General Information of the Cell Line
Cell Line ID
CL000117
Cell Line Name
SF539
Synonyms
SF-539
SF-539 BT
SF.539
SF 539
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1691
Tissue Information
Brain
Disease
Gliosarcoma (NCIt: C3796)
Gliosarcoma (ORDO: Orphanet_251576)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00844, Platelet-derived growth factor receptor beta
 Protein Info 
Compound ID Compound Name Compound Formula
CP0877991
 Compound Info 
7-Benzyl-N-(4-methoxyphenyl)-2,5-dimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine hydrochloride
   Show/Hide
C22H23ClN4O
  1
1
IC50 = 7.2 nM
 Bioactivity Info 
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CP0410331
 Compound Info 
7-benzyl-4-N-(4-methoxyphenyl)-4-N-methyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-diamine
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C21H21N5O
  1
1
IC50 = 8.1 nM
 Bioactivity Info 
   TI
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CP0906523
 Compound Info 
7-Benzyl-N-(4-methoxyphenyl)-N,2,5-trimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine hydrochloride
   Show/Hide
C23H25ClN4O
  1
1
IC50 = 10.3 nM
 Bioactivity Info 
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CP0906525
 Compound Info 
1-(7-Benzyl-2,5-dimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline hydrochloride
   Show/Hide
C25H27ClN4O
  1
1
IC50 = 30.2 nM
 Bioactivity Info 
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CP0002211
 Compound Info 
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
   Show/Hide
C22H27FN4O2
  2
1
IC50 = 83.1 nM
 Bioactivity Info 
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2
IC50 = 12200 nM
 Bioactivity Info 
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CP0897293
 Compound Info 
1-(7-Benzyl-2-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline hydrochloride
   Show/Hide
C24H25ClN4O
  1
1
IC50 = 90.3 nM
 Bioactivity Info 
   TI
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CP0091315
 Compound Info 
US9422297, AAG145-136
   Show/Hide
C17H13ClN4
  1
1
IC50 = 800 nM
 Bioactivity Info 
   TI
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CP0402194
 Compound Info 
4-N-(3-bromophenyl)-7-[(2-chlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
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C19H15BrClN5
  1
1
IC50 = 1500 nM
 Bioactivity Info 
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CP0402193
 Compound Info 
4-N-(3-bromophenyl)-7-[(3,4,5-trimethoxyphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
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C22H22BrN5O3
  1
1
IC50 = 1800 nM
 Bioactivity Info 
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CP0008706
 Compound Info 
(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one
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C15H14N2O
  1
1
IC50 = 2400 nM
 Bioactivity Info 
   TI
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CP0050064
 Compound Info 
US9422297, AAG145-135
   Show/Hide
C17H12ClFN4
  1
1
IC50 = 3600 nM
 Bioactivity Info 
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CP0016245
 Compound Info 
(3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-dihydro-1H-indol-2-one
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C17H16N2O
  2
1
IC50 = 3700 nM
 Bioactivity Info 
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2
IC50 = 3750 nM
 Bioactivity Info 
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CP0867392
 Compound Info 
N4-(4-Fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine
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C17H13FN4
  1
1
IC50 = 5900 nM
 Bioactivity Info 
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CP0011624
 Compound Info 
AG1295
   Show/Hide
C16H14N2
  1
1
IC50 = 6200 nM
 Bioactivity Info 
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CP0093436
 Compound Info 
US9422297, AAG145-164
   Show/Hide
C17H12ClFN4
  1
1
IC50 = 6400 nM
 Bioactivity Info 
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CP0093435
 Compound Info 
US9422297, AAG145-161
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C17H13FN4
  1
1
IC50 = 7100 nM
 Bioactivity Info 
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CP0160645
 Compound Info 
US9422297, AAG145-126
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C20H20N4
  1
1
IC50 = 7800 nM
 Bioactivity Info 
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CP0096083
 Compound Info 
4-N-(3-bromophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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C21H20BrN5O2
  1
1
IC50 = 8900 nM
 Bioactivity Info 
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CP0391385
 Compound Info 
4-N-(4-chlorophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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C23H18ClN5
  1
1
IC50 = 8920 nM
 Bioactivity Info 
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CP0039638
 Compound Info 
2,4-diaminofuro[2,3-d]pyrimidine, 1a
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C16H16N4O2
  1
1
IC50 = 12800 nM
 Bioactivity Info 
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CP0410666
 Compound Info 
4-N-(3-bromophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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C19H17BrN6
  1
1
IC50 = 13400 nM
 Bioactivity Info 
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CP0275218
 Compound Info 
4-N-(3-bromophenyl)-6-[(2,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C19H14BrCl2N5
  1
1
IC50 = 17000 nM
 Bioactivity Info 
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CP0039635
 Compound Info 
2,4-diaminofuro[2,3-d]pyrimidine, 13
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C19H24N4O2
  1
1
IC50 = 17400 nM
 Bioactivity Info 
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CP0416275
 Compound Info 
US9422297, AAG145-124
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C20H20N4
  1
1
IC50 = 21700 nM
 Bioactivity Info 
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CP0864074
 Compound Info 
N4-(4-(Trifluoromethyl)phenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine
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C18H13F3N4
  1
1
IC50 = 23100 nM
 Bioactivity Info 
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CP0400032
 Compound Info 
4-N-(4-chloro-2-fluorophenyl)-6-[(2,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C19H13Cl3FN5
  1
1
IC50 = 24600 nM
 Bioactivity Info 
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CP0372838
 Compound Info 
4-N-(3-bromophenyl)-7-[(2,4-dichlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C19H14BrCl2N5
  1
1
IC50 = 34200 nM
 Bioactivity Info 
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CP0954268
 Compound Info 
N4-(4-Bromophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine
   Show/Hide
C17H13BrN4
  1
1
IC50 = 38900 nM
 Bioactivity Info 
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CP0454238
 Compound Info 
6-[(2,4-dichlorophenyl)methyl]-4-N-(2-propan-2-ylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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C22H21Cl2N5
  1
1
IC50 = 43000 nM
 Bioactivity Info 
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CP0093434
 Compound Info 
US9422297, AAG145-158
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C17H14N4
  1
1
IC50 = 43100 nM
 Bioactivity Info 
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CP0395235
 Compound Info 
4-N-(4-chlorophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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C21H20ClN5O2
  1
1
IC50 = 44300 nM
 Bioactivity Info 
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CP0167979
 Compound Info 
4-N-(3-bromophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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C20H18BrN5
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0392884
 Compound Info 
4-N-(4-chloro-2-fluorophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C20H17ClFN5
  1
1
IC50 > 50000 nM
 Bioactivity Info 
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CP0473414
 Compound Info 
5-chloro-4-N-(3-methoxyphenyl)-9H-pyrimido[4,5-b]indole-2,4-diamine
   Show/Hide
C17H14ClN5O
  1
1
IC50 = 50500 nM
 Bioactivity Info 
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CP0111386
 Compound Info 
5-naphthalen-1-ylsulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
   Show/Hide
C20H15N5S
  1
1
IC50 = 58200 nM
 Bioactivity Info 
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CP0267274
 Compound Info 
5-(4-methoxyphenyl)sulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
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C17H15N5OS
  1
1
IC50 = 60500 nM
 Bioactivity Info 
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CP0431281
 Compound Info 
N-(4-anilino-5-chloro-9H-pyrimido[4,5-b]indol-2-yl)-2,2-dimethylpropanamide
   Show/Hide
C21H20ClN5O
  1
1
IC50 = 70600 nM
 Bioactivity Info 
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CP0250195
 Compound Info 
US9422297, AAG145-159
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C18H16N4O
  1
1
IC50 = 75500 nM
 Bioactivity Info 
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CP0037987
 Compound Info 
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
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C22H23N3O4
  1
1
IC50 = 83100 nM
 Bioactivity Info 
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CP0727218
 Compound Info 
5-[(Z/E)-2-(20-Methoxyphenyl)pent-1-en-1-yl]furo[2,3-d]-pyrimidine-2,4-diamine
   Show/Hide
C18H20N4O2
  1
1
IC50 = 88200 nM
 Bioactivity Info 
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CP0469395
 Compound Info 
N-[4-(3-bromo-4-fluoroanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
   Show/Hide
C24H24BrFN6O
  1
1
IC50 = 89700 nM
 Bioactivity Info 
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CP0199922
 Compound Info 
5-naphthalen-2-ylsulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
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C20H15N5S
  1
1
IC50 = 90100 nM
 Bioactivity Info 
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CP0464065
 Compound Info 
7-benzyl-4-(6-methoxy-3,4-dihydro-2H-quinolin-1-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine
   Show/Hide
C23H23N5O
  1
1
IC50 > 200 nM
 Bioactivity Info 
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CP0910286
 Compound Info 
7-Benzyl-4-(5-methoxyindolin-1-yl)-2-methyl-5H-pyrrolo[3,2-d]pyrimidine hydrochloride
   Show/Hide
C23H23ClN4O
  1
1
IC50 > 200 nM
 Bioactivity Info 
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Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0003433
 Compound Info 
(Arylindolyl)maleimide deriv. 27
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 C21H16N4O2  1
1
LC50 = 42400 nM
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CP0006369
 Compound Info 
6-[3-[4-[1-(5-cyanopentyl)indol-3-yl]-1-hydroxy-2,5-dioxopyrrol-3-yl]indol-1-yl]hexanenitrile
   Show/Hide
 C32H31N5O3  1
1
LC50 > 100000 nM
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CP0015738
 Compound Info 
(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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 C24H36N4O6S2  1
1
GI50 = 3.6 nM
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CP0062042
 Compound Info 
5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-N-(2-pyridin-2-yl-ethyl)-benzamide
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 C21H21N3O4  1
1
GI50 = 29000 nM
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CP0082019
 Compound Info 
(2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid
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 C22H21NO2S  1
1
GI50 = 790 nM
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CP0085832
 Compound Info 
(1R,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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 C24H36N4O6S2  1
1
GI50 = 3.6 nM
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CP0086475
 Compound Info 
2-[(4-methoxyphenyl)-diphenylmethyl]sulfanylethanamine
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 C22H23NOS  1
1
GI50 = 250 nM
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CP0184260
 Compound Info 
N-[2-(4-bromophenyl)ethyl]-5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzamide
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 C22H21BrN2O4  1
1
GI50 = 15800 nM
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CP0212776
 Compound Info 
5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-N-phenethyl-benzamide
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 C22H22N2O4  1
1
GI50 = 17000 nM
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CP0267543
 Compound Info 
5-(2,5-Dihydroxy-benzylamino)-N-hexyl-2-hydroxy-benzamide
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 C20H26N2O4  1
1
GI50 = 2300 nM
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CP0270683
 Compound Info 
5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-N-(3-phenyl-propyl)-benzamide
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 C23H24N2O4  1
1
GI50 = 16000 nM
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CP0370065
 Compound Info 
5-(4-chlorophenyl)-2-(4-methoxyphenyl)-[1,3]thiazolo[3,2-b][1,2,4]triazole
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 C17H12ClN3OS  1
1
LC50 > 50000 nM
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CP0451721
 Compound Info 
(1S,7R,10S,16E,21R)-7-benzyl-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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 C26H34N4O6S2  1
1
GI50 = 3.3 nM
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CP0465282
 Compound Info 
4-N-(4-methoxyphenyl)-4-N-methyl-9H-pyrimido[4,5-b]indole-2,4-diamine
   Show/Hide
 C18H17N5O  1
1
GI50 = 24.2 nM
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CP0517983
 Compound Info 
N-[4-[2-[(2S,3S,5S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-1,3-dithian-2-yl]phenyl]-N'-hydroxyoctanediamide
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 C34H52N4O7S2Si  1
1
GI50 = 4570.88 nM
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Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Brain)
Cell Line Name Organism Disease
TS603
 Cell Line Info 
Homo sapiens (Human) Anaplastic oligodendroglioma
H4
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
1321N1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
SNB-19
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
U-251MG
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
U-373MG ATCC
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
LN-308
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
CCF-STTG1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
LN-319
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
P2X7-1321N1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
MDA-MB-361
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
JEG-3
 Cell Line Info 
Homo sapiens (Human) Gestational choriocarcinoma
D3 [Human glioblastoma]
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN-229
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN-18
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
A-172
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
UC-11MG
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
T98G
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN229-V6R
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
MED1
 Cell Line Info 
Homo sapiens (Human) Medulloblastoma, non-WNT/non-SHH, group 4
Kelly
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
PFSK-1
 Cell Line Info 
Homo sapiens (Human) Primitive neuroectodermal tumor
DU145
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
DU145-TxR
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
GL261
 Cell Line Info 
Mus musculus (Mouse) Mouse glioblastoma
C6
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
C6-BU-1
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
RG2
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
ReNcell VM
 Cell Line Info 
Homo sapiens (Human) -
hCMEC/D3
 Cell Line Info 
Homo sapiens (Human) -
BV-2
 Cell Line Info 
Mus musculus (Mouse) -
C17.2
 Cell Line Info 
Mus musculus (Mouse) -
ScGT1
 Cell Line Info 
Mus musculus (Mouse) -
bEnd.4
 Cell Line Info 
Mus musculus (Mouse) -
N39
 Cell Line Info 
Mus musculus (Mouse) -
GT1-7
 Cell Line Info 
Mus musculus (Mouse) -
N27-A
 Cell Line Info 
Rattus norvegicus (Rat) -
RBE4
 Cell Line Info 
Rattus norvegicus (Rat) -