Brief Information of the Cell Line and Protein
Cell Line ID: CL000077 , Ba/F3
Synonyms
BA/F3
BaF3
BAF3
Baf3
Category Factor-dependent cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0161
Protein ID: PT00951 , Proto-oncogene tyrosine-protein kinase receptor Ret
Gene Name RET
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P07949
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000077  Protein ID: PT00951
 
Compound ID Compound Name Compound Formula
CP0046394
BMS-907351
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C28H24FN3O5
 5
1
GI50 = 10 nM
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2
GI50 = 50 nM
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3
GI50 = 890 nM
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4
GI50 = 910 nM
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5
IC50 = 180 nM
   TI
   LI
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CP0065824
3-(5-cyclopropyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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C14H16N6O
 4
1
GI50 = 80 nM
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2
GI50 = 90 nM
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3
GI50 = 320 nM
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4
GI50 = 500 nM
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CP0421231
N-[[1-[4-[[3-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]carbamoylamino]-2-(trifluoromethyl)phenyl]piperidin-4-yl]methyl]propanamide
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C34H36F3N5O5
 1
1
GI50 = 120 nM
   TI
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CP0441015
N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]propanamide
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C30H31F3N6OS
 1
1
GI50 = 200 nM
   TI
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CP0062729
3-(2-phenylethynyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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C16H15N5
 4
1
GI50 = 350 nM
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2
GI50 = 610 nM
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3
GI50 = 2600 nM
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4
GI50 = 5430 nM
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CP0230028
3-(5-cyclopropyl-1,2-oxazol-3-yl)-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine
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C16H18N6O2
 2
1
GI50 = 440 nM
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2
GI50 = 1930 nM
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CP0156701
1-cyclohexyl-3-(5-cyclopropyl-1,2-oxazol-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine
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C17H20N6O
 2
1
GI50 = 520 nM
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2
GI50 = 2000 nM
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CP0065873
1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone
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C26H29N7O2
 1
1
GI50 = 650 nM
   TI
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CP0140879
1-propan-2-yl-3-(5-pyridin-2-yl-1,2-oxazol-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine
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C16H15N7O
 2
1
GI50 = 700 nM
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2
GI50 = 1110 nM
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CP0156708
3-(5-ethyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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C13H16N6O
 2
1
GI50 = 1560 nM
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2
GI50 = 5770 nM
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CP0364644
1-[4-amino-3-(5-cyclopropyl-1,2-oxazol-3-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropan-2-ol
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C15H18N6O2
 2
1
GI50 = 1770 nM
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2
GI50 = 6750 nM
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CP0083897
1-propan-2-yl-3-(5-propan-2-yl-1,2-oxazol-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine
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C14H18N6O
 2
1
GI50 = 2400 nM
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2
GI50 = 5900 nM
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CP0095871
3-(5-cyclopropyl-1,2-oxazol-3-yl)-1-methylpyrazolo[3,4-d]pyrimidin-4-amine
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C12H12N6O
 2
1
GI50 = 2670 nM
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2
GI50 = 5560 nM
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CP0106777
3-(1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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C11H12N6O
 2
1
GI50 = 3210 nM
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2
GI50 = 8940 nM
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CP0304455
3-(5-phenyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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C17H16N6O
 2
1
GI50 = 3460 nM
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2
GI50 = 4970 nM
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CP0071780
3-(5-cyclohexyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C17H22N6O
 2
1
GI50 = 4730 nM
   TI
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2
GI50 = 9500 nM
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CP0089052
3-(5-cyclopropyl-1,2-oxazol-3-yl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
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C11H10N6O
 2
1
GI50 = 5340 nM
   TI
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2
GI50 > 10000 nM
   TI
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CP0174992
3-(5-tert-butyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C15H20N6O
 2
1
GI50 = 6120 nM
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2
GI50 = 7310 nM
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CP0309740
3-(5-phenyl-4,5-dihydro-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C17H18N6O
 2
1
GI50 = 6240 nM
   TI
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2
GI50 > 10000 nM
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CP0198875
3-(5-cyclopentyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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C16H20N6O
 2
1
GI50 = 7120 nM
   TI
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2
GI50 > 10000 nM
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CP0198308
3-[(E)-phenylmethoxyiminomethyl]-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C16H18N6O
 2
1
GI50 = 7410 nM
   TI
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2
GI50 > 10000 nM
   TI
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CP0095875
1-benzyl-3-(5-cyclopropyl-1,2-oxazol-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C18H16N6O
 1
1
GI50 > 10000 nM
   TI
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CP0174991
3-(5-benzyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C18H18N6O
 1
1
GI50 > 10000 nM
   TI
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CP0174993
3-(5-cyclopropyl-1,2-oxazol-3-yl)-1-heptylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C18H24N6O
 1
1
GI50 > 10000 nM
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CP0181070
3-[5-(4-fluorophenyl)-1,2-oxazol-3-yl]-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
   Show/Hide
C17H15FN6O
 1
1
GI50 > 10000 nM
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CP0401663
(NE)-N-[(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)methylidene]hydroxylamine
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C9H12N6O
 1
1
GI50 > 10000 nM
   TI
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CP0061016
3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenol
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C17H18N4O
 1
1
IC50 = 4 nM
   TI
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CP0388620
methyl N-[4-[7-amino-3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxypyrazolo[1,5-a]pyrimidin-6-yl]phenyl]carbamate
   Show/Hide
C28H32N6O5
 1
1
IC50 = 6 nM
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CP0418567
3-[4-amino-7-[3-(hydroxymethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-5-yl]phenol
   Show/Hide
C17H18N4O2
 1
1
IC50 = 51 nM
   TI
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CP0165616
N-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N',N'-dimethylpropane-1,3-diamine
   Show/Hide
C18H21N5O2
 2
1
IC50 = 110 nM
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2
IC50 = 4000 nM
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CP0388616
3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine
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C26H29N5O3
 1
1
IC50 = 170 nM
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CP0388615
3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-(1,3-thiazol-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
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C23H26N6O3S
 1
1
IC50 = 210 nM
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CP0081362
4-fluoro-2-[5-[[(1R)-2-hydroxy-1-phenylethyl]amino]-3-(3-methyl-2H-indazol-5-yl)pyridin-2-yl]phenol
   Show/Hide
C27H23FN4O2
 1
1
IC50 = 315.7 nM
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CP0356495
N-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N',N'-dimethylethane-1,2-diamine
   Show/Hide
C17H19N5O2
 1
1
IC50 = 740 nM
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CP0138866
1-[4-[3-[4-amino-5-(2-fluoro-5-hydroxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone
   Show/Hide
C22H25FN6O2
 1
1
IC50 = 920 nM
   TI
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CP0476295
3-(1,3-benzodioxol-5-yl)-N-(pyridin-2-ylmethyl)pyrazolo[1,5-a]pyrimidin-5-amine
   Show/Hide
C19H15N5O2
 1
1
IC50 = 1100 nM
   TI
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CP0225753
3-(1,3-benzodioxol-5-yl)-N-(piperidin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-5-amine
   Show/Hide
C19H21N5O2
 1
1
IC50 = 1300 nM
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CP0019908
BDBM50242742
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C30H40ClN7O3S
 1
1
IC50 = 1385 nM
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CP0037988
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
   Show/Hide
C22H24BrFN4O2
 1
1
IC50 = 1500 nM
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CP0356492
3-(1,3-benzodioxol-5-yl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-5-amine
   Show/Hide
C19H15N5O2
 1
1
IC50 = 1500 nM
   TI
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CP0225749
3-(1H-indazol-6-yl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-5-amine
   Show/Hide
C19H15N7
 1
1
IC50 = 2800 nM
   TI
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CP0661487
3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea monophosphate
   Show/Hide
C26H34Cl2N7O7P
 1
1
IC50 = 3352 nM
   TI
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CP0385508
2-[4-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acid
   Show/Hide
C27H28FN7O2
 1
1
IC50 = 3700 nM
   TI
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CP0462095
4-[5-(pyridin-2-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide
   Show/Hide
C19H16N6O
 1
1
IC50 = 3700 nM
   TI
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CP0237973
4-[5-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide
   Show/Hide
C19H16N6O
 1
1
IC50 = 3900 nM
   TI
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   TS
CP0551221
4-[5-(pyridin-4-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide
   Show/Hide
C19H16N6O
 1
1
IC50 = 4400 nM
   TI
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CP0388864
4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile
   Show/Hide
C20H15N5
 1
1
IC50 = 4900 nM
   TI
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CP0385511
1-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol
   Show/Hide
C26H27FN6O
 1
1
IC50 = 6000 nM
   TI
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   TS
CP0088325
2-[[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]amino]ethanol
   Show/Hide
C15H14N4O3
 1
1
IC50 = 6800 nM
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CP0395047
6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-pyridin-2-ylimidazo[1,2-b]pyridazine
   Show/Hide
C21H18FN5
 1
1
IC50 = 8000 nM
   TI
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CP0160448
4-[5-(pyridin-4-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzenesulfonamide
   Show/Hide
C18H16N6O2S
 1
1
IC50 > 10000 nM
   TI
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CP0575427
4-[5-[2-(dimethylamino)ethylamino]pyrazolo[1,5-a]pyrimidin-3-yl]benzamide
   Show/Hide
C17H20N6O
 1
1
IC50 > 10000 nM
   TI
   LI
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   TS