Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(5-cyclopropyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
    Show/Hide
 PubChem ID
CID: 126591927
Canonical SMILES
CC(C)n1nc(-c2cc(on2)C2CC2)c2c(N)ncnc12
    Show/Hide
Compound Formula C14H16N6O
Compound Structure
Protein Name
 Protein Info 
Proto-oncogene tyrosine-protein kinase receptor Ret
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Ret family
Uniprot ID
P07949
Gene Name
RET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  4
1
GI50 = 80 nM
   TI
   LI
   LO
   TS
2
GI50 = 90 nM
   TI
   LI
   LO
   TS
3
GI50 = 320 nM
   TI
   LI
   LO
   TS
4
GI50 = 500 nM
   TI
   LI
   LO
   TS
CL000425 TT
 Cell Line Info 
Homo sapiens (Human)  1
1
GI50 = 240 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.4 nM
2 IC50 = 2 nM
3 IC50 = 3 nM
4 IC50 = 4 nM
5 IC50 = 6 nM
6 IC50 = 10 nM
7 IC50 = 21 nM