| Compound ID |
Compound Name |
Compound Formula |
|
CP0115798
|
(3R,6S,9R,12R)-6-cyclopropyl-12-[(4-fluorophenyl)methyl]-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione
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|
C30H39FN4O4
|
2
|
| 1 |
EC50 = 1 nM
|
|
|
| 2 |
EC50 = 5 nM
|
|
|
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CP0151994
|
(6S,12R)-12-[(4-hydroxyphenyl)methyl]-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione
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|
C28H38N4O5
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0205852
|
(6S,12R)-12-benzyl-8-methyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione
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|
C28H38N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0213740
|
(6S,9R,12R)-12-benzyl-6-cyclopropyl-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione
Show/Hide
|
C29H38N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0213761
|
(6S,9R,12R)-6-cyclopropyl-21-fluoro-12-[(4-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(18),19,21-triene-7,10,13-trione
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|
C29H36F2N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0238497
|
(3S,6S,9R,12R)-6-cyclopropyl-12-[(4-fluorophenyl)methyl]-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione
Show/Hide
|
C30H39FN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0238556
|
(6S,9R,12R)-6-[(2S)-butan-2-yl]-12-[(4-chlorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione
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|
C30H41ClN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0260064
|
(6S,9R,12R)-12-benzyl-6-[(2S)-butan-2-yl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione
Show/Hide
|
C30H42N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0284752
|
(6S,9R,12R)-6-cyclopropyl-8,9-dimethyl-12-[[4-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione
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|
C30H37F3N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0851210
|
(5S,11S)-5-isobutyl-11-(4-methoxybenzyl)-2,3,4,5,10,11,13,14-octahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
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|
C33H44N4O5
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0851619
|
(5S,11S)-11-(3-chlorobenzyl)-5-isobutyl-2,3,4,5,10,11,13,14-octahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
Show/Hide
|
C32H41ClN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0851639
|
(5S,8R,11R)-11-benzyl-5-sec-butyl-7,8-dimethyl-4,5,7,8,10,11,13,14-octahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
Show/Hide
|
C30H40N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0851656
|
(5S,8R,11R)-5-sec-butyl-7,8-dimethyl-11-(naphthalen-2-ylmethyl)-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
Show/Hide
|
C34H44N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0858819
|
(5S,8R,11R)-5-sec-butyl-11-isobutyl-7,8-dimethyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
Show/Hide
|
C28H46N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0864408
|
(5S,11R)-11-((1H-indol-3-yl)methyl)-7-methyl-5-propyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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|
C30H39N5O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0864461
|
(5S,11S)-5-sec-butyl-11-(4-chlorobenzyl)-2,3,4,4',5,5',10,11,13,14-decahydro-2'H-spiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,3'-furan]-6,9,12(7H)-trione
Show/Hide
|
C31H39ClN4O5
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0864948
|
(5S,11S)-11-(4-chlorobenzyl)-5-isobutyl-2,3,4,5,10,11,13,14-octahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
Show/Hide
|
C32H41ClN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0864951
|
(5S,8R,11R)-5-cyclopropyl-11-(2,4-dichlorobenzyl)-7,8-dimethyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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|
C29H36Cl2N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0864952
|
(1aS,5S,11R,19bS)-11-sec-butyl-5-(3-chlorobenzyl)-2,3,5,6,11,12,13,14-octahydro-1H-spiro[benzo[q]cyclopropa[o][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-4,7,10(1aH,9H,19bH)-trione
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|
C33H43ClN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0869427
|
N-((5S,8R,11R)-5-cyclopropyl-11-(4-fluorobenzyl)-7,8-dimethyl-6,9,12-trioxo-3,4,5,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecin-18-yl)methanesulfonamide
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|
C30H40FN5O6S
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0871225
|
(5S,11S)-11-(4-fluorobenzyl)-5-isobutyl-2,3,4,5,10,11,13,14-octahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
Show/Hide
|
C32H41FN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0875141
|
(5S,8R,11R)-5-sec-butyl-11-(4-fluorobenzyl)-7,8-dimethyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
Show/Hide
|
C30H41FN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0875150
|
(7R,10R,13S)-13-cyclopropyl-7-[(4-fluorophenyl)methyl]-10,11-dimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(18),19,21-trien-2-yne-6,9,12-trione
Show/Hide
|
C29H33FN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0883415
|
(5S,11S)-11-benzyl-5-isobutyl-2,3,4,5,10,11,13,14-octahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
Show/Hide
|
C32H42N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0883416
|
(5S,11S)-11-(4-chlorobenzyl)-5-cyclopropyl-2,3,4,5,10,11,13,14-octahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
Show/Hide
|
C31H37ClN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0883418
|
(5S,8R,11R)-5-sec-butyl-11-(2-chlorobenzyl)-7,8-dimethyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
Show/Hide
|
C30H41ClN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0883419
|
(5S,8R,11R)-5-sec-butyl-11-(4-methoxybenzyl)-7,8-dimethyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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|
C31H44N4O5
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0883420
|
(5S,8R,11R)-5-sec-butyl-7,8-dimethyl-11-(naphthalen-1-ylmethyl)-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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|
C34H44N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0894008
|
(S)-11-(3-chlorobenzyl)-8,8-dimethyl-3,4,7,8,10,11,13,14-octahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-5,1'-cyclopentane]-6,9,12(2H)-trione
Show/Hide
|
C30H37ClN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0895644
|
(3S,6R,9R)-9-benzyl-3-sec-butyl-5,6-dimethyl-2,3,5,6,8,9,12,13-octahydrobenzo[l][1,4,7,10]tetraazacyclooctadecine-4,7,10(1H,11H,16H)-trione
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|
C31H42N4O3
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0899599
|
(5S,8R,11R)-5-cyclopropyl-7,8-dimethyl-11-(perfluorobenzyl)-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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|
C29H33F5N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0899603
|
(5S,8R,11R)-5-sec-butyl-11-(4-hydroxybenzyl)-7,8-dimethyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
Show/Hide
|
C30H42N4O5
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0901794
|
(5S,8R,11R)-11-(biphenyl-4-ylmethyl)-5-sec-butyl-7,8-dimethyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
Show/Hide
|
C36H46N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0902767
|
(5S,8R,11R)-11-(4-chlorobenzyl)-5-cyclopropyl-7,8-dimethyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
Show/Hide
|
C29H37ClN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0906041
|
(2S,5S,8R,11R)-11-benzyl-5-sec-butyl-2,7,8-trimethyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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|
C31H44N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0911194
|
(6R,9R,12S)-6-benzyl-12-sec-butyl-9,10-dimethyl-3,4,6,7,9,10,13,14,15,16-decahydrobenzo[n][1,4,7,10]tetraazacyclooctadecine-5,8,11(12H)-trione
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|
C31H42N4O3
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0911463
|
(5S,11S)-5-sec-butyl-11-(3-chlorobenzyl)-2,3,4,5,10,11,13,14-octahydro-1H-spiro[benzo[n][1,4,7,10]tetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
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|
C33H43ClN4O3
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0911470
|
(5S,11S)-5,11-diisobutyl-2,3,4,5,10,11,13,14-octahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
Show/Hide
|
C29H44N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0913576
|
(5S,11S)-11-(2-chlorobenzyl)-5-isobutyl-2,3,4,5,10,11,13,14-octahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
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|
C32H41ClN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0914437
|
(5S,8R,11R)-5-cyclopropyl-11-(4-fluorobenzyl)-7,8-dimethyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-pyrido[2,3-q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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|
C28H36FN5O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0930894
|
CHEMBL3932434
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C32H40N4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0933076
|
(8R,11S)-11-(3-chlorobenzyl)-8-methyl-3,4,7,8,10,11,13,14-octahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-5,1'-cyclopentane]-6,9,12(2H)-trione
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|
C29H35ClN4O4
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0952678
|
(5S,11S)-11-benzyl-5-isopropyl-2,3,4,4',5,5',10,11,13,14-decahydro-2'H-spiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,3'-furan]-6,9,12(7H)-trione
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|
C30H38N4O5
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
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CP0329376
|
(6S,9S,12R)-12-benzyl-8,9-dimethyl-6-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione
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|
C29H40N4O4
|
1
|
| 1 |
EC50 = 16.6 nM
|
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CP0084691
|
(6S,9R,12R)-6-cyclopropyl-12-[(4-fluorophenyl)methyl]-4,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione
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C30H39FN4O4
|
1
|
| 1 |
EC50 = 100 nM
|
|
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CP0094817
|
(6S,9R,12R)-12-benzyl-6-[(2S)-butan-2-yl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[15.4.0]henicosa-1(21),17,19-triene-7,10,13-trione
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C29H40N4O4
|
1
|
| 1 |
EC50 = 100 nM
|
|
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CP0274331
|
(3R,6R,9S)-3-benzyl-9-[(2S)-butan-2-yl]-6,7-dimethyl-1,4,7,10-tetrazacyclooctadecane-2,5,8-trione
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C27H44N4O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
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CP0354581
|
(6S,9R,12R)-12-benzyl-6-[(2S)-butan-2-yl]-8,9-dimethyl-5,8,11,14-tetrazabicyclo[17.4.0]tricosa-1(23),19,21-triene-7,10,13-trione
Show/Hide
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C32H46N4O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
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CP0851641
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(5S,11S)-11-benzyl-5-isobutyl-2,3,4,5,10,11,13,14,15,16-decahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
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|
C32H44N4O4
|
1
|
| 1 |
EC50 = 100 nM
|
|
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CP0858820
|
(4S,7R,10R)-10-benzyl-4-sec-butyl-6,7-dimethyl-3,4,6,7,9,10,12,13,14,15-decahydro-1H-benzo[m][1,4,7,10]tetraazacycloheptadecine-5,8,11(2H)-trione
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C30H42N4O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
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CP0864947
|
(5S,11S)-11-benzyl-5-isobutyl-2,3,4,5,10,11,13,14,15,16-decahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopropane]-6,9,12(7H)-trione
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|
C30H40N4O4
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
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CP0864949
|
(3S,6R,9R)-9-benzyl-3-sec-butyl-5,6-dimethyl-2,3,5,6,8,9,12,13,14,15-decahydro-1H-benzo[l][1,4,7,10]tetraazacycloheptadecine-4,7,10(11H)-trione
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C30H42N4O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
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CP0867091
|
(5S,8R,11R)-5-sec-butyl-7,8-dimethyl-11-(pyridin-3-ylmethyl)-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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|
C29H41N5O4
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
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CP0867094
|
(3S,6R,9R)-9-benzyl-3-sec-butyl-5,6-dimethyl-2,3,5,6,8,9,11,12-octahydro-1H-benzo[l][1,4,7,10]tetraazacycloheptadecine-4,7,10(15H)-trione
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C30H40N4O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
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CP0875142
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(5S,11S)-11-benzyl-5-isopropyl-2,3,4,5,10,11,13,14,15,16-decahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
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C31H42N4O4
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1
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| 1 |
EC50 = 100 nM
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CP0883269
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(1aS,5S,8S,11R,19bS)-11-cyclopropyl-5-(4-fluorobenzyl)-8,9-dimethyl-1,1a,2,3,5,6,8,9,11,12,13,14-dodecahydrobenzo[q]cyclopropa[o][1,4,7,10,13]oxatetraazacyclooctadecine-4,7,10(19bH)-trione
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C30H37FN4O4
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1
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| 1 |
EC50 = 100 nM
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CP0888295
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(5S,8R,11R)-11-benzyl-5-sec-butyl-7,8-dimethyl-2,3,4,5,7,8,10,11,14,15-decahydro-1H-benzo[n][1,4,7,10]tetraazacyclononadecine-6,9,12(13H)-trione
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C32H44N4O3
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1
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| 1 |
EC50 = 100 nM
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CP0894009
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(5S,8R,11R)-11-benzyl-7,8-dimethyl-5-propyl-4,5,7,8,10,11,13,14-octahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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C29H38N4O4
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1
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| 1 |
EC50 = 100 nM
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CP0899615
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(5S,8R,11R)-11-benzyl-5-sec-butyl-7,8-dimethyl-1-oxa-4,7,10,13-tetraazacyclooctadec-16-ene-6,9,12-trione
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C26H40N4O4
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1
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| 1 |
EC50 = 100 nM
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CP0902763
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(3S,6R,9R)-9-benzyl-3-sec-butyl-5,6-dimethyl-2,3,5,6,8,9,11,12,13,14,15,16-dodecahydrobenzo[1][1,4,7,10]tetraazacyclooctadecine-4,7,10(1H)-trione
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C31H44N4O3
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1
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| 1 |
EC50 = 100 nM
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CP0903686
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9-benzyl-3-sec-butyl-5,6-dimethyl-2,3,5,6,8,9,12,13,14,15-decahydro-1H-benzo[l][1,4,7,10]tetraazacycloheptadecine-4,7,10(11H)-trione
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C30H42N4O3
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1
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| 1 |
EC50 = 100 nM
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CP0903690
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3-benzyl-9-sec-butyl-6,7-dimethyl-1,4,7,10-tetraazacyclooctadecane-2,5,8-trione
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C27H44N4O3
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1
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| 1 |
EC50 = 100 nM
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CP0903692
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(5S,11S)-5-sec-butyl-11-(3-chlorobenzyl)-18-fluoro-2,3,4,5,10,11,13,14,15,16-decahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
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C32H42ClFN4O4
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1
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| 1 |
EC50 = 100 nM
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CP0906045
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(5S,11R)-11-benzyl-7-methyl-5-propyl-4,5,7,8,10,11,13,14-octahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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C28H36N4O4
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1
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| 1 |
EC50 = 100 nM
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CP0913577
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6-benzyl-12-sec-butyl-9,10-dimethyl-3,4,6,7,9,10,13,14,15,16-decahydrobenzo[n][1,4,7,10]tetraazacyclooctadecine-5,8,11(12H)-trione
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C31H42N4O3
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1
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| 1 |
EC50 = 100 nM
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CP0913578
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(5S,11R)-11-benzyl-5-isobutyl-2,3,4,5,10,11,13,14,15,16-decahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
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C32H44N4O4
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1
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| 1 |
EC50 = 100 nM
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CP0913579
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(5S,11S)-11-benzyl-5-isopropyl-2,2',3,3',4,5,5',6',10,11,13,14-dodecahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,4'-pyran]-6,9,12(7H)-trione
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C31H40N4O5
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1
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| 1 |
EC50 = 100 nM
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CP0864953
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(5S,11R)-11-benzyl-5-butyl-7-methyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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C29H40N4O4
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1
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| 1 |
EC50 = 104 nM
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CP0864954
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(5S,11R)-11-benzyl-5-isopropyl-7-methyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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C28H38N4O4
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1
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| 1 |
EC50 = 134 nM
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CP0869402
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(5S,8R,11R)-11-benzyl-5-sec-butyl-8-methyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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C29H40N4O4
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1
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| 1 |
EC50 = 163 nM
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CP0906044
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(5S,11R)-11-benzyl-7-ethyl-5-propyl-4,5,7,8,10,11,13,14,15,16-decahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-6,9,12(3H)-trione
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C29H40N4O4
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1
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| 1 |
EC50 = 298 nM
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CP0851211
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CHEMBL3961696
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C29H42N4O4
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1
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| 1 |
EC50 > 1000 nM
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CP0864465
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(2S,5S,11S)-5-sec-butyl-11-(3-chlorobenzyl)-2-methyl-2,3,4,5,10,11,13,14,15,16-decahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
Show/Hide
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C33H45ClN4O4
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1
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| 1 |
EC50 > 1000 nM
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CP0864940
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(2R,5S,11S)-5-sec-butyl-11-(3-chlorobenzyl)-2-methyl-2,3,4,5,10,11,13,14,15,16-decahydrospiro[benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-8,1'-cyclopentane]-6,9,12(7H)-trione
Show/Hide
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C33H45ClN4O4
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1
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| 1 |
EC50 > 1000 nM
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CP0864950
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(5S,8R,11R)-11-benzyl-5-sec-butyl-7,8-dimethyl-6,9,12-trioxo-3,4,5,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-2H-benzo[q][1,4,7,10,13]oxatetraazacyclooctadecine-18-carboxylic acid
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C31H42N4O6
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1
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| 1 |
EC50 > 1000 nM
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CP0875145
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(4aS,7R,10R)-10-benzyl-6,7-dimethyl-2,3,4,4a,6,7,9,10,12,13,14,15,21,22-tetradecahydrobenzo[q]pyrido[1,2-d][1,4,7,10,13]oxatetraazacyclooctadecine-5,8,11(1H)-trione
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C30H40N4O4
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1
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| 1 |
EC50 > 1000 nM
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CP0525227
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2,4-diaminopyrimidine derivative, 8b
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C25H24N6O3
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2
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| 1 |
IC50 = 0.2 nM
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| 2 |
IC50 = 5.8 nM
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CP0263325
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2,4-diaminopyrimidine derivative, 8c
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C26H27N5O3S
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2
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| 1 |
IC50 = 0.3 nM
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| 2 |
IC50 = 7.2 nM
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CP0453289
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2,4-diaminopyrimidine derivative, 11a
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C25H24N6O3
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2
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| 1 |
IC50 = 0.8 nM
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| 2 |
IC50 = 16 nM
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CP0933744
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6-[(benzyloxy)methyl]-5-[4-({4-[(trifluoromethyl)sulfonyl]-benzyl}amino)phenyl]pyrimidine-2,4-diamine
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C26H22F5N5O3S
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2
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| 1 |
IC50 = 1 nM
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| 2 |
IC50 = 85 nM
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CP0435441
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1-(4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)amino]methyl}phenyl)ethan-1-one
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C27H27N5O2
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2
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| 1 |
IC50 = 1.2 nM
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| 2 |
IC50 = 10 nM
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CP0432765
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2,4-diaminopyrimidine derivative, 8f
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C24H23ClN6O
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2
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| 1 |
IC50 = 1.5 nM
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| 2 |
IC50 = 3.6 nM
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CP0046899
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(2'-chlorobiphenyl-4-yl)methanone
Show/Hide
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C27H24ClN3O2
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1
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| 1 |
IC50 = 2.1 nM
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CP0435438
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2,4-diaminopyrimidine derivative, 7c
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C20H21F2N5O2S
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2
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| 1 |
IC50 = 2.4 nM
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| 2 |
IC50 = 45 nM
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CP0376076
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2,4-diaminopyrimidine derivative, 8g
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C26H24N6O
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2
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| 1 |
IC50 = 2.8 nM
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| 2 |
IC50 = 19 nM
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CP0435440
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2,4-diaminopyrimidine derivative, 8h
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C26H24F3N5O
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2
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| 1 |
IC50 = 2.9 nM
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| 2 |
IC50 = 97 nM
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CP0150346
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(2'-methylbiphenyl-4-yl)methanone
Show/Hide
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C28H27N3O2
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1
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| 1 |
IC50 = 2.9 nM
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CP0430052
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3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethyl)-isoxazole-4-carboxylic acid (4-diethylamino-cyclohexyl)-amide
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C26H35Cl2N3O4
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2
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| 1 |
IC50 = 3 nM
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| 2 |
IC50 = 87 nM
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CP0453288
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2,4-diaminopyrimidine derivative, 13
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C21H25N5O2S
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2
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| 1 |
IC50 = 3.7 nM
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| 2 |
IC50 = 32 nM
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CP0421211
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2,4-diaminopyrimidine-based antagonist, 7
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C21H22N6O2S
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2
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| 1 |
IC50 = 4 nM
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| 2 |
IC50 = 11 nM
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CP0038738
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(2'-(trifluoromethyl)biphenyl-4-yl)methanone
Show/Hide
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C28H24F3N3O2
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1
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| 1 |
IC50 = 4.1 nM
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CP0516145
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2,4-diaminopyrimidine derivative, 12a
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C20H22ClN5O2S
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2
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| 1 |
IC50 = 4.2 nM
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| 2 |
IC50 = 11 nM
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CP0408086
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2,4-diaminopyrimidine derivative, 12b
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C20H22BrN5O2S
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2
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| 1 |
IC50 = 5.7 nM
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| 2 |
IC50 = 42 nM
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CP0171189
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3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
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C26H29Cl2N3O4
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3
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| 1 |
IC50 = 6 nM
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| 2 |
IC50 = 14 nM
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| 3 |
IC50 = 19 nM
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CP0038741
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(biphenyl-4-yl)methanone
Show/Hide
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C27H25N3O2
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1
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| 1 |
IC50 = 6 nM
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CP0523094
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2,4-diaminopyrimidine derivative, 8i
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C23H22ClN5OS
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2
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| 1 |
IC50 = 6.3 nM
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| 2 |
IC50 = 170 nM
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CP0379507
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2,4-diaminopyrimidine derivative, 10a
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C26H26N4O4S
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2
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| 1 |
IC50 = 6.9 nM
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| 2 |
IC50 = 48 nM
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CP0041790
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2,4-diaminopyrimidine-based antagonist, 14c
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C23H28N6O2
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1
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| 1 |
IC50 = 7 nM
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CP0334435
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2,4-diaminopyrimidine-based antagonist, 14g
Show/Hide
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C27H28N6O2
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1
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| 1 |
IC50 = 7 nM
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CP0135116
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2,4-diaminopyrimidine-based antagonist, 4c
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C20H23N5O2S
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4
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| 1 |
IC50 = 7 nM
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| 2 |
IC50 = 7.4 nM
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| 3 |
IC50 = 12 nM
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| 4 |
IC50 = 19 nM
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CP0096129
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4'-methoxybiphenyl-4-yl)methanone
Show/Hide
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C28H27N3O3
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1
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| 1 |
IC50 = 7 nM
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CP0432764
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2,4-diaminopyrimidine derivative, 8j
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C26H27N5O2
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2
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| 1 |
IC50 = 7.7 nM
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| 2 |
IC50 = 90 nM
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CP0500761
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3-(2,6-Dichloro-phenyl)-5-[2-(2-oxo-piperidin-1-yl)-ethyl]-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
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C27H30Cl2N4O3
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2
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| 1 |
IC50 = 8 nM
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| 2 |
IC50 = 9 nM
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CP0367751
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2,4-diaminopyrimidine-based antagonist, 8a
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C26H30N6O2S
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2
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| 1 |
IC50 = 8 nM
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| 2 |
IC50 = 109 nM
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CP0467279
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((S)-4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(2-fluoro-2'-methylbiphenyl-4-yl)methanone
Show/Hide
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C28H26FN3O2
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1
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| 1 |
IC50 = 9 nM
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CP0062983
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(2'-fluorobiphenyl-4-yl)methanone
Show/Hide
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C27H24FN3O2
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1
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| 1 |
IC50 = 9.1 nM
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CP0376068
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2,4-diaminopyrimidine derivative, 11b
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C19H20N6O2
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2
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| 1 |
IC50 = 9.2 nM
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| 2 |
IC50 = 190 nM
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CP0376079
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2,4-diaminopyrimidine derivative, 11c
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C20H23N5O2S
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2
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| 1 |
IC50 = 9.8 nM
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| 2 |
IC50 = 120 nM
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CP0496916
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3-(2,6-Dichloro-phenyl)-5-[2-(3-methyl-2-oxo-imidazolidin-1-yl)-ethyl]-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
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C26H29Cl2N5O3
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2
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| 1 |
IC50 = 10 nM
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| 2 |
IC50 = 21 nM
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CP0502550
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2,4-diaminopyrimidine-based antagonist, 14f
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C27H28N6O2
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1
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| 1 |
IC50 = 10 nM
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CP0370138
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3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethyl)-isoxazole-4-carboxylic acid (4-diethylamino-2-methyl-phenyl)-amide
Show/Hide
|
C27H31Cl2N3O4
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1
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| 1 |
IC50 = 10 nM
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CP0432767
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2,4-diaminopyrimidine derivative, 7d
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C19H20N6O2
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2
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| 1 |
IC50 = 11 nM
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| 2 |
IC50 = 23 nM
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CP0064085
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3'-methoxybiphenyl-4-yl)methanone
Show/Hide
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C28H27N3O3
|
1
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| 1 |
IC50 = 12 nM
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CP0489657
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3-fluoro-4-(pyridin-4-yl)phenyl)methanone
Show/Hide
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C26H23FN4O2
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1
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| 1 |
IC50 = 12.2 nM
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CP0489656
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4-(pyridin-4-yl)phenyl)methanone
Show/Hide
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C26H24N4O2
|
1
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| 1 |
IC50 = 12.7 nM
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CP0453278
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1-[4-({[4-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]amino}methyl)phenyl]ethan-1-ol
Show/Hide
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C21H25N5O
|
2
|
| 1 |
IC50 = 13 nM
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| 2 |
IC50 = 110 nM
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CP0440049
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(6-(2-chlorophenyl)pyridin-3-yl)methanone
Show/Hide
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C26H23ClN4O2
|
1
|
| 1 |
IC50 = 13 nM
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CP0469637
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3-methylbiphenyl-4-yl)methanone
Show/Hide
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C28H27N3O2
|
1
|
| 1 |
IC50 = 14.3 nM
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CP0392695
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3-(2,6-Dichloro-phenyl)-5-[2-(2,2-dimethyl-5-oxo-pyrrolidin-1-yl)-ethyl]-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C28H32Cl2N4O3
|
2
|
| 1 |
IC50 = 15 nM
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| 2 |
IC50 = 39 nM
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CP0529104
|
2,4-diaminopyrimidine-based antagonist, 8b
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C27H26N6O2S
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2
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| 1 |
IC50 = 16 nM
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| 2 |
IC50 = 249 nM
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CP0506894
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(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3-fluorobiphenyl-4-yl)methanone
Show/Hide
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C27H24FN3O2
|
1
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| 1 |
IC50 = 17.7 nM
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CP0464607
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3-(2,6-Dichloro-phenyl)-5-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C26H28Cl2N4O3
|
1
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| 1 |
IC50 = 18 nM
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CP0408505
|
2,4-diaminopyrimidine-based antagonist, 13e
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|
C24H27N5O2
|
2
|
| 1 |
IC50 = 18 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0439047
|
5-[2-(Acetyl-methyl-amino)-ethyl]-3-(2,6-dichloro-phenyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C25H28Cl2N4O3
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 34 nM
|
|
|
|
CP0280928
|
2,4-diaminopyrimidine derivative, 8a
Show/Hide
|
C25H24ClN5O
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 180 nM
|
|
|
|
CP0467280
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(6-phenylpyridin-3-yl)methanone
Show/Hide
|
C26H24N4O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0445557
|
2,4-diaminopyrimidine derivative, 8k
Show/Hide
|
C24H24N6O
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 86 nM
|
|
|
|
CP0871034
|
6-ethyl-5-[4-(4-trifluoromethanesulfonyl-benzylamino)-phenyl]-pyrimidine-2,4-diamine
Show/Hide
|
C20H18F5N5O2S
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 690 nM
|
|
|
|
CP0496868
|
3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxolan-2-yl-ethyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C25H27Cl2N3O4
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
IC50 = 56 nM
|
|
|
|
CP0384287
|
(4-(1H-indole-6-carbonyl)piperazin-1-yl)(3'-methoxybiphenyl-4-yl)methanone
Show/Hide
|
C27H25N3O3
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0237917
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(2'-methoxybiphenyl-4-yl)methanone
Show/Hide
|
C28H27N3O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0500751
|
3-(2,6-Dichloro-phenyl)-5-[2-(tetrahydro-pyran-4-yl)-ethyl]-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C27H31Cl2N3O3
|
2
|
| 1 |
IC50 = 29 nM
|
|
|
| 2 |
IC50 = 146 nM
|
|
|
|
CP0440052
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4-(3-fluoropyridin-4-yl)phenyl)methanone
Show/Hide
|
C26H23FN4O2
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0052534
|
5-(2-Benzo[1,3]dioxol-5-yl-ethyl)-3-(2,6-dichloro-phenyl)-isoxazole-4-carboxylic acid (4-diethylamino-cyclohexyl)-amide
Show/Hide
|
C29H33Cl2N3O4
|
2
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
IC50 = 54 nM
|
|
|
|
CP0526327
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(2-(2-fluorophenyl)thiazol-4-yl)methanone
Show/Hide
|
C24H21FN4O2S
|
1
|
| 1 |
IC50 = 33.7 nM
|
|
|
|
CP0382090
|
1-benzyl-3-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)urea
Show/Hide
|
C26H26N6O2
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0156306
|
2,4-diaminopyrimidine-based antagonist, 13m
Show/Hide
|
C26H25N5O2
|
2
|
| 1 |
IC50 = 37 nM
|
|
|
| 2 |
IC50 = 408 nM
|
|
|
|
CP0467281
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(5-(2-chlorophenyl)pyridin-2-yl)methanone
Show/Hide
|
C26H23ClN4O2
|
1
|
| 1 |
IC50 = 37.2 nM
|
|
|
|
CP0496896
|
3-(2,6-Dichloro-phenyl)-5-[2-(tetrahydro-pyran-2-yl)-ethyl]-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C27H31Cl2N3O3
|
2
|
| 1 |
IC50 = 39 nM
|
|
|
| 2 |
IC50 = 102 nM
|
|
|
|
CP0367518
|
3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-2-methyl-phenyl)-amide
Show/Hide
|
C22H23Cl2N3O2
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0334440
|
2,4-diaminopyrimidine-based antagonist, 13l
Show/Hide
|
C24H22BrN5O2S
|
2
|
| 1 |
IC50 = 41 nM
|
|
|
| 2 |
IC50 = 137 nM
|
|
|
|
CP0152858
|
3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-2-ethyl-phenyl)-amide
Show/Hide
|
C23H25Cl2N3O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0440051
|
((S)-4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3-fluoro-4-(3-fluoropyridin-4-yl)phenyl)methanone
Show/Hide
|
C26H22F2N4O2
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0469569
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4-(pyridin-2-yl)phenyl)methanone
Show/Hide
|
C26H24N4O2
|
1
|
| 1 |
IC50 = 42.2 nM
|
|
|
|
CP0432762
|
2,4-diaminopyrimidine derivative, 8l
Show/Hide
|
C23H22ClN5OS
|
2
|
| 1 |
IC50 = 43 nM
|
|
|
| 2 |
IC50 = 320 nM
|
|
|
|
CP0075409
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3'-(trifluoromethoxy)biphenyl-4-yl)methanone
Show/Hide
|
C28H24F3N3O3
|
1
|
| 1 |
IC50 = 46.5 nM
|
|
|
|
CP0430051
|
5-(2-Benzo[1,3]dioxol-5-yl-ethyl)-3-(2,6-dichloro-phenyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C29H27Cl2N3O4
|
2
|
| 1 |
IC50 = 47 nM
|
|
|
| 2 |
IC50 = 93 nM
|
|
|
|
CP0485204
|
2,4-diaminopyrimidine-based antagonist, 13n
Show/Hide
|
C27H27N5O2
|
2
|
| 1 |
IC50 = 47 nM
|
|
|
| 2 |
IC50 = 343 nM
|
|
|
|
CP0516144
|
2,4-diaminopyrimidine derivative, 8m
Show/Hide
|
C25H25N5O
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 980 nM
|
|
|
|
CP0394703
|
3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-cyclohexyl)-amide
Show/Hide
|
C21H27Cl2N3O2
|
2
|
| 1 |
IC50 = 53 nM
|
|
|
| 2 |
IC50 = 57 nM
|
|
|
|
CP0283223
|
1-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)-3-propan-2-ylurea
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0500760
|
3-(2,6-Dichloro-phenyl)-5-[2-(tetrahydro-furan-2-yl)-ethyl]-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C26H29Cl2N3O3
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0432766
|
1-[4-({[4-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]amino}methyl)phenyl]ethan-1-one
Show/Hide
|
C21H23N5O
|
2
|
| 1 |
IC50 = 57 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0123312
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4'-fluorobiphenyl-4-yl)methanone
Show/Hide
|
C27H24FN3O2
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0510515
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4-(thiazol-5-yl)phenyl)methanone
Show/Hide
|
C24H22N4O2S
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0456880
|
2,4-diaminopyrimidine-based antagonist, 13d
Show/Hide
|
C22H23N5O2
|
2
|
| 1 |
IC50 = 66 nM
|
|
|
| 2 |
IC50 = 188 nM
|
|
|
|
CP0376075
|
2,4-diaminopyrimidine derivative, 8n
Show/Hide
|
C23H29N5O
|
2
|
| 1 |
IC50 = 67 nM
|
|
|
| 2 |
IC50 = 700 nM
|
|
|
|
CP0467278
|
(R)-(4-(1H-indole-6-carbonyl)-2-methylpiperazin-1-yl)(3'-methoxybiphenyl-4-yl)methanone
Show/Hide
|
C28H27N3O3
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0394064
|
2,4-diaminopyrimidine-based antagonist, 13k
Show/Hide
|
C24H23N5O2S
|
2
|
| 1 |
IC50 = 70 nM
|
|
|
| 2 |
IC50 = 382 nM
|
|
|
|
CP0527707
|
2,4-diaminopyrimidine-based antagonist, 13c
Show/Hide
|
C23H27N5O2
|
2
|
| 1 |
IC50 = 72 nM
|
|
|
| 2 |
IC50 = 108 nM
|
|
|
|
CP0038751
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3'-(trifluoromethyl)biphenyl-4-yl)methanone
Show/Hide
|
C28H24F3N3O2
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0435439
|
2,4-diaminopyrimidine derivative, 10b
Show/Hide
|
C26H23N5O2
|
2
|
| 1 |
IC50 = 83 nM
|
|
|
| 2 |
IC50 = 3610 nM
|
|
|
|
CP0058929
|
2,4-diaminopyrimidine-based antagonist, 14d
Show/Hide
|
C25H24N6O2
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0467259
|
3-(2,6-Dichloro-phenyl)-5-(2-oxo-pyrrolidin-1-ylmethyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C25H26Cl2N4O3
|
2
|
| 1 |
IC50 = 98 nM
|
|
|
| 2 |
IC50 = 122 nM
|
|
|
|
CP0064084
|
(4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-4-yl)methanone
Show/Hide
|
C26H23N3O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0377913
|
3-(2,6-Dichloro-phenyl)-5-[2-(tetrahydro-furan-2-yl)-ethyl]-isoxazole-4-carboxylic acid (4-diethylamino-cyclohexyl)-amide
Show/Hide
|
C26H35Cl2N3O3
|
2
|
| 1 |
IC50 = 103 nM
|
|
|
| 2 |
IC50 = 194 nM
|
|
|
|
CP0406584
|
3-(2,6-Dichloro-phenyl)-5-(2-methoxy-ethyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C23H25Cl2N3O3
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 115 nM
|
|
|
|
CP0381539
|
2,4-diaminopyrimidine derivative, 7i
Show/Hide
|
C18H19ClN6
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 220 nM
|
|
|
|
CP0384288
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4-(1H-pyrazol-4-yl)phenyl)methanone
Show/Hide
|
C24H23N5O2
|
1
|
| 1 |
IC50 = 123 nM
|
|
|
|
CP0540271
|
2,4-diaminopyrimidine-based antagonist, 13j
Show/Hide
|
C23H21N5O2S
|
2
|
| 1 |
IC50 = 126 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0006991
|
3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C21H21Cl2N3O2
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
IC50 = 180 nM
|
|
|
|
CP0379508
|
2,4-diaminopyrimidine derivative, 8o
Show/Hide
|
C28H26N6O
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
IC50 = 780 nM
|
|
|
|
CP0374522
|
3-(2,6-Dichloro-phenyl)-5-propyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C23H25Cl2N3O2
|
2
|
| 1 |
IC50 = 131 nM
|
|
|
| 2 |
IC50 = 492 nM
|
|
|
|
CP0496839
|
3-(2,6-Dichloro-phenyl)-5-(3-hydroxy-propyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C23H25Cl2N3O3
|
2
|
| 1 |
IC50 = 132 nM
|
|
|
| 2 |
IC50 = 308 nM
|
|
|
|
CP0046909
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4'-(trifluoromethoxy)biphenyl-4-yl)methanone
Show/Hide
|
C28H24F3N3O3
|
1
|
| 1 |
IC50 = 136 nM
|
|
|
|
CP0467147
|
3-(2,6-Dichloro-phenyl)-5-[2-(2-oxo-piperidin-1-yl)-ethyl]-isoxazole-4-carboxylic acid (4-diethylamino-cyclohexyl)-amide
Show/Hide
|
C27H36Cl2N4O3
|
2
|
| 1 |
IC50 = 139 nM
|
|
|
| 2 |
IC50 = 190 nM
|
|
|
|
CP0469638
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4-(pyridin-3-yl)phenyl)methanone
Show/Hide
|
C26H24N4O2
|
1
|
| 1 |
IC50 = 143 nM
|
|
|
|
CP0374521
|
3-(2,6-Dichloro-phenyl)-5-ethyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C22H23Cl2N3O2
|
2
|
| 1 |
IC50 = 147 nM
|
|
|
| 2 |
IC50 = 319 nM
|
|
|
|
CP0046902
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3'-fluorobiphenyl-4-yl)methanone
Show/Hide
|
C27H24FN3O2
|
1
|
| 1 |
IC50 = 147 nM
|
|
|
|
CP0498490
|
3-(2,6-Dichloro-phenyl)-5-isopropyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C23H25Cl2N3O2
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
IC50 = 861 nM
|
|
|
|
CP0393868
|
2,4-diaminopyrimidine derivative, 7g
Show/Hide
|
C20H20N6
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 = 780 nM
|
|
|
|
CP0496870
|
5-(2-Benzo[1,3]dioxol-4-yl-ethyl)-3-(2,6-dichloro-phenyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C29H27Cl2N3O4
|
2
|
| 1 |
IC50 = 162 nM
|
|
|
| 2 |
IC50 = 564 nM
|
|
|
|
CP0421157
|
2,4-diaminopyrimidine-based antagonist, 13b
Show/Hide
|
C21H23N5O2
|
2
|
| 1 |
IC50 = 221 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0376996
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4-(3,5-dimethylisoxazol-4-yl)phenyl)methanone
Show/Hide
|
C26H26N4O3
|
1
|
| 1 |
IC50 = 244.6 nM
|
|
|
|
CP0005801
|
3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C21H22ClN3O2
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0111596
|
3-(2-Bromo-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C21H22BrN3O2
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0539610
|
(S)-(4-(1H-indole-6-carbonyl)-2-methylpiperazin-1-yl)(3'-methoxybiphenyl-4-yl)methanone
Show/Hide
|
C28H27N3O3
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0523095
|
2,4-diaminopyrimidine derivative, 7j
Show/Hide
|
C17H18ClN5S
|
2
|
| 1 |
IC50 = 290 nM
|
|
|
| 2 |
IC50 = 790 nM
|
|
|
|
CP0376078
|
2,4-diaminopyrimidine derivative, 11d
Show/Hide
|
C19H20ClN5
|
2
|
| 1 |
IC50 = 300 nM
|
|
|
| 2 |
IC50 = 3150 nM
|
|
|
|
CP0381536
|
2,4-diaminopyrimidine derivative, 7a
Show/Hide
|
C19H20ClN5
|
3
|
| 1 |
IC50 = 310 nM
|
|
|
| 2 |
IC50 = 1380 nM
|
|
|
| 3 |
IC50 = 1400 nM
|
|
|
|
CP0510516
|
(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4-morpholinophenyl)methanone
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
IC50 = 338.7 nM
|
|
|
|
CP0394702
|
3-(2,6-Dichloro-phenyl)-5-[2-(2-methoxy-phenyl)-ethyl]-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C29H29Cl2N3O3
|
2
|
| 1 |
IC50 = 389 nM
|
|
|
| 2 |
IC50 = 714 nM
|
|
|
|
CP0408504
|
2,4-diaminopyrimidine-based antagonist, 13g
Show/Hide
|
C23H25N5O3
|
2
|
| 1 |
IC50 = 391 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0082096
|
3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [2-(azepane-1-carbonyl)-phenyl]-amide
Show/Hide
|
C24H23Cl2N3O3
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0083621
|
3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [4-(ethyl-propyl-amino)-phenyl]-amide
Show/Hide
|
C22H23Cl2N3O2
|
1
|
| 1 |
IC50 = 510 nM
|
|
|
|
CP0013808
|
5-Methyl-3-(2-nitro-phenyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
Show/Hide
|
C21H22N4O4
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0060368
|
(R)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3'-methoxybiphenyl-4-yl)methanone
Show/Hide
|
C28H27N3O3
|
1
|
| 1 |
IC50 = 640 nM
|
|
|
|
CP0431946
|
2,4-diaminopyrimidine-based antagonist, 13f
Show/Hide
|
C25H29N5O2
|
2
|
| 1 |
IC50 = 1670 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0370121
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3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [2-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenyl]-amide
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C28H25Cl2N3O2
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1
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| 1 |
IC50 = 1700 nM
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CP0456500
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2,4-diaminopyrimidine-based antagonist, 13a
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C20H21N5O2
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2
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| 1 |
IC50 = 2270 nM
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| 2 |
IC50 > 10000 nM
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CP0250114
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3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [2-(piperidine-1-carbonyl)-phenyl]-amide
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C23H21Cl2N3O3
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1
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| 1 |
IC50 = 2300 nM
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CP0333137
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3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (2-diethylcarbamoyl-phenyl)-amide
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C22H21Cl2N3O3
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1
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| 1 |
IC50 = 2500 nM
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CP0061848
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3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-2-ethyl-phenyl)-amide
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C22H23Cl2N3O3
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1
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| 1 |
IC50 = 2900 nM
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CP0540272
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2,4-diaminopyrimidine-based antagonist, 13h
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C24H22N6O2
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2
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| 1 |
IC50 = 3080 nM
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| 2 |
IC50 > 10000 nM
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CP0225195
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3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid {4-[ethyl-(2-hydroxy-ethyl)-amino]-phenyl}-amide
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C21H21Cl2N3O3
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1
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| 1 |
IC50 = 3100 nM
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CP0109680
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2,4-diaminopyrimidine derivative, 9
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C25H24ClN5
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2
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| 1 |
IC50 = 3170 nM
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| 2 |
IC50 = 3350 nM
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CP0225214
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3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (2-cyano-4-diethylamino-phenyl)-amide
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C22H20Cl2N4O2
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1
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| 1 |
IC50 = 4500 nM
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CP0152861
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3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [4-(ethyl-methyl-amino)-phenyl]-amide
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C20H19Cl2N3O2
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1
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| 1 |
IC50 = 4700 nM
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CP0370122
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3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid {2-[(benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-phenyl}-amide
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C26H19Cl2N3O5
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1
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| 1 |
IC50 = 4900 nM
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CP0180252
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3-(4-Chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
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C21H22ClN3O2
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1
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| 1 |
IC50 = 6000 nM
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CP0184651
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3-Biphenyl-2-yl-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
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C27H27N3O2
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1
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| 1 |
IC50 = 6300 nM
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CP0430422
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(4-(1H-indole-6-carbonyl)-1,4-diazepan-1-yl)(biphenyl-4-yl)methanone
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C27H25N3O2
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1
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| 1 |
IC50 = 6500 nM
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CP0111597
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3-(2-Methoxy-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
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C22H25N3O3
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1
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| 1 |
IC50 = 6800 nM
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CP0137589
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3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethyl)-isoxazole-4-carboxylic acid [2-(piperidine-1-carbonyl)-phenyl]-amide
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C28H29Cl2N3O5
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1
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| 1 |
IC50 = 7400 nM
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CP0003133
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5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide
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C21H23N3O2
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1
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| 1 |
IC50 = 7600 nM
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CP0431944
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2,4-diaminopyrimidine-based antagonist, 13i
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C25H24N6O2
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2
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| 1 |
IC50 > 10000 nM
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| 2 |
IC50 > 1000 nM
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CP0523102
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1-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)-3-methyl-3-propan-2-ylurea
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C23H28N6O2
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1
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| 1 |
IC50 > 10000 nM
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CP0152859
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3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-3-methyl-phenyl)-amide
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C22H23Cl2N3O2
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1
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| 1 |
IC50 > 10000 nM
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CP0225215
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3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-2-trifluoromethyl-phenyl)-amide
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C22H20Cl2F3N3O2
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1
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| 1 |
IC50 > 10000 nM
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CP0040929
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3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (2-benzylcarbamoyl-phenyl)-amide
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C25H19Cl2N3O3
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1
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| 1 |
IC50 = 10500 nM
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