Compound ID |
Compound Name |
Compound Formula |
CP0221964
|
2-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-6-methoxy-1H-benzimidazole
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|
C21H16N4O
|
1
|
1 |
EC50 = 30 nM
|
|
|
CP0093283
|
6-fluoro-2-[3-(7-fluoroimidazo[1,2-a]pyridin-2-yl)phenyl]-1H-benzimidazole
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|
C20H12F2N4
|
1
|
1 |
EC50 = 37 nM
|
|
|
CP0093287
|
6-fluoro-2-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-1H-benzimidazole
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|
C20H13FN4
|
1
|
1 |
EC50 = 120 nM
|
|
|
CP0083415
|
3-[5-(3-methoxyphenyl)-1H-imidazol-2-yl]-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide
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|
C27H28N4O4S
|
1
|
1 |
EC50 = 179 nM
|
|
|
CP0077754
|
3-(6-fluoro-1H-benzimidazol-2-yl)-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide
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|
C24H23FN4O3S
|
1
|
1 |
EC50 = 230 nM
|
|
|
CP0436649
|
6-fluoro-2-[3-[2-[6-(trifluoromethoxy)-1H-indol-3-yl]-1H-imidazol-5-yl]phenyl]-1H-benzimidazole
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|
C25H15F4N5O
|
1
|
1 |
EC50 = 290 nM
|
|
|
CP0093281
|
N-tert-butyl-2-[3-(6-methoxy-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine
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|
C25H25N5O
|
1
|
1 |
EC50 = 310 nM
|
|
|
CP0436648
|
6-fluoro-2-[3-[2-(6-fluoro-1H-indol-3-yl)-1H-imidazol-5-yl]phenyl]-1H-benzimidazole
Show/Hide
|
C24H15F2N5
|
1
|
1 |
EC50 = 350 nM
|
|
|
CP0413439
|
N-[3-[2-(6-fluoro-1H-indol-3-yl)-1H-imidazol-5-yl]phenyl]pyridine-3-carboxamide
Show/Hide
|
C23H16FN5O
|
1
|
1 |
EC50 = 410 nM
|
|
|
CP0077742
|
3-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]-5-(5-phenyl-1H-imidazol-2-yl)benzamide
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|
C26H26N4O3S
|
1
|
1 |
EC50 = 450 nM
|
|
|
CP0475007
|
N-[3-[2-(1H-indol-3-yl)-1H-imidazol-5-yl]phenyl]pyridine-3-carboxamide
Show/Hide
|
C23H17N5O
|
1
|
1 |
EC50 = 480 nM
|
|
|
CP0420349
|
3-[2-(1H-indol-3-yl)-1H-imidazol-5-yl]-N-pyridin-4-ylbenzamide
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|
C23H17N5O
|
1
|
1 |
EC50 = 590 nM
|
|
|
CP0447153
|
3-[5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]phenyl]-1H-imidazol-2-yl]-6-(trifluoromethoxy)-1H-indole
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|
C27H17F4N5O
|
1
|
1 |
EC50 = 670 nM
|
|
|
CP0403363
|
6-fluoro-3-[5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]phenyl]-1H-imidazol-2-yl]-1H-indole
Show/Hide
|
C26H17F2N5
|
1
|
1 |
EC50 = 810 nM
|
|
|
CP0420345
|
3-[2-(1H-indol-3-yl)-1H-imidazol-5-yl]-N-pyridin-3-ylbenzamide
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|
C23H17N5O
|
1
|
1 |
EC50 = 880 nM
|
|
|
CP0080789
|
N-tert-butyl-2-[3-(6-fluoro-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine
Show/Hide
|
C24H22FN5
|
1
|
1 |
EC50 = 930 nM
|
|
|
CP0420346
|
3-[2-(1H-indol-3-yl)-1H-imidazol-5-yl]-N-phenylbenzamide
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|
C24H18N4O
|
1
|
1 |
EC50 = 1210 nM
|
|
|
CP0420348
|
N-(4-fluorophenyl)-3-[2-(1H-indol-3-yl)-1H-imidazol-5-yl]benzamide
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|
C24H17FN4O
|
1
|
1 |
EC50 = 1330 nM
|
|
|
CP0132641
|
2-[3-(1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridine
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|
C20H14N4
|
1
|
1 |
EC50 = 1550 nM
|
|
|
CP0077747
|
N-tert-butyl-2-[4-(6-methoxy-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine
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|
C25H25N5O
|
1
|
1 |
EC50 = 2405 nM
|
|
|
CP0369611
|
US9315520, 19
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|
C18H21N5O3S2
|
1
|
1 |
IC50 = 0.014 nM
|
|
|
CP0080989
|
(4S,6R)-4-[2,4-difluoro-5-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]phenyl]-4,6-dimethyl-5,6-dihydro-1,3-thiazin-2-amine
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|
C17H20F5N3S
|
1
|
1 |
IC50 = 0.024 nM
|
|
|
CP0232239
|
2-[(4aR,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-N-(6-methoxypyridin-2-yl)-1,3-thiazole-5-carboxamide
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|
C18H21N5O3S2
|
1
|
1 |
IC50 = 0.033 nM
|
|
|
CP0346856
|
N-[2-[(4aR,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-4-methoxybenzamide
Show/Hide
|
C19H22N4O3S2
|
1
|
1 |
IC50 = 0.034 nM
|
|
|
CP0446346
|
2-[(4aR,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-N-(3-methoxyphenyl)-1,3-thiazole-5-carboxamide
Show/Hide
|
C19H22N4O3S2
|
1
|
1 |
IC50 = 0.11 nM
|
|
|
CP0093593
|
US8940748, 34
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|
C17H17ClFN5O3S
|
1
|
1 |
IC50 < 0.54 nM
|
|
|
CP0232211
|
N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-1-(difluoromethyl)-1H-pyrazole-3-carboxamide
Show/Hide
|
C16H18F2N6O2S2
|
1
|
1 |
IC50 = 0.64 nM
|
|
|
CP0177658
|
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4,5-difluorophenyl]-5-methoxypyrazine-2-carboxamide
Show/Hide
|
C22H22F2N6O3S
|
1
|
1 |
IC50 = 0.7 nM
|
|
|
CP0561923
|
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C22H20ClF2N5O2S
|
1
|
1 |
IC50 = 0.7 nM
|
|
|
CP0080988
|
(4S)-4-[2,4-difluoro-5-[(propan-2-ylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C15H21F2N3S
|
1
|
1 |
IC50 = 2 nM
|
|
|
CP0445151
|
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-5-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C22H21ClFN5O2S
|
1
|
1 |
IC50 = 2.3 nM
|
|
|
CP0097508
|
US9315520, 45
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|
C19H21F2N5O3S2
|
1
|
1 |
IC50 = 2.9 nM
|
|
|
CP0124822
|
US9315520, 7
Show/Hide
|
C17H18ClN5O2S2
|
1
|
1 |
IC50 = 3.8 nM
|
|
|
CP0484759
|
N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-5-cyanopyridine-2-carboxamide
Show/Hide
|
C18H18N6O2S2
|
1
|
1 |
IC50 = 3.9 nM
|
|
|
CP0080980
|
(4S)-4-[5-[(1-bicyclo[1.1.1]pentanylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C17H21F2N3S
|
1
|
1 |
IC50 = 4 nM
|
|
|
CP0210813
|
(4S)-4-[2,4-difluoro-5-[[[(2R)-1-methoxypropan-2-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C16H23F2N3OS
|
1
|
1 |
IC50 = 4 nM
|
|
|
CP0179937
|
US9315520, 17
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|
C18H18F3N5O2S2
|
1
|
1 |
IC50 = 4.8 nM
|
|
|
CP0561925
|
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C21H19ClFN5O2S
|
1
|
1 |
IC50 = 5 nM
|
|
|
CP0097523
|
US9315520, 1
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|
C18H19F2N5O3S2
|
1
|
1 |
IC50 = 5.1 nM
|
|
|
CP0080992
|
(4S)-4-[2,4-difluoro-5-[(2-methoxyethylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C15H21F2N3OS
|
1
|
1 |
IC50 = 6 nM
|
|
|
CP0097501
|
N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-5-(difluoromethoxy)pyrazine-2-carboxamide
Show/Hide
|
C17H18F2N6O3S2
|
1
|
1 |
IC50 = 7.2 nM
|
|
|
CP0420059
|
(4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C20H19F2N5OS
|
1
|
1 |
IC50 = 8 nM
|
|
|
CP0080983
|
(4S)-4-[5-(ethylaminomethyl)-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
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|
C14H19F2N3S
|
1
|
1 |
IC50 = 8 nM
|
|
|
CP0210815
|
(4S)-4-[5-[[[1-(difluoromethyl)cyclopropyl]amino]methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C16H19F4N3S
|
1
|
1 |
IC50 = 12 nM
|
|
|
CP0446351
|
US9315520, 20
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|
C18H18F3N5O3S2
|
1
|
1 |
IC50 = 12.5 nM
|
|
|
CP0308349
|
(4S)-4-[5-[(cyclopropylmethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
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|
C16H21F2N3S
|
1
|
1 |
IC50 = 14 nM
|
|
|
CP0213393
|
(4S)-4-[2,4-difluoro-5-[[[3-(trifluoromethyl)oxetan-3-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C16H18F5N3OS
|
1
|
1 |
IC50 = 17 nM
|
|
|
CP0210820
|
(4S)-4-[2,4-difluoro-5-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C16H18F5N3S
|
1
|
1 |
IC50 = 18 nM
|
|
|
CP0528855
|
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-bromopyridine-2-carboxamide
Show/Hide
|
C21H19BrFN5O2S
|
1
|
1 |
IC50 = 22 nM
|
|
|
CP0274274
|
(4S)-4-[5-[(dimethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C14H19F2N3S
|
1
|
1 |
IC50 = 22 nM
|
|
|
CP0097502
|
US9315520, 9
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|
C17H18FN5O2S2
|
1
|
1 |
IC50 = 23.7 nM
|
|
|
CP0086745
|
US9403846, 2
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|
C16H18F2N2OS
|
1
|
1 |
IC50 = 24 nM
|
|
|
CP0210814
|
1-[[5-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-2,4-difluorophenyl]methylamino]cyclopropane-1-carbonitrile
Show/Hide
|
C16H18F2N4S
|
1
|
1 |
IC50 = 24 nM
|
|
|
CP0089046
|
(4aR,6S,8aS)-8a-(2,4-difluorophenyl)-6-(2-methylpropyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C17H22F2N2OS
|
1
|
1 |
IC50 = 25 nM
|
|
|
CP0076103
|
US9315520, 13
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|
C18H20FN5O2S2
|
1
|
1 |
IC50 = 26.9 nM
|
|
|
CP0086746
|
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(methoxymethyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C15H18F2N2O2S
|
2
|
1 |
IC50 = 30 nM
|
|
|
2 |
IC50 = 855 nM
|
|
|
CP0460337
|
(4S,6S)-4-[3-chloro-5-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C22H21ClN4OS2
|
1
|
1 |
IC50 = 30 nM
|
|
|
CP0207107
|
(4S)-4-[5-[(cyclopropylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C15H19F2N3S
|
1
|
1 |
IC50 = 30 nM
|
|
|
CP0561924
|
N-[5-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-2,4-difluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C22H20ClF2N5O2S
|
1
|
1 |
IC50 = 31 nM
|
|
|
CP0359991
|
(4S)-4-[2,4-difluoro-5-[[(1,1,1-trifluoro-2-methylpropan-2-yl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C16H20F5N3S
|
1
|
1 |
IC50 = 31 nM
|
|
|
CP0115128
|
US8865706, 16
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|
C18H20F2N4OS
|
1
|
1 |
IC50 = 34 nM
|
|
|
CP0558517
|
(4S)-4-[2,4-difluoro-5-[[(3R)-3-methoxypyrrolidin-1-yl]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C17H23F2N3OS
|
1
|
1 |
IC50 = 38 nM
|
|
|
CP0097529
|
N-[3-[(4aR,7aS)-2-amino-4a,5,6,7-tetrahydro-4H-cyclopenta[d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide
Show/Hide
|
C19H18F2N4OS
|
1
|
1 |
IC50 = 38.4 nM
|
|
|
CP0108321
|
(4aR,6S,8aS)-8a-(2,4-difluorophenyl)-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C14H16F2N2OS
|
1
|
1 |
IC50 = 39 nM
|
|
|
CP0238478
|
US9315520, 10
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|
C17H20N6O3S2
|
1
|
1 |
IC50 = 47.6 nM
|
|
|
CP0724426
|
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1-methyl-1H-pyrazol-4-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C17H18F2N4OS
|
1
|
1 |
IC50 = 52 nM
|
|
|
CP0123099
|
US8865706, 13
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|
C18H18F3N3O2S
|
1
|
1 |
IC50 = 53 nM
|
|
|
CP0236143
|
(4S)-4-[2,4-difluoro-5-[(3-methoxypropylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C16H23F2N3OS
|
1
|
1 |
IC50 = 53 nM
|
|
|
CP0210817
|
(4S)-4-[5-[(2,2-difluoroethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C14H17F4N3S
|
1
|
1 |
IC50 = 58 nM
|
|
|
CP0313510
|
(4aR,6R,8aS)-6-(difluoromethyl)-8a-(2,4-difluorophenyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C14H14F4N2OS
|
1
|
1 |
IC50 = 59 nM
|
|
|
CP0365888
|
(4aR,6S,8aS)-8a-(2,4-difluorophenyl)-6-ethyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C15H18F2N2OS
|
1
|
1 |
IC50 = 59 nM
|
|
|
CP0508014
|
(4S,6S)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-[4-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-5,6-dihydro-4H-1,3-thiazin-2-amine
Show/Hide
|
C21H20N4OS2
|
1
|
1 |
IC50 = 60 nM
|
|
|
CP0210818
|
(4S)-4-[2,4-difluoro-5-[(2,2,2-trifluoroethylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C14H16F5N3S
|
1
|
1 |
IC50 = 60 nM
|
|
|
CP0343449
|
US8933221, 4
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|
C14H15F3N2OS
|
2
|
1 |
IC50 = 61 nM
|
|
|
2 |
IC50 = 1070 nM
|
|
|
CP0123098
|
US8865706, 22
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|
C18H19F3N4OS
|
1
|
1 |
IC50 = 63 nM
|
|
|
CP0207108
|
(4S)-4-[2,4-difluoro-5-[[[(2R)-1,1,1-trifluoropropan-2-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C15H18F5N3S
|
1
|
1 |
IC50 = 64 nM
|
|
|
CP0420061
|
(4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Show/Hide
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C19H17F2N5OS
|
2
|
1 |
IC50 = 70 nM
|
|
|
2 |
IC50 = 200 nM
|
|
|
CP0123096
|
US8865706, 9
Show/Hide
|
C18H19F2N3O2S
|
1
|
1 |
IC50 = 74 nM
|
|
|
CP0187394
|
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(3-methyl-1,2-oxazol-5-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C17H17F2N3O2S
|
1
|
1 |
IC50 = 78 nM
|
|
|
CP0123101
|
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(4-methyl-1,3-oxazol-2-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C17H17F2N3O2S
|
1
|
1 |
IC50 = 84 nM
|
|
|
CP0460340
|
3-[5-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-2,4-difluorophenyl]pyridine-2-carbonitrile
Show/Hide
|
C22H19F2N5OS
|
1
|
1 |
IC50 = 87 nM
|
|
|
CP0120434
|
4-[[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxo-2lambda6-thia-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]-2-propan-2-yloxyphenol
Show/Hide
|
C24H32FN3O4S
|
1
|
1 |
IC50 = 100 nM
|
|
|
CP0118373
|
US8962616, 22
Show/Hide
|
C18H19F2N3O2S
|
1
|
1 |
IC50 = 103 nM
|
|
|
CP0460338
|
1-[4-[(4S,6S)-2-amino-4-(2,4-difluorophenyl)-4-methyl-5,6-dihydro-1,3-thiazin-6-yl]-3-methyl-1,2-oxazol-5-yl]-2-methylpropan-2-ol
Show/Hide
|
C19H23F2N3O2S
|
1
|
1 |
IC50 = 110 nM
|
|
|
CP0149411
|
(4aR,6S,8aR)-6-methyl-8a-thiophen-2-yl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C12H16N2OS2
|
1
|
1 |
IC50 = 110 nM
|
|
|
CP0058522
|
(4S,4aR,6R,8aS)-8a-(2,4-difluorophenyl)-4-(fluoromethyl)-6-(4-methyl-1,3-oxazol-2-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C18H18F3N3O2S
|
1
|
1 |
IC50 = 116 nM
|
|
|
CP0543109
|
(4S,6S)-4-(2,4-difluorophenyl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C16H17F2N3OS
|
1
|
1 |
IC50 = 150 nM
|
|
|
CP0414546
|
N-[3-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-2-fluorophenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C22H21ClFN5O2S
|
1
|
1 |
IC50 = 160 nM
|
|
|
CP0495227
|
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C21H19F2N3OS
|
1
|
1 |
IC50 = 160 nM
|
|
|
CP0540590
|
(4aR,6S,8aS)-6-methyl-8a-thiophen-3-yl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C12H16N2OS2
|
1
|
1 |
IC50 = 170 nM
|
|
|
CP0561926
|
(4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-6-methyl-6-(5-methyl-1,2-oxazol-4-yl)-4,5-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C19H17F2N5OS
|
1
|
1 |
IC50 = 180 nM
|
|
|
CP0531981
|
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-(5-methyl-3-pyridin-3-yl-1,2-oxazol-4-yl)-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C20H18F2N4OS
|
1
|
1 |
IC50 = 180 nM
|
|
|
CP0475484
|
(4S,6S)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-(3-pyrimidin-5-ylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Show/Hide
|
C19H19N5OS
|
1
|
1 |
IC50 = 230 nM
|
|
|
CP0534902
|
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-(3-methyl-5-phenyl-1,2-oxazol-4-yl)-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C21H19F2N3OS
|
1
|
1 |
IC50 = 230 nM
|
|
|
CP0334115
|
4-[[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxo-2lambda6-thia-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]phenol
Show/Hide
|
C21H26FN3O3S
|
1
|
1 |
IC50 = 240 nM
|
|
|
CP0179938
|
(4aR,6S,8aS)-8a-(3-fluoropyridin-2-yl)-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C13H16FN3OS
|
1
|
1 |
IC50 = 250 nM
|
|
|
CP0495225
|
(4S,6S)-4-(2,4-difluorophenyl)-6-(3-ethyl-5-methyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C17H19F2N3OS
|
1
|
1 |
IC50 = 250 nM
|
|
|
CP0322280
|
US8933221, 1
Show/Hide
|
C13H14F2N2OS
|
1
|
1 |
IC50 = 265 nM
|
|
|
CP0080546
|
(4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C15H14F2N4S
|
1
|
1 |
IC50 = 270 nM
|
|
|
CP0103382
|
(5R,7S)-8-[(3-ethyl-2H-indazol-5-yl)methyl]-1-(3-fluorophenyl)-3,7-dimethyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C24H30FN5O2S
|
1
|
1 |
IC50 = 290 nM
|
|
|
CP0475485
|
(4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-6-(3,4-dimethoxyphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Show/Hide
|
C22H20F2N4O2S
|
1
|
1 |
IC50 = 290 nM
|
|
|
CP0549993
|
3-[5-[(4S,6S)-2-amino-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5,6-dihydro-4H-1,3-thiazin-4-yl]thiophen-3-yl]benzonitrile
Show/Hide
|
C20H18N4OS2
|
1
|
1 |
IC50 = 300 nM
|
|
|
CP0534901
|
(4S,6S)-4-(3-chlorothiophen-2-yl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C14H16ClN3OS2
|
1
|
1 |
IC50 = 300 nM
|
|
|
CP0574763
|
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-(3-methyl-1,2-oxazol-4-yl)-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C15H15F2N3OS
|
1
|
1 |
IC50 = 300 nM
|
|
|
CP0189779
|
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-pyrimidin-5-yl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C15H14F2N4S
|
1
|
1 |
IC50 = 310 nM
|
|
|
CP0574762
|
(4S,6S)-4-(2,4-difluorophenyl)-6-[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C21H18F3N3OS
|
1
|
1 |
IC50 = 320 nM
|
|
|
CP0334730
|
2-chloro-4-[[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxo-2lambda6-thia-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]phenol
Show/Hide
|
C21H25ClFN3O3S
|
1
|
1 |
IC50 = 350 nM
|
|
|
CP0528535
|
(4S,6S)-4-(2,4-difluorophenyl)-4-methyl-6-(2-methylpyrazol-3-yl)-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C15H16F2N4S
|
1
|
1 |
IC50 = 350 nM
|
|
|
CP0089044
|
(4aS,7aS)-7a-(2,4-difluorophenyl)-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C12H12F2N2OS
|
1
|
1 |
IC50 = 375 nM
|
|
|
CP0210816
|
(4S)-4-[2,4-difluoro-5-[(3,3,3-trifluoropropylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C15H18F5N3S
|
1
|
1 |
IC50 = 400 nM
|
|
|
CP0538025
|
(4S,6S)-4-(2,4-difluorophenyl)-6-[5-(4-fluorophenyl)-3-methyl-1,2-oxazol-4-yl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C21H18F3N3OS
|
1
|
1 |
IC50 = 410 nM
|
|
|
CP0468885
|
(4S,6S)-6-[5-(difluoromethyl)-3-methyl-1,2-oxazol-4-yl]-4-(2,4-difluorophenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C16H15F4N3OS
|
1
|
1 |
IC50 = 420 nM
|
|
|
CP0567858
|
(4S,6S)-6-(3,5-diethyl-1,2-oxazol-4-yl)-4-(2,4-difluorophenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C18H21F2N3OS
|
1
|
1 |
IC50 = 420 nM
|
|
|
CP0538024
|
(4S,6S)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-4-phenyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C16H19N3OS
|
1
|
1 |
IC50 = 480 nM
|
|
|
CP0917265
|
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1H-pyrazol-4-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C16H16F2N4OS
|
1
|
1 |
IC50 = 599 nM
|
|
|
CP0482933
|
(4S,6S)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-(4-fluorophenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C16H18FN3OS
|
1
|
1 |
IC50 = 600 nM
|
|
|
CP0123103
|
US8962616, 1
Show/Hide
|
C16H15F2N3O2S
|
1
|
1 |
IC50 = 614 nM
|
|
|
CP0204357
|
(5R,7S)-8-[[3-(2-chlorophenyl)phenyl]methyl]-1-(3-fluorophenyl)-7-methyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C26H27ClFN3O2S
|
1
|
1 |
IC50 = 710 nM
|
|
|
CP0120435
|
(5R,7S)-1-(3-fluorophenyl)-8-(1H-indol-5-ylmethyl)-3,7-dimethyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C23H27FN4O2S
|
1
|
1 |
IC50 = 770 nM
|
|
|
CP0303653
|
(4R,4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(methoxymethyl)-4-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C16H20F2N2O2S
|
1
|
1 |
IC50 = 800 nM
|
|
|
CP0097510
|
(4aR,6S,8aS)-6-methyl-8a-phenyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C14H18N2OS
|
1
|
1 |
IC50 = 820 nM
|
|
|
CP0089048
|
(4S,5S)-4-(2,4-difluorophenyl)-5-(methoxymethyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C13H16F2N2OS
|
1
|
1 |
IC50 = 850 nM
|
|
|
CP0097509
|
(4aR,6S,8aS)-8a-(2-methoxyphenyl)-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C15H20N2O2S
|
1
|
1 |
IC50 = 850 nM
|
|
|
CP0207155
|
(4S)-4-[2,4-difluoro-5-[[methyl(2,2,2-trifluoroethyl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C15H18F5N3S
|
1
|
1 |
IC50 = 1013 nM
|
|
|
CP0377179
|
(4S,6S)-6-(3,4-dimethoxyphenyl)-4-(3-pyrimidin-5-ylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Show/Hide
|
C22H22N4O2S
|
1
|
1 |
IC50 = 1100 nM
|
|
|
CP0207109
|
(4S)-4-[2,4-difluoro-5-[[(5-methylpyridin-2-yl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C18H20F2N4S
|
1
|
1 |
IC50 = 1350 nM
|
|
|
CP0330104
|
(5R,7S)-1-(3-fluorophenyl)-7-methyl-3-propan-2-yl-8-[(3-propan-2-yloxyphenyl)methyl]-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C26H36FN3O3S
|
1
|
1 |
IC50 = 1400 nM
|
|
|
CP0300576
|
2-ethoxy-4-[[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxo-2lambda6-thia-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]phenol
Show/Hide
|
C23H30FN3O4S
|
1
|
1 |
IC50 = 1600 nM
|
|
|
CP0103378
|
(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-8-[(3-propan-2-yloxyphenyl)methyl]-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C24H32FN3O3S
|
1
|
1 |
IC50 = 1800 nM
|
|
|
CP0189453
|
(4aR,6S,8aR)-6-methyl-8a-(1,3-thiazol-2-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C11H15N3OS2
|
1
|
1 |
IC50 = 2050 nM
|
|
|
CP0147175
|
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[(3-propan-2-yloxyphenyl)methyl]-3-pyrimidin-2-yl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C27H32FN5O3S
|
1
|
1 |
IC50 = 2500 nM
|
|
|
CP0211698
|
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[(3-propan-2-yloxyphenyl)methyl]-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C23H30FN3O3S
|
1
|
1 |
IC50 = 2900 nM
|
|
|
CP0361400
|
(4aR,6S,8aS)-6-methyl-8a-[2-(trifluoromethyl)phenyl]-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Show/Hide
|
C15H17F3N2OS
|
1
|
1 |
IC50 = 2920 nM
|
|
|
CP0315690
|
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[(3-propan-2-yloxyphenyl)methyl]-3-pyridin-4-yl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C28H33FN4O3S
|
1
|
1 |
IC50 = 3000 nM
|
|
|
CP0211701
|
(5R,7S)-8-[(3-ethoxyphenyl)methyl]-1-(3-fluorophenyl)-7-methyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C22H28FN3O3S
|
1
|
1 |
IC50 = 3300 nM
|
|
|
CP0355943
|
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[(3-propan-2-yloxyphenyl)methyl]-3-pyridin-3-yl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C28H33FN4O3S
|
1
|
1 |
IC50 = 3600 nM
|
|
|
CP0472077
|
(4S,6S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methyl-4,5-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C20H19F2N5OS
|
1
|
1 |
IC50 = 3700 nM
|
|
|
CP0555996
|
(4S,5R)-4-(2,4-difluorophenyl)-5-(methoxymethyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Show/Hide
|
C13H16F2N2OS
|
1
|
1 |
IC50 = 3940 nM
|
|
|
CP0355958
|
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[(3-propan-2-yloxyphenyl)methyl]-3-(1,3-thiazol-2-yl)-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C26H31FN4O3S2
|
1
|
1 |
IC50 = 4100 nM
|
|
|
CP0204358
|
(5R,7S)-8-[(3-cyclopentyloxyphenyl)methyl]-1-(3-fluorophenyl)-7-methyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C25H32FN3O3S
|
1
|
1 |
IC50 = 5300 nM
|
|
|
CP0315691
|
(5R,7S)-1-(3-fluorophenyl)-7-methyl-8-[[3-(2-methylpropoxy)phenyl]methyl]-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C24H32FN3O3S
|
1
|
1 |
IC50 = 7100 nM
|
|
|
CP0368958
|
N-[4-[[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxo-2lambda6-thia-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]phenyl]acetamide
Show/Hide
|
C23H29FN4O3S
|
1
|
1 |
IC50 = 7400 nM
|
|
|
CP0300577
|
(5R,7S)-1-(3-fluorophenyl)-7-methyl-3-(1,3-oxazol-2-yl)-8-[(3-propan-2-yloxyphenyl)methyl]-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
Show/Hide
|
C26H31FN4O4S
|
1
|
1 |
IC50 > 10200 nM
|
|
|