Brief Information of the Cell Line and Protein
Cell Line ID: CL000077 , Ba/F3
 Cell Line Info 
Synonyms
BA/F3
BaF3
BAF3
Baf3
Category Factor-dependent cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0161
Protein ID: PT07205 , Tyrosine-protein kinase Mer
 Protein Info 
Gene Name MERTK
Organism Mus musculus, Mouse
Protein Classification Enzyme
Uniprot ID Q60805
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000077
 Cell Line Info 
 Protein ID: PT07205
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0365521
 Compound Info 
N-[3-fluoro-4-[[7-(1-methylazetidin-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C31H31F2N7O4
  1
1
IC50 = 24 nM
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CP0365520
 Compound Info 
N-[4-[[6-(cyclopropanecarbonyl)-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C30H26F2N6O5
  1
1
IC50 = 34 nM
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CP0553459
 Compound Info 
1-cyclopentyl-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxamide
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C36H39F2N7O4
  1
1
IC50 = 34 nM
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CP0563698
 Compound Info 
N-[3-fluoro-4-[[6-[2-(1-methylpiperidin-4-yl)acetyl]-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C34H35F2N7O5
  1
1
IC50 = 39 nM
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CP0550346
 Compound Info 
1-(cyclopropylmethyl)-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxamide
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C35H37F2N7O4
  1
1
IC50 = 51 nM
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CP0569553
 Compound Info 
N-[3-fluoro-4-[[7-(1-methylpiperidin-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C33H35F2N7O4
  1
1
IC50 = 55 nM
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CP0553500
 Compound Info 
3-(4-fluorophenyl)-N-[4-[6-[[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]amino]pyrimidin-4-yl]oxyphenyl]-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C35H40FN9O5
  1
1
IC50 = 61 nM
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CP0491412
 Compound Info 
N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C34H37F2N7O4
  1
1
IC50 = 78 nM
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CP0550345
 Compound Info 
N-[4-[[7-[1-(cyclopropylmethyl)piperidin-4-yl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C36H39F2N7O4
  1
1
IC50 = 79 nM
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CP0572087
 Compound Info 
N-[3-fluoro-4-[[6-[(1-methylpiperidin-4-yl)methyl]-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C33H35F2N7O4
  1
1
IC50 = 80 nM
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CP0368963
 Compound Info 
N-[3-fluoro-4-[[7-[(1-methylazetidin-3-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C32H33F2N7O4
  1
1
IC50 = 92 nM
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CP0539200
 Compound Info 
N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-1-(2-methylpropyl)-2,4-dioxopyrimidine-5-carboxamide
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C35H39F2N7O4
  1
1
IC50 = 110 nM
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CP0553458
 Compound Info 
N-[3-fluoro-4-[[6-[2-(4-methylpiperazin-1-yl)acetyl]-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C33H34F2N8O5
  1
1
IC50 = 110 nM
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CP0562289
 Compound Info 
1-(2-fluoroethyl)-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxamide
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C33H34F3N7O4
  1
1
IC50 = 130 nM
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CP0568458
 Compound Info 
1-(cyclobutylmethyl)-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxamide
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C36H39F2N7O4
  1
1
IC50 = 130 nM
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CP0562288
 Compound Info 
N-[3-fluoro-4-[[7-[2-(1-methylpiperidin-4-yl)acetyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C35H37F2N7O5
  1
1
IC50 = 150 nM
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CP0563696
 Compound Info 
1-cyclopentyl-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(5-methylpyridin-2-yl)-2,4-dioxopyrimidine-5-carboxamide
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C36H41FN8O4
  1
1
IC50 = 180 nM
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CP0550347
 Compound Info 
1-(cyclopropylmethyl)-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(5-methylpyridin-2-yl)-2,4-dioxopyrimidine-5-carboxamide
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C35H39FN8O4
  1
1
IC50 = 210 nM
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CP0550344
 Compound Info 
N-[3-fluoro-4-[[6-(oxan-4-ylmethyl)-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C32H32F2N6O5
  1
1
IC50 = 240 nM
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CP0539198
 Compound Info 
N-[3-fluoro-4-[(6-oxo-5,7-dihydropyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C26H20F2N6O5
  1
1
IC50 = 280 nM
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CP0568643
 Compound Info 
3-(4-fluorophenyl)-N-[3-fluoro-4-[[6-(3-pyrrolidin-1-ylpropanoyl)-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C33H33F2N7O5
  1
1
IC50 = 280 nM
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CP0563477
 Compound Info 
3-(4-fluorophenyl)-N-[3-fluoro-4-[[7-(3-pyrrolidin-1-ylpropanoyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C34H35F2N7O5
  1
1
IC50 = 290 nM
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CP0568457
 Compound Info 
N-[4-[[7-[2-(azetidin-1-yl)-2-oxoethyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C32H31F2N7O5
  1
1
IC50 = 370 nM
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CP0571003
 Compound Info 
N-[3-fluoro-4-[[7-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C34H36F2N8O5
  1
1
IC50 = 370 nM
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CP0368962
 Compound Info 
N-[4-[[7-(cyclobutanecarbonyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C32H30F2N6O5
  1
1
IC50 = 440 nM
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CP0565414
 Compound Info 
N-[3-fluoro-4-[(7-methyl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl)oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C28H26F2N6O4
  1
1
IC50 = 570 nM
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CP0368965
 Compound Info 
N-[3-fluoro-4-[[7-(1-methylpiperidine-4-carbonyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C34H35F2N7O5
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1
IC50 = 630 nM
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CP0564987
 Compound Info 
N-[3-fluoro-4-[[6-(2-morpholin-4-ylacetyl)-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C32H31F2N7O6
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1
IC50 = 730 nM
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CP0565415
 Compound Info 
N-[3-fluoro-4-[(6-methyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl)oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C28H26F2N6O4
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1
IC50 = 810 nM
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CP0539199
 Compound Info 
N-[3-fluoro-4-[[7-(2-morpholin-4-ylacetyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C33H33F2N7O6
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1
IC50 = 910 nM
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CP0568456
 Compound Info 
N-[3-fluoro-4-[(6-methyl-5,7-dihydropyrrolo[3,4-d]pyrimidin-4-yl)oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
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C27H24F2N6O4
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1
IC50 = 2600 nM
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CP0562062
 Compound Info 
1-cyclopropyl-N-[3-fluoro-4-[[7-[(1-methylpiperidin-4-yl)methyl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxamide
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C34H35F2N7O4
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1
IC50 = 4110 nM
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