Brief Information of the Compound and Protein
Compound Name
(4aR,6S,8aS)-8a-(2-methoxyphenyl)-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
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PubChem ID
CID: 145965420
Canonical SMILES
COc1ccccc1[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2
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Compound Formula C15H20N2O2S
Compound Structure
Protein Name
Beta-secretase 1
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Uniprot ID
P56817
Gene Name
BACE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000008 H4 Homo sapiens (Human)  1
1
IC50 = 850 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6060 nM