Protein Information

General Information of the Protein

Protein ID	PT01155
Protein Name	Growth hormone secretagogue receptor type 1
Secondarily Protein Name	GH-releasing peptide receptor Ghrelin receptor
Gene Name	GHSR
Sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Short peptide receptor (family A GPCR) > GRP-related receptor
Function	Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). Show/Hide
Uniprot ID	Primary ID: Q92847 Secondarily ID: Q14D12 Q6ISR8 Q92848 Q96RJ7 Show/Hide
HGNC ID	HGNC:4267
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000051 , BHK-21

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0885533 Compound Info	(S)-5-Phenethyl-3-(3-piperidin-1-yl-propyl)-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-imidazolidine-2,4-dione Show/Hide	C33H37N7O2	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0854017 Compound Info	(S)-5-Phenethyl-3-(3-pyrrolidin-1-yl-propyl)-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-imidazolidine-2,4-dione Show/Hide	C32H35N7O2	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0885520 Compound Info	(S)-5-Phenethyl-3-(3-piperidin-1-yl-propyl)-1-{4-[2-(2H-tetrazol-5-yl)-phenyl]-thiophen-2-ylmethyl}-imidazolidine-2,4-dione Show/Hide	C31H35N7O2S	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0914989 Compound Info	(S)-1-[3-Fluoro-2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-phenethyl-3-(3-piperidin-1-yl-propyl)-imidazolidine-2,4-dione Show/Hide	C33H36FN7O2	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0907730 Compound Info	(S)-3-(3-Dimethylamino-propyl)-5-phenethyl-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-imidazolidine-2,4-dione Show/Hide	C30H33N7O2	1
1	IC50 = 4000 nM Bioactivity Info	TI LI LO TS
CP0945109 Compound Info	(S)-3-(3-Dimethylamino-propyl)-5-phenethyl-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-thioxo-imidazolidin-4-one Show/Hide	C30H33N7OS	1
1	IC50 = 8200 nM Bioactivity Info	TI LI LO TS
CP0950536 Compound Info	(S)-5-Phenethyl-3-(3-piperidin-1-yl-propyl)-1-{5-[2-(2H-tetrazol-5-yl)-phenyl]-thiophen-2-ylmethyl}-imidazolidine-2,4-dione Show/Hide	C31H35N7O2S	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0854272 Compound Info	(S)-5-Benzyl-3-(3-dimethylamino-propyl)-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-thioxo-imidazolidin-4-one Show/Hide	C29H31N7OS	1
1	IC50 = 35000 nM Bioactivity Info	TI LI LO TS
CP0925503 Compound Info	(S)-3-(3-Dimethylamino-propyl)-5-phenyl-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-thioxo-imidazolidin-4-one Show/Hide	C28H29N7OS	1
1	IC50 = 35000 nM Bioactivity Info	TI LI LO TS
CP0917651 Compound Info	(S)-3-(3-Morpholin-4-yl-propyl)-5-phenethyl-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-thioxo-imidazolidin-4-one Show/Hide	C32H35N7O2S	1
1	IC50 = 45000 nM Bioactivity Info	TI LI LO TS
CP0845400 Compound Info	(S)-5-(1H-Indol-3-ylmethyl)-3-piperidin-4-yl-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-imidazolidine-2,4-dione Show/Hide	C31H30N8O2	1
1	IC50 = 50000 nM Bioactivity Info	TI LI LO TS
CP0845325 Compound Info	3-{(S)-2,5-Dioxo-4-phenethyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-imidazolidin-1-yl}-N,N-dimethyl-propionamide Show/Hide	C30H31N7O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0896728 Compound Info	(S)-3-(3-Amino-propyl)-5-phenethyl-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-imidazolidine-2,4-dione Show/Hide	C28H29N7O2	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0906746 Compound Info	(S)-3-(4-Dimethylamino-phenyl)-5-phenethyl-1-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-thioxo-imidazolidin-4-one Show/Hide	C33H31N7OS	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000643 , CHO-K1/CRE-Luc

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000008 , H4

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000131 , HEK293-F

Cell Line Info

Cell Line ID: CL000009 , LLC-PK1

Cell Line Info

Cell Line ID: CL000041 , LTK-

Cell Line Info

Cell Line ID: CL000043 , U2OS

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0037119 Compound Info	1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-yl}-1-oxopropan-2-yl]carbamoyl}-1-methylethan-1-aminium Show/Hide	C27H36N4O5S	8
1	Activity = 0.3 nM
2	EC50 = 0.1995 nM
3	IC50 = 0.4 nM
4	IC50 = 0.63 nM
5	IC50 = 32 nM
6	IC50 = 300 nM
7	Kd = 0.14 nM
8	Ki = 0.24 nM
CP0048653 Compound Info	2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone Show/Hide	C29H32N6OS	1
1	Activity = 11200000 nM
CP0280449 Compound Info	Ghrelin Show/Hide	C149H249N47O42	1
1	IC50 = 0.25 nM
CP0263325 Compound Info	2,4-diaminopyrimidine derivative, 8c Show/Hide	C26H27N5O3S	1
1	IC50 = 0.3 nM
CP0419825 Compound Info	US8546435, 3 Show/Hide	C38H36N8O3	1
1	IC50 = 0.6 nM
CP0663159 Compound Info	5-((1R,5S)-8-acetyl-8-azabicyclo[3.2.1]oct-3-en-3-yl)-N-(((S)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-2-((2,3-dihydrobenzofuran-6-yl)methylamino)nicotinamide Show/Hide	C33H34N4O5	1
1	IC50 = 0.96 nM
CP0284845 Compound Info	US8546435, 4 Show/Hide	C36H35N7O3	1
1	IC50 = 1.3 nM
CP0510760 Compound Info	US8546435, 8 Show/Hide	C36H40N8O3	1
1	IC50 = 1.4 nM
CP0229128 Compound Info	US8546435, 6 Show/Hide	C32H34N6O4	1
1	IC50 = 3 nM
CP0327955 Compound Info	US8546435, 9 Show/Hide	C35H38N8O3	1
1	IC50 = 3.2 nM
CP0126988 Compound Info	US8546435, 5 Show/Hide	C35H33N7O3	1
1	IC50 = 3.4 nM
CP0475496 Compound Info	US8546435, 7 Show/Hide	C35H39N7O4	1
1	IC50 = 3.4 nM
CP0171189 Compound Info	3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide Show/Hide	C26H29Cl2N3O4	1
1	IC50 = 6 nM
CP0722711 Compound Info	2-(1-amino-1-methylethylcarboxamido)-3-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-3-oxo-(2R)-propyl octanoate; Trifluoroacetate Show/Hide	C30H45F3N4O8S	1
1	IC50 = 8.12 nM
CP0370138 Compound Info	3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethyl)-isoxazole-4-carboxylic acid (4-diethylamino-2-methyl-phenyl)-amide Show/Hide	C27H31Cl2N3O4	1
1	IC50 = 9 nM
CP0135116 Compound Info	2,4-diaminopyrimidine-based antagonist, 4c Show/Hide	C20H23N5O2S	1
1	IC50 = 9.7 nM
CP0134612 Compound Info	GHRELIN Show/Hide	C147H245N45O42	2
1	IC50 = 9.8 nM
2	IC50 = 250 nM
CP0702454 Compound Info	Tyr-Ala-hexarelin Show/Hide	C59H72N14O9	1
1	IC50 = 12 nM
CP0306681 Compound Info	(S)-4-(3-hexylureido)-N-(4-(2-(2-hydroxy-3-(4-hydroxyphenoxy)propylamino)-2-methylpropyl)phenyl)benzenesulfonamide Show/Hide	C32H44N4O6S	1
1	IC50 = 13 nM
CP0202154 Compound Info	(+/-)isobutyl 2-((4-(diethylamino)phenyl)carbamoyl)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl(methyl)carbamate Show/Hide	C28H39N3O4	1
1	IC50 = 16 nM
CP0112074 Compound Info	ethyl N-[(1S)-1-[[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-indol-3-yl)propanoyl]amino]-2-(1H-indol-3-yl)ethyl]carbamate Show/Hide	C28H34N6O4	1
1	IC50 = 16.2 nM
CP0310947 Compound Info	2-Amino-N-[1-[(R)-(S)-1-(3-ethyl-ureido)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-(1H-indol-3-yl)-ethyl]-2-methyl-propionamide Show/Hide	C28H35N7O3	1
1	IC50 = 16.9 nM
CP0310354 Compound Info	Examorelin Show/Hide	C47H58N12O6	1
1	IC50 = 18 nM
CP0268289 Compound Info	N-[(2R)-1-[[(1R)-1-acetamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-(dimethylamino)-2-methylpropanamide Show/Hide	C29H36N6O3	1
1	IC50 = 20.1 nM
CP0235411 Compound Info	N-[(1R)-1-[[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-indol-3-yl)propanoyl]amino]-2-(1H-indol-3-yl)ethyl]piperidine-2-carboxamide Show/Hide	C31H39N7O3	1
1	IC50 = 21.5 nM
CP0303771 Compound Info	2-Amino-N-{(R)-1-[(R)-1-formylamino-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-1H-indol-3-yl-ethyl}-2-methyl-propionamide Show/Hide	C26H30N6O3	1
1	IC50 = 22.9 nM
CP0102070 Compound Info	N-[(2R)-1-[[(1R)-1-acetamido-2-(1H-indol-3-yl)ethyl]-methylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methyl-2-(methylamino)propanamide Show/Hide	C29H36N6O3	1
1	IC50 = 25.6 nM
CP0686858 Compound Info	1N-[1-benzyloxymethyl-2-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-2-oxo-(1R)-ethyl]-2-aminomethylcarboxamido-3-hydroxy-(2S)-propanamide; Trifluoroacetate Show/Hide	C30H38F3N5O9S	1
1	IC50 = 36.2 nM
CP0367518 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-2-methyl-phenyl)-amide Show/Hide	C22H23Cl2N3O2	1
1	IC50 = 37 nM
CP0112161 Compound Info	N-[(2R)-1-[[(1R)-1-formamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methyl-2-(methylamino)propanamide Show/Hide	C27H32N6O3	1
1	IC50 = 39 nM
CP0090232 Compound Info	N-[(1R)-1-[[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-indol-3-yl)propanoyl]amino]-2-(1H-indol-3-yl)ethyl]-3-methylbutanamide Show/Hide	C30H38N6O3	1
1	IC50 = 59.8 nM
CP0160317 Compound Info	N-[(2R)-1-[[(1R)-1-acetamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methyl-2-(methylamino)propanamide Show/Hide	C28H34N6O3	1
1	IC50 = 74 nM
CP0773560 Compound Info	2-[1-aminomethylcarboxamido-2-hydroxy-(1S)-ethylcarboxamido]-3-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-3-oxo-(2R)-propyl octanoate; Trifluoroacatate Show/Hide	C31H46F3N5O10S	1
1	IC50 = 128 nM
CP0006991 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide Show/Hide	C21H21Cl2N3O2	1
1	IC50 = 130 nM
CP0193125 Compound Info	2-Amino-N-{2-(1H-indol-3-yl)-1-[(R)-(R)-2-(1H-indol-3-yl)-1-propionylamino-ethylcarbamoyl]-ethyl}-2-methyl-propionamide Show/Hide	C28H34N6O3	1
1	IC50 = 185 nM
CP0735614 Compound Info	1N-[1-benzyloxymethyl-2-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-2-oxo-(1R)-ethyl]-2-amino-3-hydroxy-(2S)-propanamide; Trifluoroacetate Show/Hide	C28H35F3N4O8S	1
1	IC50 = 209 nM
CP0509277 Compound Info	N-[(1R)-2-(1H-indol-3-yl)-1-[[(2R)-3-(1H-indol-3-yl)-2-[[2-methyl-2-(methylamino)propanoyl]amino]propanoyl]amino]ethyl]-3-methylbutanamide Show/Hide	C31H40N6O3	1
1	IC50 = 213 nM
CP0111596 Compound Info	3-(2-Bromo-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide Show/Hide	C21H22BrN3O2	1
1	IC50 = 340 nM
CP0370122 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid {2-[(benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-phenyl}-amide Show/Hide	C26H19Cl2N3O5	1
1	IC50 = 350 nM
CP0152858 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-2-ethyl-phenyl)-amide Show/Hide	C23H25Cl2N3O2	1
1	IC50 = 370 nM
CP0316950 Compound Info	N-[(2R)-1-[[(1R)-1-formamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]piperidine-4-carboxamide Show/Hide	C28H32N6O3	1
1	IC50 = 391 nM
CP0083621 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [4-(ethyl-propyl-amino)-phenyl]-amide Show/Hide	C22H23Cl2N3O2	1
1	IC50 = 410 nM
CP0013808 Compound Info	5-Methyl-3-(2-nitro-phenyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide Show/Hide	C21H22N4O4	1
1	IC50 = 550 nM
CP0727184 Compound Info	2-(1-amino-1-methylethylcarboxamido)-3-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-3-oxo-(2S)-propyl octanoate; trifluoroacetate Show/Hide	C30H45F3N4O8S	1
1	IC50 = 590.5 nM
CP0061848 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-2-ethyl-phenyl)-amide Show/Hide	C22H23Cl2N3O3	1
1	IC50 = 600 nM
CP0005801 Compound Info	3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide Show/Hide	C21H22ClN3O2	1
1	IC50 = 690 nM
CP0677986 Compound Info	2-[1-amino-2-hydroxy-(1S)-ethylcarboxamido]-3-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-3-oxo-(2R)-propyl octanoate; Trifluoroacetate Show/Hide	C29H43F3N4O9S	1
1	IC50 = 828.5 nM
CP0082096 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [2-(azepane-1-carbonyl)-phenyl]-amide Show/Hide	C24H23Cl2N3O3	1
1	IC50 = 860 nM
CP0310709 Compound Info	2-[1-[1-aminomethylcarboxamido-2-heptylcarbonyloxy-(1S)-ethylcarboxamido]-2-hydroxy-(1S)-ethylcarboxamido]-3-phenyl-(2S)-propanoic acid Show/Hide	C25H38N4O8	1
1	IC50 = 889 nM
CP0370121 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [2-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenyl]-amide Show/Hide	C28H25Cl2N3O2	1
1	IC50 = 980 nM
CP0040929 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (2-benzylcarbamoyl-phenyl)-amide Show/Hide	C25H19Cl2N3O3	1
1	IC50 = 1200 nM
CP0184651 Compound Info	3-Biphenyl-2-yl-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide Show/Hide	C27H27N3O2	1
1	IC50 = 1300 nM
CP0270411 Compound Info	4-Amino-piperidine-4-carboxylic acid [1-[(R)-(R)-1-formylamino-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-(1H-indol-3-yl)-ethyl]-amide Show/Hide	C28H33N7O3	1
1	IC50 = 1791 nM
CP0333137 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (2-diethylcarbamoyl-phenyl)-amide Show/Hide	C22H21Cl2N3O3	1
1	IC50 = 1900 nM
CP0250114 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [2-(piperidine-1-carbonyl)-phenyl]-amide Show/Hide	C23H21Cl2N3O3	1
1	IC50 = 2200 nM
CP0650732 Compound Info	2-[1-aminomethylcarboxamido-2-hydroxy-(1S)-ethylcarboxamido]-3-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-3-oxo-(2S)-propyl octanoate; trifluoroactate Show/Hide	C31H46F3N5O10S	1
1	IC50 = 2670 nM
CP0302498 Compound Info	N-[(2R)-1-[[(1R)-1-acetamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-amino-2-methylpropanamide Show/Hide	C27H32N6O3	1
1	IC50 = 3852 nM
CP0111597 Compound Info	3-(2-Methoxy-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide Show/Hide	C22H25N3O3	1
1	IC50 = 4000 nM
CP0225215 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-2-trifluoromethyl-phenyl)-amide Show/Hide	C22H20Cl2F3N3O2	1
1	IC50 = 4100 nM
CP0152861 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [4-(ethyl-methyl-amino)-phenyl]-amide Show/Hide	C20H19Cl2N3O2	1
1	IC50 = 5500 nM
CP0219009 Compound Info	US9708370, GHRP-6 Show/Hide	C46H56N12O6	2
1	IC50 = 6000 nM
2	Ki = 6 nM
CP0180252 Compound Info	3-(4-Chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide Show/Hide	C21H22ClN3O2	1
1	IC50 = 7100 nM
CP0137589 Compound Info	3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethyl)-isoxazole-4-carboxylic acid [2-(piperidine-1-carbonyl)-phenyl]-amide Show/Hide	C28H29Cl2N3O5	1
1	IC50 = 7500 nM
CP0003133 Compound Info	5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide Show/Hide	C21H23N3O2	1
1	IC50 = 8200 nM
CP0225214 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (2-cyano-4-diethylamino-phenyl)-amide Show/Hide	C22H20Cl2N4O2	1
1	IC50 = 9000 nM
CP0225195 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid {4-[ethyl-(2-hydroxy-ethyl)-amino]-phenyl}-amide Show/Hide	C21H21Cl2N3O3	1
1	IC50 = 9200 nM
CP0152859 Compound Info	3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-3-methyl-phenyl)-amide Show/Hide	C22H23Cl2N3O2	1
1	IC50 > 100 nM
CP0258518 Compound Info	N-[(2R)-1-[[(1R)-1-acetamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]piperidine-4-carboxamide Show/Hide	C29H34N6O3	1
1	IC50 > 10000 nM
CP0272419 Compound Info	N-[(2R)-3-(1H-indol-3-yl)-1-[[(1R)-2-(1H-indol-3-yl)-1-(propanoylamino)ethyl]amino]-1-oxopropan-2-yl]-2-methyl-2-(methylamino)propanamide Show/Hide	C29H36N6O3	1
1	IC50 > 10000 nM
CP0238556 Compound Info	(6S,9R,12R)-6-[(2S)-butan-2-yl]-12-[(4-chlorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C30H41ClN4O4	1
1	Ki = 0.35 nM
CP0260069 Compound Info	(3R,6S,9R,12R)-6-cyclohexyl-12-[(4-fluorophenyl)methyl]-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C33H45FN4O4	1
1	Ki = 0.38 nM
CP0260072 Compound Info	(7R,10R,13S,16R)-13-cyclopropyl-7-[(4-fluorophenyl)methyl]-10,11-dimethyl-24-oxa-5,8,11,14-tetrazatricyclo[14.6.2.019,23]tetracosa-1(23),19,21-triene-6,9,12-trione Show/Hide	C31H39FN4O4	1
1	Ki = 0.9 nM
CP0213761 Compound Info	(6S,9R,12R)-6-cyclopropyl-21-fluoro-12-[(4-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(18),19,21-triene-7,10,13-trione Show/Hide	C29H36F2N4O4	1
1	Ki = 2.6 nM
CP0444784 Compound Info	(2S)-N-[(1R)-1-[5-[(1R)-1-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-2-(1H-indol-3-yl)ethyl]-4-[(4-methoxyphenyl)methyl]-1,2,4-triazol-3-yl]-2-(1H-indol-3-yl)ethyl]-2,6-diaminohexanamide Show/Hide	C50H67N11O5	1
1	Ki = 3 nM
CP0504852 Compound Info	(2S)-2-acetamido-N-[(2S)-1-[[(1R)-1-[5-[(1R)-1-[(2-hydroxyacetyl)amino]-2-(1H-indol-3-yl)ethyl]-4-[(4-methoxyphenyl)methyl]-1,2,4-triazol-3-yl]-2-(1H-indol-3-yl)ethyl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide Show/Hide	C46H57N9O6	1
1	Ki = 3 nM
CP0213740 Compound Info	(6S,9R,12R)-12-benzyl-6-cyclopropyl-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C29H38N4O4	1
1	Ki = 4.4 nM
CP0079401 Compound Info	(6S,9R,12R)-6-cyclopropyl-8,9-dimethyl-12-[(4-methylphenyl)methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C30H40N4O4	1
1	Ki = 5 nM
CP0332150 Compound Info	(6S,9R,12R)-6-cyclopropyl-12-[(2-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C29H37FN4O4	1
1	Ki = 6.2 nM
CP0260064 Compound Info	(6S,9R,12R)-12-benzyl-6-[(2S)-butan-2-yl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C30H42N4O4	1
1	Ki = 6.4 nM
CP0284752 Compound Info	(6S,9R,12R)-6-cyclopropyl-8,9-dimethyl-12-[[4-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C30H37F3N4O4	1
1	Ki = 7 nM
CP0260068 Compound Info	(6S,9R,12R)-6-cyclopropyl-12-[(4-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C29H37FN4O4	1
1	Ki = 7.3 nM
CP0084691 Compound Info	(6S,9R,12R)-6-cyclopropyl-12-[(4-fluorophenyl)methyl]-4,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C30H39FN4O4	1
1	Ki = 9 nM
CP0260067 Compound Info	(3R,6S,9R,12R)-12-[(4-chlorophenyl)methyl]-6-cyclopropyl-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C30H39ClN4O4	1
1	Ki = 15 nM
CP0191601 Compound Info	(6S,9R,12R)-12-benzyl-8,9-dimethyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C29H40N4O4	1
1	Ki = 16 nM
CP0726922 Compound Info	(2R,5S,8R,11R)-5-cyclopropyl-11-(4-fluorobenzyl)-2,7,8-trimethyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione hydrochloride hydrate Show/Hide	C30H42ClFN4O5	1
1	Ki = 16 nM
CP0151998 Compound Info	(6S,9R,12R)-6-cyclopropyl-12-[(3-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C29H37FN4O4	1
1	Ki = 21 nM
CP0260123 Compound Info	(6S,9R,12R)-12-benzyl-8,9-dimethyl-6-(2-methylpropyl)-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C30H42N4O4	1
1	Ki = 25 nM
CP0151997 Compound Info	(6S,9R,12R)-6-[(2S)-butan-2-yl]-8,9-dimethyl-12-(2-phenylethyl)-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C31H44N4O4	1
1	Ki = 43 nM
CP0238497 Compound Info	(3S,6S,9R,12R)-6-cyclopropyl-12-[(4-fluorophenyl)methyl]-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C30H39FN4O4	1
1	Ki = 56 nM
CP0213743 Compound Info	(6S,9R,12R)-6-cyclopropyl-20-fluoro-12-[(4-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(18),19,21-triene-7,10,13-trione Show/Hide	C29H36F2N4O4	1
1	Ki = 58 nM
CP0205852 Compound Info	(6S,12R)-12-benzyl-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C28H38N4O4	1
1	Ki = 68 nM
CP0354581 Compound Info	(6S,9R,12R)-12-benzyl-6-[(2S)-butan-2-yl]-8,9-dimethyl-5,8,11,14-tetrazabicyclo[17.4.0]tricosa-1(23),19,21-triene-7,10,13-trione Show/Hide	C32H46N4O3	1
1	Ki = 78 nM
CP0274269 Compound Info	(7R,10R,13S)-7-benzyl-13-[(2S)-butan-2-yl]-10,11-dimethyl-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione Show/Hide	C31H44N4O3	1
1	Ki = 81 nM
CP0354578 Compound Info	(6S,12R,16E)-12-benzyl-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione Show/Hide	C28H36N4O4	1
1	Ki = 86 nM
CP0151994 Compound Info	(6S,12R)-12-[(4-hydroxyphenyl)methyl]-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C28H38N4O5	1
1	Ki = 120 nM
CP0084690 Compound Info	(3R,6R,9S,15E)-3-benzyl-9-[(2S)-butan-2-yl]-6,7-dimethyl-1,4,7,10-tetrazacyclooctadec-15-ene-2,5,8-trione Show/Hide	C27H42N4O3	1
1	Ki = 160 nM
CP0051354 Compound Info	(S,E)-2-amino-N-(2-(benzyloxy)-1-(1-cinnamyl-1H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C23H28N6O2	1
1	Ki = 190 nM
CP0261719 Compound Info	(S)-2-amino-N-(2-(benzyloxy)-1-(1-(3-phenylpropyl)-1H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C23H30N6O2	1
1	Ki = 200 nM
CP0094817 Compound Info	(6S,9R,12R)-12-benzyl-6-[(2S)-butan-2-yl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[15.4.0]henicosa-1(21),17,19-triene-7,10,13-trione Show/Hide	C29H40N4O4	1
1	Ki = 210 nM
CP0379087 Compound Info	(2S)-2,6-diamino-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]hexanamide Show/Hide	C49H66N10O6	1
1	Ki = 255 nM
CP0332885 Compound Info	(S)-benzyl 5-(5-(1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl)-1H-tetrazol-1-yl)pentylcarbamate Show/Hide	C27H37N7O4	1
1	Ki = 320 nM
CP0155470 Compound Info	(6S,12S)-12-benzyl-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C28H38N4O4	1
1	Ki = 380 nM
CP0238558 Compound Info	(6R,9R,12S)-6-benzyl-12-[(2S)-butan-2-yl]-9,10-dimethyl-4,7,10,13-tetrazabicyclo[15.4.0]henicosa-1(21),17,19-triene-5,8,11-trione Show/Hide	C30H42N4O3	1
1	Ki = 400 nM
CP0284751 Compound Info	(6S,12R)-12-butyl-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C25H40N4O4	1
1	Ki = 400 nM
CP0051292 Compound Info	methyl 2-[5-[(1S)-1-[(2-amino-2-methylpropanoyl)amino]-2-phenylmethoxyethyl]tetrazol-1-yl]-2-phenylacetate Show/Hide	C23H28N6O4	1
1	Ki = 470 nM
CP0260065 Compound Info	(6S,9R,12R)-12-benzyl-9-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C28H38N4O4	1
1	Ki = 500 nM
CP0329376 Compound Info	(6S,9S,12R)-12-benzyl-8,9-dimethyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C29H40N4O4	1
1	Ki = 580 nM
CP0284750 Compound Info	(6S,12R)-6,12-dibenzyl-8-methyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C32H38N4O4	1
1	Ki = 670 nM
CP0035111 Compound Info	2-amino-N-{(S)-2-benzyloxy-1-[1-(2-phenethylcarbamoyl-ethyl)-1H-tetrazol-5-yl]-ethyl}-2-methyl-propionamide Show/Hide	C25H33N7O3	1
1	Ki = 780 nM
CP0165849 Compound Info	2-amino-N-((S)-2-benzyloxy-1-{1-[2-(3-phenyl-propylcarbamoyl)-ethyl]-1H-tetrazol-5-yl}-ethyl)-2-methyl-propionamide Show/Hide	C26H35N7O3	1
1	Ki = 820 nM
CP0165860 Compound Info	(S)-2-amino-N-(2-(benzyloxy)-1-(1-(2-(1-(methylsulfonyl)-1H-indol-2-yl)ethyl)-1H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C25H31N7O4S	1
1	Ki = 970 nM
CP0370661 Compound Info	2-amino-N-{(S)-1-[1-(2-benzylcarbamoyl-ethyl)-1H-tetrazol-5-yl]-2-benzyloxy-ethyl}-2-methyl-propionamide Show/Hide	C24H31N7O3	1
1	Ki = 1070 nM
CP0084688 Compound Info	(6S,12R)-6-(4-aminobutyl)-12-benzyl-8-methyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C29H41N5O4	1
1	Ki = 1100 nM
CP0151993 Compound Info	(6R,12R)-12-benzyl-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C28H38N4O4	1
1	Ki = 1200 nM
CP0079826 Compound Info	(S)-2-amino-N-(2-(benzyloxy)-1-(2-(2-(1-(methylsulfonyl)-1H-indol-2-yl)ethyl)-2H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C25H31N7O4S	1
1	Ki = 1270 nM
CP0370660 Compound Info	2-amino-N-{(R)-1-[1-(2-butylcarbamoyl-ethyl)-1H-tetrazol-5-yl]-3-phenyl-propyl}-2-methyl-propionamide Show/Hide	C21H33N7O2	1
1	Ki = 1370 nM
CP0274331 Compound Info	(3R,6R,9S)-3-benzyl-9-[(2S)-butan-2-yl]-6,7-dimethyl-1,4,7,10-tetrazacyclooctadecane-2,5,8-trione Show/Hide	C27H44N4O3	1
1	Ki = 1500 nM
CP0500552 Compound Info	2-amino-N-((S)-2-(benzyloxy)-1-(1-((1-(methylsulfonyl)indolin-3-yl)methyl)-1H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C24H31N7O4S	1
1	Ki = 1590 nM
CP0145444 Compound Info	(S)-2-amino-N-(2-(benzyloxy)-1-(1-(3-(2-(N-methylmethan-4-ylsulfonamido)phenyl)propyl)-1H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C25H35N7O4S	1
1	Ki = 1720 nM
CP0370662 Compound Info	(S)-4-(5-(1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl)-1H-tetrazol-1-yl)-N-butylbutanamide Show/Hide	C22H35N7O3	1
1	Ki = 1780 nM
CP0051352 Compound Info	(S)-2-amino-N-(1-(1-benzyl-1H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-methylpropanamide Show/Hide	C21H26N6O2	1
1	Ki = 1900 nM
CP0541779 Compound Info	2-amino-N-{(S)-2-benzyloxy-1-[1-(2-butylcarbamoyl-ethyl)-1H-tetrazol-5-yl]-ethyl}-2-methyl-propionamide Show/Hide	C21H33N7O3	1
1	Ki = 2190 nM
CP0165856 Compound Info	(S)-N-(1-(1-(2-(methylsulfonamido)phenethyl)-1H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-amino-2-methylpropanamide Show/Hide	C23H31N7O4S	1
1	Ki = 2200 nM
CP0165851 Compound Info	(S)-methyl 4-(5-(1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl)-1H-tetrazol-1-yl)butanoate Show/Hide	C19H28N6O4	1
1	Ki = 2380 nM
CP0079827 Compound Info	(S)-2-amino-N-(2-(benzyloxy)-1-(2-(3-(2-(methylsulfonamido)phenyl)propyl)-2H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C24H33N7O4S	1
1	Ki = 2390 nM
CP0215202 Compound Info	(S)-N-(1-(2-(2-(methylsulfonamido)phenethyl)-2H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-amino-2-methylpropanamide Show/Hide	C23H31N7O4S	1
1	Ki = 2660 nM
CP0285233 Compound Info	(S)-2-amino-N-(2-(benzyloxy)-1-(1-(2-cyanoethyl)-1H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C17H23N7O2	1
1	Ki = 2940 nM
CP0051294 Compound Info	(S)-2-amino-N-(2-(benzyloxy)-1-(1-(4-cyanobutyl)-1H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C19H27N7O2	1
1	Ki = 3120 nM
CP0222631 Compound Info	(S)-methyl 3-(5-(1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl)-1H-tetrazol-1-yl)propanoate Show/Hide	C18H26N6O4	1
1	Ki = 3380 nM
CP0145445 Compound Info	(S)-2-amino-N-(2-(benzyloxy)-1-(1-(cyanomethyl)-1H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C16H21N7O2	1
1	Ki = 4170 nM
CP0296915 Compound Info	(S)-N-(1-(1-(2-(methylsulfonamido)benzyl)-1H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-amino-2-methylpropanamide Show/Hide	C22H29N7O4S	1
1	Ki = 4450 nM
CP0296917 Compound Info	(S)-2-amino-N-(1-(2-benzyl-2H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-methylpropanamide Show/Hide	C21H26N6O2	1
1	Ki = 4750 nM
CP0241192 Compound Info	(S)-N-(1-(1-(2-(1H-tetrazol-5-yl)ethyl)-1H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-amino-2-methylpropanamide Show/Hide	C17H24N10O2	1
1	Ki = 5000 nM
CP0051349 Compound Info	(R)-methyl 3-(5-(1-(2-amino-2-methylpropanamido)-2-(1H-indol-3-yl)ethyl)-1H-tetrazol-1-yl)propanoate Show/Hide	C19H25N7O3	1
1	Ki > 5000 nM
CP0075566 Compound Info	(S)-2-amino-N-(2-(benzyloxy)-1-(2-(cyanomethyl)-2H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C16H21N7O2	1
1	Ki > 5000 nM
CP0075567 Compound Info	(S)-2-amino-N-(2-(benzyloxy)-1-(2-(4-cyanobutyl)-2H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C19H27N7O2	1
1	Ki > 5000 nM
CP0075568 Compound Info	(S)-2-amino-N-(2-(benzyloxy)-1-(1-(5-(methylsulfonamido)pentyl)-1H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C20H33N7O4S	1
1	Ki > 5000 nM
CP0103666 Compound Info	(S)-N-(1-(2-(2-(methylsulfonamido)benzyl)-2H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-amino-2-methylpropanamide Show/Hide	C22H29N7O4S	1
1	Ki > 5000 nM
CP0165853 Compound Info	(S)-N-(1-(2-(4-(methylsulfonamido)benzyl)-2H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-amino-2-methylpropanamide Show/Hide	C22H29N7O4S	1
1	Ki > 5000 nM
CP0241188 Compound Info	(S,E)-2-amino-N-(2-(benzyloxy)-1-(2-cinnamyl-2H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C23H28N6O2	1
1	Ki > 5000 nM
CP0241189 Compound Info	2-amino-N-((S)-2-(benzyloxy)-1-(2-((1-(methylsulfonyl)indolin-2-yl)methyl)-2H-tetrazol-5-yl)ethyl)-2-methylpropanamide Show/Hide	C24H31N7O4S	1
1	Ki > 5000 nM
CP0241190 Compound Info	methyl 2-[5-[(1S)-1-[(2-amino-2-methylpropanoyl)amino]-2-phenylmethoxyethyl]tetrazol-2-yl]-2-phenylacetate Show/Hide	C23H28N6O4	1
1	Ki > 5000 nM
CP0261718 Compound Info	(S)-N-(1-(1-(3-(methylsulfonamido)benzyl)-1H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-amino-2-methylpropanamide Show/Hide	C22H29N7O4S	1
1	Ki > 5000 nM
CP0296916 Compound Info	(S)-N-(1-(2-(3-(methylsulfonamido)benzyl)-2H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-amino-2-methylpropanamide Show/Hide	C22H29N7O4S	1
1	Ki > 5000 nM
CP0332882 Compound Info	(S)-N-(1-(1-(4-(methylsulfonamido)benzyl)-1H-tetrazol-5-yl)-2-(benzyloxy)ethyl)-2-amino-2-methylpropanamide Show/Hide	C22H29N7O4S	1
1	Ki > 5000 nM
CP0084689 Compound Info	(6S,12R)-12-(3-aminopropyl)-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C24H39N5O4	1
1	Ki > 10000 nM
CP0205853 Compound Info	3-[(6S,12R)-12-benzyl-8-methyl-7,10,13-trioxo-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-6-yl]propanoic acid Show/Hide	C28H36N4O6	1
1	Ki > 10000 nM
CP0205854 Compound Info	(6S,12R)-12-(hydroxymethyl)-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C22H34N4O5	1
1	Ki > 10000 nM
CP0238495 Compound Info	3-[(6S,12R)-8-methyl-7,10,13-trioxo-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-12-yl]propanoic acid Show/Hide	C24H36N4O6	1
1	Ki > 10000 nM
CP0238530 Compound Info	(6S,12R)-12-benzyl-6-(hydroxymethyl)-8-methyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione Show/Hide	C26H34N4O5	1
1	Ki > 10000 nM
CP0260071 Compound Info	(3R,6R,9S)-3-benzyl-9-[(2S)-butan-2-yl]-6,7-dimethyl-1,4,7,10-tetrazacycloheptadecane-2,5,8-trione Show/Hide	C26H42N4O3	1
1	Ki > 10000 nM

Clinical Information about the Protein

Target 1 ( Growth hormone secretagogue receptor 1 (GHSR) )

Target Type	Successful Target
Disease	7 Target-related Diseases				7
1	Fibromyalgia [ICD-11: MG30.01]
2	Somatotropin deficiency [ICD-11: 5A61.0]
3	Gastrointestinal disease [ICD-11: DE2Z]
4	Growth hormone deficiency [ICD-11: 5A61.3]
5	Frailty [ICD-11: MG2A]
6	Postoperative ileus [ICD-11: DA91-DB30]
7	Type-2 diabetes [ICD-11: 5A11]
Approved Drug(s)	2 Approved Drugs				2
1	Ibutamoren	Drug Info	Approved	Fibromyalgia
2	Macimorelin	Drug Info	Approved	Somatotropin deficiency
Clinical Trial Drug(s)	6 Clinical Trial Drugs				6
1	TZP-101	Drug Info	Phase 2b	Gastrointestinal disease
2	Ibutamoren mesylate	Drug Info	Phase 2	Growth hormone deficiency
3	RQ-00000005	Drug Info	Phase 2	Frailty
4	Tabimorelin	Drug Info	Phase 2	Growth hormone deficiency
5	Ipamorelin	Drug Info	Phase 1/2	Postoperative ileus
6	PF-05190457	Drug Info	Phase 1	Type-2 diabetes

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT04369	Mas-related G-protein coupled receptor member X1	Homo sapiens, Human	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han