General Information of the Protein
Protein ID
PT06051
Protein Name
Thrombopoietin receptor
Secondarily
Protein Name
Myeloproliferative leukemia protein
Proto-oncogene c-Mpl
Gene Name
MPL
Secondarily
Gene Name
TPOR
Sequence
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
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Uniprot ID
Primary ID:
P40238

Secondarily ID:
Q5JUZ0
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HGNC ID
HGNC:7217
Subcellular Location
Cell membrane
Golgi apparatus
Cell surface
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000077 , Ba/F3
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0846717
 Compound Info 
1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)hydrazinecarbonothioyl)indoline-5-carboxylic acid
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C25H25N5O3S
  1
1
EC50 = 3 nM
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CP0940585
 Compound Info 
1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)hydrazinecarbonothioyl)indoline-5-carboxylic acid
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C24H25N5O3S
  1
1
EC50 = 6 nM
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CP0520021
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]-4-[[6-(3-hydroxyazetidin-1-yl)pyrimidin-4-yl]amino]benzamide
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C24H18F4N6O3S
  1
1
EC50 = 7 nM
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CP0456689
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-[[6-(3-hydroxyazetidin-1-yl)pyrimidin-4-yl]amino]benzamide
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C24H18F4N6O2S
  1
1
EC50 = 9 nM
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CP0474802
 Compound Info 
1-(2,6-dichloro-4-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)phenyl)piperidine-4-carboxylic acid
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C23H17Cl2F4N3O3S
  1
1
EC50 = 10 nM
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CP0456713
 Compound Info 
N-[5-chloro-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-[[6-(dimethylamino)pyrimidin-4-yl]amino]benzamide
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C23H17ClF4N6OS
  1
1
EC50 = 11 nM
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CP0507870
 Compound Info 
N-[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl]-4-[[6-(3-hydroxyazetidin-1-yl)pyrimidin-4-yl]amino]benzamide
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C23H17F4N7O2S
  1
1
EC50 = 13 nM
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CP0847172
 Compound Info 
4-{N'-[1-(4-tert-Butyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
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C24H24N4O5S
  1
1
EC50 = 20 nM
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CP0489986
 Compound Info 
2-(7-(4-butylphenyl)-6-fluoro-5,10-dihydroindeno[1,2-b]indol-2-ylamino)-2-oxoacetic acid
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C27H23FN2O3
  1
1
EC50 = 21 nM
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CP0516150
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-[[6-[2-hydroxyethyl(methyl)amino]pyrimidin-4-yl]amino]benzamide
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C24H20F4N6O2S
  1
1
EC50 = 22 nM
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CP0846718
 Compound Info 
1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)hydrazinecarbonothioyl)-N-methylindoline-5-carboxamide
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C25H28N6O2S
  1
1
EC50 = 22 nM
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CP0511584
 Compound Info 
4-(6-(azetidin-1-yl)pyrimidin-4-ylamino)-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide
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C24H18F4N6OS
  1
1
EC50 = 23 nM
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CP0467585
 Compound Info 
N-[7-(4-butylphenyl)-6-fluoro-5,10-dihydroindeno[1,2-b]indol-2-yl]acetamide
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C27H25FN2O
  1
1
EC50 = 25 nM
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CP0500954
 Compound Info 
6-fluoro-7-(4-fluoro-3-methylphenyl)-5,10-dihydroindeno[1,2-b]indole-2-carboxylic acid
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C23H15F2NO2
  1
1
EC50 = 26 nM
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CP0548923
 Compound Info 
9-(4-butylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C27H25NO3
  1
1
EC50 = 26 nM
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CP0890147
 Compound Info 
1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)hydrazinecarbonothioyl)-N-ethylindoline-5-carboxamide
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C26H30N6O2S
  1
1
EC50 = 26 nM
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CP0461133
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(7-trifluoromethyl-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-benzamide
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C23H16F3N5O2S
  1
1
EC50 = 27 nM
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CP0891960
 Compound Info 
(Z)-N-(4-(3,4-difluorophenyl)thiazol-2-yl)-4-((2,4-dioxothiazolidin-5-ylidene)methyl)benzamide
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C20H11F2N3O3S2
  1
1
EC50 = 28 nM
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CP0514679
 Compound Info 
6-(4-carbamoylpiperidin-1-yl)-5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)nicotinamide
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C22H18ClF4N5O2S
  1
1
EC50 = 28 nM
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CP0436347
 Compound Info 
N-[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl]-4-[[6-[[2-hydroxy-1-(hydroxyamino)ethyl]-methylamino]pyrimidin-4-yl]amino]benzamide
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C23H20F4N8O3S
  1
1
EC50 = 29 nM
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CP0507871
 Compound Info 
N-[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl]-4-[[6-(2-hydroxyethylamino)pyrimidin-4-yl]amino]benzamide
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C22H17F4N7O2S
  1
1
EC50 = 30 nM
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CP0920375
 Compound Info 
N'-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)-5-(morpholine-4-carbonyl)indoline-1-carbothiohydrazide
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C28H32N6O3S
  1
1
EC50 = 31 nM
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CP0449123
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C21H13F4N5O2S
  1
1
EC50 = 32 nM
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CP0559826
 Compound Info 
N-[4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C21H12F5N5OS
  1
1
EC50 = 33 nM
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CP0471039
 Compound Info 
1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
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C22H17ClF4N4O3S
  1
1
EC50 = 33 nM
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CP0388637
 Compound Info 
5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)-6-(4-sulfamoylpiperidin-1-yl)nicotinamide
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C21H18ClF4N5O3S2
  1
1
EC50 = 34 nM
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CP0417193
 Compound Info 
N-[4-[2-fluoro-3-(2-methylpropyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C24H22FN5OS
  1
1
EC50 = 35 nM
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CP0528226
 Compound Info 
9-(4-fluoro-3-methylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C24H18FNO3
  1
1
EC50 = 35 nM
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CP0860208
 Compound Info 
1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)hydrazinecarbonothioyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid
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C26H27N5O3S
  1
1
EC50 = 35 nM
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CP0467586
 Compound Info 
6-fluoro-7-(4-propylphenyl)-5,10-dihydroindeno[1,2-b]indole-2-carboxylic acid
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C25H20FNO2
  1
1
EC50 = 37 nM
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CP0516151
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-[(6-methoxypyrimidin-4-yl)amino]benzamide
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C22H15F4N5O2S
  1
1
EC50 = 38 nM
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CP0635260
 Compound Info 
eltrombopag
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C25H22N4O4
  1
1
EC50 = 38 nM
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CP0860595
 Compound Info 
3-Hydroxy-4-{N'-[3-methyl-5-oxo-1-(3-trifluoromethyl-phenyl)-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-naphthalene-1-sulfonic acid
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C21H15F3N4O5S
  1
1
EC50 = 40 nM
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CP0893227
 Compound Info 
4-{N'-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
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C22H20N4O5S
  1
1
EC50 = 40 nM
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CP0372848
 Compound Info 
2-hydroxy-9-(4-propoxyphenyl)-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C26H23NO4
  1
1
EC50 = 41 nM
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CP0920376
 Compound Info 
1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)hydrazinecarbonyl)indoline-5-carboxylic acid
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C24H25N5O4
  1
1
EC50 = 42 nM
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CP0394479
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-[(6-methylpyrimidin-4-yl)amino]benzamide
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C22H15F4N5OS
  1
1
EC50 = 43 nM
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CP0522827
 Compound Info 
4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(3-(4-fluoro-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-5-yl)benzamide
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C22H17F4N7OS
  1
1
EC50 = 43 nM
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CP0512217
 Compound Info 
2-hydroxy-9-(3-propoxyphenyl)-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C26H23NO4
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1
EC50 = 43 nM
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CP0520022
 Compound Info 
(4R)-1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)-4-methylpyrrolidine-3-carboxylic acid
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C22H17ClF4N4O3S
  1
1
EC50 = 43 nM
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CP0924403
 Compound Info 
4-(2-(1-(5-fluoro-2-oxo-1-p-tolylindolin-3-ylidene)ethyl)hydrazinecarbonothioyl)benzoic acid
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C25H20FN3O3S
  1
1
EC50 = 44 nM
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CP0559828
 Compound Info 
4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-5-methylthiazol-2-yl)benzamide
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C24H20F4N6OS
  1
1
EC50 = 45 nM
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CP0920377
 Compound Info 
1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)hydrazinecarbonyl)indoline-5-carboxylic acid
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C25H25N5O4
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1
EC50 = 46 nM
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CP0565564
 Compound Info 
1-(3-bromo-5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
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C22H17BrF4N4O3S
  1
1
EC50 = 50 nM
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CP0427700
 Compound Info 
4-(6-(4-butylphenyl)-7-fluoro-1H-indol-2-yl)-2-hydroxybenzoic acid
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C25H22FNO3
  1
1
EC50 = 51 nM
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CP0446527
 Compound Info 
N-[4-(3-butyl-2-fluorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C24H22FN5OS
  1
1
EC50 = 53 nM
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CP0461134
 Compound Info 
4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide
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C23H18F4N6OS
  1
1
EC50 = 54 nM
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CP0510081
 Compound Info 
9-(4-butylphenyl)-10-fluoro-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C27H24FNO2
  1
1
EC50 = 55 nM
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CP0457696
 Compound Info 
1-(2-chloro-4-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)phenyl)piperidine-4-carboxylic acid
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C23H18ClF4N3O3S
  1
1
EC50 = 56 nM
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CP0457694
 Compound Info 
(R)-2-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-ylamino)propanoic acid
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C19H13ClF4N4O3S
  1
1
EC50 = 57 nM
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CP0506512
 Compound Info 
1-(3-chloro-5-(5-fluoro-4-(4-fluoro-3-isobutylphenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
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C25H25ClF2N4O3S
  1
1
EC50 = 58 nM
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CP0449126
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C21H13F4N5OS
  1
1
EC50 = 60 nM
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CP0940586
 Compound Info 
1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)hydrazinecarbonothioyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid
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C25H27N5O3S
  1
1
EC50 = 64 nM
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CP0501905
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-[[6-(2-hydroxyethylamino)pyrimidin-4-yl]amino]benzamide
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C23H18F4N6O2S
  1
1
EC50 = 65 nM
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CP0387911
 Compound Info 
9-(3,4-dimethylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C25H21NO3
  1
1
EC50 = 65 nM
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CP0438706
 Compound Info 
1-(3-chloro-5-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-5-methylthiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
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C23H19ClF4N4O3S
  1
1
EC50 = 66 nM
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CP0372653
 Compound Info 
9-(3,5-dimethylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C25H21NO3
  1
1
EC50 = 67 nM
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CP0647201
 Compound Info 
3-Hydroxy-4-(1-hydroxy-naphthalen-2-ylazo)-naphthalene-1-sulfonic acid
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C20H14N2O5S
  1
1
EC50 = 70 nM
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CP0862778
 Compound Info 
4-{N'-[1-(3-tert-Butyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
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C24H24N4O5S
  1
1
EC50 = 70 nM
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CP0927604
 Compound Info 
3-Hydroxy-4-{N'-[1-(4-isopropyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-naphthalene-1-sulfonic acid
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C23H22N4O5S
  1
1
EC50 = 70 nM
 Bioactivity Info 
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CP0457917
 Compound Info 
4-(6-(bis(3-hydroxypropyl)amino)pyrimidin-4-ylamino)-N-(3-(4-fluoro-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-5-yl)benzamide
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C26H25F4N7O3S
  1
1
EC50 = 71 nM
 Bioactivity Info 
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CP0387913
 Compound Info 
9-(4-butylphenyl)-6,11-dihydro-5H-benzo[a]carbazole-3-carboxamide
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C27H26N2O
  1
1
EC50 = 76 nM
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CP0424763
 Compound Info 
4-(6-(azetidin-1-yl)pyrimidin-4-ylamino)-N-(3-(4-fluoro-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-5-yl)benzamide
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C23H17F4N7OS
  1
1
EC50 = 81 nM
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CP0935331
 Compound Info 
4-(2-(1-(1-(3,4-dimethylphenyl)-2-oxoindolin-3-ylidene)ethyl)hydrazinecarbonothioyl)benzoic acid
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C26H23N3O3S
  1
1
EC50 = 82 nM
 Bioactivity Info 
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CP0424757
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(4-(2,3,4-trifluorophenyl)thiazol-2-yl)benzamide
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C20H12F3N5OS
  1
1
EC50 = 84 nM
 Bioactivity Info 
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CP0511585
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-[[6-[2-methoxyethyl(methyl)amino]pyrimidin-4-yl]amino]benzamide
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C25H22F4N6O2S
  1
1
EC50 = 84 nM
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CP0500958
 Compound Info 
7-(4-butylphenyl)-5,10-dihydroindeno[1,2-b]indole-2-carboxamide
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C26H24N2O
  1
1
EC50 = 86 nM
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CP0516531
 Compound Info 
1-(3-chloro-5-(5-chloro-4-(4-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
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C22H16Cl2F4N4O3S
  1
1
EC50 = 86 nM
 Bioactivity Info 
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CP0456708
 Compound Info 
N-[4-[2,3-difluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C21H12F5N5OS
  1
1
EC50 = 87 nM
 Bioactivity Info 
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CP0417990
 Compound Info 
1-(3-chloro-5-(5-fluoro-4-(4-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C22H16ClF5N4O3S
  1
1
EC50 = 89 nM
 Bioactivity Info 
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CP0854484
 Compound Info 
4-{N'-[1-(3,4-Dimethyl-phenyl)-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
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C21H18N4O5S
  1
1
EC50 = 100 nM
 Bioactivity Info 
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CP0932567
 Compound Info 
3-Hydroxy-4-{N'-[3-methyl-5-oxo-1-(4-trifluoromethyl-phenyl)-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-naphthalene-1-sulfonic acid
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C21H15F3N4O5S
  1
1
EC50 = 100 nM
 Bioactivity Info 
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CP0513786
 Compound Info 
N-[4-(3-bromo-2-fluorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C20H13BrFN5OS
  1
1
EC50 = 100 nM
 Bioactivity Info 
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CP0514289
 Compound Info 
1-(3-chloro-5-(4-(4-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C22H17ClF4N4O3S
  1
1
EC50 = 100 nM
 Bioactivity Info 
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CP0918842
 Compound Info 
4-(2-(1-(1-(3,4-dimethylphenyl)-5-fluoro-2-oxoindolin-3-ylidene)ethyl)hydrazinecarbonothioyl)benzoic acid
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C26H22FN3O3S
  1
1
EC50 = 103 nM
 Bioactivity Info 
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CP0467393
 Compound Info 
2-hydroxy-9-p-tolyl-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C24H19NO3
  1
1
EC50 = 109 nM
 Bioactivity Info 
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CP0427696
 Compound Info 
9-(4-butylphenyl)-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C27H25NO2
  1
1
EC50 = 111 nM
 Bioactivity Info 
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CP0480278
 Compound Info 
7-(4-butylphenyl)-6-fluoro-10,10-dimethyl-5,10-dihydroindeno[1,2-b]indole-2-carboxylic acid
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C28H26FNO2
  1
1
EC50 = 111 nM
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CP0427701
 Compound Info 
4-(6-(4-butylphenyl)-7-fluoro-3-methyl-1H-indol-2-yl)-2-hydroxybenzoic acid
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C26H24FNO3
  1
1
EC50 = 116 nM
 Bioactivity Info 
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CP0427699
 Compound Info 
4-(6-(4-butylphenyl)-7-fluoro-1H-indol-2-yl)benzoic acid
   Show/Hide
C25H22FNO2
  1
1
EC50 = 117 nM
 Bioactivity Info 
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CP0372654
 Compound Info 
9-(4-butylphenyl)-3-(1H-tetrazol-5-yl)-6,11-dihydro-5H-benzo[a]carbazole
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C27H25N5
  1
1
EC50 = 119 nM
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CP0456690
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyridazin-4-ylamino)benzamide
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C21H13F4N5OS
  1
1
EC50 = 120 nM
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CP0529141
 Compound Info 
9-(4-butylphenyl)-N,N-dimethyl-6,11-dihydro-5H-benzo[a]carbazole-3-carboxamide
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C29H30N2O
  1
1
EC50 = 127 nM
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CP0422391
 Compound Info 
4-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperazine-2-carboxylic acid
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C21H16ClF4N5O3S
  1
1
EC50 = 129 nM
 Bioactivity Info 
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CP0507867
 Compound Info 
4-(6-(ethylamino)pyrimidin-4-ylamino)-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide
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C23H18F4N6OS
  1
1
EC50 = 130 nM
 Bioactivity Info 
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CP0522828
 Compound Info 
N-[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl]-4-[[6-[2-methoxyethyl(methyl)amino]pyrimidin-4-yl]amino]benzamide
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C24H21F4N7O2S
  1
1
EC50 = 130 nM
 Bioactivity Info 
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CP0516546
 Compound Info 
1-(3-chloro-5-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-5-propylthiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C25H23ClF4N4O3S
  1
1
EC50 = 130 nM
 Bioactivity Info 
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CP0497723
 Compound Info 
1-(5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-3-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C23H17F7N4O3S
  1
1
EC50 = 134 nM
 Bioactivity Info 
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CP0422392
 Compound Info 
1-(3-cyano-5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C23H17F4N5O3S
  1
1
EC50 = 138 nM
 Bioactivity Info 
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CP0515125
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(6-(trifluoromethyl)-4H-chromeno[4,3-d]thiazol-2-yl)benzamide
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C22H14F3N5O2S
  1
1
EC50 = 140 nM
 Bioactivity Info 
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CP0449124
 Compound Info 
N-[4-(3-ethyl-2-fluorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C22H18FN5OS
  1
1
EC50 = 143 nM
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CP0479532
 Compound Info 
2-hydroxy-9-(trifluoromethyl)-11H-benzo[a]carbazole-3-carboxylic acid
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C18H10F3NO3
  1
1
EC50 = 143 nM
 Bioactivity Info 
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CP0503469
 Compound Info 
2-hydroxy-9-(3-(trifluoromethyl)phenyl)-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C24H16F3NO3
  1
1
EC50 = 148 nM
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CP0439342
 Compound Info 
4-(6-(4-butylphenyl)-7-fluoro-1H-indol-2-yl)benzamide
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C25H23FN2O
  1
1
EC50 = 160 nM
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CP0486391
 Compound Info 
7-(4-butylphenyl)-5,10-dihydroindeno[1,2-b]indole-2-carboxylic acid
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C26H23NO2
  1
1
EC50 = 160 nM
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CP0416468
 Compound Info 
1-(3-chloro-5-(5-ethyl-4-(4-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C24H21ClF4N4O3S
  1
1
EC50 = 160 nM
 Bioactivity Info 
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CP0480284
 Compound Info 
4-(6-(4-butylphenyl)-1H-benzo[d]imidazol-2-yl)-2-hydroxybenzoic acid
   Show/Hide
C24H22N2O3
  1
1
EC50 = 179 nM
 Bioactivity Info 
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CP0456688
 Compound Info 
N-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-5-methyl-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C22H15F4N5OS
  1
1
EC50 = 180 nM
 Bioactivity Info 
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CP0401352
 Compound Info 
2-hydroxy-9-m-tolyl-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C24H19NO3
  1
1
EC50 = 194 nM
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CP0653083
 Compound Info 
3-Hydroxy-4-(2-hydroxy-naphthalen-1-ylazo)-naphthalene-1-sulfonic acid
   Show/Hide
C20H14N2O5S
  1
1
EC50 = 200 nM
 Bioactivity Info 
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CP0862968
 Compound Info 
1-(4-tert-Butyl-phenyl)-4-[(2-hydroxy-4-sulfo-naphthalen-1-yl)-hydrazono]-5-oxo-4,5-dihydro-1H-pyrazole-3-carboxylic acid tert-butyl ester
   Show/Hide
C28H30N4O7S
  1
1
EC50 = 200 nM
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CP0869561
 Compound Info 
3-Hydroxy-4-(10-hydroxy-phenanthren-9-ylazo)-naphthalene-1-sulfonic acid
   Show/Hide
C24H16N2O5S
  1
1
EC50 = 200 nM
 Bioactivity Info 
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CP0914389
 Compound Info 
4-{N'-[1-(3,4-Dichloro-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
   Show/Hide
C20H14Cl2N4O5S
  1
1
EC50 = 200 nM
 Bioactivity Info 
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CP0926802
 Compound Info 
4-{N'-[1-(4-Benzyloxy-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
   Show/Hide
C27H22N4O6S
  1
1
EC50 = 200 nM
 Bioactivity Info 
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CP0528306
 Compound Info 
N-[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl]-4-[[6-[2-hydroxyethyl(methyl)amino]pyrimidin-4-yl]amino]benzamide
   Show/Hide
C23H19F4N7O2S
  1
1
EC50 = 220 nM
 Bioactivity Info 
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CP0504295
 Compound Info 
1-(5-(4-(3-butyl-4-fluorophenyl)-5-fluorothiazol-2-ylcarbamoyl)-3-chloropyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C25H25ClF2N4O3S
  1
1
EC50 = 220 nM
 Bioactivity Info 
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CP0468422
 Compound Info 
4-(6-(4-butylphenyl)-3-ethyl-7-fluoro-1H-indol-2-yl)-2-hydroxybenzoic acid
   Show/Hide
C27H26FNO3
  1
1
EC50 = 228 nM
 Bioactivity Info 
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CP0394478
 Compound Info 
N-[4-(4-chloro-2-fluorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H13ClFN5OS
  1
1
EC50 = 232 nM
 Bioactivity Info 
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CP0502189
 Compound Info 
9-(2,6-dimethylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C25H21NO3
  1
1
EC50 = 232 nM
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CP0436346
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(4-(6-(trifluoromethyl)pyridin-2-yl)thiazol-2-yl)benzamide
   Show/Hide
C20H13F3N6OS
  1
1
EC50 = 244 nM
 Bioactivity Info 
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CP0457697
 Compound Info 
1-(5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-3-methylpyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C23H20F4N4O3S
  1
1
EC50 = 253 nM
 Bioactivity Info 
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CP0449121
 Compound Info 
N-[4-[2-fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H13F4N5OS
  1
1
EC50 = 259 nM
 Bioactivity Info 
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CP0388189
 Compound Info 
6-fluoro-7-(4-fluoro-3-methylphenyl)-5,10-dihydroindeno[1,2-b]indole-2-carboxamide
   Show/Hide
C23H16F2N2O
  1
1
EC50 = 277 nM
 Bioactivity Info 
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CP0507866
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(4-(3-(trifluoromethoxy)phenyl)thiazol-2-yl)benzamide
   Show/Hide
C21H14F3N5O2S
  1
1
EC50 = 284 nM
 Bioactivity Info 
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CP0529137
 Compound Info 
9-(4-(dimethylamino)phenyl)-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C25H22N2O3
  1
1
EC50 = 284 nM
 Bioactivity Info 
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CP0456710
 Compound Info 
N-[4-[3-fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H13F4N5OS
  1
1
EC50 = 288 nM
 Bioactivity Info 
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CP0497722
 Compound Info 
1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-3-carboxylic acid
   Show/Hide
C22H17ClF4N4O3S
  1
1
EC50 = 294 nM
 Bioactivity Info 
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CP0849679
 Compound Info 
3-Hydroxy-4-{N'-[1-(4-iodo-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-naphthalene-1-sulfonic acid
   Show/Hide
C20H15IN4O5S
  1
1
EC50 = 300 nM
 Bioactivity Info 
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CP0885834
 Compound Info 
3-Hydroxy-4-(2-hydroxy-7-methoxy-naphthalen-1-ylazo)-naphthalene-1-sulfonic acid
   Show/Hide
C21H16N2O6S
  1
1
EC50 = 300 nM
 Bioactivity Info 
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CP0918831
 Compound Info 
4-{N'-[3-tert-Butyl-1-(3,4-dimethyl-phenyl)-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
   Show/Hide
C25H26N4O5S
  1
1
EC50 = 300 nM
 Bioactivity Info 
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CP0925501
 Compound Info 
3-Hydroxy-4-{N'-[3-methyl-1-(3-nitro-phenyl)-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-naphthalene-1-sulfonic acid
   Show/Hide
C20H15N5O7S
  1
1
EC50 = 300 nM
 Bioactivity Info 
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CP0454123
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-5-ylamino)benzamide
   Show/Hide
C21H13F4N5OS
  1
1
EC50 = 320 nM
 Bioactivity Info 
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CP0532853
 Compound Info 
2-hydroxy-8-(trifluoromethyl)-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C18H12F3NO3
  1
1
EC50 = 333 nM
 Bioactivity Info 
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CP0486829
 Compound Info 
N-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H13Cl2N5OS
  1
1
EC50 = 347 nM
 Bioactivity Info 
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CP0437887
 Compound Info 
2-hydroxy-9-phenyl-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C23H17NO3
  1
1
EC50 = 373 nM
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CP0452460
 Compound Info 
3-acetamido-7-(4-butylphenyl)-6-fluoro-5,10-dihydroindeno[1,2-b]indole-2-carboxylic acid
   Show/Hide
C28H25FN2O3
  1
1
EC50 = 376 nM
 Bioactivity Info 
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CP0845323
 Compound Info 
3-Hydroxy-4-{N'-[3-methyl-1-(4-nitro-phenyl)-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-naphthalene-1-sulfonic acid
   Show/Hide
C20H15N5O7S
  1
1
EC50 = 400 nM
 Bioactivity Info 
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CP0424762
 Compound Info 
N-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyridazin-4-ylamino)benzamide
   Show/Hide
C21H13F4N5OS
  1
1
EC50 = 400 nM
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CP0461135
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyridin-4-ylamino)benzamide
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C22H14F4N4OS
  1
1
EC50 = 400 nM
 Bioactivity Info 
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CP0515127
 Compound Info 
N-[3-[4-fluoro-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl]-4-(pyrimidin-4-ylamino)benzamide
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C20H12F4N6OS
  1
1
EC50 = 410 nM
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CP0449127
 Compound Info 
N-[4-(2,3-difluorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C20H13F2N5OS
  1
1
EC50 = 415 nM
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CP0509979
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide
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C21H14F3N5OS
  1
1
EC50 = 418 nM
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CP0554988
 Compound Info 
1-(5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
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C22H18F4N4O3S
  1
1
EC50 = 430 nM
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CP0427698
 Compound Info 
9-(4-Butyl-phenyl)-5,5-dioxo-6,11-dihydro-5H-5lambda*6*-thia-11-aza-benzo[a]fluorene-3-carboxylic acid
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C26H23NO4S
  1
1
EC50 = 449 nM
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CP0491414
 Compound Info 
2-hydroxy-9-(4-(methoxymethyl)phenyl)-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C25H21NO4
  1
1
EC50 = 452 nM
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CP0401354
 Compound Info 
2-hydroxy-9-(trifluoromethyl)-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C18H12F3NO3
  1
1
EC50 = 473 nM
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CP0506511
 Compound Info 
1-(3-chloro-5-(4-(3-chloro-4-fluorophenyl)-5-fluorothiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
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C21H16Cl2F2N4O3S
  1
1
EC50 = 480 nM
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CP0522684
 Compound Info 
6-(4-(2H-tetrazol-5-yl)piperidin-1-yl)-5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)nicotinamide
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C22H17ClF4N8OS
  1
1
EC50 = 485 nM
 Bioactivity Info 
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CP0516149
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide
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C21H14F3N5OS
  1
1
EC50 = 492 nM
 Bioactivity Info 
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CP0869562
 Compound Info 
4-{N'-[1-(4-Fluoro-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
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C20H15FN4O5S
  1
1
EC50 = 500 nM
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CP0456711
 Compound Info 
N-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C20H13Cl2N5OS
  1
1
EC50 = 510 nM
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CP0507868
 Compound Info 
4-(1,3,5-triazin-2-ylamino)-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide
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C20H12F4N6OS
  1
1
EC50 = 540 nM
 Bioactivity Info 
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CP0515126
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-5-methyl-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C22H15F4N5OS
  1
1
EC50 = 540 nM
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CP0456691
 Compound Info 
N-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]-4-(pyridazin-4-ylamino)benzamide
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C20H13F2N5OS
  1
1
EC50 = 550 nM
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CP0441225
 Compound Info 
2-hydroxy-8-phenyl-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C23H17NO3
  1
1
EC50 = 569 nM
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CP0471040
 Compound Info 
1-(3-chloro-5-(3-(4-fluoro-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-5-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
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C21H16ClF4N5O3S
  1
1
EC50 = 574 nM
 Bioactivity Info 
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CP0918913
 Compound Info 
4-{N'-[1-(3,4-Dimethyl-phenyl)-3-ethoxy-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
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C23H22N4O6S
  1
1
EC50 = 600 nM
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CP0417195
 Compound Info 
N-[4-(3-chloro-2-fluorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C20H13ClFN5OS
  1
1
EC50 = 612 nM
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CP0373481
 Compound Info 
1-(3-chloro-5-(5-fluoro-4-(4-fluoro-3-(trifluoromethoxy)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
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C22H16ClF5N4O4S
  1
1
EC50 = 620 nM
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CP0478116
 Compound Info 
N-[4-(3-bromophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C20H14BrN5OS
  1
1
EC50 = 645 nM
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CP0523822
 Compound Info 
1-(5-(4-(3-bromo-4-fluorophenyl)-5-fluorothiazol-2-ylcarbamoyl)-3-chloropyridin-2-yl)piperidine-4-carboxylic acid
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C21H16BrClF2N4O3S
  1
1
EC50 = 670 nM
 Bioactivity Info 
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CP0869568
 Compound Info 
3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-m-tolyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-naphthalene-1-sulfonic acid
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C21H18N4O5S
  1
1
EC50 = 700 nM
 Bioactivity Info 
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CP0481230
 Compound Info 
1-(3-chloro-5-(5-fluoro-4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
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C22H16ClF5N4O3S
  1
1
EC50 = 702 nM
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CP0461137
 Compound Info 
N-[3-(3,4-difluorophenyl)-1,2,4-thiadiazol-5-yl]-4-(pyrimidin-4-ylamino)benzamide
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C19H12F2N6OS
  1
1
EC50 = 720 nM
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CP0449119
 Compound Info 
N-[4-(3,4-dimethylphenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C22H19N5OS
  1
1
EC50 = 784 nM
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CP0469709
 Compound Info 
10-fluoro-2-hydroxy-7-(trifluoromethyl)-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
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C18H11F4NO3
  1
1
EC50 = 799 nM
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CP0372847
 Compound Info 
2-hydroxy-9-methyl-11H-benzo[a]carbazole-3-carboxylic acid
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C18H13NO3
  1
1
EC50 = 870 nM
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CP0875248
 Compound Info 
4-{N'-[1-(3,4-Dimethyl-phenyl)-5-oxo-3-phenyl-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
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C27H22N4O5S
  1
1
EC50 = 900 nM
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CP0373021
 Compound Info 
1-(3-chloro-5-(5-fluoro-4-(4-fluoro-3-(2,2,2-trifluoroethoxy)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
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C23H18ClF5N4O4S
  1
1
EC50 = 950 nM
 Bioactivity Info 
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CP0456694
 Compound Info 
N-[3-[2-fluoro-3-(trifluoromethoxy)phenyl]-1,2,4-thiadiazol-5-yl]-4-(pyrimidin-4-ylamino)benzamide
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C20H12F4N6O2S
  1
1
EC50 = 970 nM
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CP0845077
 Compound Info 
4-{N'-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-carboxylic acid
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C23H20N4O4
  1
1
EC50 = 1000 nM
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CP0510784
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(4-p-tolylthiazol-2-yl)benzamide
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C21H17N5OS
  1
1
EC50 = 1200 nM
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CP0498050
 Compound Info 
4-(6-(4-butylphenyl)-1H-benzo[d]imidazol-2-yl)benzoic acid
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C24H22N2O2
  1
1
EC50 = 1260 nM
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CP0461138
 Compound Info 
N-[3-(2,4-difluorophenyl)-1,2,4-thiadiazol-5-yl]-4-(pyrimidin-4-ylamino)benzamide
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C19H12F2N6OS
  1
1
EC50 = 1300 nM
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CP0401353
 Compound Info 
methyl 2-hydroxy-11H-benzo[a]carbazole-3-carboxylate
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C18H13NO3
  1
1
EC50 = 1300 nM
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CP0417191
 Compound Info 
N-[4-(2,3-dichlorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C20H13Cl2N5OS
  1
1
EC50 = 1340 nM
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CP0507872
 Compound Info 
N-[1-[2-fluoro-3-(trifluoromethyl)phenyl]pyrazol-3-yl]-4-(pyrimidin-4-ylamino)benzamide
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C21H14F4N6O
  1
1
EC50 = 1400 nM
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CP0480282
 Compound Info 
10-fluoro-9-(4-fluoro-3-methylphenyl)-6,11-dihydrochromeno[4,3-b]indole-3-carboxamide
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C23H16F2N2O2
  1
1
EC50 = 1430 nM
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CP0446530
 Compound Info 
N-[3-[2-fluoro-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H12F4N6OS
  1
1
EC50 = 1500 nM
 Bioactivity Info 
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CP0421847
 Compound Info 
N-(3-phenyl-1,2,4-thiadiazol-5-yl)-4-(pyrimidin-4-ylamino)benzamide
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C19H14N6OS
  1
1
EC50 = 1600 nM
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CP0486833
 Compound Info 
N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-4-(pyridazin-4-ylamino)benzamide
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C20H14ClN5OS
  1
1
EC50 = 1600 nM
 Bioactivity Info 
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CP0854160
 Compound Info 
3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-p-tolyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-naphthalene-1-sulfonic acid
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C21H18N4O5S
  1
1
EC50 = 2000 nM
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CP0862820
 Compound Info 
4-(2,6-Dihydroxy-naphthalen-1-ylazo)-3-hydroxy-naphthalene-1-sulfonic acid
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C20H14N2O6S
  1
1
EC50 = 2000 nM
 Bioactivity Info 
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CP0862966
 Compound Info 
1-(4-tert-Butyl-phenyl)-4-[(2-hydroxy-4-sulfo-naphthalen-1-yl)-hydrazono]-5-oxo-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester
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C26H26N4O7S
  1
1
EC50 = 2000 nM
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CP0886226
 Compound Info 
3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-p-tolyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-naphthalene-1-carboxylic acid
   Show/Hide
C22H18N4O4
  1
1
EC50 = 2000 nM
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CP0897132
 Compound Info 
4-{N'-[1-(3-Chloro-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
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C20H15ClN4O5S
  1
1
EC50 = 2000 nM
 Bioactivity Info 
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CP0899350
 Compound Info 
4-{N'-[1-(4-Chloro-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
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C20H15ClN4O5S
  1
1
EC50 = 2000 nM
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CP0916449
 Compound Info 
4-(2,7-Dihydroxy-naphthalen-1-ylazo)-3-hydroxy-naphthalene-1-sulfonic acid
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C20H14N2O6S
  1
1
EC50 = 2000 nM
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CP0921497
 Compound Info 
4-(2,3-Dihydroxy-naphthalen-1-ylazo)-3-hydroxy-naphthalene-1-sulfonic acid
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C20H14N2O6S
  1
1
EC50 = 2000 nM
 Bioactivity Info 
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CP0947403
 Compound Info 
3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-naphthalene-1-sulfonic acid
   Show/Hide
C20H16N4O5S
  1
1
EC50 = 2000 nM
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CP0562517
 Compound Info 
N-[1-[4-fluoro-3-(trifluoromethyl)phenyl]pyrazol-3-yl]-4-(pyrimidin-4-ylamino)benzamide
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C21H14F4N6O
  1
1
EC50 = 2000 nM
 Bioactivity Info 
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CP0507869
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyridin-2-ylamino)benzamide
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C22H14F4N4OS
  1
1
EC50 = 2200 nM
 Bioactivity Info 
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CP0507865
 Compound Info 
N-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C22H19N5OS
  1
1
EC50 = 2260 nM
 Bioactivity Info 
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CP0454360
 Compound Info 
N-[2-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]-4-(pyrimidin-4-ylamino)benzamide
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C21H13F4N5O2
  1
1
EC50 = 2300 nM
 Bioactivity Info 
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CP0464184
 Compound Info 
N-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
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C20H14FN5OS
  1
1
EC50 = 2560 nM
 Bioactivity Info 
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CP0849876
 Compound Info 
3-Hydroxy-4-(2-hydroxy-5-methyl-phenylazo)-naphthalene-1-sulfonic acid
   Show/Hide
C17H14N2O5S
  1
1
EC50 = 3000 nM
 Bioactivity Info 
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CP0880185
 Compound Info 
3-Hydroxy-4-(4-hydroxy-2-methoxy-naphthalen-1-ylazo)-naphthalene-1-sulfonic acid
   Show/Hide
C21H16N2O6S
  1
1
EC50 = 3000 nM
 Bioactivity Info 
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CP0907683
 Compound Info 
3-Hydroxy-4-{N'-[1-(4-methanesulfonyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-naphthalene-1-sulfonic acid
   Show/Hide
C21H18N4O7S2
  1
1
EC50 = 3000 nM
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CP0486832
 Compound Info 
N-[4-(3-chlorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H14ClN5OS
  1
1
EC50 = 3030 nM
 Bioactivity Info 
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CP0486831
 Compound Info 
N-[4-(2-fluoro-3-methoxyphenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H16FN5O2S
  1
1
EC50 = 3130 nM
 Bioactivity Info 
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CP0422390
 Compound Info 
1-(5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)pyrrolidine-3-carboxylic acid
   Show/Hide
C21H16F4N4O3S
  1
1
EC50 = 3300 nM
 Bioactivity Info 
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CP0372844
 Compound Info 
2-hydroxy-11H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C17H11NO3
  1
1
EC50 = 3400 nM
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CP0449117
 Compound Info 
N-(4-phenyl-1,3-thiazol-2-yl)-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H15N5OS
  1
1
EC50 = 3440 nM
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CP0457920
 Compound Info 
N-[3-(3,4-dichlorophenyl)-1,2,4-thiadiazol-5-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C19H12Cl2N6OS
  1
1
EC50 = 4400 nM
 Bioactivity Info 
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CP0862031
 Compound Info 
4-(2,4-Dihydroxy-naphthalen-1-ylazo)-3-hydroxy-naphthalene-1-sulfonic acid
   Show/Hide
C20H14N2O6S
  1
1
EC50 = 5000 nM
 Bioactivity Info 
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CP0886227
 Compound Info 
4-{N'-[3-Amino-1-(4-tert-butyl-phenyl)-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
   Show/Hide
C23H23N5O5S
  1
1
EC50 = 5000 nM
 Bioactivity Info 
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CP0917454
 Compound Info 
3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-naphthalene-1-carboxylic acid
   Show/Hide
C21H16N4O4
  1
1
EC50 = 5000 nM
 Bioactivity Info 
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CP0449120
 Compound Info 
N-[4-[2-fluoro-5-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H13F4N5OS
  1
1
EC50 = 5190 nM
 Bioactivity Info 
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CP0461139
 Compound Info 
N-[5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H13F4N5OS
  1
1
EC50 = 6700 nM
 Bioactivity Info 
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CP0461132
 Compound Info 
N-[4-(2-fluorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H14FN5OS
  1
1
EC50 = 6850 nM
 Bioactivity Info 
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CP0862899
 Compound Info 
3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-pyridin-2-yl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-naphthalene-1-sulfonic acid
   Show/Hide
C19H15N5O5S
  1
1
EC50 = 7000 nM
 Bioactivity Info 
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CP0559829
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-2-ylamino)benzamide
   Show/Hide
C21H13F4N5OS
  1
1
EC50 = 7700 nM
 Bioactivity Info 
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CP0503470
 Compound Info 
2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3,9-dicarboxylic acid
   Show/Hide
C18H13NO5
  1
1
EC50 = 7790 nM
 Bioactivity Info 
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CP0528225
 Compound Info 
2-hydroxy-10-(trifluoromethyl)-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C18H12F3NO3
  1
1
EC50 = 7830 nM
 Bioactivity Info 
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CP0456692
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrazin-2-ylamino)benzamide
   Show/Hide
C21H13F4N5OS
  1
1
EC50 = 7900 nM
 Bioactivity Info 
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CP0456693
 Compound Info 
N-[2-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H13F4N5O2
  1
1
EC50 = 7900 nM
 Bioactivity Info 
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CP0875099
 Compound Info 
3-Hydroxy-4-{N'-[3-methyl-1-(2-nitro-phenyl)-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-naphthalene-1-sulfonic acid
   Show/Hide
C20H15N5O7S
  1
1
EC50 = 8000 nM
 Bioactivity Info 
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CP0559830
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyridin-3-ylamino)benzamide
   Show/Hide
C22H14F4N4OS
  1
1
EC50 = 8600 nM
 Bioactivity Info 
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CP0513788
 Compound Info 
N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H14ClN5OS
  1
1
EC50 = 9000 nM
 Bioactivity Info 
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CP0504187
 Compound Info 
2-(2-hydroxy-9-methyl-11H-benzo[a]carbazol-3-yl)acetic acid
   Show/Hide
C19H15NO3
  1
1
EC50 = 9200 nM
 Bioactivity Info 
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CP0853993
 Compound Info 
3-Hydroxy-4-(2-hydroxy-4-sulfo-naphthalen-1-ylazo)-naphthalene-2-carboxylic acid
   Show/Hide
C21H14N2O7S
  1
1
EC50 = 10000 nM
 Bioactivity Info 
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CP0880367
 Compound Info 
4-{N'-[1-(3-Ethylsulfamoyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
   Show/Hide
C22H21N5O7S2
  1
1
EC50 = 10000 nM
 Bioactivity Info 
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CP0910247
 Compound Info 
3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-o-tolyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-naphthalene-1-sulfonic acid
   Show/Hide
C21H18N4O5S
  1
1
EC50 = 10000 nM
 Bioactivity Info 
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CP0384340
 Compound Info 
N-[4-(5-chloro-2-hydroxyphenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H14ClN5O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0399700
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-[(2-methylpyrimidin-4-yl)amino]benzamide
   Show/Hide
C22H15F4N5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0399701
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyridazin-3-ylamino)benzamide
   Show/Hide
C21H13F4N5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0417197
 Compound Info 
N-(3-phenyl-1,2-thiazol-5-yl)-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H15N5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0421845
 Compound Info 
4-anilino-N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]benzamide
   Show/Hide
C23H15F4N3OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0424759
 Compound Info 
N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H14N6O3S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0424760
 Compound Info 
4-(2,6-dimethylpyrimidin-4-ylamino)-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide
   Show/Hide
C23H17F4N5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0454122
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-N-methyl-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C22H15F4N5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0456709
 Compound Info 
N-[4-(2,6-difluorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H13F2N5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0456712
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(4-(2-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide
   Show/Hide
C21H14F3N5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0457729
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-pyrimidin-4-yloxybenzamide
   Show/Hide
C21H12F4N4O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0457730
 Compound Info 
N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-[methyl(pyrimidin-4-yl)amino]benzamide
   Show/Hide
C22H15F4N5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0457918
 Compound Info 
N-[1-(3,4-dichlorophenyl)pyrazol-4-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H14Cl2N6O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0457919
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(3-(3-(trifluoromethoxy)phenyl)-1,2,4-thiadiazol-5-yl)benzamide
   Show/Hide
C20H13F3N6O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0461131
 Compound Info 
N-[4-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H12Cl2F3N5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0461136
 Compound Info 
N-[3-(4-chlorophenyl)-1,2-thiazol-5-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H14ClN5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0471356
 Compound Info 
N-[5-[2-fluoro-3-(trifluoromethoxy)phenyl]-1,2,4-thiadiazol-3-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H12F4N6O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0486819
 Compound Info 
N-[4-(3-fluorophenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H14FN5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0501906
 Compound Info 
4-(1,2,4-triazin-3-ylamino)-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide
   Show/Hide
C20H12F4N6OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0501907
 Compound Info 
N-[5-[2-fluoro-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H12F4N6OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0509994
 Compound Info 
N-[4-[4-(difluoromethoxy)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H15F2N5O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0513787
 Compound Info 
4-(pyrimidin-4-ylamino)-N-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)benzamide
   Show/Hide
C21H14F3N5O2S
  1
1
EC50 = 10000 nM
 Bioactivity Info 
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CP0522829
 Compound Info 
N-[1-[2-fluoro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H14F4N6O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0543509
 Compound Info 
N-[3-[3-fluoro-4-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C20H12F4N6OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0559827
 Compound Info 
N-[4-(5-chloro-2-methoxyphenyl)-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H16ClN5O2S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0560205
 Compound Info 
N-[1-[4-fluoro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H14F4N6O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0560206
 Compound Info 
N-[5-(3,4-difluorophenyl)-1,2,4-thiadiazol-3-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C19H12F2N6OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0562520
 Compound Info 
N-[5-[2-fluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-4-(pyrimidin-4-ylamino)benzamide
   Show/Hide
C21H13F4N5OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0457695
 Compound Info 
5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)-6-(piperidin-1-yl)nicotinamide
   Show/Hide
C21H17ClF4N4OS
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0847670
 Compound Info 
4-{N'-[1-(2-Chloro-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-3-hydroxy-naphthalene-1-sulfonic acid
   Show/Hide
C20H15ClN4O5S
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0863241
 Compound Info 
4-[N'-(1-Benzyl-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-3-hydroxy-naphthalene-1-sulfonic acid
   Show/Hide
C21H18N4O5S
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0403137
 Compound Info 
11-Fluoro-10-(4-fluoro-3-methyl-phenyl)-7-oxo-5,12-dihydro-7H-6-oxa-12-aza-dibenzo[a,e]azulene-3-carboxylic acid amide
   Show/Hide
C24H16F2N2O3
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0372846
 Compound Info 
2-methoxy-11H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C18H13NO3
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0387907
 Compound Info 
2-hydroxy-11-methyl-11H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C18H13NO3
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0504164
 Compound Info 
8-cyano-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C18H12N2O3
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0510091
 Compound Info 
9-cyclohexyl-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C23H23NO3
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0522118
 Compound Info 
2-hydroxy-7-phenyl-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid
   Show/Hide
C23H17NO3
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0529140
 Compound Info 
3-(4,5-dihydro-1H-imidazol-2-yl)-10-fluoro-9-(4-fluoro-3-methylphenyl)-6,11-dihydro-5H-benzo[a]carbazole
   Show/Hide
C26H21F2N3
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0548914
 Compound Info 
3-(hydroxymethyl)-11H-benzo[a]carbazol-2-ol
   Show/Hide
C17H13NO2
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0844964
 Compound Info 
4-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-5-fluoro-2-oxoindolin-3-ylidene)ethyl)hydrazinecarbonothioyl)benzoic acid
   Show/Hide
C27H22FN3O3S
  1
1
EC50 > 200 nM
 Bioactivity Info 
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CP0905102
 Compound Info 
4-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-2-oxoindolin-3-ylidene)ethyl)hydrazinecarbonothioyl)benzoic acid
   Show/Hide
C27H23N3O3S
  1
1
EC50 > 200 nM
 Bioactivity Info 
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CP0416500
 Compound Info 
1-(3-chloro-5-(1-(2-fluoro-3-(trifluoromethyl)phenyl)-1H-pyrazol-3-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C22H18ClF4N5O3
  1
1
EC50 > 811 nM
 Bioactivity Info 
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CP0516532
 Compound Info 
1-(3-chloro-5-(5-cyano-4-(4-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C23H16ClF4N5O3S
  1
1
EC50 > 898 nM
 Bioactivity Info 
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CP0504294
 Compound Info 
1-(3-chloro-5-(4-(3-(ethoxymethyl)-4-fluorophenyl)-5-fluorothiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C24H23ClF2N4O4S
  1
1
EC50 > 970 nM
 Bioactivity Info 
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CP0498049
 Compound Info 
4-(6-(4-butylphenyl)-7-fluoro-3-isopropyl-1H-indol-2-yl)-2-hydroxybenzoic acid
   Show/Hide
C28H28FNO3
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0457698
 Compound Info 
1-(3-fluoro-5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C22H17F5N4O3S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0493404
 Compound Info 
1-(5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-3-methoxypyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C23H20F4N4O4S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0438707
 Compound Info 
1-(3-chloro-5-(4-(3,4-dichlorophenyl)-5-fluorothiazol-2-ylcarbamoyl)pyridin-2-yl)piperidine-4-carboxylic acid
   Show/Hide
C21H16Cl3FN4O3S
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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Clinical Information about the Protein
Target 1 ( Thrombopoietin receptor (MPL) )
Target Type Successful Target
Disease 1 Target-related Disease  1
1 Thrombocytopenia [ICD-11: 3B64]
Approved Drug(s) 3 Approved Drugs  3
1 Eltrombopag
 Drug Info 
Approved
Thrombocytopenia
2 Lusutrombopag
 Drug Info 
Approved
Thrombocytopenia
3 Romiplostim
 Drug Info 
Approved
Thrombocytopenia