General Information of the Compound
| Compound ID |
CP0008706
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| Compound Name |
(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one
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| Synonyms |
Romiplostim
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| Structure |
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| Formula |
C15H14N2O
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| Molecular Weight |
238.29
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| Canonical SMILES |
Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1
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| InChI |
InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
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| InChIKey |
WUWDLXZGHZSWQZ-WQLSENKSSA-N
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| CAS |
204005-46-9
194413-58-6
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
Protein ID: PT00844, Platelet-derived growth factor receptor beta
Protein ID: PT00951, Proto-oncogene tyrosine-protein kinase receptor Ret
Protein ID: PT01065, Serine/threonine-protein kinase mTOR
Protein ID: PT00846, Tyrosine-protein kinase ZAP-70
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Clinical Information about the Compound
Drug 1 ( Romiplostim )
| Drug Name | Romiplostim | ||
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| Company | Amgen | ||
| Indication | |||
| Target(s) |
Aryl hydrocarbon receptor (AHR)
Modulator
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