Protein Information

General Information of the Protein

Protein ID	PT01557
Protein Name	Indoleamine 2,3-dioxygenase 1
Secondarily Protein Name	Indoleamine-pyrrole 2,3-dioxygenase
Gene Name	IDO1
Secondarily Gene Name	IDO INDO
Sequence	MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Oxidoreductase
Function	Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). Show/Hide
Uniprot ID	Primary ID: P14902 Secondarily ID: E5RGR8 F6M9T7 Q540B4 Show/Hide
Ensembl ID	ENSG00000131203
HGNC ID	HGNC:6059
Subcellular Location	Cytoplasm Cytosol

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000052 , A-431

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0784875 Compound Info	S-(4-Chlorobenzyl)isothiourea hydrochloride Show/Hide	C8H10Cl2N2S	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0774168 Compound Info	S-(4-Bromobenzyl)isothiourea hydrobromide Show/Hide	C8H10Br2N2S	1
1	IC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0036589 Compound Info	3,4-Dichlorobenzenemethanethiol Show/Hide	C7H6Cl2S	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0302197 Compound Info	4-Chlorobenzenemethanethiol Show/Hide	C7H7ClS	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0778294 Compound Info	S-(2,4-Dichlorobenzyl)isothiourea hydrobromide Show/Hide	C8H9BrCl2N2S	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0807117 Compound Info	S-(4-Trifluoromethylbenzyl)isothiourea hydrochloride Show/Hide	C9H10ClF3N2S	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0774166 Compound Info	S-(3-Chlorobenzyl)isothiourea hydrochloride Show/Hide	C8H10Cl2N2S	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0269207 Compound Info	4-Fluorobenzenemethanethiol Show/Hide	C7H7FS	1
1	IC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0807120 Compound Info	S-(4-Fluorobenzyl)isothiourea hydrochloride Show/Hide	C8H10ClFN2S	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0678207 Compound Info	S-(4-Nitrobenzyl)isothiourea hydrochloride Show/Hide	C8H10ClN3O2S	1
1	IC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0807119 Compound Info	S-(4-Ethylbenzyl)isothiourea hydrochloride Show/Hide	C10H15ClN2S	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0801526 Compound Info	S-(4-Cyanobenzyl)isothiourea hydrobromide Show/Hide	C9H10BrN3S	1
1	IC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0146631 Compound Info	2,4-Dichlorobenzenemethanethiol Show/Hide	C7H6Cl2S	1
1	IC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0807118 Compound Info	S-(2-Chlorobenzyl)isothiourea hydrochloride Show/Hide	C8H10Cl2N2S	1
1	IC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0309908 Compound Info	4-Methylbenzenemethanethiol Show/Hide	C8H10S	1
1	IC50 = 6500 nM Bioactivity Info	TI LI LO TS
CP0920849 Compound Info	S-(4-Methylbenzyl)isothiourea hydrochloride Show/Hide	C9H13ClN2S	1
1	IC50 = 6800 nM Bioactivity Info	TI LI LO TS
CP0678206 Compound Info	S-(3,4-Dichlorobenzyl)isothiourea hydrochloride Show/Hide	C8H9Cl3N2S	1
1	IC50 = 7300 nM Bioactivity Info	TI LI LO TS
CP0402400 Compound Info	4-Methoxybenzenemethanethiol Show/Hide	C8H10OS	1
1	IC50 = 9400 nM Bioactivity Info	TI LI LO TS
CP0784874 Compound Info	S-(4-Methoxybenzyl)isothiourea hydrochloride Show/Hide	C9H13ClN2OS	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0795291 Compound Info	S-Benzylisothiourea hydrochloride Show/Hide	C8H11ClN2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0814302 Compound Info	S-(4-Methanesulfonylbenzyl)isothiourea hydrobromide Show/Hide	C9H13BrN2O2S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0269206 Compound Info	Benzenemethanethiol Show/Hide	C7H8S	1
1	IC50 = 13000 nM Bioactivity Info	TI LI LO TS
CP0036588 Compound Info	2-Chlorobenzenemethanethiol Show/Hide	C7H7ClS	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0171461 Compound Info	1-(4-CHLOROPHENYL)METHANAMINE Show/Hide	C7H8ClN	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0302196 Compound Info	4-chlorophenylthiourea Show/Hide	C7H7ClN2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0309909 Compound Info	4-Chloro-benzenethiol Show/Hide	C6H5ClS	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0320914 Compound Info	2-(4-chlorophenyl)ethylamine Show/Hide	C8H10ClN	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0320915 Compound Info	4-Chlorobenzylalcohol Show/Hide	C7H7ClO	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0497260 Compound Info	(4-chlorophenyl)methylurea Show/Hide	C8H9ClN2O	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0507844 Compound Info	2-(4-chlorophenyl)ethylthiourea Show/Hide	C9H11ClN2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0507845 Compound Info	4-Chlorobenzenesulfonic acid Show/Hide	C6H5ClO3S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0678208 Compound Info	S-(4-Chlorophenethyl)isothiourea hydrobromide Show/Hide	C9H12BrClN2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0678210 Compound Info	N-(4-Chlorophenethyl)-S-methylisothiourea hydroiodide Show/Hide	C10H14ClIN2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0773197 Compound Info	N-(4-Chlorophenyl)-S-methylisothiourea hydroiodide Show/Hide	C8H10ClIN2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0774167 Compound Info	S-(2-Chlorophenethyl)isothiourea hydrobromide Show/Hide	C9H12BrClN2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0784876 Compound Info	S-(4-Carboxybenzyl)isothiourea hydrochloride Show/Hide	C9H11ClN2O2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0784896 Compound Info	S-(4-Benzoylbenzyl)isothiourea hydrobromide Show/Hide	C15H15BrN2OS	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0795290 Compound Info	4-tert-butylbenzyl carbamimidothioate hydrobromide Show/Hide	C12H19BrN2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0807121 Compound Info	S-(3-Chlorophenethyl)isothiourea hydrobromide Show/Hide	C9H12BrClN2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0807122 Compound Info	S-(4-Chlorobenzyl)-N,N'-dimethylthiourea hydroperchlorate Show/Hide	C10H14Cl2N2O4S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0859751 Compound Info	4-Chlorobenzenesulfinate natrium Show/Hide	C6H4ClNaO2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0889178 Compound Info	S-(4-Isopropylbenzyl)isothiourea hydrobromide Show/Hide	C11H17BrN2S	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000438 , A-172

Cell Line Info

Cell Line ID: CL000045 , A-375

Cell Line Info

Cell Line ID: CL000338 , DV3-M15

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000979 , LLTC

Cell Line Info

Cell Line ID: CL000111 , MDA-MB-231

Cell Line Info

Cell Line ID: CL000784 , P815B

Cell Line Info

Cell Line ID: CL000084 , SK-OV-3

Cell Line Info

Cell Line ID: CL000058 , T-REx-293

Cell Line Info

Cell Line ID: CL000040 , THP-1

Cell Line Info

Cell Line ID: CL000102 , U-87MG ATCC

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0670151 Compound Info	3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione Show/Hide	C12H9FN2O2	9
1	IC50 = 0.12 nM
2	IC50 = 150 nM
3	IC50 = 370 nM
4	IC50 = 410 nM
5	IC50 = 1700 nM
6	IC50 = 4700 nM
7	Kd = 320 nM
8	Kd = 14000 nM
9	Kd = 22300 nM
CP0165127 Compound Info	CHEMBL4161733 Show/Hide	C24H24ClFN2O	4
1	IC50 = 1.1 nM
2	IC50 = 1.7 nM
3	IC50 = 3.4 nM
4	Kd = 470 nM
CP0355662 Compound Info	1-(3-chloro-4-fluorophenyl)-6-fluorobenzo[f]benzotriazole-4,9-dione Show/Hide	C16H6ClF2N3O2	1
1	IC50 = 5 nM
CP0364042 Compound Info	ethyl (4S)-6-bromo-4-(1H-indazole-7-carbonylamino)spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C24H25BrN4O4	1
1	IC50 = 5.4 nM
CP0081974 Compound Info	US10034864, Example 1 Show/Hide	C11H13BrFN7O4S	15
1	IC50 = 10 nM
2	IC50 = 58 nM
3	IC50 = 64.6 nM
4	IC50 = 66 nM
5	IC50 = 71.8 nM
6	IC50 = 72 nM
7	IC50 = 73 nM
8	IC50 = 75 nM
9	IC50 = 77.8 nM
10	IC50 = 80 nM
11	IC50 = 87.4 nM
12	IC50 = 90 nM
13	IC50 = 91 nM
14	IC50 = 93 nM
15	IC50 = 125 nM
CP0352408 Compound Info	N'-(3-bromo-4-fluorophenyl)-4-[2-[(N-cyano-S-methylsulfonimidoyl)amino]ethylamino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C13H14BrFN8O3S	1
1	IC50 = 11 nM
CP0119011 Compound Info	(1R,4r)-4-((R)-2-((S)-6-fluoro-5H-imidazo[5,1- a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol Show/Hide	C18H21FN2O2	7
1	IC50 = 13 nM
2	IC50 = 28 nM
3	IC50 = 75 nM
4	IC50 = 450 nM
5	Ki = 5.8 nM
6	Ki = 19 nM
7	Ki = 28 nM
CP0361239 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[2-[1-(sulfamoylamino)cyclopropyl]ethylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C14H17BrFN7O4S	1
1	IC50 = 18 nM
CP0169133 Compound Info	1-cyclohexyl-2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)ethanol Show/Hide	C18H21FN2O	2
1	IC50 = 19 nM
2	IC50 = 30 nM
CP0564188 Compound Info	(1S)-1-cyclohexyl-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]ethanol Show/Hide	C18H22N2O	1
1	IC50 = 21 nM
CP0353566 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-3-yl]methyl]-3-(4-chlorophenyl)urea Show/Hide	C19H16BrClN4O2S	1
1	IC50 = 25.8 nM
CP0102032 Compound Info	1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol Show/Hide	C18H22N2O	8
1	IC50 = 28 nM
2	IC50 = 38 nM
3	IC50 = 50 nM
4	IC50 = 60 nM
5	IC50 < 1000 nM
6	Kd = 3300 nM
7	Ki = 7 nM
8	Ki = 7.2 nM
CP0025028 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[2-[4-(2-hydroxyethoxymethyl)triazol-1-yl]ethylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C16H18BrFN8O4	1
1	IC50 = 28 nM
CP0353563 Compound Info	N'-(3-bromophenyl)-5-chloro-N-hydroxythiophene-2-carboximidamide Show/Hide	C11H8BrClN2OS	1
1	IC50 = 29.8 nM
CP0098775 Compound Info	1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl)ethyl)piperidin-1-yl)-2-phenylethanone; Show/Hide	C25H27N3O2	1
1	IC50 = 31 nM
CP0563805 Compound Info	4-chloro-2-[3-[(5-fluoro-1H-indol-2-yl)methyl]imidazol-4-yl]phenol Show/Hide	C18H13ClFN3O	1
1	IC50 = 33.8 nM
CP0279122 Compound Info	1-acetyl-N'-(4-bromophenyl)-2,3-dihydroindole-5-sulfonohydrazide Show/Hide	C16H16BrN3O3S	1
1	IC50 = 34.6 nM
CP0022060 Compound Info	N'-(4-bromophenyl)-2-oxo-1,3-dihydroindole-5-sulfonohydrazide Show/Hide	C14H12BrN3O3S	1
1	IC50 = 35.8 nM
CP0532740 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-3-yl]methyl]-3-(4-fluorophenyl)urea Show/Hide	C19H16BrFN4O2S	1
1	IC50 = 36.8 nM
CP0238987 Compound Info	2-[3-[(5-bromo-1H-indol-2-yl)methyl]imidazol-4-yl]-4-chlorophenol Show/Hide	C18H13BrClN3O	1
1	IC50 = 37.9 nM
CP0148155 Compound Info	N-[2-(dimethylamino)ethyl]-9-methylsulfanyl-5,12-dioxoindolizino[3,2-g]quinoline-11-carboxamide Show/Hide	C21H20N4O3S	1
1	IC50 = 39 nM
CP0204650 Compound Info	2-(4-fluorophenyl)-1-(4-(1-hydroxy-2-(5H- imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1- yl)ethanone Show/Hide	C25H26FN3O2	1
1	IC50 = 40 nM
CP0158824 Compound Info	(1S,4r)-4-((S)-2-((S)-6-fluoro-5H-imidazo[5,1- a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol Show/Hide	C18H21FN2O2	1
1	IC50 = 42 nM
CP0119008 Compound Info	4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5- yl)ethyl)-N-phenylpiperidine-1-carboxamide Show/Hide	C24H26N4O2	1
1	IC50 = 45 nM
CP0266145 Compound Info	1-(4,4-difluorocyclohexyl)-2-(5H-imidazo[5,1- a]isoindol-5-yl)ethanol; Show/Hide	C18H20F2N2O	1
1	IC50 = 46 nM
CP0452493 Compound Info	N'-(4-bromophenyl)-1,3-dimethyl-2-oxobenzimidazole-5-sulfonohydrazide Show/Hide	C15H15BrN4O3S	1
1	IC50 = 47 nM
CP0219363 Compound Info	N-[2-(dimethylamino)ethyl]-8-methylsulfanyl-5,12-dioxoindolizino[2,3-g]quinoline-6-carboxamide Show/Hide	C21H20N4O3S	1
1	IC50 = 50 nM
CP0119002 Compound Info	N-((1r,4r)-4-(1-hydroxy-2-(5H-imidazo[5,1- a]isoindol-5-yl)ethyl)cyclohexyl)benzamide Show/Hide	C25H27N3O2	1
1	IC50 = 50 nM
CP0249982 Compound Info	N'-(4-bromophenyl)-3,3-difluoro-2-oxo-1H-indole-5-sulfonohydrazide Show/Hide	C14H10BrF2N3O3S	1
1	IC50 = 52.3 nM
CP0236732 Compound Info	4-amino-N-(3-chloro-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C9H7ClFN5O2	5
1	IC50 = 53 nM
2	IC50 = 73 nM
3	IC50 = 91 nM
4	IC50 = 210 nM
5	Ki = 34000 nM
CP0090036 Compound Info	N'-(4-bromophenyl)-2-oxo-1,3-dihydrobenzimidazole-5-sulfonohydrazide Show/Hide	C13H11BrN4O3S	1
1	IC50 = 57.3 nM
CP0570390 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-3-yl]methyl]-3-(4-cyanophenyl)urea Show/Hide	C20H16BrN5O2S	1
1	IC50 = 61.6 nM
CP0570584 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-2-yl]methyl]-3-(4-cyanophenyl)urea Show/Hide	C20H16BrN5O2S	1
1	IC50 = 64.9 nM
CP0071523 Compound Info	N'-(4-bromophenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonohydrazide Show/Hide	C16H16BrN3O3S	1
1	IC50 = 68.1 nM
CP0577768 Compound Info	2-chloro-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,3-thiazole-5-carboximidamide Show/Hide	C10H6Cl2FN3OS	1
1	IC50 = 68.3 nM
CP0239718 Compound Info	4-N-(2-aminophenyl)-1-N-[2-[[4-[N'-(3-bromo-4-fluorophenyl)-N-hydroxycarbamimidoyl]-1,2,5-oxadiazol-3-yl]amino]ethyl]benzene-1,4-dicarboxamide Show/Hide	C25H22BrFN8O4	1
1	IC50 = 69 nM
CP0414492 Compound Info	N'-(3-bromo-4-fluorophenyl)-4-[(1-cyanoiminothietan-3-yl)amino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C13H11BrFN7O2S	1
1	IC50 = 69 nM
CP0534337 Compound Info	N'-(4-bromophenyl)-3,3-dimethyl-2-oxo-1H-indole-5-sulfonohydrazide Show/Hide	C16H16BrN3O3S	1
1	IC50 = 69.9 nM
CP0542679 Compound Info	5-chloro-N'-(3-chloro-4-fluorophenyl)-N-hydroxythiophene-2-carboximidamide Show/Hide	C11H7Cl2FN2OS	1
1	IC50 = 69.9 nM
CP0571819 Compound Info	(6,6-dimethyl-7,10,11-trioxonaphtho[1,2-g][1]benzofuran-1-yl)methyl acetate Show/Hide	C21H16O6	2
1	IC50 = 70 nM
2	Ki = 230 nM
CP0566121 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-(2-sulfamoylethylamino)-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C11H12BrFN6O4S	1
1	IC50 = 71 nM
CP0119009 Compound Info	N-((1s,4s)-4-(1-hydroxy-2-(5H-imidazo[5,1- a]isoindol-5-yl)ethyl)cyclohexyl)benzamide Show/Hide	C25H27N3O2	1
1	IC50 = 72 nM
CP0369160 Compound Info	N'-(4-bromophenyl)-2-oxo-3,4-dihydro-1H-quinoline-6-sulfonohydrazide Show/Hide	C15H14BrN3O3S	1
1	IC50 = 72.7 nM
CP0219360 Compound Info	(3E)-3-[(3-bromo-4-fluoroanilino)-(hydroxyamino)methylidene]-4-[2-(sulfamoylamino)ethylimino]-1,2,5-oxadiazolidine Show/Hide	C11H15BrFN7O4S	1
1	IC50 = 73 nM
CP0570389 Compound Info	N'-(3-bromophenyl)-N-hydroxy-5-methylthiophene-2-carboximidamide Show/Hide	C12H11BrN2OS	1
1	IC50 = 73.5 nM
CP0191728 Compound Info	N'-(4-bromophenyl)-1-methyl-2-oxo-3H-indole-5-sulfonohydrazide Show/Hide	C15H14BrN3O3S	1
1	IC50 = 75.8 nM
CP0309727 Compound Info	N-[4-[(4-bromoanilino)sulfamoyl]phenyl]-3-morpholin-4-ylpropanamide Show/Hide	C19H23BrN4O4S	1
1	IC50 = 77 nM
CP0353564 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-2-yl]methyl]-3-[4-(trifluoromethyl)phenyl]urea Show/Hide	C20H16BrF3N4O2S	1
1	IC50 = 82 nM
CP0239834 Compound Info	N'-(4-bromophenyl)-2-oxo-1H-quinoline-6-sulfonohydrazide Show/Hide	C15H12BrN3O3S	1
1	IC50 = 85 nM
CP0534229 Compound Info	(5S)-6-fluoro-5-[1-[4-(1-methylpyrazol-4-yl)phenyl]piperidin-4-yl]-5H-imidazo[5,1-a]isoindole Show/Hide	C25H24FN5	1
1	IC50 = 85.16 nM
CP0222132 Compound Info	4-Amino-N-(3-chlorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C9H8ClN5O2	1
1	IC50 = 86 nM
CP0248477 Compound Info	3-[4-(2-tert-butylphenoxy)-3-[[4-(trifluoromethoxy)phenyl]carbamoylamino]phenyl]benzoic acid Show/Hide	C31H27F3N2O5	1
1	IC50 = 87 nM
CP0554096 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-(2-sulfamoylethoxyamino)-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C11H12BrFN6O5S	1
1	IC50 = 87 nM
CP0579401 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-2-yl]methyl]-3-(4-fluorophenyl)urea Show/Hide	C19H16BrFN4O2S	1
1	IC50 = 89.6 nM
CP0119013 Compound Info	(1S,4s)-4-((R)-2-((S)-6-fluoro-5H-imidazo[5,1- a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol Show/Hide	C18H21FN2O2	1
1	IC50 = 90 nM
CP0577926 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-2-yl]methyl]-3-(4-chlorophenyl)urea Show/Hide	C19H16BrClN4O2S	1
1	IC50 = 90.4 nM
CP0163136 Compound Info	N'-(3-bromo-4-fluorophenyl)-4-[2-(ethylsulfamoyl)ethylamino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C13H16BrFN6O4S	1
1	IC50 = 95 nM
CP0341678 Compound Info	N'-(3-bromo-4-fluorophenyl)-4-[3-(dimethylsulfamoyl)propylamino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C14H18BrFN6O4S	1
1	IC50 = 97 nM
CP0352012 Compound Info	N'-(3-bromo-4-fluorophenyl)-4-[(1,1-dioxothietan-3-yl)amino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C12H11BrFN5O4S	1
1	IC50 = 99 nM
CP0036589 Compound Info	3,4-Dichlorobenzenemethanethiol Show/Hide	C7H6Cl2S	1
1	IC50 = 100 nM
CP0242630 Compound Info	2-[3-[(5-bromo-1H-indol-2-yl)methyl]imidazol-4-yl]-4-fluorophenol Show/Hide	C18H13BrFN3O	1
1	IC50 = 100 nM
CP0098778 Compound Info	1-(4,4-difluorocyclohexyl)-2-(6-fluoro-5H- imidazo[5,1-a]isoindol-5-yl)ethanol; Show/Hide	C18H19F3N2O	1
1	IC50 = 100 nM
CP0115062 Compound Info	8-nitroindolo[2,1-b]quinazoline-6,12-dione Show/Hide	C15H7N3O4	2
1	IC50 = 103 nM
2	Ki = 54 nM
CP0568783 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-3-yl]methyl]-3-(3-fluorophenyl)urea Show/Hide	C19H16BrFN4O2S	1
1	IC50 = 103.2 nM
CP0068584 Compound Info	N'-(3-bromo-4-fluorophenyl)-4-[2-(dimethylsulfamoyl)ethylamino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C13H16BrFN6O4S	1
1	IC50 = 105 nM
CP0542680 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-2-yl]methyl]-3-(3-fluorophenyl)urea Show/Hide	C19H16BrFN4O2S	1
1	IC50 = 105.6 nM
CP0574897 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-2-yl]methyl]-3-(3-chlorophenyl)urea Show/Hide	C19H16BrClN4O2S	1
1	IC50 = 105.6 nM
CP0566120 Compound Info	N'-(3-bromo-4-fluorophenyl)-4-hydrazinyl-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C9H8BrFN6O2	1
1	IC50 = 108 nM
CP0565953 Compound Info	US11447477, Compound 8 Show/Hide	C14H17BrFN7O4S	1
1	IC50 = 108.7 nM
CP0198326 Compound Info	(1R)-1-cyclohexyl-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]ethanol Show/Hide	C18H22N2O	1
1	IC50 = 110 nM
CP0072202 Compound Info	5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone, Nec-1 Show/Hide	C13H13N3OS	5
1	IC50 = 110 nM
2	IC50 = 76900 nM
3	IC50 = 100000 nM
4	Ki = 11400 nM
5	Ki = 11600 nM
CP0549198 Compound Info	N'-(4-bromophenyl)-2-oxo-1,3,4,5-tetrahydro-1-benzazepine-7-sulfonohydrazide Show/Hide	C16H16BrN3O3S	1
1	IC50 = 111.8 nM
CP0335118 Compound Info	4-fluoro-2-[3-[(5-fluoro-1H-indol-2-yl)methyl]imidazol-4-yl]phenol Show/Hide	C18H13F2N3O	1
1	IC50 = 113 nM
CP0670149 Compound Info	(R)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione Show/Hide	C12H9FN2O2	7
1	IC50 = 120 nM
2	IC50 = 200 nM
3	IC50 = 2500 nM
4	Kd = 150 nM
5	Kd = 160 nM
6	Kd = 6000 nM
7	Kd = 7000 nM
CP0323382 Compound Info	(E)-3-(8-fluoro-6,12-dioxoindolo[2,1-b]quinazolin-2-yl)prop-2-enoic acid Show/Hide	C18H9FN2O4	1
1	IC50 = 120 nM
CP0071578 Compound Info	2-amino-N'-(4-bromophenyl)-3H-benzimidazole-5-sulfonohydrazide Show/Hide	C13H12BrN5O2S	1
1	IC50 = 121.6 nM
CP0339197 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[2-(hydroxysulfamoyl)ethylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C11H12BrFN6O5S	1
1	IC50 = 126 nM
CP0339198 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-(3-sulfamoylpropylamino)-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C12H14BrFN6O4S	1
1	IC50 = 126 nM
CP0116110 Compound Info	N-[2-(dimethylamino)ethyl]-5,12-dioxoindolizino[2,3-g]quinoline-6-carboxamide Show/Hide	C20H18N4O3	1
1	IC50 = 127 nM
CP0534936 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-2-yl]methyl]-3-(3-methylphenyl)urea Show/Hide	C20H19BrN4O2S	1
1	IC50 = 127.5 nM
CP0357517 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-3-yl]methyl]-3-(3-cyanophenyl)urea Show/Hide	C20H16BrN5O2S	1
1	IC50 = 128.8 nM
CP0564017 Compound Info	5-(3-bromoanilino)-2,3-dimethoxycyclohexa-2,5-diene-1,4-dione Show/Hide	C14H12BrNO4	1
1	IC50 = 130 nM
CP0578883 Compound Info	3-[bis(2-chloroethyl)amino]-N-[2-[[4-[N'-(3-bromo-4-fluorophenyl)-N-hydroxycarbamimidoyl]-1,2,5-oxadiazol-3-yl]amino]ethyl]benzamide Show/Hide	C22H23BrCl2FN7O3	1
1	IC50 = 130 nM
CP0124065 Compound Info	N-(2-methylphenyl)-5,12-dioxoindolizino[3,2-g]quinoline-11-carboxamide Show/Hide	C23H15N3O3	1
1	IC50 = 134 nM
CP0369249 Compound Info	5-(2-cyclohexylethyl)-5H-imidazo[5,1-a]isoindole Show/Hide	C18H22N2	1
1	IC50 = 135 nM
CP0121711 Compound Info	N'-(3-bromo-4-fluorophenyl)-4-[2-(hydrazinesulfonyl)ethylamino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C11H13BrFN7O4S	1
1	IC50 = 135 nM
CP0574898 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-2-yl]methyl]-3-(3-cyanophenyl)urea Show/Hide	C20H16BrN5O2S	1
1	IC50 = 137.5 nM
CP0563996 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[[(3R)-1-sulfamoylpiperidin-3-yl]methylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C15H19BrFN7O4S	1
1	IC50 = 139.1 nM
CP0541125 Compound Info	US10233190, Example 1363 Show/Hide	C22H29N3O3	1
1	IC50 = 140 nM
CP0163137 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[2-(2,2,2-trifluoroethylsulfamoyl)ethylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C13H13BrF4N6O4S	1
1	IC50 = 140 nM
CP0569762 Compound Info	1-(chloromethyl)-6,6-dimethylnaphtho[1,2-g][1]benzofuran-7,10,11-trione Show/Hide	C19H13ClO4	1
1	IC50 = 140 nM
CP0563993 Compound Info	US11447477, Compound 9 Show/Hide	C14H17BrFN7O4S	1
1	IC50 = 146.4 nM
CP0571154 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-2-yl]methyl]-3-(2-fluorophenyl)urea Show/Hide	C19H16BrFN4O2S	1
1	IC50 = 147.9 nM
CP0574899 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-3-yl]methyl]-3-(3-chlorophenyl)urea Show/Hide	C19H16BrClN4O2S	1
1	IC50 = 158.6 nM
CP0204648 Compound Info	1-cyclopentyl-2-(5H-imidazo[5,1-a]isoindol-5- yl)ethanol Show/Hide	C17H20N2O	1
1	IC50 = 160 nM
CP0578578 Compound Info	1-(hydroxymethyl)-6,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-7,10,11-trione Show/Hide	C19H16O5	1
1	IC50 = 160 nM
CP0570089 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-3-yl]methyl]-3-[4-(trifluoromethyl)phenyl]urea Show/Hide	C20H16BrF3N4O2S	1
1	IC50 = 161.8 nM
CP0577767 Compound Info	N'-(3-bromophenyl)-6-chloro-N-hydroxypyridine-3-carboximidamide Show/Hide	C12H9BrClN3O	1
1	IC50 = 171.8 nM
CP0542837 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[[(3S)-1-sulfamoylpiperidin-3-yl]methylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C15H19BrFN7O4S	1
1	IC50 = 178.1 nM
CP0577028 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-3-yl]methyl]-3-[3-(trifluoromethyl)phenyl]urea Show/Hide	C20H16BrF3N4O2S	1
1	IC50 = 179.9 nM
CP0518104 Compound Info	2-[3-[(5-bromo-1H-indol-2-yl)methyl]imidazol-4-yl]phenol Show/Hide	C18H14BrN3O	1
1	IC50 = 180 nM
CP0189118 Compound Info	N-[2-(dimethylamino)ethyl]-5,12-dioxoindolizino[3,2-g]quinoline-11-carboxamide Show/Hide	C20H18N4O3	1
1	IC50 = 188 nM
CP0666099 Compound Info	1-(5-Chloro-2-oxoindolin-3-ylidene)pentane-2,4-dione Show/Hide	C13H10ClNO3	1
1	IC50 = 190 nM
CP0329967 Compound Info	ethyl (E)-3-(8-fluoro-6,12-dioxoindolo[2,1-b]quinazolin-2-yl)prop-2-enoate Show/Hide	C20H13FN2O4	1
1	IC50 = 190 nM
CP0387130 Compound Info	4-[2-(azetidin-1-ylsulfonyl)ethylamino]-N'-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C14H16BrFN6O4S	1
1	IC50 = 191 nM
CP0119010 Compound Info	4-(2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)- 1-hydroxyethyl)cyclohexanol; Show/Hide	C18H21FN2O2	1
1	IC50 = 200 nM
CP0134809 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[(1-imino-1-oxothietan-3-yl)amino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C12H12BrFN6O3S	1
1	IC50 = 208 nM
CP0071553 Compound Info	O-[(4-iodophenyl)methyl]hydroxylamine;hydrochloride Show/Hide	C7H9ClINO	2
1	IC50 = 210 nM
2	Ki = 164 nM
CP0266144 Compound Info	2-(7-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyclohexylethanol Show/Hide	C18H21ClN2O	1
1	IC50 = 210 nM
CP0559655 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[(1-oxothietan-3-yl)amino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C12H11BrFN5O3S	1
1	IC50 = 212 nM
CP0136721 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-(2-sulfamoylhydrazinyl)-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C9H9BrFN7O4S	1
1	IC50 = 218 nM
CP0341677 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[2-(prop-2-ynylsulfamoyl)ethylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C14H14BrFN6O4S	1
1	IC50 = 218 nM
CP0350803 Compound Info	1-(hydroxymethyl)-6,6-dimethylnaphtho[1,2-g][1]benzofuran-7,10,11-trione Show/Hide	C19H14O5	2
1	IC50 = 220 nM
2	IC50 = 370 nM
CP0082578 Compound Info	CHEBI:27924 Show/Hide	C6H8N2	1
1	IC50 = 230 nM
CP0204658 Compound Info	1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl)ethyl)piperidin-1-yl)-2-(pyridin-4- yl)ethanone Show/Hide	C24H26N4O2	1
1	IC50 = 230 nM
CP0352136 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[[(2S)-1-sulfamoylpiperidin-2-yl]methylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C15H19BrFN7O4S	1
1	IC50 = 261.7 nM
CP0270602 Compound Info	1-cyclohexyl-2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)ethanone Show/Hide	C18H19FN2O	1
1	IC50 = 279 nM
CP0119006 Compound Info	CHEMBL4461858 Show/Hide	C20H24N2O3	1
1	IC50 = 280 nM
CP0542681 Compound Info	1-[[5-[N'-(3-bromophenyl)-N-hydroxycarbamimidoyl]thiophen-2-yl]methyl]-3-(2-methylphenyl)urea Show/Hide	C20H19BrN4O2S	1
1	IC50 = 289.8 nM
CP0098869 Compound Info	O-[(3-chlorophenyl)methyl]hydroxylamine;hydrochloride Show/Hide	C7H9Cl2NO	2
1	IC50 = 300 nM
2	Ki = 154 nM
CP0384248 Compound Info	4-chloro-2-fluoro-6-(1H-imidazol-5-yl)phenol Show/Hide	C9H6ClFN2O	1
1	IC50 = 300 nM
CP0139487 Compound Info	N'-(3-bromo-4-fluorophenyl)-4-[2-(cyclopropylmethylsulfamoyl)ethylamino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C15H18BrFN6O4S	1
1	IC50 = 312 nM
CP0242629 Compound Info	2-[3-[(5-fluoro-1H-indol-2-yl)methyl]imidazol-4-yl]phenol Show/Hide	C18H14FN3O	1
1	IC50 = 322 nM
CP0204649 Compound Info	2-(5H-imidazo[5,1-a]isoindol-5-yl)-1- phenylethanol Show/Hide	C18H16N2O	1
1	IC50 = 330 nM
CP0574184 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[2-(1-sulfamoylpiperidin-3-yl)ethylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C16H21BrFN7O4S	1
1	IC50 = 359.7 nM
CP0688886 Compound Info	5-Chloro-3-(2-oxopropylidene)indole-2-one Show/Hide	C11H8ClNO2	1
1	IC50 = 360 nM
CP0579187 Compound Info	1,6,6-trimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-7,10,11-trione Show/Hide	C19H16O4	1
1	IC50 = 360 nM
CP0552669 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[[(3S)-1-methylsulfonylpiperidin-3-yl]methylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C16H20BrFN6O4S	1
1	IC50 = 360.3 nM
CP0552670 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[[(3R)-1-methylsulfonylpiperidin-3-yl]methylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C16H20BrFN6O4S	1
1	IC50 = 363.2 nM
CP0098771 Compound Info	2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(pyridin-4- yl)ethanol Show/Hide	C17H15N3O	1
1	IC50 = 370 nM
CP0778294 Compound Info	S-(2,4-Dichlorobenzyl)isothiourea hydrobromide Show/Hide	C8H9BrCl2N2S	1
1	IC50 = 400 nM
CP0579363 Compound Info	[(7S)-1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-7-yl] acetate Show/Hide	C21H20O5	1
1	IC50 = 400 nM
CP0119004 Compound Info	1-cyclohexyl-2-(7-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)ethanol Show/Hide	C18H21FN2O	1
1	IC50 = 420 nM
CP0569395 Compound Info	1-(fluoromethyl)-6,6-dimethylnaphtho[1,2-g][1]benzofuran-7,10,11-trione Show/Hide	C19H13FO4	1
1	IC50 = 420 nM
CP0560224 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[[(1R,3R)-3-(sulfamoylamino)cyclohexyl]methylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C16H21BrFN7O4S	1
1	IC50 = 425.7 nM
CP0542836 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[[(2R)-1-methylsulfonylpyrrolidin-2-yl]methylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C15H18BrFN6O4S	1
1	IC50 = 443.3 nM
CP0666136 Compound Info	1-(3-Hydroxy-2-oxoindolin-3-yl)pentane-2,4-dione Show/Hide	C13H13NO4	1
1	IC50 = 450 nM
CP0329966 Compound Info	methyl 1-[(8-fluoro-6,12-dioxoindolo[2,1-b]quinazolin-2-yl)methyl]pyrrolidine-2-carboxylate Show/Hide	C22H18FN3O4	1
1	IC50 = 460 nM
CP0359321 Compound Info	8-fluoro-6,12-dioxoindolo[2,1-b]quinazoline-2-carbaldehyde Show/Hide	C16H7FN2O3	1
1	IC50 = 460 nM
CP0185837 Compound Info	1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanone Show/Hide	C18H20N2O	2
1	IC50 = 468 nM
2	IC50 < 1000 nM
CP0271852 Compound Info	N'-(3-bromo-4-fluorophenyl)-4-[(1-cyclopropylsulfonylpiperidin-3-yl)methylamino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C18H22BrFN6O4S	1
1	IC50 = 476.9 nM
CP0323384 Compound Info	1-[(8-fluoro-6,12-dioxoindolo[2,1-b]quinazolin-2-yl)methyl]piperidine-4-carboxylic acid Show/Hide	C22H18FN3O4	1
1	IC50 = 480 nM
CP0533459 Compound Info	N'-(3-bromo-4-fluorophenyl)-4-[[1-(difluoromethylsulfonyl)piperidin-3-yl]methylamino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C16H18BrF3N6O4S	1
1	IC50 = 489.6 nM
CP0118993 Compound Info	4-chloro-2-(1H-imidazol-5-yl)phenol Show/Hide	C9H7ClN2O	1
1	IC50 = 490 nM
CP0579211 Compound Info	8-hydroxy-1,6,6-trimethyl-7,8-dihydronaphtho[1,2-g][1]benzofuran-9,10,11-trione Show/Hide	C19H16O5	1
1	IC50 = 490 nM
CP0159403 Compound Info	8-fluoro-2-[(4-methylpiperazin-1-yl)methyl]indolo[2,1-b]quinazoline-6,12-dione Show/Hide	C21H19FN4O2	1
1	IC50 = 500 nM
CP0431574 Compound Info	8-fluoro-2-(4-methylpiperazin-1-yl)indolo[2,1-b]quinazoline-6,12-dione Show/Hide	C20H17FN4O2	1
1	IC50 = 500 nM
CP0258724 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[[(3S)-1-methylsulfonylpyrrolidin-3-yl]methylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C15H18BrFN6O4S	1
1	IC50 = 529 nM
CP0210843 Compound Info	8-fluoranylindolo[2,1-b]quinazoline-6,12-dione Show/Hide	C15H7FN2O2	3
1	IC50 = 534 nM
2	Kd = 46800 nM
3	Ki = 161 nM
CP0359319 Compound Info	1-[(8-fluoro-6,12-dioxoindolo[2,1-b]quinazolin-2-yl)methyl]pyrrolidine-2-carboxylic acid Show/Hide	C21H16FN3O4	1
1	IC50 = 550 nM
CP0341828 Compound Info	1-[(8-fluoro-6,12-dioxoindolo[2,1-b]quinazolin-2-yl)methyl]piperidine-3-carboxylic acid Show/Hide	C22H18FN3O4	1
1	IC50 = 570 nM
CP0075092 Compound Info	8-Bromotryptanthrin Show/Hide	C15H7BrN2O2	2
1	IC50 = 574 nM
2	Ki = 389 nM
CP0579210 Compound Info	(7S)-7-hydroxy-1-(hydroxymethyl)-6,6-dimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione Show/Hide	C19H18O5	1
1	IC50 = 590 nM
CP0098779 Compound Info	4-(2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)- 1-hydroxyethyl)cyclohexanone; Show/Hide	C18H19FN2O2	1
1	IC50 = 600 nM
CP0554093 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-(2-methylsulfonylhydrazinyl)-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C10H10BrFN6O4S	1
1	IC50 = 609 nM
CP0234124 Compound Info	2-(6-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyclohexylethanol Show/Hide	C18H21ClN2O	1
1	IC50 = 610 nM
CP0731354 Compound Info	(2S)-2-acetamido-3-(2-oxoindolin-3-yl)propanoic acid Show/Hide	C13H14N2O4	1
1	IC50 = 620 nM
CP0751153 Compound Info	(3Z)-1H-indole-2,3-dione 3-[(4-chlorophenyl)hydrazone] Show/Hide	C14H10ClN3O	1
1	IC50 = 630 nM
CP0361242 Compound Info	2-(1H-imidazol-5-yl)-4-methylphenol Show/Hide	C10H10N2O	1
1	IC50 = 640 nM
CP0063998 Compound Info	US10233190, Example 1425 Show/Hide	C24H31N3O2	1
1	IC50 = 670 nM
CP0550329 Compound Info	[(7S)-7-hydroxy-6,6-dimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-1-yl]methyl acetate Show/Hide	C21H20O6	1
1	IC50 = 670 nM
CP0118998 Compound Info	1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl)ethyl)piperidin-1-yl)-2-(pyrimidin-5- yl)ethanone Show/Hide	C23H25N5O2	1
1	IC50 = 700 nM
CP0542835 Compound Info	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[[(2S)-1-methylsulfonylpyrrolidin-2-yl]methylamino]-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C15H18BrFN6O4S	1
1	IC50 = 716.8 nM
CP0569270 Compound Info	N'-(3-bromo-4-fluorophenyl)-6-chloro-N-hydroxypyridine-3-carboximidamide Show/Hide	C12H8BrClFN3O	1
1	IC50 = 742.4 nM
CP0576805 Compound Info	[(7S)-1-(hydroxymethyl)-6,6-dimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-7-yl] acetate Show/Hide	C21H20O6	1
1	IC50 = 750 nM
CP0369248 Compound Info	4-bromo-2-(1H-imidazol-5-yl)phenol Show/Hide	C9H7BrN2O	1
1	IC50 = 760 nM
CP0367249 Compound Info	8-fluoro-2-(triazol-1-ylmethyl)indolo[2,1-b]quinazoline-6,12-dione Show/Hide	C18H10FN5O2	1
1	IC50 = 780 nM
CP0222969 Compound Info	2-(5H-imidazo[5,1-a]isoindol-5-yl)-1- (tetrahydro-2H-pyran-4-yl)ethanol Show/Hide	C17H20N2O2	1
1	IC50 = 790 nM
CP0361249 Compound Info	US10233190, Example 1460 Show/Hide	C20H25N3O3	1
1	IC50 = 810 nM
CP0578579 Compound Info	[(7S)-1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-7-yl] methanesulfonate Show/Hide	C20H20O6S	1
1	IC50 = 810 nM
CP0577766 Compound Info	6-chloro-N'-(3-chloro-4-fluorophenyl)-N-hydroxypyridine-3-carboximidamide Show/Hide	C12H8Cl2FN3O	1
1	IC50 = 900.4 nM
CP0361245 Compound Info	1-cyclohexyl-3-(5H-imidazo[5,1-a]isoindol-5- yl)propan-2-ol; Show/Hide	C19H24N2O	1
1	IC50 = 906 nM
CP0579362 Compound Info	1,6,6-trimethylnaphtho[1,2-g][1]benzofuran-7,10,11-trione Show/Hide	C19H14O4	1
1	IC50 = 980 nM
CP0130138 Compound Info	4-amino-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C10H11N5O2	1
1	IC50 = 1000 nM
CP0188708 Compound Info	O-[(3-bromophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H13BrClNO	1
1	IC50 = 1000 nM
CP0576804 Compound Info	PRZEWAQUINONE A Show/Hide	C19H18O4	1
1	IC50 = 1070 nM
CP0164767 Compound Info	1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5- yl)ethanamine Show/Hide	C18H23N3	1
1	IC50 = 1100 nM
CP0258970 Compound Info	1-cyclohexyl-2-(5,6-dihydroimidazo[1,5-c]quinazolin-5-yl)ethanol Show/Hide	C18H23N3O	1
1	IC50 = 1139 nM
CP0036588 Compound Info	2-Chlorobenzenemethanethiol Show/Hide	C7H7ClS	1
1	IC50 = 1200 nM
CP0324896 Compound Info	2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-methylpyrazol-4-yl)ethanol Show/Hide	C16H16N4O	1
1	IC50 = 1200 nM
CP0388564 Compound Info	methyl 1-[(8-fluoro-6,12-dioxoindolo[2,1-b]quinazolin-2-yl)methyl]piperidine-4-carboxylate Show/Hide	C23H20FN3O4	1
1	IC50 = 1200 nM
CP0324177 Compound Info	5-bromo-2-[(5-phenylimidazol-1-yl)methyl]-1H-indole Show/Hide	C18H14BrN3	1
1	IC50 = 1250 nM
CP0691624 Compound Info	(2S)-2-(benzyloxycarbonylamino)-3-(2-oxoindolin-3-yl)propanoic acid Show/Hide	C19H18N2O5	1
1	IC50 = 1280 nM
CP0309908 Compound Info	4-Methylbenzenemethanethiol Show/Hide	C8H10S	1
1	IC50 = 1300 nM
CP0774168 Compound Info	S-(4-Bromobenzyl)isothiourea hydrobromide Show/Hide	C8H10Br2N2S	1
1	IC50 = 1300 nM
CP0402400 Compound Info	4-Methoxybenzenemethanethiol Show/Hide	C8H10OS	1
1	IC50 = 1400 nM
CP0222140 Compound Info	4-Amino-N-(3-chlorophenyl)-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C9H8ClN5O	1
1	IC50 = 1400 nM
CP0329965 Compound Info	methyl 1-[(8-fluoro-6,12-dioxoindolo[2,1-b]quinazolin-2-yl)methyl]piperidine-3-carboxylate Show/Hide	C23H20FN3O4	1
1	IC50 = 1430 nM
CP0577463 Compound Info	1-[2-[bis(2-methylpropyl)amino]-5-[N'-(3-bromo-4-fluorophenyl)-N-hydroxycarbamimidoyl]phenyl]-3-(4-chlorophenyl)urea Show/Hide	C28H32BrClFN5O2	1
1	IC50 = 1490 nM
CP0578083 Compound Info	9-bromo-1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione Show/Hide	C19H17BrO3	1
1	IC50 = 1500 nM
CP0580021 Compound Info	1-[2-[bis(2-methylpropyl)amino]-5-[N-hydroxy-N'-(4-methylphenyl)carbamimidoyl]phenyl]-3-(4-methylphenyl)urea Show/Hide	C30H39N5O2	1
1	IC50 = 1560 nM
CP0118491 Compound Info	3-[[5-(5-bromo-1H-indol-2-yl)imidazol-1-yl]methyl]phenol Show/Hide	C18H14BrN3O	1
1	IC50 = 1600 nM
CP0269206 Compound Info	Benzenemethanethiol Show/Hide	C7H8S	1
1	IC50 = 1700 nM
CP0090856 Compound Info	2-(1H-imidazol-4-yl)phenol Show/Hide	C9H8N2O	3
1	IC50 = 1700 nM
2	IC50 = 4800 nM
3	Ki = 8900 nM
CP0164763 Compound Info	3-(2-cyclohexylethoxy)-2-(1H-imidazol-5-yl)phenol Show/Hide	C17H22N2O2	1
1	IC50 = 1700 nM
CP0571820 Compound Info	(6,6-dimethyl-7,10,11-trioxo-8,9-dihydronaphtho[1,2-g][1]benzofuran-1-yl)methyl acetate Show/Hide	C21H18O6	1
1	IC50 = 1730 nM
CP0368208 Compound Info	(8-fluoro-6,12-dioxoindolo[2,1-b]quinazolin-2-yl)boronic acid Show/Hide	C15H8BFN2O4	1
1	IC50 = 1790 nM
CP0269207 Compound Info	4-Fluorobenzenemethanethiol Show/Hide	C7H7FS	1
1	IC50 = 1800 nM
CP0159004 Compound Info	2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(thiazol-5- yl)ethanol; Show/Hide	C15H13N3OS	1
1	IC50 = 1800 nM
CP0309909 Compound Info	4-Chloro-benzenethiol Show/Hide	C6H5ClS	1
1	IC50 = 1900 nM
CP0917558 Compound Info	5-(3-Bromophenyl)-4-phenyl-1H-imidazole Show/Hide	C15H11BrN2	1
1	IC50 = 1900 nM
CP0159001 Compound Info	4-chloro-2-(3-cyclohexylimidazol-4-yl)phenol Show/Hide	C15H17ClN2O	1
1	IC50 = 1900 nM
CP0353560 Compound Info	5-chloro-N'-(3-chloro-4-fluorophenyl)-N-hydroxypyridine-2-carboximidamide Show/Hide	C12H8Cl2FN3O	1
1	IC50 = 1922.7 nM
CP0060327 Compound Info	O-[(3,4-dichlorophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H12Cl3NO	1
1	IC50 = 2000 nM
CP0239393 Compound Info	O-[(3,5-dichlorophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H12Cl3NO	1
1	IC50 = 2000 nM
CP0085227 Compound Info	4-Amino-N'-hydroxy-N-(3-isopropylphenyl)-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C12H15N5O2	1
1	IC50 = 2100 nM
CP0784875 Compound Info	S-(4-Chlorobenzyl)isothiourea hydrochloride Show/Hide	C8H10Cl2N2S	1
1	IC50 = 2200 nM
CP0580020 Compound Info	1-[2-[bis(2-methylpropyl)amino]-5-[N'-(3-bromo-4-fluorophenyl)-N-hydroxycarbamimidoyl]phenyl]-3-(4-methylphenyl)urea Show/Hide	C29H35BrFN5O2	1
1	IC50 = 2300 nM
CP0552813 Compound Info	1-[2-[bis(2-methylpropyl)amino]-5-[N-hydroxy-N'-(4-methylphenyl)carbamimidoyl]phenyl]-3-pyrimidin-5-ylurea Show/Hide	C27H35N7O2	1
1	IC50 = 2320 nM
CP0119007 Compound Info	1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl)ethyl)piperidin-1-yl)ethanone; Show/Hide	C19H23N3O2	1
1	IC50 = 2500 nM
CP0807117 Compound Info	S-(4-Trifluoromethylbenzyl)isothiourea hydrochloride Show/Hide	C9H10ClF3N2S	1
1	IC50 = 2600 nM
CP0070605 Compound Info	2,8-difluoroindolo[2,1-b]quinazoline-6,12-dione Show/Hide	C15H6F2N2O2	2
1	IC50 = 2720 nM
2	Ki = 5480 nM
CP0811077 Compound Info	N-(4-(4-(3-Bromophenyl)-1H-imidazol-5-yl)phenyl)acetamide Show/Hide	C17H14BrN3O	1
1	IC50 = 2800 nM
CP0569394 Compound Info	8-hydroxy-1,6,6-trimethylnaphtho[1,2-g][1]benzofuran-9,10,11-trione Show/Hide	C19H14O5	1
1	IC50 = 2880 nM
CP0260915 Compound Info	1-[2-[bis(2-methylpropyl)amino]-5-[N'-(3-bromo-4-fluorophenyl)-N-hydroxycarbamimidoyl]phenyl]-3-propylurea Show/Hide	C25H35BrFN5O2	1
1	IC50 = 2900 nM
CP0060322 Compound Info	O-[bis(4-chlorophenyl)methyl]hydroxylamine;hydrochloride Show/Hide	C13H12Cl3NO	1
1	IC50 = 3000 nM
CP0060323 Compound Info	5-aminooxy-5-(3-chlorophenyl)-N-phenylpentanamide;hydrochloride Show/Hide	C17H20Cl2N2O2	1
1	IC50 = 3000 nM
CP0324895 Compound Info	5H-imidazo[5,1-a]isoindol-9-ol Show/Hide	C10H8N2O	1
1	IC50 = 3100 nM
CP0302197 Compound Info	4-Chlorobenzenemethanethiol Show/Hide	C7H7ClS	1
1	IC50 = 3200 nM
CP0569181 Compound Info	N,N-diethyl-6,6-dimethyl-7,10,11-trioxonaphtho[1,2-g][1]benzofuran-1-carboxamide Show/Hide	C23H21NO5	1
1	IC50 = 3270 nM
CP0146631 Compound Info	2,4-Dichlorobenzenemethanethiol Show/Hide	C7H6Cl2S	1
1	IC50 = 3500 nM
CP0324894 Compound Info	5-[2-(2-cyclohexylethoxy)phenyl]-1H-imidazole Show/Hide	C17H22N2O	1
1	IC50 = 3800 nM
CP0202340 Compound Info	4-[[5-(5-bromo-1H-indol-2-yl)imidazol-1-yl]methyl]benzonitrile Show/Hide	C19H13BrN4	1
1	IC50 = 3810 nM
CP0060691 Compound Info	O-[(2,4-dichlorophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H12Cl3NO	1
1	IC50 = 4000 nM
CP0243946 Compound Info	O-[(3,5-difluorophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H12ClF2NO	1
1	IC50 = 4000 nM
CP0119005 Compound Info	1-cyclohexyl-2-(8-fluoro-5H-imidazo[5,1- a]isoindol-5-yl)ethanol; Show/Hide	C18H21FN2O	1
1	IC50 = 4000 nM
CP0335111 Compound Info	2-[(5-phenylimidazol-1-yl)methyl]-1H-indole Show/Hide	C18H15N3	1
1	IC50 = 4440 nM
CP0831974 Compound Info	4-(Thiophen-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1H-imidazole Show/Hide	C14H9F3N2OS	1
1	IC50 = 4500 nM
CP0230210 Compound Info	(4S,5S)-5-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol Show/Hide	C17H16N4O	1
1	IC50 = 4500 nM
CP0578577 Compound Info	6,6-dimethyl-7,10,11-trioxonaphtho[1,2-g][1]benzofuran-1-carboxylic acid Show/Hide	C19H12O6	1
1	IC50 = 4570 nM
CP0774166 Compound Info	S-(3-Chlorobenzyl)isothiourea hydrochloride Show/Hide	C8H10Cl2N2S	1
1	IC50 = 4600 nM
CP0118490 Compound Info	3-[3-[(5-fluoro-1H-indol-2-yl)methyl]imidazol-4-yl]phenol Show/Hide	C18H14FN3O	1
1	IC50 = 4640 nM
CP0767222 Compound Info	5-(3-Chlorophenyl)-4-phenyl-1H-imidazole Show/Hide	C15H11ClN2	1
1	IC50 = 4700 nM
CP0060692 Compound Info	O-[(3-fluorophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H13ClFNO	1
1	IC50 = 5000 nM
CP0243947 Compound Info	O-[(4-chlorophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H13Cl2NO	1
1	IC50 = 5000 nM
CP0492095 Compound Info	2-(3-bromo-4-fluorophenyl)imino-2-(hydroxyamino)-N-[3-(methanesulfonamido)propyl]acetamide Show/Hide	C12H16BrFN4O4S	1
1	IC50 = 5000 nM
CP0545404 Compound Info	3-Hydroxytanshinone Show/Hide	C19H18O4	1
1	IC50 = 5120 nM
CP0063996 Compound Info	2-(5H-imidazo[5,1-a]isoindol-5-yl)-1- phenylethanone Show/Hide	C18H14N2O	1
1	IC50 = 5200 nM
CP0182071 Compound Info	2-(1H-imidazol-4-yl)benzene-1,3-diol Show/Hide	C9H8N2O2	1
1	IC50 = 5300 nM
CP0243838 Compound Info	5H-imidazo[5,1-a]isoindole Show/Hide	C10H8N2	1
1	IC50 = 5700 nM
CP0275023 Compound Info	4-Amino-N-(4-chlorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide Show/Hide	C9H8ClN5O2	1
1	IC50 = 6000 nM
CP0060331 Compound Info	O-[[2-fluoro-3-(trifluoromethyl)phenyl]-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C14H12ClF4NO	1
1	IC50 = 6000 nM
CP0105361 Compound Info	(5aR,6R)-8-fluoro-6-hydroxy-5a,6-dihydro-5H-indolo[2,1-b]quinazolin-12-one Show/Hide	C15H11FN2O2	2
1	IC50 = 6210 nM
2	Ki = 4540 nM
CP0239207 Compound Info	2-[[5-(5-bromo-1H-indol-2-yl)imidazol-1-yl]methyl]phenol Show/Hide	C18H14BrN3O	1
1	IC50 = 6400 nM
CP0327840 Compound Info	2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol Show/Hide	C12H12N2O	1
1	IC50 = 6700 nM
CP0118999 Compound Info	2-(8-chloro-5H-imidazo[5,1-a]isoindol-5-yl)-1- cyclohexylethanol; Show/Hide	C18H21ClN2O	1
1	IC50 = 6900 nM
CP0179152 Compound Info	O-[3-(3-chlorophenyl)-1-phenylpropyl]hydroxylamine;hydrochloride Show/Hide	C15H17Cl2NO	1
1	IC50 = 7000 nM
CP0357003 Compound Info	O-[(2,4-difluorophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H12ClF2NO	1
1	IC50 = 7000 nM
CP0075091 Compound Info	indolo[2,1-b]quinazoline-6,12-dione Show/Hide	C15H8N2O2	2
1	IC50 = 7150 nM
2	Ki = 4810 nM
CP0204647 Compound Info	1-(5H-imidazo[5,1-a]isoindol-5-yl)-2- methylpropan-2-ol Show/Hide	C14H16N2O	1
1	IC50 = 7700 nM
CP0188710 Compound Info	O-[(2,3-dichlorophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H12Cl3NO	1
1	IC50 = 8000 nM
CP0326779 Compound Info	O-[[2-fluoro-5-(trifluoromethyl)phenyl]-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C14H12ClF4NO	1
1	IC50 = 8000 nM
CP0210794 Compound Info	7-chloroindolo[2,1-b]quinazoline-6,12-dione Show/Hide	C15H7ClN2O2	2
1	IC50 = 8190 nM
2	Ki = 9650 nM
CP0239397 Compound Info	O-[bis(4-fluorophenyl)methyl]hydroxylamine;hydrochloride Show/Hide	C13H12ClF2NO	1
1	IC50 = 9000 nM
CP0459331 Compound Info	5-[2-(2-phenylethoxy)phenyl]-1H-imidazole Show/Hide	C17H16N2O	1
1	IC50 = 9100 nM
CP0807118 Compound Info	S-(2-Chlorobenzyl)isothiourea hydrochloride Show/Hide	C8H10Cl2N2S	1
1	IC50 = 10000 nM
CP0102036 Compound Info	1-cyclohexyl-2-(5H-triazolo[5,1-a]isoindol-5-yl)ethanol Show/Hide	C17H21N3O	2
1	IC50 = 10000 nM
2	IC50 > 10000 nM
CP0537449 Compound Info	(E)-3-[4-[bis(2-methylpropyl)amino]-3-[[(E)-(2-fluorophenyl)methylideneamino]carbamoylamino]phenyl]but-2-enoic acid Show/Hide	C26H33FN4O3	1
1	IC50 = 10100 nM
CP0238482 Compound Info	(E)-3-[4-[bis(2-methylpropyl)amino]-3-[[(E)-(4-chlorophenyl)methylideneamino]carbamoylamino]phenyl]but-2-enoic acid Show/Hide	C26H33ClN4O3	1
1	IC50 = 10230 nM
CP0535042 Compound Info	2-(3-chloro-4-fluorophenyl)imino-2-(hydroxyamino)-N-[3-(sulfamoylamino)propyl]acetamide Show/Hide	C11H15ClFN5O4S	1
1	IC50 = 10300 nM
CP0678207 Compound Info	S-(4-Nitrobenzyl)isothiourea hydrochloride Show/Hide	C8H10ClN3O2S	1
1	IC50 = 11000 nM
CP0355585 Compound Info	N-(4-chlorophenyl)-2H-triazol-4-amine Show/Hide	C8H7ClN4	1
1	IC50 = 11300 nM
CP0060324 Compound Info	O-[(2-fluorophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H13ClFNO	1
1	IC50 = 12000 nM
CP0362076 Compound Info	(E)-3-[4-(dibutylamino)-3-[[(E)-[2-(trifluoromethyl)phenyl]methylideneamino]carbamoylamino]phenyl]but-2-enoic acid Show/Hide	C27H33F3N4O3	1
1	IC50 = 12350 nM
CP0807120 Compound Info	S-(4-Fluorobenzyl)isothiourea hydrochloride Show/Hide	C8H10ClFN2S	1
1	IC50 = 13000 nM
CP0111908 Compound Info	8-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolo[2,1-b]quinazoline-6,12-dione Show/Hide	C21H18BFN2O4	1
1	IC50 = 13090 nM
CP0356914 Compound Info	2-(3-benzylimidazol-4-yl)-5-bromo-1H-indole Show/Hide	C18H14BrN3	1
1	IC50 = 13600 nM
CP0155221 Compound Info	(E)-3-[3-[[(E)-(4-chlorophenyl)methylideneamino]carbamoylamino]-4-(dibutylamino)phenyl]but-2-enoic acid Show/Hide	C26H33ClN4O3	1
1	IC50 = 14440 nM
CP0807119 Compound Info	S-(4-Ethylbenzyl)isothiourea hydrochloride Show/Hide	C10H15ClN2S	1
1	IC50 = 16000 nM
CP0283376 Compound Info	(5aR,6R)-6-hydroxy-5a,6-dihydro-5H-indolo[2,1-b]quinazolin-12-one Show/Hide	C15H12N2O2	2
1	IC50 = 16000 nM
2	Ki = 8580 nM
CP0247994 Compound Info	O-[1-(2-fluorophenyl)-3-phenylpropyl]hydroxylamine;hydrochloride Show/Hide	C15H17ClFNO	1
1	IC50 = 16000 nM
CP0678206 Compound Info	S-(3,4-Dichlorobenzyl)isothiourea hydrochloride Show/Hide	C8H9Cl3N2S	1
1	IC50 = 17000 nM
CP0326780 Compound Info	O-[(2-bromophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H13BrClNO	1
1	IC50 = 17000 nM
CP0060332 Compound Info	O-[(2-chlorophenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C13H13Cl2NO	1
1	IC50 = 18000 nM
CP0169740 Compound Info	3,4,5-triethoxy-N-[(2-hydroxynaphthalen-1-yl)carbamothioyl]benzamide Show/Hide	C24H26N2O5S	2
1	IC50 = 18000 nM
2	IC50 = 18700 nM
CP0266784 Compound Info	(1S)-1-cyclohexyl-2-[(5R)-5H-imidazo[5,1-a]isoindol-5-yl]ethanol Show/Hide	C18H22N2O	1
1	IC50 = 18000 nM
CP0801526 Compound Info	S-(4-Cyanobenzyl)isothiourea hydrobromide Show/Hide	C9H10BrN3S	1
1	IC50 = 19000 nM
CP0324178 Compound Info	2-[5-(5-bromo-1H-indol-2-yl)imidazol-1-yl]-1-phenylethanol Show/Hide	C19H16BrN3O	1
1	IC50 = 19700 nM
CP0807122 Compound Info	S-(4-Chlorobenzyl)-N,N'-dimethylthiourea hydroperchlorate Show/Hide	C10H14Cl2N2O4S	1
1	IC50 = 21000 nM
CP0331002 Compound Info	5-chloro-2-[3-[(5-fluoro-1H-indol-2-yl)methyl]imidazol-4-yl]phenol Show/Hide	C18H13ClFN3O	1
1	IC50 = 21000 nM
CP0561823 Compound Info	5-bromo-2-[3-[(4-methylphenyl)methyl]imidazol-4-yl]-1H-indole Show/Hide	C19H16BrN3	1
1	IC50 = 21600 nM
CP0353789 Compound Info	2-chloro-6-[3-[(5-fluoro-1H-indol-2-yl)methyl]imidazol-4-yl]phenol Show/Hide	C18H13ClFN3O	1
1	IC50 = 22700 nM
CP0239395 Compound Info	O-[(2-methoxyphenyl)-phenylmethyl]hydroxylamine;hydrochloride Show/Hide	C14H16ClNO2	1
1	IC50 = 23000 nM
CP0157863 Compound Info	4-PIM Show/Hide	C9H8N2	3
1	IC50 = 27000 nM
2	IC50 = 48000 nM
3	Ki = 4400 nM
CP0920849 Compound Info	S-(4-Methylbenzyl)isothiourea hydrochloride Show/Hide	C9H13ClN2S	1
1	IC50 = 30000 nM
CP0202342 Compound Info	5-bromo-2-[3-[(4-phenylphenyl)methyl]imidazol-4-yl]-1H-indole Show/Hide	C24H18BrN3	1
1	IC50 = 34200 nM
CP0238990 Compound Info	2-(3-benzylimidazol-4-yl)-1H-indole Show/Hide	C18H15N3	1
1	IC50 = 34800 nM
CP0817341 Compound Info	(S)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione Show/Hide	C12H9FN2O2	2
1	IC50 = 38000 nM
2	IC50 = 54000 nM
CP0106138 Compound Info	8-fluoro-2-[(4-phenyltriazol-1-yl)methyl]indolo[2,1-b]quinazoline-6,12-dione Show/Hide	C24H14FN5O2	2
1	IC50 = 39100 nM
2	Ki = 63300 nM
CP0521483 Compound Info	3-chloro-2-[3-[(5-fluoro-1H-indol-2-yl)methyl]imidazol-4-yl]phenol Show/Hide	C18H13ClFN3O	1
1	IC50 = 44800 nM
CP0364707 Compound Info	2-[[5-(5-bromo-1H-indol-2-yl)imidazol-1-yl]methyl]aniline Show/Hide	C18H15BrN4	1
1	IC50 = 50600 nM
CP0784874 Compound Info	S-(4-Methoxybenzyl)isothiourea hydrochloride Show/Hide	C9H13ClN2OS	1
1	IC50 = 52000 nM
CP0678208 Compound Info	S-(4-Chlorophenethyl)isothiourea hydrobromide Show/Hide	C9H12BrClN2S	1
1	IC50 = 57000 nM
CP0176763 Compound Info	(E)-3-[3-[4-[(4-fluoroanilino)methyl]triazol-1-yl]-4-morpholin-4-ylphenyl]but-2-enoic acid Show/Hide	C23H24FN5O3	1
1	IC50 = 58350 nM
CP0795291 Compound Info	S-Benzylisothiourea hydrochloride Show/Hide	C8H11ClN2S	1
1	IC50 = 61000 nM
CP0212292 Compound Info	9-chloroindolo[2,1-b]quinazoline-6,12-dione Show/Hide	C15H7ClN2O2	2
1	IC50 = 74370 nM
2	Ki = 49370 nM
CP0357715 Compound Info	2-(3-chloro-4-fluorophenyl)imino-2-(hydroxyamino)acetamide Show/Hide	C8H7ClFN3O2	1
1	IC50 = 78000 nM
CP0239205 Compound Info	4-[3-[(5-fluoro-1H-indol-2-yl)methyl]imidazol-4-yl]phenol Show/Hide	C18H14FN3O	1
1	IC50 = 83300 nM
CP0071950 Compound Info	(S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid Show/Hide	C12H14N2O2	9
1	IC50 = 98500 nM
2	IC50 = 100000 nM
3	Ki = 19000 nM
4	Ki = 30000 nM
5	Ki = 34000 nM
6	Ki = 37000 nM
7	Ki = 42300 nM
8	Ki = 53200 nM
9	Km = 62000 nM
CP0507844 Compound Info	2-(4-chlorophenyl)ethylthiourea Show/Hide	C9H11ClN2S	1
1	IC50 = 100000 nM
CP0528193 Compound Info	4-[2-(2-phenylethyl)phenyl]-2H-triazole Show/Hide	C16H15N3	1
1	IC50 = 100000 nM
CP0528081 Compound Info	1-[2-[bis(2-methylpropyl)amino]-5-[N'-(3-bromo-4-fluorophenyl)-N-hydroxycarbamimidoyl]phenyl]-3-butylurea Show/Hide	C26H37BrFN5O2	1
1	IC50 > 3000 nM
CP0573546 Compound Info	1-[2-[bis(2-methylpropyl)amino]-5-[N'-(3-bromo-4-fluorophenyl)-N-hydroxycarbamimidoyl]phenyl]-3-cyclohexylurea Show/Hide	C28H39BrFN5O2	1
1	IC50 > 3000 nM
CP0573547 Compound Info	1-[2-[bis(2-methylpropyl)amino]-5-[N'-(3-bromo-4-fluorophenyl)-N-hydroxycarbamimidoyl]phenyl]-3-[4-(trifluoromethyl)phenyl]urea Show/Hide	C29H32BrF4N5O2	1
1	IC50 > 3000 nM
CP0578025 Compound Info	1-[2-[bis(2-methylpropyl)amino]-5-[N'-(3-bromo-4-fluorophenyl)-N-hydroxycarbamimidoyl]phenyl]-3-pyrimidin-5-ylurea Show/Hide	C26H31BrFN7O2	1
1	IC50 > 3000 nM
CP0181074 Compound Info	1-cyclohexyl-2-(3-methyl-5H-imidazo[5,1-a]isoindol-5-yl)ethanol Show/Hide	C19H24N2O	1
1	IC50 > 10000 nM
CP0222970 Compound Info	(1R)-1-cyclohexyl-2-[(5R)-5H-imidazo[5,1-a]isoindol-5-yl]ethanol Show/Hide	C18H22N2O	1
1	IC50 > 25000 nM
CP0353856 Compound Info	N-(4-chlorophenyl)-2-oxo-2-(4-phenylpiperidin-1-yl)acetamide Show/Hide	C19H19ClN2O2	1
1	IC50 > 60000 nM
CP0367369 Compound Info	N'-(3-chloro-4-fluorophenyl)-N-hydroxy-2-oxo-2-(4-phenylpiperidin-1-yl)ethanimidamide Show/Hide	C19H19ClFN3O2	1
1	IC50 > 60000 nM
CP0553681 Compound Info	N-(3-chloro-4-fluorophenyl)-2-oxo-2-(4-phenylpiperidin-1-yl)acetamide Show/Hide	C19H18ClFN2O2	1
1	IC50 > 60000 nM
CP0171461 Compound Info	1-(4-CHLOROPHENYL)METHANAMINE Show/Hide	C7H8ClN	1
1	IC50 > 100000 nM
CP0302196 Compound Info	4-chlorophenylthiourea Show/Hide	C7H7ClN2S	1
1	IC50 > 100000 nM
CP0320914 Compound Info	2-(4-chlorophenyl)ethylamine Show/Hide	C8H10ClN	1
1	IC50 > 100000 nM
CP0320915 Compound Info	4-Chlorobenzylalcohol Show/Hide	C7H7ClO	1
1	IC50 > 100000 nM
CP0497260 Compound Info	(4-chlorophenyl)methylurea Show/Hide	C8H9ClN2O	1
1	IC50 > 100000 nM
CP0507845 Compound Info	4-Chlorobenzenesulfonic acid Show/Hide	C6H5ClO3S	1
1	IC50 > 100000 nM
CP0678210 Compound Info	N-(4-Chlorophenethyl)-S-methylisothiourea hydroiodide Show/Hide	C10H14ClIN2S	1
1	IC50 > 100000 nM
CP0773197 Compound Info	N-(4-Chlorophenyl)-S-methylisothiourea hydroiodide Show/Hide	C8H10ClIN2S	1
1	IC50 > 100000 nM
CP0774167 Compound Info	S-(2-Chlorophenethyl)isothiourea hydrobromide Show/Hide	C9H12BrClN2S	1
1	IC50 > 100000 nM
CP0784876 Compound Info	S-(4-Carboxybenzyl)isothiourea hydrochloride Show/Hide	C9H11ClN2O2S	1
1	IC50 > 100000 nM
CP0784896 Compound Info	S-(4-Benzoylbenzyl)isothiourea hydrobromide Show/Hide	C15H15BrN2OS	1
1	IC50 > 100000 nM
CP0795290 Compound Info	4-tert-butylbenzyl carbamimidothioate hydrobromide Show/Hide	C12H19BrN2S	1
1	IC50 > 100000 nM
CP0807121 Compound Info	S-(3-Chlorophenethyl)isothiourea hydrobromide Show/Hide	C9H12BrClN2S	1
1	IC50 > 100000 nM
CP0814302 Compound Info	S-(4-Methanesulfonylbenzyl)isothiourea hydrobromide Show/Hide	C9H13BrN2O2S2	1
1	IC50 > 100000 nM
CP0859751 Compound Info	4-Chlorobenzenesulfinate natrium Show/Hide	C6H4ClNaO2S	1
1	IC50 > 100000 nM
CP0889178 Compound Info	S-(4-Isopropylbenzyl)isothiourea hydrobromide Show/Hide	C11H17BrN2S	1
1	IC50 > 100000 nM
CP0118492 Compound Info	5-bromo-2-[3-[[4-(trifluoromethyl)phenyl]methyl]imidazol-4-yl]-1H-indole Show/Hide	C19H13BrF3N3	1
1	IC50 > 100000 nM
CP0242631 Compound Info	5-bromo-2-[3-(piperidin-2-ylmethyl)imidazol-4-yl]-1H-indole Show/Hide	C17H19BrN4	1
1	IC50 > 100000 nM
CP0543718 Compound Info	5-(1H-indol-3-yl)-2,1,3-benzoselenadiazole Show/Hide	C14H9N3Se	1
1	IC50 > 100000 nM
CP0545501 Compound Info	5-(1H-indol-3-yl)-2,1,3-benzoxadiazole Show/Hide	C14H9N3O	1
1	IC50 > 100000 nM
CP0564602 Compound Info	6-(1H-indol-3-yl)-[1,2,5]selenadiazolo[3,4-b]pyridine Show/Hide	C13H8N4Se	1
1	IC50 > 100000 nM
CP0567909 Compound Info	6-(1H-indol-3-yl)-[1,2,5]thiadiazolo[3,4-b]pyridine Show/Hide	C13H8N4S	1
1	IC50 > 100000 nM
CP0579745 Compound Info	5-(1H-indol-3-yl)-2,1,3-benzothiadiazole Show/Hide	C14H9N3S	1
1	IC50 > 100000 nM
CP0574235 Compound Info	N-(4-fluorophenyl)-3-[4-[4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl]phenyl]oxetane-3-carboxamide Show/Hide	C23H18F4N2O3	2
1	Kd = 0.158 nM
2	Ki = 0.15 nM
CP0475041 Compound Info	(3E)-3-[[4-(3-hydroxyphenyl)-1,3-thiazol-2-yl]hydrazinylidene]inden-1-one Show/Hide	C18H13N3O2S	1
1	Kd = 9828 nM
CP0572932 Compound Info	N-(4-fluorophenyl)-3-[4-[4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl]phenyl]oxetane-3-carboxamide Show/Hide	C25H22F4N2O3	1
1	Ki = 0.11 nM
CP0049432 Compound Info	β-Lapachone (A3) Show/Hide	C15H14O3	1
1	Ki = 100 nM
CP0168477 Compound Info	1-Methyltryptophan, 1 Show/Hide	C12H14N2O2	4
1	Ki = 30000 nM
2	Ki = 34000 nM
3	Ki = 38000 nM
4	Ki = 62000 nM

Clinical Information about the Protein

Target 1 ( Indoleamine 2,3-dioxygenase 1 (IDO1) )

Target Type	Successful Target
Disease	6 Target-related Diseases				6
1	Depression [ICD-11: 6A70-6A7Z]
2	Non-small-cell lung cancer [ICD-11: 2C25.Y]
3	Melanoma [ICD-11: 2C30]
4	Urothelial carcinoma [ICD-11: 2C92.0]
5	Glioma [ICD-11: 2A00.0]
6	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Approved Drug(s)	1 Approved Drug				1
1	L-Tryptophan	Drug Info	Approved	Depression
Clinical Trial Drug(s)	5 Clinical Trial Drugs				5
1	Avastin+/-Tarceva	Drug Info	Phase 3	Non-small-cell lung cancer
2	BMS-986205	Drug Info	Phase 3	Melanoma
3	INCB24360	Drug Info	Phase 3	Urothelial carcinoma
4	NLG8189	Drug Info	Phase 2/3	Melanoma
5	PF-06840003	Drug Info	Phase 1	Glioma
Preclinical Drug(s)	1 Preclinical Drug				1
1	1-methyl-L-tryptophan	Drug Info	Preclinical	Solid tumour/cancer

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT03388	Indoleamine 2,3-dioxygenase 1	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han