Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US9403846, 2
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 PubChem ID
CID: 75593344
Canonical SMILES
NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C1CC1)c1ccc(F)cc1F
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Compound Formula C16H18F2N2OS
Compound Structure
Protein Name
 Protein Info 
Beta-secretase 1
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Uniprot ID
P56817
Gene Name
BACE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000008 H4
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 280 nM