Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one
    Show/Hide
 PubChem ID
CID: 5329098
SID: 14847387
Canonical SMILES
Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1
    Show/Hide
Compound Formula C15H14N2O
Compound Structure
Protein Name
 Protein Info 
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 12900 nM
   TI
   LI
   LO
   TS
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
ED50 = 930 nM
   TI
   LI
   LO
   TS
2
IC50 = 884 nM
   TI
   LI
   LO
   TS
CL000118 U-251MG
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 2430 nM
   TI
   LI
   LO
   TS
2
IC50 = 12000 nM
   TI
   LI
   LO
   TS
3
IC50 = 12900 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 110 nM
2 IC50 = 200 nM
3 IC50 = 220 nM
4 IC50 = 230 nM
5 IC50 = 700 nM
6 IC50 = 1000 nM
7 IC50 = 1230 nM
8 IC50 = 10600 nM
9 IC50 = 12900 nM