General Information of the Compound
Compound ID
CP0238103
Compound Name
(1S,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-1,2,3,4-tetrahydronaphthalen-1-ol
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Structure
Formula
C20H18N2O
Molecular Weight
302.377
Canonical SMILES
O[C@H]1[C@@H](CCc2ccccc12)[C@H]1c2ccccc2-c2cncn12
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InChI
InChI=1S/C20H18N2O/c23-20-14-6-2-1-5-13(14)9-10-17(20)19-16-8-4-3-7-15(16)18-11-21-12-22(18)19/h1-8,11-12,17,19-20,23H,9-10H2/t17-,19+,20+/m0/s1
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InChIKey
VKUCRVDZHQWVKF-DFQSSKMNSA-N
Physicochemical Property
logP
3.7489
Rotatable Bonds
1
Heavy Atom Count
23
Polar Areas
38.05
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 129283174
ChEMBL ID
CHEMBL4577396
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01557, Indoleamine 2,3-dioxygenase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000438 A-172 Homo sapiens (Human)  1
1
EC50 = 240 nM
   TI
   LI
   LO
   TS
Protein ID: PT02896, Tryptophan 2,3-dioxygenase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000518 SW48 Homo sapiens (Human)  1
1
EC50 = 32 nM
   TI
   LI
   LO
   TS