General Information of the Compound
Compound ID
CP0094817
Compound Name
(6S,9R,12R)-12-benzyl-6-[(2S)-butan-2-yl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[15.4.0]henicosa-1(21),17,19-triene-7,10,13-trione
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Structure
Formula
C29H40N4O4
Molecular Weight
508.663
Canonical SMILES
CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O
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InChI
InChI=1S/C29H40N4O4/c1-5-20(2)26-29(36)33(4)21(3)27(34)32-24(19-22-11-7-6-8-12-22)28(35)31-16-15-23-13-9-10-14-25(23)37-18-17-30-26/h6-14,20-21,24,26,30H,5,15-19H2,1-4H3,(H,31,35)(H,32,34)/t20-,21+,24+,26-/m0/s1
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InChIKey
DQJXOEHBWVVKTL-MIUUGJTFSA-N
Physicochemical Property
logP
2.3164
Rotatable Bonds
4
Heavy Atom Count
37
Polar Areas
99.77
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56926785
SID: 135609122
ChEMBL ID
CHEMBL1923634
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01155, Growth hormone secretagogue receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 530 nM
   TI
   LI
   LO
   TS
2
Ki = 100 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 210 nM