General Information of the Cell Line
Cell Line ID
CL000946
Cell Line Name
DU145-TxR
Category
Cancer cell line
Organism
Homo sapiens (Human)
Tissue Information
Brain
Disease
Prostate carcinoma (NCIt: C4863)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01546, ATP-dependent translocase ABCB1
 Protein Info 
Compound ID Compound Name Compound Formula
CP0420680
 Compound Info 
2-[2-oxo-2-[[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]amino]ethyl]sulfanyl-N-(3,4,5-trimethoxyphenyl)acetamide
   Show/Hide
C31H34N4O5S
  4
1
IC50 = 0.07 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 0.64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 1.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
IC50 = 185 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0435474
 Compound Info 
N-(1,3-benzothiazol-6-yl)-2-[2-oxo-2-[[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]amino]ethyl]sulfanylacetamide
   Show/Hide
C29H27N5O2S2
  4
1
IC50 = 0.78 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 2.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 34 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
IC50 = 172 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0484088
 Compound Info 
N-naphthalen-2-yl-2-[2-oxo-2-[[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]amino]ethyl]sulfanylacetamide
   Show/Hide
C32H30N4O2S
  4
1
IC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 46 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
IC50 = 153 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0476494
 Compound Info 
2-[2-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-2-oxoethyl]sulfanyl-N-[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]acetamide
   Show/Hide
C36H34N4O2S
  4
1
IC50 = 4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 52 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
IC50 = 164 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0435473
 Compound Info 
5-bromo-N-[3-[2-oxo-2-[[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]amino]ethyl]sulfanylphenyl]pyridine-3-carboxamide
   Show/Hide
C32H28BrN5O2S
  4
1
IC50 = 6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
IC50 = 56 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0470736
 Compound Info 
2-[2-(benzhydrylamino)-2-oxoethyl]sulfanyl-N-[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]acetamide
   Show/Hide
C35H34N4O2S
  4
1
IC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 16 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 56 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
IC50 = 160 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420668
 Compound Info 
2-[2-(1-adamantylamino)-2-oxoethyl]sulfanyl-N-[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]acetamide
   Show/Hide
C32H38N4O2S
  4
1
IC50 = 13 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 21 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 109 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
IC50 = 231 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0435475
 Compound Info 
N-[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide
   Show/Hide
C29H25N7OS
  3
1
IC50 = 17 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 21 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 426 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420667
 Compound Info 
2-[2-(9H-fluoren-2-yl)-2-oxoethyl]sulfanyl-N-[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]acetamide
   Show/Hide
C35H31N3O2S
  4
1
IC50 = 57 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 62 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 154 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
IC50 = 266 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0435472
 Compound Info 
2-[(5-cyclopropyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]acetamide
   Show/Hide
C25H26N6OS
  4
1
IC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 101 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 194 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
IC50 = 629 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0431675
 Compound Info 
N-[(4-fluorophenyl)methyl]-2-[2-oxo-2-[[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]amino]ethyl]sulfanylacetamide
   Show/Hide
C29H29FN4O2S
  4
1
IC50 = 131 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 192 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
IC50 = 379 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
IC50 = 458 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Brain)
Cell Line Name Organism Disease
TS603
 Cell Line Info 
Homo sapiens (Human) Anaplastic oligodendroglioma
H4
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
1321N1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
SNB-19
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
U-251MG
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
U-373MG ATCC
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
LN-308
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
CCF-STTG1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
LN-319
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
P2X7-1321N1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
MDA-MB-361
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
JEG-3
 Cell Line Info 
Homo sapiens (Human) Gestational choriocarcinoma
D3 [Human glioblastoma]
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN-229
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN-18
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
A-172
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
UC-11MG
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
T98G
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN229-V6R
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
SF539
 Cell Line Info 
Homo sapiens (Human) Gliosarcoma
MED1
 Cell Line Info 
Homo sapiens (Human) Medulloblastoma, non-WNT/non-SHH, group 4
Kelly
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
PFSK-1
 Cell Line Info 
Homo sapiens (Human) Primitive neuroectodermal tumor
DU145
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
GL261
 Cell Line Info 
Mus musculus (Mouse) Mouse glioblastoma
C6
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
C6-BU-1
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
RG2
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
ReNcell VM
 Cell Line Info 
Homo sapiens (Human) -
hCMEC/D3
 Cell Line Info 
Homo sapiens (Human) -
BV-2
 Cell Line Info 
Mus musculus (Mouse) -
C17.2
 Cell Line Info 
Mus musculus (Mouse) -
ScGT1
 Cell Line Info 
Mus musculus (Mouse) -
bEnd.4
 Cell Line Info 
Mus musculus (Mouse) -
N39
 Cell Line Info 
Mus musculus (Mouse) -
GT1-7
 Cell Line Info 
Mus musculus (Mouse) -
N27-A
 Cell Line Info 
Rattus norvegicus (Rat) -
RBE4
 Cell Line Info 
Rattus norvegicus (Rat) -