General Information of the Protein
| Protein ID |
PT03388
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| Protein Name |
Indoleamine 2,3-dioxygenase 1
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| Secondarily Protein Name |
Indoleamine-pyrrole 2,3-dioxygenase
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| Gene Name |
IDO1
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| Secondarily Gene Name |
Ido
Indo
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| Sequence |
MALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLIENGQLREEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASPAIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKCSSKLPEGLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMREYMPPAHRNFLFFLESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMKPSKKKPTDGDKSEEPSNVESRGTGGTNPMTFLRSVKDTTEKALLSWP
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| Organism |
Mus musculus, Mouse
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| Protein Classification |
Enzyme
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Oxidoreductase
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| Function |
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity (PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection (PubMed:15063630).
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| Uniprot ID | |||||
| Ensembl ID | |||||
| Subcellular Location |
Cytoplasm
Cytosol
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000087 , B16
Cell Line ID: CL000025 , HEK-293T
Cell Line ID: CL000006 , HEK293
Cell Line ID: CL000784 , P815B
Cell Line ID: CL000527 , Panc02
Biochemical Assays
| Compound ID | Compound Name | Compound Formula | |
| CP0670151 |
3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione
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C12H9FN2O2
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1 |
| 1 | IC50 = 1500 nM | ||
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Similar Protein(s) and Bioactivity Statistics
50% Identity
| Protein ID | Protein Name | Protein Organism | |
| PT01557 | Indoleamine 2,3-dioxygenase 1 | Homo sapiens, Human | |
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