General Information of the Compound
Compound ID
CP0420668
Compound Name
2-[2-(1-adamantylamino)-2-oxoethyl]sulfanyl-N-[2-phenyl-5-(2,4,5-trimethylphenyl)pyrazol-3-yl]acetamide
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Structure
Formula
C32H38N4O2S
Molecular Weight
542.749
Canonical SMILES
Cc1cc(C)c(cc1C)-c1cc(NC(=O)CSCC(=O)NC23CC4CC(CC(C4)C2)C3)n(n1)-c1ccccc1
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InChI
InChI=1S/C32H38N4O2S/c1-20-9-22(3)27(10-21(20)2)28-14-29(36(35-28)26-7-5-4-6-8-26)33-30(37)18-39-19-31(38)34-32-15-23-11-24(16-32)13-25(12-23)17-32/h4-10,14,23-25H,11-13,15-19H2,1-3H3,(H,33,37)(H,34,38)
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InChIKey
NJMLZLFEPYDIKZ-UHFFFAOYSA-N
Physicochemical Property
logP
6.22126
Rotatable Bonds
8
Heavy Atom Count
39
Polar Areas
76.02
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 135185937
ChEMBL ID
CHEMBL4552725
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000946 DU145-TxR Homo sapiens (Human)  4
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
2
IC50 = 21 nM
   TI
   LI
   LO
   TS
3
IC50 = 109 nM
   TI
   LI
   LO
   TS
4
IC50 = 231 nM
   TI
   LI
   LO
   TS