General Information of the Cell Line
Cell Line ID
CL000478
Cell Line Name
RBE4
Synonyms
RBE-4
Rat Brain Endothelial 4
Category
Transformed cell line
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_0495
Tissue Information
Brain
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT06330, Monocarboxylate transporter 1
 Protein Info 
Compound ID Compound Name Compound Formula
CP0850969
 Compound Info 
(E)-2-cyano-3-(4-(dibutylamino)-2-methoxyphenyl)acrylic acid
   Show/Hide
C19H26N2O3
  2
1
IC50 = 7.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0865377
 Compound Info 
(E)-2-cyano-3-(4-(diphenylamino)-2-methoxyphenyl)acrylic acid
   Show/Hide
C23H18N2O3
  1
1
IC50 = 8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0881331
 Compound Info 
(E)-2-cyano-3-(4-(dipropylamino)-2-methoxyphenyl)acrylic acid
   Show/Hide
C17H22N2O3
  2
1
IC50 = 9.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0950405
 Compound Info 
(E)-2-cyano-3-(4-(dipropylamino)phenyl)acrylic acid
   Show/Hide
C16H20N2O2
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0859813
 Compound Info 
(E)-2-cyano-3-(4-(diisobutylamino)-2-methoxyphenyl)acrylic acid
   Show/Hide
C19H26N2O3
  2
1
IC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 15 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0919619
 Compound Info 
(E)-2-cyano-3-(4-(diphenylamino)-2-methoxyphenyl)acrylate sodium
   Show/Hide
C23H17N2NaO3
  1
1
IC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519919
 Compound Info 
US9296728, 19
   Show/Hide
C25H22N2O3
  1
1
IC50 = 19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0917630
 Compound Info 
(E)-2-cyano-3-(4-(dipentylamino)-2-methoxyphenyl)acrylic acid
   Show/Hide
C21H30N2O3
  2
1
IC50 = 23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 34 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0968060
 Compound Info 
(E)-2-cyano-3-(2-methoxy-4-(piperidin-1-yl)phenyl)acrylic acid sodium
   Show/Hide
C16H17N2NaO3
  1
1
IC50 = 25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0919618
 Compound Info 
(E)-2-cyano-3-(4-(diallylamino)-2-methoxyphenyl)acrylic acid
   Show/Hide
C17H18N2O3
  2
1
IC50 = 25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 29 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0861056
 Compound Info 
(E)-2-cyano-3-(4-(dibutylamino)phenyl)acrylic acid
   Show/Hide
C18H24N2O2
  2
1
IC50 = 26 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413036
 Compound Info 
(E)-2-cyano-3-[4-(N-phenylanilino)phenyl]prop-2-enoic acid
   Show/Hide
C22H16N2O2
  1
1
IC50 = 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0531097
 Compound Info 
US9296728, 10
   Show/Hide
C24H20N2O2
  1
1
IC50 = 43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0952245
 Compound Info 
(E)-2-cyano-3-(2-methoxy-4-(pyrrolidin-1-yl)phenyl)acrylic acid sodium
   Show/Hide
C15H15N2NaO3
  1
1
IC50 = 48 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0566013
 Compound Info 
US9296728, 25
   Show/Hide
C24H19NO4
  1
1
IC50 = 48 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0514976
 Compound Info 
US9296728, 21
   Show/Hide
C15H16N2O3
  1
1
IC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0425200
 Compound Info 
(E)-2-cyano-3-(4-pyrrolidin-1-ylphenyl)prop-2-enoic acid
   Show/Hide
C14H14N2O2
  2
1
IC50 = 64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 70 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0402663
 Compound Info 
(E)-3-[4-[bis(2-methylpropyl)amino]phenyl]-2-cyanoprop-2-enoic acid
   Show/Hide
C18H24N2O2
  2
1
IC50 = 66 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0915626
 Compound Info 
2-cyano-3-(4-(diethylamino)phenyl)acrylic acid
   Show/Hide
C14H16N2O2
  1
1
IC50 = 70 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519918
 Compound Info 
(E)-3-[4-[bis(prop-2-enyl)amino]phenyl]-2-cyanoprop-2-enoic acid
   Show/Hide
C16H16N2O2
  2
1
IC50 = 88 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0506729
 Compound Info 
US9296728, 17
   Show/Hide
C17H14N2O3
  1
1
IC50 = 91 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545425
 Compound Info 
(E)-2-cyano-3-(4-piperidin-1-ylphenyl)prop-2-enoic acid
   Show/Hide
C15H16N2O2
  2
1
IC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 140 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0578171
 Compound Info 
US9296728, 29
   Show/Hide
C26H19NO8
  1
1
IC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0406145
 Compound Info 
(E)-2-cyano-3-[4-(dipentylamino)phenyl]prop-2-enoic acid
   Show/Hide
C20H28N2O2
  2
1
IC50 = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 140 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0261005
 Compound Info 
(2E)-2-cyano-3-[4-(dimethylamino)phenyl]prop-2-enoic acid
   Show/Hide
C12H12N2O2
  1
1
IC50 = 140 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0412713
 Compound Info 
US9296728, 24
   Show/Hide
C16H11NO4
  1
1
IC50 = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0514977
 Compound Info 
US9296728, 27
   Show/Hide
C24H17F2NO4
  1
1
IC50 = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0435114
 Compound Info 
2-oxo-7-pyrrolidin-1-ylchromene-3-carboxylic acid
   Show/Hide
C14H13NO4
  1
1
IC50 = 220 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0464408
 Compound Info 
US9296728, 23
   Show/Hide
C16H15NO4
  1
1
IC50 = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0383728
 Compound Info 
US9296728, 22
   Show/Hide
C16H19NO4
  1
1
IC50 = 299 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0385947
 Compound Info 
(E)-3-[4-[bis(prop-2-ynyl)amino]phenyl]-2-cyanoprop-2-enoic acid
   Show/Hide
C16H12N2O2
  2
1
IC50 = 340 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0062570
 Compound Info 
(2E)-2-cyano-3-(4-methylphenyl)prop-2-enoic acid
   Show/Hide
C11H9NO2
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0155722
 Compound Info 
(2E)-2-cyano-3-(4-fluorophenyl)prop-2-enoic acid
   Show/Hide
C10H6FNO2
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0192758
 Compound Info 
(2E)-2-cyano-3-(4-nitrophenyl)prop-2-enoic acid
   Show/Hide
C10H6N2O4
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0196001
 Compound Info 
(2E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoic acid
   Show/Hide
C11H9NO3
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0550044
 Compound Info 
(E)-3-(4-chlorophenyl)-2-cyanoprop-2-enoic acid
   Show/Hide
C10H6ClNO2
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0950627
 Compound Info 
3-(benzo[d][1,3]dioxol-5-yl)-2-cyanoacrylic acid
   Show/Hide
C11H7NO4
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0959150
 Compound Info 
2-cyano-3-(4-ethylphenyl)acrylic acid
   Show/Hide
C12H11NO2
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0959534
 Compound Info 
2-cyano-3-(4-cyanophenyl)acrylic acid
   Show/Hide
C11H6N2O2
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0960199
 Compound Info 
3-(4-bromophenyl)-2-cyanoacrylic acid
   Show/Hide
C10H6BrNO2
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0418353
 Compound Info 
(E)-2-cyano-3-[4-(dihexylamino)phenyl]prop-2-enoic acid
   Show/Hide
C22H32N2O2
  2
1
IC50 = 880 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 950 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0559924
 Compound Info 
US9296728, 28
   Show/Hide
C24H17Cl2NO4
  1
1
IC50 = 920 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Brain)
Cell Line Name Organism Disease
TS603
 Cell Line Info 
Homo sapiens (Human) Anaplastic oligodendroglioma
H4
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
1321N1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
SNB-19
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
U-251MG
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
U-373MG ATCC
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
LN-308
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
CCF-STTG1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
LN-319
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
P2X7-1321N1
 Cell Line Info 
Homo sapiens (Human) Astrocytoma
MDA-MB-361
 Cell Line Info 
Homo sapiens (Human) Breast adenocarcinoma
JEG-3
 Cell Line Info 
Homo sapiens (Human) Gestational choriocarcinoma
D3 [Human glioblastoma]
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN-229
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN-18
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
A-172
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
UC-11MG
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
T98G
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
LN229-V6R
 Cell Line Info 
Homo sapiens (Human) Glioblastoma
SF539
 Cell Line Info 
Homo sapiens (Human) Gliosarcoma
MED1
 Cell Line Info 
Homo sapiens (Human) Medulloblastoma, non-WNT/non-SHH, group 4
Kelly
 Cell Line Info 
Homo sapiens (Human) Neuroblastoma
PFSK-1
 Cell Line Info 
Homo sapiens (Human) Primitive neuroectodermal tumor
DU145
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
DU145-TxR
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
GL261
 Cell Line Info 
Mus musculus (Mouse) Mouse glioblastoma
C6
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
C6-BU-1
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
RG2
 Cell Line Info 
Rattus norvegicus (Rat) Rat malignant glioma
ReNcell VM
 Cell Line Info 
Homo sapiens (Human) -
hCMEC/D3
 Cell Line Info 
Homo sapiens (Human) -
BV-2
 Cell Line Info 
Mus musculus (Mouse) -
C17.2
 Cell Line Info 
Mus musculus (Mouse) -
ScGT1
 Cell Line Info 
Mus musculus (Mouse) -
bEnd.4
 Cell Line Info 
Mus musculus (Mouse) -
N39
 Cell Line Info 
Mus musculus (Mouse) -
GT1-7
 Cell Line Info 
Mus musculus (Mouse) -
N27-A
 Cell Line Info 
Rattus norvegicus (Rat) -