General Information of the Protein
Protein ID
PT00936
Protein Name
NT-3 growth factor receptor
Secondarily
Protein Name
GP145-TrkC
Neurotrophic tyrosine kinase receptor type 3
TrkC tyrosine kinase
Gene Name
NTRK3
Secondarily
Gene Name
TRKC
Sequence
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Trk family
Function
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
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Uniprot ID
Primary ID:
Q16288

Secondarily ID:
B7Z4C5
E9PG56
H0YND1
O75682
Q12827
Q16289
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Ensembl ID
ENSG00000140538
HGNC ID
HGNC:8033
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000077 , Ba/F3
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0137907
 Compound Info 
2-(4-methylpiperazin-1-yl)-N-[4-methyl-5-[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]-1,3-thiazol-2-yl]acetamide
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C25H27N7OS
  2
1
EC50 = 29 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
GI50 = 27.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0385508
 Compound Info 
2-[4-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acid
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C27H28FN7O2
  1
1
IC50 < 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0395047
 Compound Info 
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-pyridin-2-ylimidazo[1,2-b]pyridazine
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C21H18FN5
  1
1
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0385511
 Compound Info 
1-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol
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C26H27FN6O
  1
1
IC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433699
 Compound Info 
1-[6-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol
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C26H27FN6O
  1
1
IC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433700
 Compound Info 
4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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C23H18FN5
  1
1
IC50 = 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0859348
 Compound Info 
N-[3-(6-{[(3-Fluorophenyl)methyl]amino}imidazo[1,2-b]pyridazin-3-yl)phenyl]oxane-4-carboxamide
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C25H24FN5O2
  1
1
IC50 = 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0543110
 Compound Info 
4-[6-[(3-fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]benzenesulfonamide
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C19H16FN5O2S
  1
1
IC50 = 4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0488257
 Compound Info 
4-[6-[(3-fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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C20H14FN5
  1
1
IC50 = 6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0530865
 Compound Info 
4-[6-[2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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C23H18FN5
  1
1
IC50 = 8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0561248
 Compound Info 
4-[6-[2-(3-fluorophenyl)piperidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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C24H20FN5
  1
1
IC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0542684
 Compound Info 
4-[6-[3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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C23H18FN5O
  1
1
IC50 = 19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0510926
 Compound Info 
4-[6-[benzyl(methyl)amino]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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C21H17N5
  1
1
IC50 = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0510927
 Compound Info 
[4-[6-[(3-fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol
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C20H17FN4O
  1
1
IC50 = 40 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0856137
 Compound Info 
4-(6-{[(2-Methoxyphenyl)methyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzonitrile
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C21H17N5O
  1
1
IC50 = 75 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0388864
 Compound Info 
4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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C20H15N5
  1
1
IC50 = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0922172
 Compound Info 
3-[6-(Benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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C20H15N5
  1
1
IC50 = 230 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0388615
 Compound Info 
3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-(1,3-thiazol-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
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C23H26N6O3S
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0061016
 Compound Info 
3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenol
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C17H18N4O
  1
1
IC50 = 510 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0418567
 Compound Info 
3-[4-amino-7-[3-(hydroxymethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-5-yl]phenol
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C17H18N4O2
  1
1
IC50 = 920 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0395369
 Compound Info 
4-[6-[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
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C23H18FN5
  1
1
IC50 = 980 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0388620
 Compound Info 
methyl N-[4-[7-amino-3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxypyrazolo[1,5-a]pyrimidin-6-yl]phenyl]carbamate
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C28H32N6O5
  1
1
IC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0388616
 Compound Info 
3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine
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C26H29N5O3
  1
1
IC50 > 11000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0138866
 Compound Info 
1-[4-[3-[4-amino-5-(2-fluoro-5-hydroxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
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C22H25FN6O2
  1
1
IC50 > 8100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Cell Line ID: CL000043 , U2OS
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0020453
 Compound Info 
US10081622, Compound 11
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C31H34F2N6O2
  3
1 IC50 = 1 nM
2 IC50 = 5 nM
3 IC50 < 10 nM
CP0137907
 Compound Info 
2-(4-methylpiperazin-1-yl)-N-[4-methyl-5-[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]-1,3-thiazol-2-yl]acetamide
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C25H27N7OS
  1
1 IC50 = 2.62 nM
Clinical Information about the Protein
Target 1 ( NT-3 growth factor receptor (TrkC) )
Target Type Successful Target
Disease 3 Target-related Diseases  3
1 Non-small-cell lung cancer [ICD-11: 2C25]
2 Alzheimer disease [ICD-11: 8A20]
3 Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Approved Drug(s) 2 Approved Drugs  2
1 Entrectinib
 Drug Info 
Approved
Non-small-cell lung cancer
2 Larotrectinib
 Drug Info 
Approved
Solid tumour/cancer
Clinical Trial Drug(s) 2 Clinical Trial Drugs  2
1 MK-2461
 Drug Info 
Phase 1/2
Alzheimer disease
2 Altiratinib
 Drug Info 
Phase 1
Solid tumour/cancer