| Compound ID |
Compound Name |
Compound Formula |
|
CP0012129
|
INCB-018424
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|
C17H18N6
|
1
|
| 1 |
EC50 = 186 nM
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|
|
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CP0357998
|
(E)-1-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]-4-phenylbut-2-ene-1,4-dione
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|
C30H30N6O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
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CP0219569
|
methyl (E)-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-enoate
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|
C25H30N6O2
|
1
|
| 1 |
IC50 = 10.3 nM
|
|
|
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CP0136525
|
(E)-1-(4-methylphenyl)-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-ene-1,4-dione
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|
C31H32N6O2
|
1
|
| 1 |
IC50 = 12.8 nM
|
|
|
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CP0143654
|
(E)-4-(dimethylamino)-1-[7-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-en-1-one
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|
C26H33N7O
|
1
|
| 1 |
IC50 = 24.5 nM
|
|
|
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CP0466385
|
(E)-4-(dimethylamino)-1-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-en-1-one
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|
C26H33N7O
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
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CP0561585
|
(E)-1-(4-methylphenyl)-4-[7-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-ene-1,4-dione
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|
C31H32N6O2
|
1
|
| 1 |
IC50 = 50.5 nM
|
|
|
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CP0142408
|
2-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]acetonitrile
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|
C22H25N7
|
1
|
| 1 |
IC50 = 57.8 nM
|
|
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CP0357574
|
(E)-1-[7-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]-4-phenylbut-2-ene-1,4-dione
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|
C30H30N6O2
|
1
|
| 1 |
IC50 = 61.2 nM
|
|
|
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CP0466322
|
2-[7-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]acetonitrile
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|
C22H25N7
|
1
|
| 1 |
IC50 = 75.5 nM
|
|
|
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CP0466326
|
methyl (E)-4-[7-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-enoate
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|
C25H30N6O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
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CP0466323
|
(E)-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-enoic acid
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|
C24H28N6O2
|
1
|
| 1 |
IC50 = 128 nM
|
|
|
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CP0007710
|
2-[[1-[2-fluoro-4-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]phenyl]piperidin-4-yl]-methylamino]ethanol
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|
C25H34FN7O
|
1
|
| 1 |
IC50 = 145 nM
|
|
|
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CP0553266
|
(E)-N-tert-butyl-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-enamide
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|
C28H37N7O
|
1
|
| 1 |
IC50 = 145 nM
|
|
|
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CP0422139
|
3-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]propanenitrile
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|
C23H27N7
|
1
|
| 1 |
IC50 = 177 nM
|
|
|
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CP0422129
|
4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]butan-1-ol
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|
C24H32N6O
|
1
|
| 1 |
IC50 = 234 nM
|
|
|
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CP0549513
|
(E)-N,N-diethyl-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-enamide
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|
C28H37N7O
|
1
|
| 1 |
IC50 = 287 nM
|
|
|
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CP0426514
|
2-(2-ethoxyethyl)-N-[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]-3,4-dihydro-1H-isoquinolin-6-amine
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|
C24H32N6O
|
1
|
| 1 |
IC50 = 302 nM
|
|
|
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CP0549517
|
5-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]pentan-1-ol
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|
C25H34N6O
|
1
|
| 1 |
IC50 = 354 nM
|
|
|
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CP0571801
|
3-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]propan-1-ol
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|
C23H30N6O
|
1
|
| 1 |
IC50 = 365 nM
|
|
|
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CP0466331
|
3-[6-[[5-fluoro-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]propan-1-ol
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|
C22H27FN6O
|
1
|
| 1 |
IC50 = 392 nM
|
|
|
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CP0563063
|
5-[6-[[5-fluoro-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]pentan-1-ol
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|
C24H31FN6O
|
1
|
| 1 |
IC50 = 420 nM
|
|
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CP0565768
|
2-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]ethanol
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|
C22H28N6O
|
1
|
| 1 |
IC50 = 431 nM
|
|
|
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CP0549518
|
4-[6-[[5-fluoro-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]butan-1-ol
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|
C23H29FN6O
|
1
|
| 1 |
IC50 = 445 nM
|
|
|
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CP0533189
|
N-[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]-2-prop-2-enyl-3,4-dihydro-1H-isoquinolin-6-amine
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|
C23H28N6
|
1
|
| 1 |
IC50 = 452 nM
|
|
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CP0466328
|
2-butyl-N-[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]-3,4-dihydro-1H-isoquinolin-6-amine
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|
C24H32N6
|
1
|
| 1 |
IC50 = 640 nM
|
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CP0565878
|
1-[6-[[5-fluoro-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]-2-hydroxyethanone
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|
C21H23FN6O2
|
1
|
| 1 |
IC50 = 679 nM
|
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CP0422131
|
N-[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]-2-prop-2-ynyl-3,4-dihydro-1H-isoquinolin-6-amine
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|
C23H26N6
|
1
|
| 1 |
IC50 = 695 nM
|
|
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CP0466324
|
2-[6-[[5-fluoro-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]ethanol
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|
C21H25FN6O
|
1
|
| 1 |
IC50 = 760 nM
|
|
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CP0507670
|
1-(4-methylphenyl)-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]butane-1,4-dione
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|
C31H34N6O2
|
1
|
| 1 |
IC50 = 784 nM
|
|
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CP0549512
|
2-but-2-ynyl-N-[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]-3,4-dihydro-1H-isoquinolin-6-amine
Show/Hide
|
C24H28N6
|
1
|
| 1 |
IC50 = 908 nM
|
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CP0466377
|
methyl 4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]butanoate
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|
C25H32N6O2
|
1
|
| 1 |
IC50 = 938 nM
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|
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CP0426511
|
(E)-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-piperidin-1-ylethyl)but-2-enamide
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|
C31H42N8O
|
1
|
| 1 |
IC50 = 1200 nM
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CP0426508
|
6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-N-propyl-3,4-dihydro-1H-isoquinoline-2-carboxamide
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|
C24H31N7O
|
1
|
| 1 |
IC50 = 1210 nM
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CP0425707
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3-[2-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]propan-1-ol
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|
C22H29N7O
|
1
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| 1 |
IC50 = 1430 nM
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CP0139390
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N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide
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|
C23H22N6O2
|
1
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| 1 |
IC50 = 1500 nM
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CP0422128
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N-ethyl-6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinoline-2-carboxamide
Show/Hide
|
C23H29N7O
|
1
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| 1 |
IC50 = 1890 nM
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CP0553269
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N-(3-chlorophenyl)-6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinoline-2-carboxamide
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|
C27H28ClN7O
|
1
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| 1 |
IC50 = 2180 nM
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CP0565766
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2-[5-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-1,3-dihydroisoindol-2-yl]ethanol
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|
C21H26N6O
|
1
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| 1 |
IC50 = 2330 nM
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CP0466327
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4-(dimethylamino)-1-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]butan-1-one
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|
C26H35N7O
|
1
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| 1 |
IC50 = 2480 nM
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CP0466383
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2-[7-fluoro-6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]ethanol
Show/Hide
|
C22H27FN6O
|
1
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| 1 |
IC50 = 2570 nM
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CP0532772
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2-[5-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-2,3-dihydroindol-1-yl]ethanol
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|
C21H26N6O
|
1
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| 1 |
IC50 = 4390 nM
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