General Information of the Cell Line
Cell Line ID
CL000008
Cell Line Name
H4
Synonyms
H-4
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1239
Tissue Information
Brain
Disease
Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01020, Beta-secretase 1
Compound ID Compound Name Compound Formula
CP0221964
2-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-6-methoxy-1H-benzimidazole
   Show/Hide
C21H16N4O
 1
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0093283
6-fluoro-2-[3-(7-fluoroimidazo[1,2-a]pyridin-2-yl)phenyl]-1H-benzimidazole
   Show/Hide
C20H12F2N4
 1
1
EC50 = 37 nM
   TI
   LI
   LO
   TS
CP0093287
6-fluoro-2-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-1H-benzimidazole
   Show/Hide
C20H13FN4
 1
1
EC50 = 120 nM
   TI
   LI
   LO
   TS
CP0083415
3-[5-(3-methoxyphenyl)-1H-imidazol-2-yl]-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide
   Show/Hide
C27H28N4O4S
 1
1
EC50 = 179 nM
   TI
   LI
   LO
   TS
CP0077754
3-(6-fluoro-1H-benzimidazol-2-yl)-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide
   Show/Hide
C24H23FN4O3S
 1
1
EC50 = 230 nM
   TI
   LI
   LO
   TS
CP0436649
6-fluoro-2-[3-[2-[6-(trifluoromethoxy)-1H-indol-3-yl]-1H-imidazol-5-yl]phenyl]-1H-benzimidazole
   Show/Hide
C25H15F4N5O
 1
1
EC50 = 290 nM
   TI
   LI
   LO
   TS
CP0093281
N-tert-butyl-2-[3-(6-methoxy-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine
   Show/Hide
C25H25N5O
 1
1
EC50 = 310 nM
   TI
   LI
   LO
   TS
CP0436648
6-fluoro-2-[3-[2-(6-fluoro-1H-indol-3-yl)-1H-imidazol-5-yl]phenyl]-1H-benzimidazole
   Show/Hide
C24H15F2N5
 1
1
EC50 = 350 nM
   TI
   LI
   LO
   TS
CP0413439
N-[3-[2-(6-fluoro-1H-indol-3-yl)-1H-imidazol-5-yl]phenyl]pyridine-3-carboxamide
   Show/Hide
C23H16FN5O
 1
1
EC50 = 410 nM
   TI
   LI
   LO
   TS
CP0077742
3-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]-5-(5-phenyl-1H-imidazol-2-yl)benzamide
   Show/Hide
C26H26N4O3S
 1
1
EC50 = 450 nM
   TI
   LI
   LO
   TS
CP0475007
N-[3-[2-(1H-indol-3-yl)-1H-imidazol-5-yl]phenyl]pyridine-3-carboxamide
   Show/Hide
C23H17N5O
 1
1
EC50 = 480 nM
   TI
   LI
   LO
   TS
CP0420349
3-[2-(1H-indol-3-yl)-1H-imidazol-5-yl]-N-pyridin-4-ylbenzamide
   Show/Hide
C23H17N5O
 1
1
EC50 = 590 nM
   TI
   LI
   LO
   TS
CP0447153
3-[5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]phenyl]-1H-imidazol-2-yl]-6-(trifluoromethoxy)-1H-indole
   Show/Hide
C27H17F4N5O
 1
1
EC50 = 670 nM
   TI
   LI
   LO
   TS
CP0403363
6-fluoro-3-[5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]phenyl]-1H-imidazol-2-yl]-1H-indole
   Show/Hide
C26H17F2N5
 1
1
EC50 = 810 nM
   TI
   LI
   LO
   TS
CP0420345
3-[2-(1H-indol-3-yl)-1H-imidazol-5-yl]-N-pyridin-3-ylbenzamide
   Show/Hide
C23H17N5O
 1
1
EC50 = 880 nM
   TI
   LI
   LO
   TS
CP0080789
N-tert-butyl-2-[3-(6-fluoro-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine
   Show/Hide
C24H22FN5
 1
1
EC50 = 930 nM
   TI
   LI
   LO
   TS
CP0420346
3-[2-(1H-indol-3-yl)-1H-imidazol-5-yl]-N-phenylbenzamide
   Show/Hide
C24H18N4O
 1
1
EC50 = 1210 nM
   TI
   LI
   LO
   TS
CP0420348
N-(4-fluorophenyl)-3-[2-(1H-indol-3-yl)-1H-imidazol-5-yl]benzamide
   Show/Hide
C24H17FN4O
 1
1
EC50 = 1330 nM
   TI
   LI
   LO
   TS
CP0132641
2-[3-(1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridine
   Show/Hide
C20H14N4
 1
1
EC50 = 1550 nM
   TI
   LI
   LO
   TS
CP0077747
N-tert-butyl-2-[4-(6-methoxy-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine
   Show/Hide
C25H25N5O
 1
1
EC50 = 2405 nM
   TI
   LI
   LO
   TS
CP0369611
US9315520, 19
   Show/Hide
C18H21N5O3S2
 1
1
IC50 = 0.014 nM
   TI
   LI
   LO
   TS
CP0080989
(4S,6R)-4-[2,4-difluoro-5-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]phenyl]-4,6-dimethyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C17H20F5N3S
 1
1
IC50 = 0.024 nM
   TI
   LI
   LO
   TS
CP0232239
2-[(4aR,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-N-(6-methoxypyridin-2-yl)-1,3-thiazole-5-carboxamide
   Show/Hide
C18H21N5O3S2
 1
1
IC50 = 0.033 nM
   TI
   LI
   LO
   TS
CP0346856
N-[2-[(4aR,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-4-methoxybenzamide
   Show/Hide
C19H22N4O3S2
 1
1
IC50 = 0.034 nM
   TI
   LI
   LO
   TS
CP0446346
2-[(4aR,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-N-(3-methoxyphenyl)-1,3-thiazole-5-carboxamide
   Show/Hide
C19H22N4O3S2
 1
1
IC50 = 0.11 nM
   TI
   LI
   LO
   TS
CP0093593
US8940748, 34
   Show/Hide
C17H17ClFN5O3S
 1
1
IC50 < 0.54 nM
   TI
   LI
   LO
   TS
CP0232211
N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-1-(difluoromethyl)-1H-pyrazole-3-carboxamide
   Show/Hide
C16H18F2N6O2S2
 1
1
IC50 = 0.64 nM
   TI
   LI
   LO
   TS
CP0177658
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4,5-difluorophenyl]-5-methoxypyrazine-2-carboxamide
   Show/Hide
C22H22F2N6O3S
 1
1
IC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0561923
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
   Show/Hide
C22H20ClF2N5O2S
 1
1
IC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0080988
(4S)-4-[2,4-difluoro-5-[(propan-2-ylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C15H21F2N3S
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0445151
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-5-fluorophenyl]-5-chloropyridine-2-carboxamide
   Show/Hide
C22H21ClFN5O2S
 1
1
IC50 = 2.3 nM
   TI
   LI
   LO
   TS
CP0097508
US9315520, 45
   Show/Hide
C19H21F2N5O3S2
 1
1
IC50 = 2.9 nM
   TI
   LI
   LO
   TS
CP0124822
US9315520, 7
   Show/Hide
C17H18ClN5O2S2
 1
1
IC50 = 3.8 nM
   TI
   LI
   LO
   TS
CP0484759
N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-5-cyanopyridine-2-carboxamide
   Show/Hide
C18H18N6O2S2
 1
1
IC50 = 3.9 nM
   TI
   LI
   LO
   TS
CP0080980
(4S)-4-[5-[(1-bicyclo[1.1.1]pentanylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C17H21F2N3S
 1
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
CP0210813
(4S)-4-[2,4-difluoro-5-[[[(2R)-1-methoxypropan-2-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C16H23F2N3OS
 1
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
CP0179937
US9315520, 17
   Show/Hide
C18H18F3N5O2S2
 1
1
IC50 = 4.8 nM
   TI
   LI
   LO
   TS
CP0561925
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
   Show/Hide
C21H19ClFN5O2S
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0097523
US9315520, 1
   Show/Hide
C18H19F2N5O3S2
 1
1
IC50 = 5.1 nM
   TI
   LI
   LO
   TS
CP0080992
(4S)-4-[2,4-difluoro-5-[(2-methoxyethylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C15H21F2N3OS
 1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0097501
N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-5-(difluoromethoxy)pyrazine-2-carboxamide
   Show/Hide
C17H18F2N6O3S2
 1
1
IC50 = 7.2 nM
   TI
   LI
   LO
   TS
CP0420059
(4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C20H19F2N5OS
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0080983
(4S)-4-[5-(ethylaminomethyl)-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C14H19F2N3S
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0210815
(4S)-4-[5-[[[1-(difluoromethyl)cyclopropyl]amino]methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C16H19F4N3S
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0446351
US9315520, 20
   Show/Hide
C18H18F3N5O3S2
 1
1
IC50 = 12.5 nM
   TI
   LI
   LO
   TS
CP0308349
(4S)-4-[5-[(cyclopropylmethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C16H21F2N3S
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0213393
(4S)-4-[2,4-difluoro-5-[[[3-(trifluoromethyl)oxetan-3-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C16H18F5N3OS
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0210820
(4S)-4-[2,4-difluoro-5-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C16H18F5N3S
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0528855
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-bromopyridine-2-carboxamide
   Show/Hide
C21H19BrFN5O2S
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0274274
(4S)-4-[5-[(dimethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C14H19F2N3S
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0097502
US9315520, 9
   Show/Hide
C17H18FN5O2S2
 1
1
IC50 = 23.7 nM
   TI
   LI
   LO
   TS
CP0086745
US9403846, 2
   Show/Hide
C16H18F2N2OS
 1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0210814
1-[[5-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-2,4-difluorophenyl]methylamino]cyclopropane-1-carbonitrile
   Show/Hide
C16H18F2N4S
 1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0089046
(4aR,6S,8aS)-8a-(2,4-difluorophenyl)-6-(2-methylpropyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C17H22F2N2OS
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0076103
US9315520, 13
   Show/Hide
C18H20FN5O2S2
 1
1
IC50 = 26.9 nM
   TI
   LI
   LO
   TS
CP0086746
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(methoxymethyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C15H18F2N2O2S
 2
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
2
IC50 = 855 nM
   TI
   LI
   LO
   TS
CP0460337
(4S,6S)-4-[3-chloro-5-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C22H21ClN4OS2
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0207107
(4S)-4-[5-[(cyclopropylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C15H19F2N3S
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0561924
N-[5-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-2,4-difluorophenyl]-5-chloropyridine-2-carboxamide
   Show/Hide
C22H20ClF2N5O2S
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0359991
(4S)-4-[2,4-difluoro-5-[[(1,1,1-trifluoro-2-methylpropan-2-yl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C16H20F5N3S
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0115128
US8865706, 16
   Show/Hide
C18H20F2N4OS
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0558517
(4S)-4-[2,4-difluoro-5-[[(3R)-3-methoxypyrrolidin-1-yl]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C17H23F2N3OS
 1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
CP0097529
N-[3-[(4aR,7aS)-2-amino-4a,5,6,7-tetrahydro-4H-cyclopenta[d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide
   Show/Hide
C19H18F2N4OS
 1
1
IC50 = 38.4 nM
   TI
   LI
   LO
   TS
CP0108321
(4aR,6S,8aS)-8a-(2,4-difluorophenyl)-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C14H16F2N2OS
 1
1
IC50 = 39 nM
   TI
   LI
   LO
   TS
CP0238478
US9315520, 10
   Show/Hide
C17H20N6O3S2
 1
1
IC50 = 47.6 nM
   TI
   LI
   LO
   TS
CP0724426
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1-methyl-1H-pyrazol-4-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C17H18F2N4OS
 1
1
IC50 = 52 nM
   TI
   LI
   LO
   TS
CP0123099
US8865706, 13
   Show/Hide
C18H18F3N3O2S
 1
1
IC50 = 53 nM
   TI
   LI
   LO
   TS
CP0236143
(4S)-4-[2,4-difluoro-5-[(3-methoxypropylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C16H23F2N3OS
 1
1
IC50 = 53 nM
   TI
   LI
   LO
   TS
CP0210817
(4S)-4-[5-[(2,2-difluoroethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C14H17F4N3S
 1
1
IC50 = 58 nM
   TI
   LI
   LO
   TS
CP0313510
(4aR,6R,8aS)-6-(difluoromethyl)-8a-(2,4-difluorophenyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C14H14F4N2OS
 1
1
IC50 = 59 nM
   TI
   LI
   LO
   TS
CP0365888
(4aR,6S,8aS)-8a-(2,4-difluorophenyl)-6-ethyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C15H18F2N2OS
 1
1
IC50 = 59 nM
   TI
   LI
   LO
   TS
CP0508014
(4S,6S)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[4-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-5,6-dihydro-4H-1,3-thiazin-2-amine
   Show/Hide
C21H20N4OS2
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0210818
(4S)-4-[2,4-difluoro-5-[(2,2,2-trifluoroethylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C14H16F5N3S
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0343449
US8933221, 4
   Show/Hide
C14H15F3N2OS
 2
1
IC50 = 61 nM
   TI
   LI
   LO
   TS
2
IC50 = 1070 nM
   TI
   LI
   LO
   TS
CP0123098
US8865706, 22
   Show/Hide
C18H19F3N4OS
 1
1
IC50 = 63 nM
   TI
   LI
   LO
   TS
CP0207108
(4S)-4-[2,4-difluoro-5-[[[(2R)-1,1,1-trifluoropropan-2-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C15H18F5N3S
 1
1
IC50 = 64 nM
   TI
   LI
   LO
   TS
CP0420061
(4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5,6-dihydro-4H-1,3-thiazin-2-amine
   Show/Hide
C19H17F2N5OS
 2
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
2
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0123096
US8865706, 9
   Show/Hide
C18H19F2N3O2S
 1
1
IC50 = 74 nM
   TI
   LI
   LO
   TS
CP0187394
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(3-methyl-1,2-oxazol-5-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C17H17F2N3O2S
 1
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
CP0123101
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(4-methyl-1,3-oxazol-2-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C17H17F2N3O2S
 1
1
IC50 = 84 nM
   TI
   LI
   LO
   TS
CP0460340
3-[5-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-2,4-difluorophenyl]pyridine-2-carbonitrile
   Show/Hide
C22H19F2N5OS
 1
1
IC50 = 87 nM
   TI
   LI
   LO
   TS
CP0120434
4-[[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxo-2lambda6-thia-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]-2-propan-2-yloxyphenol
   Show/Hide
C24H32FN3O4S
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0118373
US8962616, 22
   Show/Hide
C18H19F2N3O2S
 1
1
IC50 = 103 nM
   TI
   LI
   LO
   TS
CP0460338
1-[4-[(4S,6S)-2-amino-4-(2,4-difluorophenyl)-4-methyl-5,6-dihydro-1,3-thiazin-6-yl]-3-methyl-1,2-oxazol-5-yl]-2-methylpropan-2-ol
   Show/Hide
C19H23F2N3O2S
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0149411
(4aR,6S,8aR)-6-methyl-8a-thiophen-2-yl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C12H16N2OS2
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0058522
(4S,4aR,6R,8aS)-8a-(2,4-difluorophenyl)-4-(fluoromethyl)-6-(4-methyl-1,3-oxazol-2-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C18H18F3N3O2S
 1
1
IC50 = 116 nM
   TI
   LI
   LO
   TS
CP0543109
(4S,6S)-4-(2,4-difluorophenyl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C16H17F2N3OS
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0414546
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-2-fluorophenyl]-5-chloropyridine-2-carboxamide
   Show/Hide
C22H21ClFN5O2S
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0495227
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C21H19F2N3OS
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0540590
(4aR,6S,8aS)-6-methyl-8a-thiophen-3-yl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C12H16N2OS2
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0561926
(4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-6-methyl-6-(5-methyl-1,2-oxazol-4-yl)-4,5-dihydro-1,3-thiazin-2-amine
   Show/Hide
C19H17F2N5OS
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0531981
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-(5-methyl-3-pyridin-3-yl-1,2-oxazol-4-yl)-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C20H18F2N4OS
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0475484
(4S,6S)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-(3-pyrimidin-5-ylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
   Show/Hide
C19H19N5OS
 1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0534902
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-(3-methyl-5-phenyl-1,2-oxazol-4-yl)-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C21H19F2N3OS
 1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0334115
4-[[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxo-2lambda6-thia-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]phenol
   Show/Hide
C21H26FN3O3S
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0179938
(4aR,6S,8aS)-8a-(3-fluoropyridin-2-yl)-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C13H16FN3OS
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0495225
(4S,6S)-4-(2,4-difluorophenyl)-6-(3-ethyl-5-methyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C17H19F2N3OS
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0322280
US8933221, 1
   Show/Hide
C13H14F2N2OS
 1
1
IC50 = 265 nM
   TI
   LI
   LO
   TS
CP0080546
(4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C15H14F2N4S
 1
1
IC50 = 270 nM
   TI
   LI
   LO
   TS
CP0103382
(5R,7S)-8-[(3-ethyl-2H-indazol-5-yl)methyl]-1-(3-fluorophenyl)-3,7-dimethyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
   Show/Hide
C24H30FN5O2S
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0475485
(4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-6-(3,4-dimethoxyphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
   Show/Hide
C22H20F2N4O2S
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0549993
3-[5-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5,6-dihydro-4H-1,3-thiazin-4-yl]thiophen-3-yl]benzonitrile
   Show/Hide
C20H18N4OS2
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0534901
(4S,6S)-4-(3-chlorothiophen-2-yl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C14H16ClN3OS2
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0574763
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-(3-methyl-1,2-oxazol-4-yl)-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C15H15F2N3OS
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0189779
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-pyrimidin-5-yl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C15H14F2N4S
 1
1
IC50 = 310 nM
   TI
   LI
   LO
   TS
CP0574762
(4S,6S)-4-(2,4-difluorophenyl)-6-[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C21H18F3N3OS
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0334730
2-chloro-4-[[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxo-2lambda6-thia-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]phenol
   Show/Hide
C21H25ClFN3O3S
 1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
CP0528535
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-(2-methylpyrazol-3-yl)-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C15H16F2N4S
 1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
CP0089044
(4aS,7aS)-7a-(2,4-difluorophenyl)-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C12H12F2N2OS
 1
1
IC50 = 375 nM
   TI
   LI
   LO
   TS
CP0210816
(4S)-4-[2,4-difluoro-5-[(3,3,3-trifluoropropylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C15H18F5N3S
 1
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
CP0538025
(4S,6S)-4-(2,4-difluorophenyl)-6-[5-(4-fluorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C21H18F3N3OS
 1
1
IC50 = 410 nM
   TI
   LI
   LO
   TS
CP0468885
(4S,6S)-6-[5-(difluoromethyl)-3-methyl-1,2-oxazol-4-yl]-4-(2,4-difluorophenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C16H15F4N3OS
 1
1
IC50 = 420 nM
   TI
   LI
   LO
   TS
CP0567858
(4S,6S)-6-(3,5-diethyl-1,2-oxazol-4-yl)-4-(2,4-difluorophenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C18H21F2N3OS
 1
1
IC50 = 420 nM
   TI
   LI
   LO
   TS
CP0538024
(4S,6S)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-4-phenyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C16H19N3OS
 1
1
IC50 = 480 nM
   TI
   LI
   LO
   TS
CP0917265
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1H-pyrazol-4-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C16H16F2N4OS
 1
1
IC50 = 599 nM
   TI
   LI
   LO
   TS
CP0482933
(4S,6S)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-(4-fluorophenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C16H18FN3OS
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0123103
US8962616, 1
   Show/Hide
C16H15F2N3O2S
 1
1
IC50 = 614 nM
   TI
   LI
   LO
   TS
CP0204357
(5R,7S)-8-[[3-(2-chlorophenyl)phenyl]methyl]-1-(3-fluorophenyl)-7-methyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
   Show/Hide
C26H27ClFN3O2S
 1
1
IC50 = 710 nM
   TI
   LI
   LO
   TS
CP0120435
(5R,7S)-1-(3-fluorophenyl)-8-(1H-indol-5-ylmethyl)-3,7-dimethyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
   Show/Hide
C23H27FN4O2S
 1
1
IC50 = 770 nM
   TI
   LI
   LO
   TS
CP0303653
(4R,4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(methoxymethyl)-4-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C16H20F2N2O2S
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0097510
(4aR,6S,8aS)-6-methyl-8a-phenyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C14H18N2OS
 1
1
IC50 = 820 nM
   TI
   LI
   LO
   TS
CP0089048
(4S,5S)-4-(2,4-difluorophenyl)-5-(methoxymethyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C13H16F2N2OS
 1
1
IC50 = 850 nM
   TI
   LI
   LO
   TS
CP0097509
(4aR,6S,8aS)-8a-(2-methoxyphenyl)-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C15H20N2O2S
 1
1
IC50 = 850 nM
   TI
   LI
   LO
   TS
CP0207155
(4S)-4-[2,4-difluoro-5-[[methyl(2,2,2-trifluoroethyl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C15H18F5N3S
 1
1
IC50 = 1013 nM
   TI
   LI
   LO
   TS
CP0377179
(4S,6S)-6-(3,4-dimethoxyphenyl)-4-(3-pyrimidin-5-ylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
   Show/Hide
C22H22N4O2S
 1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0207109
(4S)-4-[2,4-difluoro-5-[[(5-methylpyridin-2-yl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
   Show/Hide
C18H20F2N4S
 1
1
IC50 = 1350 nM
   TI
   LI
   LO
   TS
CP0330104
(5R,7S)-1-(3-fluorophenyl)-7-methyl-3-propan-2-yl-8-[(3-propan-2-yloxyphenyl)methyl]-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
   Show/Hide
C26H36FN3O3S
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0300576
2-ethoxy-4-[[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxo-2lambda6-thia-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]phenol
   Show/Hide
C23H30FN3O4S
 1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0103378
(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-8-[(3-propan-2-yloxyphenyl)methyl]-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
   Show/Hide
C24H32FN3O3S
 1
1
IC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0189453
(4aR,6S,8aR)-6-methyl-8a-(1,3-thiazol-2-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C11H15N3OS2
 1
1
IC50 = 2050 nM
   TI
   LI
   LO
   TS
CP0147175
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[(3-propan-2-yloxyphenyl)methyl]-3-pyrimidin-2-yl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
   Show/Hide
C27H32FN5O3S
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0211698
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[(3-propan-2-yloxyphenyl)methyl]-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
   Show/Hide
C23H30FN3O3S
 1
1
IC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0361400
(4aR,6S,8aS)-6-methyl-8a-[2-(trifluoromethyl)phenyl]-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
   Show/Hide
C15H17F3N2OS
 1
1
IC50 = 2920 nM
   TI
   LI
   LO
   TS
CP0315690
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[(3-propan-2-yloxyphenyl)methyl]-3-pyridin-4-yl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
   Show/Hide
C28H33FN4O3S
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0211701
(5R,7S)-8-[(3-ethoxyphenyl)methyl]-1-(3-fluorophenyl)-7-methyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
   Show/Hide
C22H28FN3O3S
 1
1
IC50 = 3300 nM
   TI
   LI
   LO
   TS
CP0355943
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[(3-propan-2-yloxyphenyl)methyl]-3-pyridin-3-yl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
   Show/Hide
C28H33FN4O3S
 1
1
IC50 = 3600 nM
   TI
   LI
   LO
   TS
CP0472077
(4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methyl-4,5-dihydro-1,3-thiazin-2-amine
   Show/Hide
C20H19F2N5OS
 1
1
IC50 = 3700 nM
   TI
   LI
   LO
   TS
CP0555996
(4S,5R)-4-(2,4-difluorophenyl)-5-(methoxymethyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
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C13H16F2N2OS
 1
1
IC50 = 3940 nM
   TI
   LI
   LO
   TS
CP0355958
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[(3-propan-2-yloxyphenyl)methyl]-3-(1,3-thiazol-2-yl)-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
   Show/Hide
C26H31FN4O3S2
 1
1
IC50 = 4100 nM
   TI
   LI
   LO
   TS
CP0204358
(5R,7S)-8-[(3-cyclopentyloxyphenyl)methyl]-1-(3-fluorophenyl)-7-methyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
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C25H32FN3O3S
 1
1
IC50 = 5300 nM
   TI
   LI
   LO
   TS
CP0315691
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[[3-(2-methylpropoxy)phenyl]methyl]-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
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C24H32FN3O3S
 1
1
IC50 = 7100 nM
   TI
   LI
   LO
   TS
CP0368958
N-[4-[[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxo-2lambda6-thia-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]phenyl]acetamide
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C23H29FN4O3S
 1
1
IC50 = 7400 nM
   TI
   LI
   LO
   TS
CP0300577
(5R,7S)-1-(3-fluorophenyl)-7-methyl-3-(1,3-oxazol-2-yl)-8-[(3-propan-2-yloxyphenyl)methyl]-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
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C26H31FN4O4S
 1
1
IC50 > 10200 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Brain)
Cell Line Name Organism Disease
TS603 Homo sapiens (Human) Anaplastic oligodendroglioma
1321N1 Homo sapiens (Human) Astrocytoma
SNB-19 Homo sapiens (Human) Astrocytoma
U-251MG Homo sapiens (Human) Astrocytoma
U-373MG ATCC Homo sapiens (Human) Astrocytoma
LN-308 Homo sapiens (Human) Astrocytoma
CCF-STTG1 Homo sapiens (Human) Astrocytoma
LN-319 Homo sapiens (Human) Astrocytoma
P2X7-1321N1 Homo sapiens (Human) Astrocytoma
MDA-MB-361 Homo sapiens (Human) Breast adenocarcinoma
JEG-3 Homo sapiens (Human) Gestational choriocarcinoma
D3 [Human glioblastoma] Homo sapiens (Human) Glioblastoma
LN-229 Homo sapiens (Human) Glioblastoma
LN-18 Homo sapiens (Human) Glioblastoma
A-172 Homo sapiens (Human) Glioblastoma
UC-11MG Homo sapiens (Human) Glioblastoma
T98G Homo sapiens (Human) Glioblastoma
LN229-V6R Homo sapiens (Human) Glioblastoma
SF539 Homo sapiens (Human) Gliosarcoma
MED1 Homo sapiens (Human) Medulloblastoma, non-WNT/non-SHH, group 4
Kelly Homo sapiens (Human) Neuroblastoma
PFSK-1 Homo sapiens (Human) Primitive neuroectodermal tumor
DU145 Homo sapiens (Human) Prostate carcinoma
DU145-TxR Homo sapiens (Human) Prostate carcinoma
GL261 Mus musculus (Mouse) Mouse glioblastoma
C6 Rattus norvegicus (Rat) Rat malignant glioma
C6-BU-1 Rattus norvegicus (Rat) Rat malignant glioma
RG2 Rattus norvegicus (Rat) Rat malignant glioma
ReNcell VM Homo sapiens (Human) -
hCMEC/D3 Homo sapiens (Human) -
BV-2 Mus musculus (Mouse) -
C17.2 Mus musculus (Mouse) -
ScGT1 Mus musculus (Mouse) -
bEnd.4 Mus musculus (Mouse) -
N39 Mus musculus (Mouse) -
GT1-7 Mus musculus (Mouse) -
N27-A Rattus norvegicus (Rat) -
RBE4 Rattus norvegicus (Rat) -