Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(methoxymethyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
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 PubChem ID
CID: 73507384
Canonical SMILES
COC[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F
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Compound Formula C15H18F2N2O2S
Compound Structure
Protein Name
 Protein Info 
Beta-secretase 1
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Uniprot ID
P56817
Gene Name
BACE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000008 H4
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
2
IC50 = 855 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 850 nM