General Information of the Cell Line
Cell Line ID
CL000438
Cell Line Name
A-172
Synonyms
A172
A 172
A-172 MG
A-172MG
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0131
Tissue Information
Brain
Disease
Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01557, Indoleamine 2,3-dioxygenase 1
 Protein Info 
Compound ID Compound Name Compound Formula
CP0564188
 Compound Info 
(1S)-1-cyclohexyl-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]ethanol
   Show/Hide
C18H22N2O
  1
1
EC50 = 130 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0238103
 Compound Info 
(1S,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-1,2,3,4-tetrahydronaphthalen-1-ol
   Show/Hide
C20H18N2O
  1
1
EC50 = 240 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0552205
 Compound Info 
(5S)-5-cyclohexyl-5H-imidazo[5,1-a]isoindole
   Show/Hide
C16H18N2
  1
1
EC50 = 420 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519131
 Compound Info 
(1R,2S)-1-cyclohexyl-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]propan-1-ol
   Show/Hide
C19H24N2O
  1
1
EC50 = 670 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0387082
 Compound Info 
(7S,8S)-8-hydroxy-7-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile
   Show/Hide
C21H17N3O
  1
1
EC50 = 690 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0438720
 Compound Info 
(1R,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]cyclohexan-1-ol
   Show/Hide
C16H18N2O
  1
1
EC50 = 720 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0537143
 Compound Info 
(5S,6S)-6-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-5,6,7,8-tetrahydroisoquinolin-5-ol
   Show/Hide
C19H17N3O
  1
1
EC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0387094
 Compound Info 
(1S,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-7-methylsulfonyl-1,2,3,4-tetrahydronaphthalen-1-ol
   Show/Hide
C21H20N2O3S
  1
1
EC50 = 880 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0165568
 Compound Info 
(3S,4S)-4-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-1-methylsulfonylpiperidin-3-ol
   Show/Hide
C16H19N3O3S
  1
1
EC50 = 970 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0462096
 Compound Info 
(1S,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-6-methylsulfonyl-1,2,3,4-tetrahydronaphthalen-1-ol
   Show/Hide
C21H20N2O3S
  1
1
EC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0394145
 Compound Info 
(7S,8S)-7-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-5,6,7,8-tetrahydroisoquinolin-8-ol
   Show/Hide
C19H17N3O
  1
1
EC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0476298
 Compound Info 
(1R,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]cyclobutan-1-ol
   Show/Hide
C14H14N2O
  1
1
EC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0165569
 Compound Info 
(3S,4S)-4-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]oxan-3-ol
   Show/Hide
C15H16N2O2
  1
1
EC50 = 1600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0482242
 Compound Info 
(1R,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]cyclopentan-1-ol
   Show/Hide
C15H16N2O
  1
1
EC50 = 2200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0225409
 Compound Info 
(7S,8S)-8-hydroxy-7-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-5,6,7,8-tetrahydronaphthalene-2-carboxamide
   Show/Hide
C21H19N3O2
  1
1
EC50 = 2600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519130
 Compound Info 
(3R,4R)-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]oxan-4-ol
   Show/Hide
C15H16N2O2
  1
1
EC50 = 2900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0230210
 Compound Info 
(4S,5S)-5-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol
   Show/Hide
C17H16N4O
  1
1
EC50 = 4500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0165570
 Compound Info 
(4S,5S)-5-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-4,5,6,7-tetrahydro-2,1,3-benzoxadiazol-4-ol
   Show/Hide
C16H14N4O2
  1
1
EC50 = 4600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0327837
 Compound Info 
(1S,2S)-7-dimethylphosphoryl-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-1,2,3,4-tetrahydronaphthalen-1-ol
   Show/Hide
C22H23N2O2P
  1
1
EC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519132
 Compound Info 
(4S,5S)-5-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-1-methyl-4,5,6,7-tetrahydroindazol-4-ol
   Show/Hide
C18H18N4O
  1
1
EC50 = 13000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0537144
 Compound Info 
(3S,4S)-4-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-1-methylpiperidin-3-ol
   Show/Hide
C16H19N3O
  1
1
EC50 = 20000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0387095
 Compound Info 
1-[(3S,4S)-3-hydroxy-4-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]piperidin-1-yl]ethanone
   Show/Hide
C17H19N3O2
  1
1
EC50 > 25000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0394144
 Compound Info 
(7S,8S)-7-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-ol
   Show/Hide
C16H15N5O
  1
1
EC50 > 25000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01472, Nitric oxide synthase, inducible
 Protein Info 
Protein ID: PT02896, Tryptophan 2,3-dioxygenase
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0140704
 Compound Info 
2-[[5-chloro-2-[4-[[[3,4-dioxo-2-[2-(prop-2-enoylamino)ethylamino]cyclobuten-1-yl]amino]methyl]anilino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
 C28H27ClN8O4  1
1
IC50 = 650 nM
   TI
   LI
   LO
   TS
CP0154554
 Compound Info 
[4-(1-methylimidazole-4-carbonyl)piperazin-1-yl]-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
   Show/Hide
 C24H22N10O2  1
1
GI50 = 3162.28 nM
   TI
   LI
   LO
   TS
CP0424792
 Compound Info 
2-[[5-chloro-2-[4-[[[2-[2-[[(E)-2-cyano-3-cyclopropylprop-2-enoyl]amino]ethylamino]-3,4-dioxocyclobuten-1-yl]amino]methyl]anilino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
 C32H30ClN9O4  1
1
IC50 = 890 nM
   TI
   LI
   LO
   TS
CP0725696
 Compound Info 
N-[3-(2,5-Dimethoxybenzyloxy)-4-(methanesulfonylamino)-phenyl]-4-methoxybenzamide
   Show/Hide
 C24H26N2O7S  1
1
IC50 = 6.24 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Brain)
Cell Line Name Organism Disease
TS603
 Cell Line Info 
Homo sapiens (Human) Anaplastic oligodendroglioma
H4
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
1321N1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
SNB-19
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
U-251MG
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
U-373MG ATCC
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
LN-308
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
CCF-STTG1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
LN-319
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
P2X7-1321N1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
MDA-MB-361
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
JEG-3
 Cell Line Info 
Homo sapiens (Human) Gestational choriocarcinoma
D3 [Human glioblastoma]
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN-229
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN-18
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
UC-11MG
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
T98G
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN229-V6R
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
SF539
 Cell Line Info 
Homo sapiens (Human) Gliosarcoma
MED1
 Cell Line Info 
Homo sapiens (Human) Medulloblastoma, non-WNT/non-SHH, group 4
Kelly
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
PFSK-1
 Cell Line Info 
Homo sapiens (Human) Primitive neuroectodermal tumor
DU145
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
DU145-TxR
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
GL261
 Cell Line Info 
Mus musculus (Mouse) Mouse glioblastoma
C6
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
C6-BU-1
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
RG2
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
ReNcell VM
 Cell Line Info 
Homo sapiens (Human) -
hCMEC/D3
 Cell Line Info 
Homo sapiens (Human) -
BV-2
 Cell Line Info 
Mus musculus (Mouse) -
C17.2
 Cell Line Info 
Mus musculus (Mouse) -
ScGT1
 Cell Line Info 
Mus musculus (Mouse) -
bEnd.4
 Cell Line Info 
Mus musculus (Mouse) -
N39
 Cell Line Info 
Mus musculus (Mouse) -
GT1-7
 Cell Line Info 
Mus musculus (Mouse) -
N27-A
 Cell Line Info 
Rattus norvegicus (Rat) -
RBE4
 Cell Line Info 
Rattus norvegicus (Rat) -