 nM
|
|
|
|
CP0419587
|
US9266876, 85
Show/Hide
|
C24H24N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0471295
|
US9266876, 83
Show/Hide
|
C23H21ClN8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0471296
|
US9266876, 92
Show/Hide
|
C24H21F3N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0471297
|
US9266876, 100
Show/Hide
|
C29H26N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0471301
|
US9266876, 162
Show/Hide
|
C26H26N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0471302
|
US9266876, 165
Show/Hide
|
C26H23F3N8O2S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0471306
|
US9266876, 229
Show/Hide
|
C25H27N9OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0478041
|
US9266876, 26
Show/Hide
|
C24H21ClFN7OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0483302
|
US9266876, 193
Show/Hide
|
C22H19F6N7OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0486305
|
US9266876, 213
Show/Hide
|
C21H21F3N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0486308
|
US9266876, 171
Show/Hide
|
C22H19F3N10OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0486367
|
US9266876, 238
Show/Hide
|
C27H31F3N8O2S
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 3.3 nM
|
|
|
|
CP0490944
|
US9266876, 115
Show/Hide
|
C23H22N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0490951
|
US9266876, 159
Show/Hide
|
C24H24N8O2S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0493162
|
US9266876, 93
Show/Hide
|
C24H20ClF3N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0493164
|
US9266876, 99
Show/Hide
|
C25H26N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0493165
|
US9266876, 147
Show/Hide
|
C24H20ClF3N8OS
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 2.8 nM
|
|
|
|
CP0494876
|
US9266876, 103
Show/Hide
|
C26H23F3N6O2S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0494877
|
US9266876, 104
Show/Hide
|
C24H21F3N8O2S
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 2.6 nM
|
|
|
|
CP0499629
|
US9266876, 211
Show/Hide
|
C25H29F3N8OS
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 2.7 nM
|
|
|
|
CP0513393
|
US9266876, 172
Show/Hide
|
C25H22F3N7OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0514629
|
US9266876, 210
Show/Hide
|
C25H27F3N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0515249
|
US9266876, 202
Show/Hide
|
C24H21F3N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0519481
|
US9266876, 18
Show/Hide
|
C25H25N7OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0526124
|
US9266876, 86
Show/Hide
|
C27H30N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0526126
|
US9266876, 146
Show/Hide
|
C25H26N8OS
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 1.8 nM
|
|
|
|
CP0537475
|
US9266876, 24
Show/Hide
|
C28H31N7OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0545814
|
US9266876, 208
Show/Hide
|
C29H32F3N7OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0546731
|
US9266876, 51
Show/Hide
|
C24H21F3N8OS
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 1.6 nM
|
|
|
|
CP0554639
|
US9266876, 72
Show/Hide
|
C24H23ClN8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0554641
|
US9266876, 89
Show/Hide
|
C23H20ClFN8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0557220
|
US9266876, 84
Show/Hide
|
C24H21ClN6O3S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0557221
|
US9266876, 88
Show/Hide
|
C26H28N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0559786
|
US9266876, 192
Show/Hide
|
C23H24F3N7OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0559912
|
US9266876, 231
Show/Hide
|
C22H21F5N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0561598
|
US9266876, 22
Show/Hide
|
C25H25N7OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0562364
|
US9266876, 28
Show/Hide
|
C24H21F2N7OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0564096
|
US9266876, 190
Show/Hide
|
C27H23F3N6OS
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 23 nM
|
|
|
|
CP0564101
|
US9266876, 87
Show/Hide
|
C24H23ClN8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0564461
|
US9266876, 164
Show/Hide
|
C26H25F3N8O3S
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 2.1 nM
|
|
|
|
CP0564871
|
US9266876, 207
Show/Hide
|
C20H18BrF3N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0564873
|
US9266876, 226
Show/Hide
|
C23H19F3N8OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0576419
|
US9266876, 143
Show/Hide
|
C24H22ClN7OS
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0546730
|
3-chloro-N-[2-[4-(2-imidazo[4,5-b]pyridin-3-ylacetyl)piperazin-1-yl]phenyl]benzamide
Show/Hide
|
C25H23ClN6O2
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0513396
|
US9266876, 179
Show/Hide
|
C26H30F3N9OS
|
2
|
| 1 |
IC50 = 1.6 nM
|
|
|
| 2 |
IC50 = 2 nM
|
|
|
|
CP0406929
|
US9266876, 237
Show/Hide
|
C28H34F3N9OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0413581
|
US9266876, 215
Show/Hide
|
C25H27F3N8OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0419588
|
US9266876, 90
Show/Hide
|
C23H20F2N8OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0435120
|
US9266876, 57
Show/Hide
|
C25H24N6OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0466308
|
US9266876, 16
Show/Hide
|
C24H23N7OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0479641
|
US9266876, 119
Show/Hide
|
C26H24N6OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0483299
|
US9266876, 74
Show/Hide
|
C25H22F3N7O3S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0483323
|
US9266876, 205
Show/Hide
|
C26H21F5N6O2S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0486306
|
US9266876, 214
Show/Hide
|
C26H31F3N8OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0486365
|
US9266876, 189
Show/Hide
|
C26H23F3N8OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0490125
|
US9266876, 142
Show/Hide
|
C24H22ClN7OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0490947
|
US9266876, 144
Show/Hide
|
C24H24N8OS
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 9 nM
|
|
|
|
CP0493163
|
US9266876, 97
Show/Hide
|
C23H21FN8OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0494882
|
US9266876, 240
Show/Hide
|
C27H32F3N9OS
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 2.2 nM
|
|
|
|
CP0513395
|
US9266876, 178
Show/Hide
|
C22H23F3N8OS
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 3.2 nM
|
|
|
|
CP0516428
|
US9266876, 206
Show/Hide
|
C24H21F3N8OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0519483
|
US9266876, 31
Show/Hide
|
C25H25N7O2S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0526106
|
US9266876, 21
Show/Hide
|
C24H22FN7OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0526129
|
US9266876, 161
Show/Hide
|
C26H25F3N8O3S
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 3.2 nM
|
|
|
|
CP0529243
|
US9266876, 32
Show/Hide
|
C25H22F3N7O2S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0545815
|
US9266876, 216
Show/Hide
|
C25H27F3N8OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0554629
|
US9266876, 241
Show/Hide
|
C23H22F6N8O2S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0557376
|
US9266876, 201
Show/Hide
|
C26H23F3N8OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0562366
|
US9266876, 61
Show/Hide
|
C25H21N7OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0565790
|
US9266876, 160
Show/Hide
|
C25H23F3N8O2S
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 4.6 nM
|
|
|
|
CP0567687
|
US9266876, 180
Show/Hide
|
C23H25F3N8OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0567689
|
US9266876, 198
Show/Hide
|
C23H22F3N7O3S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0574014
|
US9266876, 30
Show/Hide
|
C25H25N7O3S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0576441
|
US9266876, 139
Show/Hide
|
C24H25N7OS
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0543476
|
2-(benzimidazol-1-yl)-1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C24H24F3N7O2S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0550340
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-(5-methylpyrazol-1-yl)ethanone
Show/Hide
|
C21H24F3N7O2S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0572651
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-imidazo[4,5-b]pyridin-3-ylethanone
Show/Hide
|
C23H23F3N8O2S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0567946
|
2-(3,5-dimethylpyrazol-1-yl)-1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C22H26F3N7O2S
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
|
CP0494881
|
US9266876, 236
Show/Hide
|
C25H25F3N10O2S
|
2
|
| 1 |
IC50 = 2.5 nM
|
|
|
| 2 |
IC50 = 3 nM
|
|
|
|
CP0569010
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[2-(trifluoromethyl)-4-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C20H20F6N8OS
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0471303
|
US9266876, 168
Show/Hide
|
C27H25F3N8O2S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0479639
|
US9266876, 118
Show/Hide
|
C27H25N5OS
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0489708
|
US9266876, 116
Show/Hide
|
C23H22N8OS
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0494883
|
US9266876, 243
Show/Hide
|
C22H23F3N8OS
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0494915
|
US9266876, 38
Show/Hide
|
C23H20BrN7OS
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0513394
|
US9266876, 177
Show/Hide
|
C27H24F3N7OS
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0515413
|
US9266876, 44
Show/Hide
|
C24H23N7OS
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0518006
|
US9266876, 35
Show/Hide
|
C24H21Cl2N7O2S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0519482
|
US9266876, 27
Show/Hide
|
C25H24ClN7OS
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0526108
|
US9266876, 46
Show/Hide
|
C24H23N7OS
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0526113
|
US9266876, 65
Show/Hide
|
C23H20ClN7OS
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0526127
|
US9266876, 152
Show/Hide
|
C25H24N6O3S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0540381
|
US9266876, 209
Show/Hide
|
C25H27F3N8OS
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 3.6 nM
|
|
|
|
CP0563766
|
US9266876, 132
Show/Hide
|
C24H23N7OS
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0565484
|
US9266876, 25
Show/Hide
|
C25H25N7O3S2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0566362
|
US9266876, 130
Show/Hide
|
C24H22N6O2S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0572652
|
1-[2-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-oxoethyl]-3H-indol-2-one
Show/Hide
|
C25H25F3N6O3S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0546734
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-(3-methylpyrazol-1-yl)ethanone
Show/Hide
|
C21H24F3N7O2S
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0952072
|
2-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-1-[(R)-2-methyl-4-(4-(4-methyl-1H-benzoimidazol-2-yl)-2-trifluoromethyl-thiazol-5-yl]-piperazin-1-yl]-ethanone
Show/Hide
|
C23H25F3N8OS
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0970424
|
2-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-1-[(R)-4-[4-(4-fluoro-6-morpholin-4yl-1H-benzoimidazol-2-yl)-2-trifluoromethyl-thiazol-5-yl]-2-methyl-piperazin-1-yl]-ethanone
Show/Hide
|
C26H29F4N9O2S
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0569956
|
3-[2-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-oxoethyl]-1,3-benzoxazol-2-one
Show/Hide
|
C24H23F3N6O4S
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0572644
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-2-methyl-4-[4-(2-propylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C24H25F3N8OS
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0571706
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[4-(2-propan-2-yloxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C22H27F3N8O2S
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0550342
|
1-[(2R)-4-[4-(2-cyclopropylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-(3,5-dimethyl-1,2,4-triazol-1-yl)ethanone
Show/Hide
|
C22H25F3N8OS
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0573963
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[4-(2-pyrrolidin-1-ylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C23H28F3N9OS
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0543561
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-2-methyl-4-[4-(2-methylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C22H21F3N8OS
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0546732
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-pyrrolo[3,2-c]pyridin-1-ylethanone
Show/Hide
|
C24H24F3N7O2S
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0962136
|
2-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-1-[(R)-4-[4-(4-fluoro-5-morpholin-4yl-1H-benzoimidazol-2-yl)-2-trifluoromethyl-thiazol-5-yl]-2-methyl-piperazin-1-yl]-ethanone
Show/Hide
|
C26H29F4N9O2S
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0964909
|
2-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-1-[(R)-2-methyl-4-(4-(5-trifluoromethoxy-1H-benzoimidazol-2-yl)-2-trifluoromethyl-thiazol-5-yl]-piperazin-1-yl]-ethanone
Show/Hide
|
C25H20F6N8O2S
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0551916
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-pyrrolo[2,3-b]pyridin-1-ylethanone
Show/Hide
|
C24H24F3N7O2S
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0567919
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-[3-(trifluoromethyl)-1,2,4-triazol-1-yl]ethanone
Show/Hide
|
C20H20F6N8O2S
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0567922
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-4-[4-(2-methoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C22H21F3N8O2S
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0571705
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-[3-(trifluoromethyl)pyrazol-1-yl]ethanone
Show/Hide
|
C21H21F6N7O2S
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0515252
|
US9266876, 242
Show/Hide
|
C25H28F3N9O2S
|
2
|
| 1 |
IC50 = 3.8 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
|
CP0477961
|
US9266876, 49
Show/Hide
|
C24H24N8OS
|
2
|
| 1 |
IC50 = 3.9 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
|
CP0970506
|
2-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-1-[(R)-4-[4-(4-fluoro-5-hydroxy-1H-benzoimidazol-2-yl)-2-trifluoromethyl-thiazol-5-yl]-2-methyl-piperazin-1-yl]-ethanone
Show/Hide
|
C22H22F4N8O2S
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0471305
|
US9266876, 228
Show/Hide
|
C26H26F3N9OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0486310
|
US9266876, 186
Show/Hide
|
C25H24N8OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0512352
|
US9266876, 108
Show/Hide
|
C24H21FN6OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0514630
|
US9266876, 212
Show/Hide
|
C21H21F3N8OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0515250
|
US9266876, 219
Show/Hide
|
C25H25F3N6OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0516439
|
US9266876, 95
Show/Hide
|
C24H21F3N8OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0518483
|
US9266876, 56
Show/Hide
|
C24H21FN6OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0519218
|
US9266876, 138
Show/Hide
|
C23H22N8OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0526107
|
US9266876, 29
Show/Hide
|
C24H22ClN7O2S
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0526128
|
US9266876, 157
Show/Hide
|
C25H22N6O3S
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0555355
|
US9266876, 37
Show/Hide
|
C25H24ClN7O2S
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0557375
|
US9266876, 188
Show/Hide
|
C25H24N8OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0561599
|
US9266876, 59
Show/Hide
|
C25H21N7OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0565452
|
US9266876, 151
Show/Hide
|
C27H28N6O2S
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0574017
|
US9266876, 55
Show/Hide
|
C24H21FN6OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0578313
|
1-[(2R)-4-[4-(2-cyclobutyloxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-(3,5-dimethyl-1,2,4-triazol-1-yl)ethanone
Show/Hide
|
C23H27F3N8O2S
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0543586
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-4-[4-(6-methoxypyridin-3-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C23H22F3N7O2S
|
1
|
| 1 |
IC50 = 4.1 nM
|
|
|
|
CP0550339
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-pyrazolo[3,4-b]pyridin-1-ylethanone
Show/Hide
|
C23H23F3N8O2S
|
1
|
| 1 |
IC50 = 4.1 nM
|
|
|
|
CP0577506
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[2-(trifluoromethyl)-4-[6-(trifluoromethyl)pyridin-3-yl]-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C21H21F6N7OS
|
1
|
| 1 |
IC50 = 4.2 nM
|
|
|
|
CP0577899
|
3-chloro-N-[2-[4-(2-imidazo[4,5-b]pyridin-3-ylacetyl)piperazin-1-yl]pyridin-3-yl]benzamide
Show/Hide
|
C24H22ClN7O2
|
1
|
| 1 |
IC50 = 4.2 nM
|
|
|
|
CP0543591
|
1-[4-[2-(1H-benzimidazol-2-yl)phenyl]piperazin-1-yl]-2-imidazo[4,5-b]pyridin-3-ylethanone
Show/Hide
|
C25H23N7O
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
|
CP0569001
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[4-(2-propylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C22H27F3N8OS
|
1
|
| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0546729
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-4-[4-[2-(2-methoxyethoxy)pyrimidin-5-yl]-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C24H25F3N8O3S
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0479642
|
US9266876, 137
Show/Hide
|
C23H22N8OS
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0493167
|
US9266876, 158
Show/Hide
|
C25H26N8O3S
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0539815
|
US9266876, 33
Show/Hide
|
C25H25N7O3S
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0545937
|
US9266876, 163
Show/Hide
|
C27H27F3N8O3S
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0564097
|
US9266876, 203
Show/Hide
|
C27H24F3N7OS
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0543592
|
2-(4-chloropyrazol-1-yl)-1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C20H21ClF3N7O2S
|
1
|
| 1 |
IC50 = 5.1 nM
|
|
|
|
CP0514634
|
US9266876, 233
Show/Hide
|
C26H30F3N9O2S
|
2
|
| 1 |
IC50 = 5.7 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
|
CP0494880
|
US9266876, 234
Show/Hide
|
C24H24F3N11OS
|
2
|
| 1 |
IC50 = 5.8 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
|
CP0517372
|
US9266876, 17
Show/Hide
|
C23H22N8OS
|
2
|
| 1 |
IC50 = 5.9 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
|
CP0471294
|
US9266876, 77
Show/Hide
|
C25H24N6O2S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0490945
|
US9266876, 140
Show/Hide
|
C23H21ClN8OS
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0514633
|
US9266876, 221
Show/Hide
|
C26H29F3N8OS
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0515245
|
US9266876, 170
Show/Hide
|
C23H20F3N9OS
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0515246
|
US9266876, 196
Show/Hide
|
C26H22F3N7O2S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0526112
|
US9266876, 62
Show/Hide
|
C25H23ClN6O2S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0557377
|
US9266876, 204
Show/Hide
|
C27H24F3N7OS
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0563434
|
US9266876, 155
Show/Hide
|
C23H21N7O3S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0565785
|
US9266876, 71
Show/Hide
|
C22H20N8O2S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0565786
|
US9266876, 73
Show/Hide
|
C26H26N8OS
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 9.7 nM
|
|
|
|
CP0577759
|
US9266876, 133
Show/Hide
|
C25H23N5OS2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0958001
|
US9266876, 79
Show/Hide
|
C24H22N8OS
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0559913
|
US9266876, 232
Show/Hide
|
C23H22F6N8OS
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 7 nM
|
|
|
|
CP0550338
|
1-[(2R)-4-[4-[2-[2-(dimethylamino)ethoxy]pyrimidin-5-yl]-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-imidazo[4,5-b]pyridin-3-ylethanone
Show/Hide
|
C25H28F3N9O2S
|
1
|
| 1 |
IC50 = 6.7 nM
|
|
|
|
CP0551814
|
1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-pyrazol-1-ylethanone
Show/Hide
|
C20H22F3N7O2S
|
1
|
| 1 |
IC50 = 6.9 nM
|
|
|
|
CP0512355
|
US9266876, 153
Show/Hide
|
C24H21FN6O3S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0575647
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-4-[4-(2-ethoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C21H25F3N8O2S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0480100
|
US9266876, 194
Show/Hide
|
C20H19F3N8OS
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0490124
|
US9266876, 131
Show/Hide
|
C25H24N6O2S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0500941
|
US9266876, 227
Show/Hide
|
C24H28F3N9OS
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0514631
|
US9266876, 218
Show/Hide
|
C24H28F3N9OS
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0515248
|
US9266876, 197
Show/Hide
|
C20H19F3N8OS
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0537476
|
US9266876, 60
Show/Hide
|
C24H21ClN6OS
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0567681
|
US9266876, 68
Show/Hide
|
C24H22N6O2S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0567688
|
US9266876, 195
Show/Hide
|
C21H20F3N7O2S
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
|
CP0546735
|
1-[(2R)-4-[4-(2-tert-butylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]-2-(3,5-dimethyl-1,2,4-triazol-1-yl)ethanone
Show/Hide
|
C23H29F3N8OS
|
1
|
| 1 |
IC50 = 8.7 nM
|
|
|
|
CP0573965
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-4-[4-(6-ethoxypyridin-3-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C22H26F3N7O2S
|
1
|
| 1 |
IC50 = 8.8 nM
|
|
|
|
CP0384801
|
US9266876, 98
Show/Hide
|
C24H24N8OS
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0400470
|
US9266876, 67
Show/Hide
|
C24H23N7OS
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0519216
|
US9266876, 113
Show/Hide
|
C26H26N8O2S
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 53 nM
|
|
|
|
CP0526110
|
US9266876, 50
Show/Hide
|
C26H28N8OS
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 14 nM
|
|
|
|
CP0579815
|
1-[4-[2-(1H-benzimidazol-2-yl)pyridin-3-yl]piperazin-1-yl]-2-imidazo[4,5-b]pyridin-3-ylethanone
Show/Hide
|
C24H22N8O
|
1
|
| 1 |
IC50 = 9.3 nM
|
|
|
|
CP0966280
|
2-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-1-[(R)-4-[4-(4-fluoro-5-(1-hydroxy-1-methyl-ethyl)-1H-benzoimidazol-2-yl)-2-trifluoromethyl-thiazol-5-yl]-2-methyl-piperazin-1-yl]-ethanone
Show/Hide
|
C25H28F4N8O2S
|
1
|
| 1 |
IC50 = 9.4 nM
|
|
|
|
CP0493161
|
US9266876, 76
Show/Hide
|
C25H25N7O3S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0515242
|
US9266876, 124
Show/Hide
|
C25H24N6OS
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0521707
|
US9266876, 34
Show/Hide
|
C24H22FN7O2S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0564103
|
US9266876, 112
Show/Hide
|
C24H23N7O3S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0970423
|
2-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-1-[(R)-4-[4-(6-methanesulfonyl-1H-benzoimidazol-2-yl)-2-trifluoromethyl-thiazol-5-yl]-2-methyl-piperazin-1-yl]-ethanone
Show/Hide
|
C23H25F3N8O3S2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0490948
|
US9266876, 145
Show/Hide
|
C25H25ClN6OS
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0526105
|
US9266876, 14
Show/Hide
|
C22H20N8OS
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 30 nM
|
|
|
|
CP0559819
|
US9266876, 78
Show/Hide
|
C24H22N6O3S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0419586
|
US9266876, 70
Show/Hide
|
C24H23N7OS
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0561600
|
US9266876, 63
Show/Hide
|
C25H23FN6OS
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0572643
|
2-imidazo[4,5-b]pyridin-3-yl-1-[(2R)-4-[4-(4-methoxyphenyl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C24H23F3N6O2S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0490941
|
US9266876, 101
Show/Hide
|
C26H27N7O4S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0490942
|
US9266876, 102
Show/Hide
|
C27H29N7O4S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0515244
|
US9266876, 154
Show/Hide
|
C25H25N7O2S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0519480
|
US9266876, 15
Show/Hide
|
C23H21N7OS
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0543593
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-4-[4-(2-ethylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C21H25F3N8OS
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0477962
|
US9266876, 53
Show/Hide
|
C24H20Cl2N6OS
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0478043
|
US9266876, 39
Show/Hide
|
C25H25N7OS
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0537473
|
US9266876, 4
Show/Hide
|
C24H22N6OS
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0563390
|
US9266876, 3
Show/Hide
|
C24H23N7O2S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0563435
|
US9266876, 183
Show/Hide
|
C27H31F3N8O2S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0565787
|
US9266876, 75
Show/Hide
|
C25H22N8O2S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0471304
|
US9266876, 222
Show/Hide
|
C27H31F3N8OS
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0952873
|
1-[(R)-4-(4-(1H-Benzoimidazol-2-yl)-2-trifluoromethyl-thiazol-5-yl]-2-methyl-piperazin-1-yl]-2-(4,4-difluoro-piperidin-1-yl)-ethanone
Show/Hide
|
C23H25F5N6OS
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0471299
|
US9266876, 120
Show/Hide
|
C26H24N6OS
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0513392
|
US9266876, 149
Show/Hide
|
C30H28N8OS
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0554642
|
US9266876, 109
Show/Hide
|
C23H21N7OS
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0478042
|
US9266876, 36
Show/Hide
|
C26H27N7O4S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0526109
|
US9266876, 47
Show/Hide
|
C23H22N8OS
|
2
|
| 1 |
IC50 = 18 nM
|
|
|
| 2 |
IC50 = 67 nM
|
|
|
|
CP0570252
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-4-[4-(6-methoxypyridin-3-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C21H24F3N7O2S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0514632
|
US9266876, 220
Show/Hide
|
C25H25F3N6OS
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0550341
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[4-(2-methylpyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]piperazin-1-yl]ethanone
Show/Hide
|
C20H23F3N8OS
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0494916
|
US9266876, 40
Show/Hide
|
C24H23N7OS
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0545816
|
US9266876, 217
Show/Hide
|
C24H25F3N8OS
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0515253
|
US9266876, 244
Show/Hide
|
C28H34F3N9OS
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0557219
|
US9266876, 81
Show/Hide
|
C30H28N8OS
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0578558
|
US9266876, 148
Show/Hide
|
C29H25FN8OS
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0546733
|
2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-4-[4-(2-methoxypyrimidin-5-yl)-2-(trifluoromethyl)-1,3-thiazol-5-yl]-2-methylpiperazin-1-yl]ethanone
Show/Hide
|
C20H23F3N8O2S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0563767
|
US9266876, 136
Show/Hide
|
C25H25N5O2S
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0413582
|
US9266876, 223
Show/Hide
|
C26H29N9OS
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0576420
|
US9266876, 182
Show/Hide
|
C24H27F3N8OS
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0480101
|
US9266876, 200
Show/Hide
|
C26H23F3N8OS
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0478040
|
US9266876, 1
Show/Hide
|
C23H21N7OS
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0515251
|
US9266876, 235
Show/Hide
|
C26H28F3N9O2S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0539878
|
US9266876, 66
Show/Hide
|
C24H23N7OS
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0162997
|
(1S,2S,4R)-1-(((S)-4-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-3-methylpiperazin-1-ylsulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-ol
Show/Hide
|
C21H29F4N3O3S
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0493556
|
(1S,2S,4R)-7,7-dimethyl-1-[[(3S)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-ol
Show/Hide
|
C21H30F3N3O3S
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0519477
|
US9266876, 5
Show/Hide
|
C20H18F3N7OS
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0562365
|
US9266876, 58
Show/Hide
|
C25H24N6OS
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0564095
|
US9266876, 185
Show/Hide
|
C24H26F3N7O2S
|
2
|
| 1 |
IC50 = 37 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0460060
|
(2S)-4-[[(1'S,4'R)-7',7'-dimethylspiro[1,3-dioxolane-2,2'-bicyclo[2.2.1]heptane]-1'-yl]methylsulfonyl]-1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-2-methylpiperazine
Show/Hide
|
C23H31F4N3O4S
|
1
|
| 1 |
IC50 = 39.81 nM
|
|
|
|
CP0545935
|
US9266876, 121
Show/Hide
|
C25H23N7OS
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0968852
|
1-[(R)-4-(4-(1H-Benzoimidazol-2-yl)-2-trifluoromethyl-thiazol-5-yl]-2-methyl-piperazin-1-yl]-2-(3-methoxy-pyrrolidin-1-yl)-ethanone
Show/Hide
|
C23H27F3N6O2S
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0512354
|
US9266876, 150
Show/Hide
|
C30H28N8OS
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0515243
|
US9266876, 128
Show/Hide
|
C25H23FN6OS
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0563415
|
US9266876, 45
Show/Hide
|
C23H22N8OS
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0878614
|
(1S,4R)-1-(((S)-4-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-3-methylpiperazin-1-ylsulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-ol
Show/Hide
|
C21H29F4N3O3S
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0545068
|
US9266876, 184
Show/Hide
|
C22H22F3N7OS
|
2
|
| 1 |
IC50 = 53 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0550334
|
US9266876, 225
Show/Hide
|
C24H24N8O2S
|
2
|
| 1 |
IC50 = 54 nM
|
|
|
| 2 |
IC50 = 171 nM
|
|
|
|
CP0957977
|
US9266876, 43
Show/Hide
|
C25H25N7O2S
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0486309
|
US9266876, 181
Show/Hide
|
C27H31F3N8OS
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0478448
|
(1S,2R,4R)-1-[[(3S)-4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-3-methylpiperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-ol
Show/Hide
|
C21H29F4N3O3S
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0493166
|
US9266876, 156
Show/Hide
|
C23H21N7O3S
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0577283
|
US9266876, 126
Show/Hide
|
C26H26N6O2S
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0970574
|
2-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-1-((R)-2-methyl-4-[4-[6-(oxetan-3-yloxy)-1H-benzoimidazol-2-yl]-2-trifluoromethyl-thiazol-5-yl]-piperazin-1-yl]-ethanone
Show/Hide
|
C25H27F3N8O3S
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0501514
|
US9266876, 69
Show/Hide
|
C24H23N7O2S
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0562855
|
US9266876, 123
Show/Hide
|
C25H24N6OS
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0567682
|
US9266876, 125
Show/Hide
|
C26H26N6OS
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0545934
|
US9266876, 117
Show/Hide
|
C27H25N5OS
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0519484
|
US9266876, 41
Show/Hide
|
C29H25N7OS
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0565333
|
US9266876, 107
Show/Hide
|
C25H24N6O2S
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0170956
|
(1S,4R)-1-(((S)-4-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-3-methylpiperazin-1-ylsulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H27F4N3O3S
|
1
|
| 1 |
IC50 = 79.43 nM
|
|
|
|
CP0512353
|
US9266876, 135
Show/Hide
|
C26H25N5O3S
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0562305
|
US9266876, 105
Show/Hide
|
C25H26N6OS
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0529276
|
US9266876, 9
Show/Hide
|
C24H23N7OS
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0529277
|
US9266876, 13
Show/Hide
|
C21H23N7OS
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0554640
|
US9266876, 82
Show/Hide
|
C30H28N8O2S
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0557374
|
US9266876, 106
Show/Hide
|
C24H24N6O2S
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0565791
|
US9266876, 224
Show/Hide
|
C27H27N7O3S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0566361
|
US9266876, 129
Show/Hide
|
C24H22ClN7OS
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0495507
|
US9266876, 64
Show/Hide
|
C24H20F3N7OS
|
1
|
| 1 |
IC50 = 111 nM
|
|
|
|
CP0526111
|
US9266876, 54
Show/Hide
|
C25H21F3N6OS
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0562363
|
US9266876, 134
Show/Hide
|
C25H22ClN5OS2
|
1
|
| 1 |
IC50 = 115 nM
|
|
|
|
CP0472356
|
(1S,4R)-7,7-dimethyl-1-[[(3S)-3-methyl-4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C20H27F3N4O3S
|
1
|
| 1 |
IC50 = 125.89 nM
|
|
|
|
CP0518005
|
US9266876, 6
Show/Hide
|
C20H21N7OS
|
1
|
| 1 |
IC50 = 130 nM
|
|
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CP0563417
|
US9266876, 52
Show/Hide
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C25H24N6O2S
|
1
|
| 1 |
IC50 = 136 nM
|
|
|
|
CP0515241
|
US9266876, 122
Show/Hide
|
C25H24N6O3S
|
1
|
| 1 |
IC50 = 152 nM
|
|
|
|
CP0441617
|
(1S,4R)-7,7-dimethyl-1-[[(3S)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H28F3N3O3S
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0453623
|
(1S,4R)-1-[[4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C20H25F4N3O3S
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0481268
|
(1S,4R)-7,7-dimethyl-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-ol
Show/Hide
|
C20H28F3N3O3S
|
1
|
| 1 |
IC50 = 158.49 nM
|
|
|
|
CP0493557
|
(1S,4R)-7,7-dimethyl-1-[[(3S)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-ol
Show/Hide
|
C21H30F3N3O3S
|
1
|
| 1 |
IC50 = 158.49 nM
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|
|
|
CP0543594
|
3-chloro-N-[3-[4-(2-imidazo[4,5-b]pyridin-3-ylacetyl)piperazin-1-yl]pyridin-2-yl]benzamide
Show/Hide
|
C24H22ClN7O2
|
1
|
| 1 |
IC50 = 177 nM
|
|
|
|
CP0435118
|
US9266876, 2
Show/Hide
|
C24H23N7OS
|
1
|
| 1 |
IC50 = 198 nM
|
|
|
|
CP0386462
|
(1S,4R)-2,7,7-trimethyl-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-ol
Show/Hide
|
C21H30F3N3O3S
|
1
|
| 1 |
IC50 = 199.53 nM
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|
|
|
CP0459501
|
1-[[(1'S,4'R)-7',7'-dimethylspiro[1,3-dioxolane-2,2'-bicyclo[2.2.1]heptane]-1'-yl]methylsulfonyl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
Show/Hide
|
C22H30F3N3O4S
|
1
|
| 1 |
IC50 = 199.53 nM
|
|
|
|
CP0459495
|
(1S,4R)-7,7-dimethyl-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C20H26F3N3O3S
|
1
|
| 1 |
IC50 = 251.19 nM
|
|
|
|
CP0511549
|
(1S,4R)-1-[[4-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C20H25ClF3N3O3S
|
1
|
| 1 |
IC50 = 251.19 nM
|
|
|
|
CP0564102
|
US9266876, 111
Show/Hide
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C23H22FN5O2S
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0519479
|
US9266876, 11
Show/Hide
|
C21H22N6OS2
|
1
|
| 1 |
IC50 = 311 nM
|
|
|
|
CP0547480
|
US9266876, 12
Show/Hide
|
C24H22N6O3S
|
1
|
| 1 |
IC50 = 314 nM
|
|
|
|
CP0486598
|
(1S,4R)-1-[[(3S)-4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-3-(hydroxymethyl)piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H27F4N3O4S
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0525944
|
(1S,2R,4R)-7,7-dimethyl-1-[[(3S)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-ol
Show/Hide
|
C21H30F3N3O3S
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0535053
|
(1S,4R)-1-[[4-[3,6-dichloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C20H24Cl2F3N3O3S
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0536719
|
(1S,4R)-7,7-dimethyl-1-[[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C19H25F3N4O3S
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0932993
|
(1S,4R)-7,7-dimethyl-1-((3-methyl-4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-ylsulfonyl)methyl)bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H28F3N3O3S
|
1
|
| 1 |
IC50 = 316.23 nM
|
|
|
|
CP0952071
|
(S)-3-(2-[(R)-4-[4-(1H-Benzoimidazol-2-yl)-2-trifluoromethylthiazol-5-yl]-2-methyl-piperazin-1-yl)-2-oxo-ethyl)-4-phenyl-oxazolidin-2-one
Show/Hide
|
C27H25F3N6O3S
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0567920
|
N-[2-[4-[(1-methylbenzimidazol-2-yl)methyl]piperazin-1-yl]phenyl]furan-2-carboxamide
Show/Hide
|
C24H25N5O2
|
1
|
| 1 |
IC50 = 372 nM
|
|
|
|
CP0526104
|
US9266876, 8
Show/Hide
|
C22H19ClN8OS
|
1
|
| 1 |
IC50 = 392 nM
|
|
|
|
CP0522802
|
(1S,4R)-1-[[3-(hydroxymethyl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H28F3N3O4S
|
1
|
| 1 |
IC50 = 398.11 nM
|
|
|
|
CP0528540
|
(1S,4R)-1-[[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C20H25ClF3N3O3S
|
1
|
| 1 |
IC50 = 398.11 nM
|
|
|
|
CP0563416
|
US9266876, 48
Show/Hide
|
C23H21N7OS
|
1
|
| 1 |
IC50 = 448 nM
|
|
|
|
CP0576909
|
US9266876, 110
Show/Hide
|
C21H20N6OS
|
1
|
| 1 |
IC50 = 487 nM
|
|
|
|
CP0567683
|
US9266876, 127
Show/Hide
|
C25H23ClN6OS
|
1
|
| 1 |
IC50 = 490 nM
|
|
|
|
CP0550337
|
1-[4-[3-(1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl]-2-imidazo[4,5-b]pyridin-3-ylethanone
Show/Hide
|
C24H22N8O
|
1
|
| 1 |
IC50 = 496 nM
|
|
|
|
CP0456662
|
(1S,4R)-1-[[(3R)-4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-3-methylpiperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H27F4N3O3S
|
1
|
| 1 |
IC50 = 501.19 nM
|
|
|
|
CP0522801
|
(1S,4R)-7,7-dimethyl-1-[[(3R)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H28F3N3O3S
|
1
|
| 1 |
IC50 = 501.19 nM
|
|
|
|
CP0466180
|
US9266876, 7
Show/Hide
|
C20H20N6OS2
|
1
|
| 1 |
IC50 = 516 nM
|
|
|
|
CP0574016
|
US9266876, 42
Show/Hide
|
C23H20ClN7OS
|
1
|
| 1 |
IC50 = 547 nM
|
|
|
|
CP0481269
|
N-[(1S,4R)-7,7-dimethyl-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]-2-bicyclo[2.2.1]heptanyl]methanesulfonamide
Show/Hide
|
C21H31F3N4O4S2
|
1
|
| 1 |
IC50 = 630.96 nM
|
|
|
|
CP0495597
|
(1S,4R)-1-[[3-ethyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C22H30F3N3O3S
|
1
|
| 1 |
IC50 = 630.96 nM
|
|
|
|
CP0508207
|
(1S,4R)-7,7-dimethyl-1-[[2-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H28F3N3O3S
|
1
|
| 1 |
IC50 = 630.96 nM
|
|
|
|
CP0531152
|
(1S,4R)-1-[[4-(5-bromopyrimidin-2-yl)piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C18H25BrN4O3S
|
1
|
| 1 |
IC50 = 630.96 nM
|
|
|
|
CP0386461
|
1-[[(1S,4R)-2-fluoro-7,7-dimethyl-1-bicyclo[2.2.1]heptanyl]methylsulfonyl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
Show/Hide
|
C20H27F4N3O2S
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0388183
|
1-[(7,7-dimethyl-1-bicyclo[2.2.1]heptanyl)methylsulfonyl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
Show/Hide
|
C20H28F3N3O2S
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0457669
|
1-[(1S,4R)-7,7-dimethyl-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]-2-bicyclo[2.2.1]heptanyl]-3-ethylurea
Show/Hide
|
C23H34F3N5O3S
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0511542
|
(1S,4R)-7,7-dimethyl-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-amine
Show/Hide
|
C20H29F3N4O2S
|
1
|
| 1 |
IC50 = 794.33 nM
|
|
|
|
CP0519478
|
US9266876, 10
Show/Hide
|
C20H22N8OS
|
1
|
| 1 |
IC50 = 1070 nM
|
|
|
|
CP0473786
|
(1S,4R)-1-[[4-(5-bromopyridin-2-yl)piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C19H26BrN3O3S
|
1
|
| 1 |
IC50 = 1584.89 nM
|
|
|
|
CP0495598
|
(1R,4R)-7,7-dimethyl-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C20H26F3N3O3S
|
1
|
| 1 |
IC50 = 1584.89 nM
|
|
|
|
CP0456660
|
(1S,4R)-1-[[4-[2-fluoro-4-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H26F4N2O3S
|
1
|
| 1 |
IC50 = 1995.26 nM
|
|
|
|
CP0508209
|
N-[(1S,4R)-7,7-dimethyl-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]-2-bicyclo[2.2.1]heptanyl]acetamide
Show/Hide
|
C22H31F3N4O3S
|
1
|
| 1 |
IC50 = 1995.26 nM
|
|
|
|
CP0969615
|
1-(2-((R)-4-[4-(1H-Benzoimidazol-2-yl)-2-trifluoromethyl-thiazol-5-yl]-2-methyl-piperazin-1-yl)-2-oxo-ethyl)-1H-pyrazole-3-carboxylic Acid
Show/Hide
|
C22H20F3N7O3S
|
1
|
| 1 |
IC50 = 2100 nM
|
|
|
|
CP0562856
|
US9266876, Reference Example 114
Show/Hide
|
C22H20N8OS
|
2
|
| 1 |
IC50 = 2990 nM
|
|
|
| 2 |
IC50 = 4205 nM
|
|
|
|
CP0459497
|
(1S,4R)-7,7-dimethyl-1-[[4-[3-nitro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C20H25F3N4O5S
|
1
|
| 1 |
IC50 = 3162.28 nM
|
|
|
|
CP0578687
|
1-[4-[4-(1H-benzimidazol-2-yl)pyridazin-3-yl]piperazin-1-yl]-2-imidazo[4,5-b]pyridin-3-ylethanone
Show/Hide
|
C23H21N9O
|
1
|
| 1 |
IC50 = 4800 nM
|
|
|
|
CP0531153
|
(1S,4R)-7,7-dimethyl-1-[[4-[6-(trifluoromethyl)pyridazin-3-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C19H25F3N4O3S
|
1
|
| 1 |
IC50 = 5011.87 nM
|
|
|
|
CP0459498
|
(1S,4R)-7,7-dimethyl-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H28F3N3O3S
|
1
|
| 1 |
IC50 = 6309.57 nM
|
|
|
|
CP0528541
|
(1S,4R)-1-[[(2R,5S)-2,5-dimethyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C22H30F3N3O3S
|
1
|
| 1 |
IC50 = 6309.57 nM
|
|
|
|
CP0473790
|
(1S,4R)-N-ethyl-7,7-dimethyl-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-amine
Show/Hide
|
C22H33F3N4O2S
|
1
|
| 1 |
IC50 = 7943.28 nM
|
|
|
|
CP0522800
|
(1S,4R)-1-[[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H27N3O3S2
|
1
|
| 1 |
IC50 > 12589.25 nM
|
|
|
|
CP0388182
|
1-[(1S,4R)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]methanesulfonamide
Show/Hide
|
C21H28F3N3O3S
|
1
|
| 1 |
IC50 = 15848.93 nM
|
|
|
|
CP0456661
|
(1S,4R)-1-[(4-isoquinolin-3-ylpiperazin-1-yl)sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C23H29N3O3S
|
1
|
| 1 |
IC50 = 15848.93 nM
|
|
|
|
CP0511548
|
(1S,4R)-7,7-dimethyl-1-[[4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C20H26F3N3O3S
|
1
|
| 1 |
IC50 = 25118.86 nM
|
|
|
|
CP0528539
|
(1S,4R)-7,7-dimethyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C20H26F3N3O3S
|
1
|
| 1 |
IC50 = 25118.86 nM
|
|
|
|
CP0388180
|
6-[4-[[(1S,4R)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]methylsulfonyl]piperazin-1-yl]pyridine-3-carbonitrile
Show/Hide
|
C20H26N4O3S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0457667
|
(1S,4R)-7,7-dimethyl-1-[[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H27F3N2O3S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0459500
|
1-[(1S,4R)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]-N-methyl-N-[2-[methyl-[5-(trifluoromethyl)pyridin-2-yl]amino]ethyl]methanesulfonamide
Show/Hide
|
C20H28F3N3O3S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0481265
|
(1S,4R)-7,7-dimethyl-1-[(4-pyridin-2-ylpiperazin-1-yl)sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C19H27N3O3S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0481266
|
(1S,4R)-7,7-dimethyl-1-[[(1S,4S)-5-[5-(trifluoromethyl)pyridin-2-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H26F3N3O3S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0481267
|
(1S,4R)-7,7-dimethyl-1-[[3-propan-2-yl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C23H32F3N3O3S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0508167
|
(1S,4R)-7,7-dimethyl-1-[[4-[[5-(trifluoromethyl)pyridin-2-yl]amino]piperidin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H28F3N3O3S
|
1
|
| 1 |
IC50 = 31622.78 nM
|
|
|
|
CP0511547
|
(1S,4R)-7,7-dimethyl-1-[[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C20H26F3N3O3S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0522804
|
(1S,4R)-7,7-dimethyl-1-[[3-phenyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
Show/Hide
|
C26H30F3N3O3S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0525850
|
(1S,4R)-1-[[4-(5-acetylpyridin-2-yl)piperazin-1-yl]sulfonylmethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Show/Hide
|
C21H29N3O4S
|
1
|
| 1 |
IC50 > 31622.78 nM
|
|
|
|
CP0531151
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(1S,4R)-7,7-dimethyl-1-[[4-(5-nitropyridin-2-yl)piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
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C19H26N4O5S
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1
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| 1 |
IC50 > 31622.78 nM
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CP0536716
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(1S,4R)-7,7-dimethyl-1-[[4-(5-methylpyridin-2-yl)piperazin-1-yl]sulfonylmethyl]bicyclo[2.2.1]heptan-2-one
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C20H29N3O3S
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1
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| 1 |
IC50 > 31622.78 nM
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