| Compound ID |
Compound Name |
Compound Formula |
|
CP0137907
|
2-(4-methylpiperazin-1-yl)-N-[4-methyl-5-[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]-1,3-thiazol-2-yl]acetamide
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|
C25H27N7OS
|
2
|
| 1 |
EC50 = 29 nM
|
|
|
| 2 |
GI50 = 27.3 nM
|
|
|
|
CP0385508
|
2-[4-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acid
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|
C27H28FN7O2
|
1
|
| 1 |
IC50 < 1 nM
|
|
|
|
CP0395047
|
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-pyridin-2-ylimidazo[1,2-b]pyridazine
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|
C21H18FN5
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0385511
|
1-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol
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|
C26H27FN6O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0433699
|
1-[6-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol
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|
C26H27FN6O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0433700
|
4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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|
C23H18FN5
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0859348
|
N-[3-(6-{[(3-Fluorophenyl)methyl]amino}imidazo[1,2-b]pyridazin-3-yl)phenyl]oxane-4-carboxamide
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|
C25H24FN5O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0543110
|
4-[6-[(3-fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]benzenesulfonamide
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|
C19H16FN5O2S
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0488257
|
4-[6-[(3-fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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|
C20H14FN5
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0530865
|
4-[6-[2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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|
C23H18FN5
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0561248
|
4-[6-[2-(3-fluorophenyl)piperidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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|
C24H20FN5
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0542684
|
4-[6-[3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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|
C23H18FN5O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0510926
|
4-[6-[benzyl(methyl)amino]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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|
C21H17N5
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0510927
|
[4-[6-[(3-fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol
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|
C20H17FN4O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0856137
|
4-(6-{[(2-Methoxyphenyl)methyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzonitrile
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|
C21H17N5O
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0388864
|
4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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|
C20H15N5
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0922172
|
3-[6-(Benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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|
C20H15N5
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0388615
|
3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-(1,3-thiazol-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
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|
C23H26N6O3S
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0061016
|
3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenol
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|
C17H18N4O
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0418567
|
3-[4-amino-7-[3-(hydroxymethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-5-yl]phenol
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|
C17H18N4O2
|
1
|
| 1 |
IC50 = 920 nM
|
|
|
|
CP0395369
|
4-[6-[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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|
C23H18FN5
|
1
|
| 1 |
IC50 = 980 nM
|
|
|
|
CP0388620
|
methyl N-[4-[7-amino-3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxypyrazolo[1,5-a]pyrimidin-6-yl]phenyl]carbamate
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|
C28H32N6O5
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0388616
|
3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine
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|
C26H29N5O3
|
1
|
| 1 |
IC50 > 11000 nM
|
|
|
|
CP0138866
|
1-[4-[3-[4-amino-5-(2-fluoro-5-hydroxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
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|
C22H25FN6O2
|
1
|
| 1 |
IC50 > 8100 nM
|
|
|
