| Compound ID |
Compound Name |
Compound Formula |
|
CP0408514
|
N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-3-tert-butylbenzamide
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|
C27H28N4O2
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0148909
|
N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C30H31F3N6O2
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0110489
|
N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C24H19F3N4O2
|
1
|
| 1 |
EC50 = 230 nM
|
|
|
|
CP0548229
|
N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-3-[(2S)-2,4-dimethylpiperazin-1-yl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C30H31F3N6O2
|
1
|
| 1 |
EC50 = 240 nM
|
|
|
|
CP0429721
|
N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-3-chlorobenzamide
Show/Hide
|
C23H19ClN4O2
|
1
|
| 1 |
EC50 = 480 nM
|
|
|
|
CP0148908
|
N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]benzamide
Show/Hide
|
C23H20N4O2
|
1
|
| 1 |
EC50 = 540 nM
|
|
|
|
CP0086011
|
N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-4-(trifluoromethyl)pyridine-2-carboxamide
Show/Hide
|
C23H18F3N5O2
|
1
|
| 1 |
EC50 = 770 nM
|
|
|
|
CP0548228
|
N-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methylphenyl]-6-(trifluoromethyl)pyridine-2-carboxamide
Show/Hide
|
C23H18F3N5O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0095082
|
DABRAFENIB
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|
C23H20F3N5O2S2
|
3
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
| 3 |
IC50 = 11 nM
|
|
|
|
CP0313189
|
US10568884, Cpd 5
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|
C24H32ClN7O4S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0652560
|
N5-(3-(9H-Purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine dihydrochloride
Show/Hide
|
C26H22Cl4N8
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0194557
|
pyridylpurine aminoisoquinoline, 1
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|
C26H19ClN8
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0230652
|
US10568884, Cpd 9
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|
C22H27ClFN7O4S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0897715
|
N-(5-chloro-3-(4-(2-(2-cyanoethylamino)pyrimidin-4-yl)-1-isopropyl-1H-pyrazol-3-yl)-2-fluorophenyl)methanesulfonamide
Show/Hide
|
C20H21ClFN7O2S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0947362
|
methyl(2S)-1-(4-(3-(5-chloro-3-(cyclopropanesulfonamido)-2-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate
Show/Hide
|
C24H29ClFN7O4S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0963330
|
methyl(2S)-1-(4-(3-(2-fluoro-3-(propylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate
Show/Hide
|
C24H32FN7O4S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0963331
|
Methyl N-[(2S)-1-[(4-{3-[5-chloro-2-fluoro-3-(propane-1-sulfonamido)phenyl]-1-(propan-2-yl)-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]propan-2-yl]carbamate
Show/Hide
|
C24H31ClFN7O4S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0215822
|
US10568884, Cpd 10
Show/Hide
|
C22H27F2N7O4S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0543036
|
US10568884, Cpd 11
Show/Hide
|
C21H25ClFN7O4S
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0774622
|
(R)-3-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethylamino)cyclohex-2-enone
Show/Hide
|
C27H25N5O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0293830
|
US10568884, Cpd 15
Show/Hide
|
C22H27ClFN7O4S
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0293831
|
US10568884, Cpd 12
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|
C23H30FN7O4S
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0762491
|
(R)-3-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethylamino)cyclopent-2-enone
Show/Hide
|
C26H23N5O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0112871
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1H-pyrazole-4-sulfonamide
Show/Hide
|
C19H13F2N9O2S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0123967
|
US10568884, Cpd 13
Show/Hide
|
C23H30ClN7O4S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0950226
|
methyl(2S)-1-(4-(3-(2,5-dichloro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate
Show/Hide
|
C22H27Cl2N7O4S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0463269
|
3-(dimethylamino)-N-[4-methyl-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]benzamide
Show/Hide
|
C26H24N8O
|
1
|
| 1 |
IC50 = 6.31 nM
|
|
|
|
CP0684485
|
(S)-1-(3-tert-butylisoxazol-5-yl)-3-(2-fluoro-5-(7-(methylamino)-2-oxo-1-(tetrahydrofuran-3-yl)-1,2-dihydro-1,6-naphthyridin-3-yl)phenyl)urea
Show/Hide
|
C27H29FN6O4
|
1
|
| 1 |
IC50 = 6.8 nM
|
|
|
|
CP0237053
|
US9216981, 4
Show/Hide
|
C20H13F2N7O2S2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0321080
|
US10568884, Cpd 20
Show/Hide
|
C22H27ClFN7O4S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0923151
|
Methyl N-[(2S)-1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1-(oxan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate
Show/Hide
|
C24H29ClFN7O5S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0302663
|
N-(4-chloro-3-methylphenyl)-4-methyl-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]benzamide
Show/Hide
|
C25H20ClN7O
|
1
|
| 1 |
IC50 = 7.13 nM
|
|
|
|
CP0751178
|
(R)-4-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethylamino)-5,6-dihydropyridin-2(1H)-one
Show/Hide
|
C26H24N6O
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0311821
|
US10568884, Cpd 7
Show/Hide
|
C24H31F2N7O4S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0868521
|
(R)-N-(1-(4-(8-Methoxy-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethyl)acetamide
Show/Hide
|
C24H23N5O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0090716
|
US9216981, 30
Show/Hide
|
C21H14F2N8O2S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0537642
|
4-methyl-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide
Show/Hide
|
C25H18F3N7O
|
1
|
| 1 |
IC50 = 10.4 nM
|
|
|
|
CP0089446
|
2-amino-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide
Show/Hide
|
C25H22F3N5O2
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0090745
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclopentanesulfonamide
Show/Hide
|
C21H19F2N7O2S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0029366
|
US8497274, 32
Show/Hide
|
C27H18F4N4O3S
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0240290
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2-fluorobenzenesulfonamide
Show/Hide
|
C22H14F3N7O2S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0950608
|
methyl(2S)-1-(4-(3-(2-chloro-3-(ethylsulfonamido)-4,5-difluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate
Show/Hide
|
C23H28ClF2N7O4S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0361445
|
US10568884, Cpd 34
Show/Hide
|
C24H31F2N7O4S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0349987
|
US10568884, Cpd 26
Show/Hide
|
C23H29F2N7O4S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0082329
|
4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide
Show/Hide
|
C24H18F3N5O
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0068741
|
3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]benzamide
Show/Hide
|
C27H25N5O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0174503
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-fluorobenzenesulfonamide
Show/Hide
|
C22H14F3N7O2S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0006321
|
PLX-4032
Show/Hide
|
C23H18ClF2N3O3S
|
6
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 33.1 nM
|
|
|
| 3 |
IC50 = 127 nM
|
|
|
| 4 |
IC50 = 150 nM
|
|
|
| 5 |
IC50 = 190 nM
|
|
|
| 6 |
IC50 = 260 nM
|
|
|
|
CP0108608
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2-methylpropane-1-sulfonamide
Show/Hide
|
C20H19F2N7O2S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0845823
|
rac-(3-(5-aminopyridin-3-yl)-5-(2-fluoro-6-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone
Show/Hide
|
C24H18FN5O2S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0313190
|
US10568884, Cpd 2
Show/Hide
|
C22H28ClN7O4S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0847663
|
rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(isoindolin-5-yl)thiophen-2-yl)methanone
Show/Hide
|
C27H22N4O2S
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0351712
|
4-methyl-N-(3-propan-2-ylphenyl)-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]benzamide
Show/Hide
|
C27H25N7O
|
1
|
| 1 |
IC50 = 19.1 nM
|
|
|
|
CP0667325
|
(R)-N-(1-(4-(8-Chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)-phenyl)ethyl)acetamide
Show/Hide
|
C23H20ClN5O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0920884
|
rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1,2,3,4-tetrahydroisoquinolin-7-yl)thiophen-2-yl)methanone
Show/Hide
|
C28H23FN4O2S
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0932302
|
rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1,2,3,4-tetrahydroisoquinolin-6-yl)thiophen-2-yl)methanone
Show/Hide
|
C28H24N4O2S
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0432241
|
1-(3-tert- butyl-1- phenyl-1H- pyrazol-5- yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
|
C30H30N6O4
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0087453
|
aminoquinazoline, 19
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|
C27H29N7
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0664425
|
1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-((S)-2-hydroxy-3,3-dimethylbutyl)urea
Show/Hide
|
C24H30FN5O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0464499
|
US9593100, Compound 24
Show/Hide
|
C24H29F2N7O4S
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0265728
|
US9216981, 5
Show/Hide
|
C19H17F2N7O2S
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0847662
|
rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1,2,3,4-tetrahydroisoquinolin-7-yl)thiophen-2-yl)methanone
Show/Hide
|
C28H24N4O2S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0481879
|
5-amino-4-(3-chloro-5-hydroxyphenyl)-2-(cyclopropylamino)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
|
C16H14ClN5O2S
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0666215
|
(R)-N-(1-(4-(7-Methoxy-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethyl)acetamide
Show/Hide
|
C24H23N5O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0838246
|
(R)-1-(2-Hydroxyethyl)-N-((R)-1-(4-(6-(pyridin-4-yl)-quinazolin-2 ylamino)phenyl)ethyl)piperidine-2-carboxamide
Show/Hide
|
C29H32N6O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0838247
|
(R)-N-(1-(4-(8-Methyl-6-(pyridin-4-yl)quinazolin-2-ylamino)-phenyl)ethyl)acetamide
Show/Hide
|
C24H23N5O
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0074825
|
aminoisoquinoline, 15
Show/Hide
|
C28H23N7
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0074823
|
aminoquinazoline, 20
Show/Hide
|
C29H26N6O
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0074828
|
4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide
Show/Hide
|
C24H19F3N4O
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0698141
|
1-(3,3-Dimethylbutyl)-3-[2-fluoro-4-methyl-5-(2-methylaminopyrido[2,3-d]pyrimidin-6-yl)phenyl]urea
Show/Hide
|
C22H27FN6O
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0096017
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]butane-2-sulfonamide
Show/Hide
|
C20H19F2N7O2S
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0942369
|
methyl(2S)-1-(4-(3-(2-fluoro-3-(3,3,3-trifluoropropylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate
Show/Hide
|
C24H29F4N7O4S
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0218262
|
US9216981, 35
Show/Hide
|
C22H15F2N7O2S
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0074821
|
aminoisoquinoline, 16
Show/Hide
|
C28H24N8S
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0056223
|
N-(3-cyanophenyl)-4-methyl-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]benzamide
Show/Hide
|
C25H18N8O
|
1
|
| 1 |
IC50 = 29.4 nM
|
|
|
|
CP0920886
|
rac-(3-(5-aminopyridin-3-yl)-5-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone
Show/Hide
|
C24H19N5O2S
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0672877
|
1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea
Show/Hide
|
C23H29FN6O
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
IC50 = 37 nM
|
|
|
|
CP0096018
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]oxolane-3-sulfonamide
Show/Hide
|
C20H17F2N7O3S
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0198701
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1,3-thiazole-2-sulfonamide
Show/Hide
|
C19H12F2N8O2S2
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0132019
|
US10568884, Cpd 32
Show/Hide
|
C22H27ClFN7O4S
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0536419
|
1-cyclopropyl-N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]methanesulfonamide
Show/Hide
|
C20H17F2N7O2S
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0215823
|
US10568884, Cpd 4
Show/Hide
|
C22H28FN7O4S
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0166667
|
aminoisoquinoline, 12b
Show/Hide
|
C25H19ClN6
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0847666
|
rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1,2,3,4-tetrahydroisoquinolin-6-yl)thiophen-2-yl)methanone
Show/Hide
|
C28H23FN4O2S
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0666154
|
(R)-N-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethyl)acetamide
Show/Hide
|
C23H21N5O
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0066994
|
3-(1-methylpyrazol-4-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;hydrochloride
Show/Hide
|
C30H27ClF3N5O3
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0074827
|
aminoisoquinoline, 13
Show/Hide
|
C26H22ClN7
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0459769
|
1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- 6-(3- morpholino- propoxy) quinazolin-4- yloxy)phenyl) urea
Show/Hide
|
C30H36N6O6
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0847665
|
rac-(5-(4-(aminomethyl)phenyl)thiophen-2-yl)(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
|
C26H21FN4O2S
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0121694
|
3-(1H-imidazol-5-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C29H24F3N5O3
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0904821
|
rac-(3-(5-(hydroxymethyl)pyridin-3-yl)-5-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone
Show/Hide
|
C25H20N4O3S
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0910581
|
N-(5-chloro-6-methylpyridin-3-yl)-5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylbenzamide
Show/Hide
|
C25H23ClN4O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0677468
|
1-(3,3-dimethylbutyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea
Show/Hide
|
C25H32FN5O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0036068
|
1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
Show/Hide
|
C24H16F6N6O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0240291
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2,2,2-trifluoroethanesulfonamide
Show/Hide
|
C18H12F5N7O2S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0261168
|
US9216981, 11
Show/Hide
|
C22H21F2N7O2S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0932303
|
rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(3-(pyrrolidin-1-ylmethyl)phenyl)thiophen-2-yl)methanone
Show/Hide
|
C30H27FN4O2S
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0237056
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclobutanesulfonamide
Show/Hide
|
C20H17F2N7O2S
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0074822
|
aminoisoquinoline, 14
Show/Hide
|
C27H22N8
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0211509
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyrrolidine-1-sulfonamide
Show/Hide
|
C20H18F2N8O2S
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0682225
|
3-Methoxy-N-methyl-N-(4-(6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)propanamide
Show/Hide
|
C24H23N5O2
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0691681
|
(R)-N-((R)-1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)-phenyl)ethyl)piperidine-2-carboxamide
Show/Hide
|
C27H28N6O
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0898127
|
(R)-1-methyl-N-((R)-1-(4-(6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethyl)piperidine-2-carboxamide
Show/Hide
|
C28H30N6O
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0866616
|
3-((methylamino)methyl)-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide dihydrochloride
Show/Hide
|
C28H29Cl2F3N4O3
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0129307
|
US9216981, 1
Show/Hide
|
C19H17F2N7O2S
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0897714
|
methyl(2S)-1-(4-(1-isopropyl-3-(2,4,5-trifluoro-3-(methylsulfonamido)phenyl)-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate
Show/Hide
|
C22H26F3N7O4S
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0367309
|
US10568884, Cpd 6
Show/Hide
|
C22H27F2N7O4S
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0724068
|
1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea
Show/Hide
|
C24H30FN5O
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0746008
|
3-((dimethylamino)methyl)-N-{(2R)-[7-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide dihydrochloride
Show/Hide
|
C29H31Cl2F3N4O3
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0875477
|
N-(4-{1-[(2-Methoxyethyl)amino]ethyl}phenyl)-6-pyridin-4-ylquinazolin-2-amine
Show/Hide
|
C24H25N5O
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0502499
|
1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- 6-(2- morpholino- ethoxy) quinazolin-4- yloxy)phenyl) urea
Show/Hide
|
C29H34N6O6
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0094505
|
aminoisoquinoline, 12a
Show/Hide
|
C26H19F3N6
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0215627
|
6-[2-[3-(dimethylsulfamoylamino)-2,6-difluoroanilino]pyridin-3-yl]-7H-purine
Show/Hide
|
C18H16F2N8O2S
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0920288
|
rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1-methyl-1H-pyrazol-4-yl)thiophen-2-yl)methanone
Show/Hide
|
C23H18FN5O2S
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0328705
|
N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-3-(1H-pyrazol-4-yl)-5-(trifluoromethyl)benzamide;hydrochloride
Show/Hide
|
C29H25ClF3N5O3
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0847668
|
rac-(5-(2-(aminomethyl)phenyl)thiophen-2-yl)(3-(5-aminopyridin-3-yl)-5-(2-fluoro-6-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
|
C26H22FN5O2S
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0066993
|
3-(ethylaminomethyl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;dihydrochloride
Show/Hide
|
C29H31Cl2F3N4O3
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0690756
|
3-(2-aminopropan-2-yl)-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide dihydrochloride
Show/Hide
|
C29H31Cl2F3N4O3
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0898128
|
N-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethyl)-acetamide
Show/Hide
|
C23H21N5O
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0505631
|
1-(5-tert- butylisoxazol- 3-yl)-3-{3- [7-methoxy- 6-(2- methoxyethoxy) quinolazin-4- yloxy]phenyl} urea hydrochloride
Show/Hide
|
C26H29N5O6
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0845822
|
rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(isoindolin-5-yl)thiophen-2-yl)methanone
Show/Hide
|
C27H21FN4O2S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0756961
|
3-Methoxy-N-((1R)-1-{4-[(6-pyridin-4-ylquinazolin-2-yl)-amino]phenyl}ethyl)propanamide
Show/Hide
|
C25H25N5O2
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0845181
|
Benzo[d]imidazo[2,1-b]thiazol-2-yl-[5-(2-hydroxy-phenyl)-3-pyridin-3-yl-4,5-dihydro-pyrazol-1-yl]-methanone
Show/Hide
|
C24H17N5O2S
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0508268
|
1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6,7- dimethoxy- quinalozin- 4-yloxy)phenyl) urea
Show/Hide
|
C24H24FN5O5
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0863937
|
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(1-phenyl-3-(1,1,1-trifluoro-2-methylpropan-2-yl)-1H-pyrazol-5-yl)urea
Show/Hide
|
C30H27F3N6O4
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0920885
|
rac-N-(5-(5-(2-hydroxyphenyl)-1-(5-(pyridin-2-yl)thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl)pyridin-3-yl)acetamide
Show/Hide
|
C26H21N5O3S
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0731363
|
N-Methyl-N-{4-[(6-pyridin-4-ylquinazolin-2-yl)amino]-phenyl}acetamide
Show/Hide
|
C22H19N5O
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0828631
|
(R)-5-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethylamino)-1,2-dihydropyridin-3(6H)-one
Show/Hide
|
C26H24N6O
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0261167
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2,2-dimethylpropane-1-sulfonamide
Show/Hide
|
C21H21F2N7O2S
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0941531
|
rac-(5-(2-(aminomethyl)phenyl)thiophen-2-yl)(3-(5-aminopyridin-3-yl)-5-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
|
C26H23N5O2S
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0112627
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]piperidine-1-sulfonamide
Show/Hide
|
C21H20F2N8O2S
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0066996
|
3-(1-aminocyclobutyl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;dihydrochloride
Show/Hide
|
C30H31Cl2F3N4O3
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0132018
|
US10568884, Cpd 30
Show/Hide
|
C17H18ClFN6O2S
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0873277
|
3-Methoxy-N-(1-{4-[(6-pyridin-4-ylquinazolin-2-yl)amino]-phenyl}ethyl)propanamide
Show/Hide
|
C25H25N5O2
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0666214
|
(R)-N-((R)-1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)-phenyl)ethyl)pyrrolidine-2-carboxamide
Show/Hide
|
C26H26N6O
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0122153
|
3-(2-methylpyrazol-3-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;hydrochloride
Show/Hide
|
C30H27ClF3N5O3
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0354458
|
US10568884, Cpd 29
Show/Hide
|
C18H20ClFN6O2S
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0134276
|
US10245267, Example 1156
Show/Hide
|
C25H25F3N4O4
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0919433
|
methyl(2S)-1-(4-(3-(3-chloro-2-(methylsulfonamido)pyridin-4-yl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate
Show/Hide
|
C21H27ClN8O4S
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0894348
|
rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone
Show/Hide
|
C24H17FN4O2S
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0521802
|
1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-ethoxy-7- methoxy- quinazolin- 4-yloxy)phenyl) urea
Show/Hide
|
C25H27N5O5
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0894347
|
rac-(5-(4-(aminomethyl)phenyl)thiophen-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
|
C26H22N4O2S
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0490284
|
1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl]urea
Show/Hide
|
C24H26N6O4
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0113988
|
CEP-32496
Show/Hide
|
C24H22F3N5O5
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0683654
|
1-(3,3-Dimethylbutyl)-3-(2-fluoro-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea
Show/Hide
|
C23H28FN5O
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0436003
|
1-(3-(6,7- dimethoxy- quinazolin- 4- ylthio)phenyl)- 3- (3-(2- fluoropropan-2- yl)isoxazol-5-yl) urea
Show/Hide
|
C23H22FN5O4S
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0853235
|
rac-(5-(2-(aminomethyl)phenyl)thiophen-2-yl)(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
|
C26H21FN4O2S
|
1
|
| 1 |
IC50 = 85 nM
|
|
|
|
CP0508016
|
1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-hydroxy- 7- methoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
|
C23H23N5O5
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0376263
|
6-[2-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluoroanilino]pyridin-3-yl]-7H-purine
Show/Hide
|
C19H18F2N8O2S
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0888596
|
rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1-methyl-1H-pyrazol-4-yl)thiophen-2-yl)methanone
Show/Hide
|
C23H19N5O2S
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0873279
|
N-(2-Methoxyethyl)-4-{[6-(4-methylpyridin-3-yl)quinazolin-2-yl]amino}benzamide
Show/Hide
|
C24H23N5O2
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0416084
|
1-[5-(1,3- difluoro-2- methylpropan- 2- yl)isoxazol- 3-yl]-3- [3- (6,7- dimethoxy- quinazolin- 4- ylthio)phenyl] urea
Show/Hide
|
C24H23F2N5O4S
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0132016
|
US10568884, Cpd 19
Show/Hide
|
C22H27F2N7O4S
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0490286
|
1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- 7-(3- morpholino- propoxy) quinazolin-4- yloxy)phenyl) urea
Show/Hide
|
C30H36N6O6
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0683304
|
1-(3-tert-butylisoxazol-5-yl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)urea
Show/Hide
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C25H27FN6O3
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1
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| 1 |
IC50 = 96 nM
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CP0023349
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N-[3-[2-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]phenyl]-3-(trifluoromethyl)benzamide
Show/Hide
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C24H19F3N6O
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1
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| 1 |
IC50 = 97 nM
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CP0531752
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1-(5-tert- Butylisoxazol- 3-yl)-3-{3- [6-methoxy- 7-(2- methoxy- quinazolin- 4-yloxy]phenyl} urea hydrochloride
Show/Hide
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C26H29N5O6
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1
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| 1 |
IC50 = 100 nM
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CP0863895
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1-(3-tert-Butylisoxazol-5-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea
Show/Hide
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C24H25N5O5
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1
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| 1 |
IC50 = 101 nM
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CP0481876
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5-amino-4-(3-chloro-5-hydroxyphenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino]thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C17H18ClN5O3S
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1
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| 1 |
IC50 = 103 nM
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CP0443926
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1-[5-(1,3- difluoro-2- methylpropan-2- yl)isoxazol- 3-yl]-3-[3- (6,7- dimethoxy- quinazolin- 4- yloxy)phenyl] urea
Show/Hide
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C24H23F2N5O5
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1
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| 1 |
IC50 = 109 nM
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CP0920883
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rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(3-(pyrrolidin-1-ylmethyl)phenyl)thiophen-2-yl)methanone
Show/Hide
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C30H28N4O2S
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1
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| 1 |
IC50 = 110 nM
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CP0480258
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1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-hydroxy- 6- methoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
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C23H23N5O5
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1
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| 1 |
IC50 = 110 nM
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CP0722470
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1-(3,3-Dimethylbutyl)-3-(2-fluoro-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea
Show/Hide
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C22H27FN6O
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1
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| 1 |
IC50 = 110 nM
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CP0557672
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5-amino-2-(cyclopropylamino)-4-(2-fluoro-3-hydroxyphenyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C16H14FN5O2S
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1
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| 1 |
IC50 = 111 nM
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CP0476794
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1-(5-tert- butylisoxazol- 3-yl)-3-(5-(6,7- dimethoxy- quinazolin- 4-yloxy)-2- fluorophenyl) urea
Show/Hide
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C24H24FN5O5
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1
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| 1 |
IC50 = 113 nM
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CP0490287
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1-(5-tert- butylisoxazol- 3-yl)- 3-(5- (6,7- dimethoxy- quinazolin- 4- yloxy)-2,4- difluorophenyl) urea
Show/Hide
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C24H23F2N5O5
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1
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| 1 |
IC50 = 113 nM
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CP0503567
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1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6,7- dimethoxy- quinazolin- 4-ylthio)phenyl) urea
Show/Hide
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C24H25N5O4S
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1
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| 1 |
IC50 = 118 nM
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CP0847667
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rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(5-(hydroxymethyl)pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(isoindolin-5-yl)thiophen-2-yl)methanone
Show/Hide
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C28H23FN4O3S
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1
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| 1 |
IC50 = 120 nM
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CP0495328
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1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6,7- dimethoxy- quinazolin- 4-yloxy) phenyl) urea
Show/Hide
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C24H25N5O5
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1
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| 1 |
IC50 = 121 nM
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CP0223908
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N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-3-(1H-pyrazol-5-yl)-5-(trifluoromethyl)benzamide
Show/Hide
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C29H24F3N5O3
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1
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| 1 |
IC50 = 121 nM
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CP0328702
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3-(1-methylimidazol-4-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;dihydrochloride
Show/Hide
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C30H28Cl2F3N5O3
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1
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| 1 |
IC50 = 123 nM
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CP0919257
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(2-hydroxyphenyl)isoxazol-3-yl)methanone
Show/Hide
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C24H18N4O4
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1
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| 1 |
IC50 = 130 nM
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CP0098452
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N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pentane-2-sulfonamide
Show/Hide
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C21H21F2N7O2S
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1
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| 1 |
IC50 = 130 nM
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CP0522490
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1-(5- cyclopentyl- isoxazol- 3-yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
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C25H25N5O5
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1
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| 1 |
IC50 = 134 nM
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CP0904819
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rac-(5-(4-(hydroxymethyl)phenyl)thiophen-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C26H21N3O3S
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1
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| 1 |
IC50 = 140 nM
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CP0762528
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(S)-N-((R)-1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)-phenyl)ethyl)piperidine-3-carboxamide
Show/Hide
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C27H28N6O
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1
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| 1 |
IC50 = 140 nM
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CP0672878
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1-(3,3-dimethylbutyl)-3-(4-methyl-3-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)urea
Show/Hide
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C24H31N5O
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1
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| 1 |
IC50 = 140 nM
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CP0863959
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1-(3-(6,7-Dimethoxyquinazolin-4-ylthio)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Show/Hide
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C24H22F3N5O4S
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1
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| 1 |
IC50 = 142 nM
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CP0104718
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2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide
Show/Hide
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C17H17F2N5O4S
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1
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| 1 |
IC50 = 150 nM
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CP0935512
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1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(3-(2-fluoropropan-2-yl)isoxazol-5-yl)urea
Show/Hide
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C23H22FN5O5
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1
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| 1 |
IC50 = 155 nM
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CP0774614
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3-Methoxy-N-((1S)-1-{4-[(6-pyridin-4-ylquinazolin-2-yl)-amino]phenyl}ethyl)propanamide
Show/Hide
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C25H25N5O2
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1
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| 1 |
IC50 = 160 nM
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CP0511297
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1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-methoxy- 7-(2- morpholino- ethoxy) quinazolin-4- yloxy)phenyl) urea
Show/Hide
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C29H34N6O6
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1
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| 1 |
IC50 = 165 nM
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CP0666212
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N-[2-(1-Methylpyrrolidin-2-yl)ethyl]-4-[(6-pyridin-4-ylquinazolin-2-yl)amino]benzamide
Show/Hide
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C27H28N6O
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1
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| 1 |
IC50 = 170 nM
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CP0534025
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1-(5-tert- butylisoxazol- 3-yl)-3-[3- (7-ethoxy-6- methoxy- quinazolin- 4-yloxy)phenyl] urea hydrochloride
Show/Hide
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C25H27N5O5
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1
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| 1 |
IC50 = 173 nM
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CP0098453
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US9216981, 19
Show/Hide
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C19H15F2N7O2S
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1
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| 1 |
IC50 = 173 nM
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CP0443927
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1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(3- (1,1,1- trifluoro-2- methylpropan-2- yl)isoxazol-5-yl) urea
Show/Hide
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C24H22F3N5O5
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1
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| 1 |
IC50 = 174 nM
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CP0090717
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N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyridine-2-sulfonamide
Show/Hide
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C21H14F2N8O2S
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1
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| 1 |
IC50 = 177 nM
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CP0455026
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1-(5-tert- butylisoxdazol- 3-yl)- 3-(3-(6,7- dimethoxy- quinazolin- 4-yloxy)-2- methylphenyl) urea
Show/Hide
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C25H27N5O5
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1
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| 1 |
IC50 = 179 nM
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CP0904820
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rac-(5-(2-(aminomethyl)phenyl)thiophen-2-yl)(3-(5-fluoropyridin-3-yl)-5-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C26H21FN4O2S
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1
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| 1 |
IC50 = 180 nM
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CP0919005
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rac-(5-(2-fluoro-6-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(1,2,3,4-tetrahydroisoquinolin-5-yl)thiophen-2-yl)methanone
Show/Hide
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C28H23FN4O2S
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1
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| 1 |
IC50 = 180 nM
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CP0741062
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Methyl N-[(2S)-1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate
Show/Hide
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C19H21ClFN7O4S
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1
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| 1 |
IC50 = 180 nM
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CP0548519
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1-(3-(6,7- dimethoxy- quinazolin- 4-yloxy)phenyl)- 3-(5-(1- (trifluoromethyl) cyclopropyl) isoxazol-3-yl) urea
Show/Hide
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C24H20F3N5O5
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1
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| 1 |
IC50 = 183 nM
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CP0311242
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N-(3-bromo-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
Show/Hide
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C17H15BrF2N4O3S
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1
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| 1 |
IC50 = 190 nM
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CP0122866
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N-(2-methoxyethyl)-4-[(6-pyridin-4-ylquinazolin-2-yl)amino]benzamide
Show/Hide
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C23H21N5O2
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1
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| 1 |
IC50 = 190 nM
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CP0898411
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(S)-N-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethyl)acetamide
Show/Hide
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C23H21N5O
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1
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| 1 |
IC50 = 190 nM
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CP0134020
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(3S)-N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-hydroxypyrrolidine-1-sulfonamide
Show/Hide
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C20H18F2N8O3S
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1
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| 1 |
IC50 = 201 nM
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CP0524917
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5-amino-2-(cyclopropylamino)-4-(3-hydroxy-4-methylphenyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C17H17N5O2S
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1
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| 1 |
IC50 = 202 nM
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CP0174663
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3-[(1S)-1-amino-2-hydroxyethyl]-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;hydrochloride
Show/Hide
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C28H28ClF3N4O4
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1
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| 1 |
IC50 = 207 nM
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CP0853260
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rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(2-methylthiazol-4-yl)thiophen-2-yl)methanone
Show/Hide
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C23H18N4O2S2
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1
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| 1 |
IC50 = 210 nM
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CP0419493
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5-amino-2-(cyclopropylamino)-4-(3-hydroxyphenyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C16H15N5O2S
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1
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| 1 |
IC50 = 212 nM
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CP0474656
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1-(5-tert- butylisoxazol- 3-yl)-3- (2-chloro-5-(6,7- dimethoxy- quinazolin- 4-yloxy) phenyl)urea
Show/Hide
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C24H24ClN5O5
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1
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| 1 |
IC50 = 229 nM
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CP0725622
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N-[2-(Dimethylamino)ethyl]-4-[(6-pyridin-4-ylquinazolin-2-yl)amino]benzamide
Show/Hide
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C24H24N6O
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1
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| 1 |
IC50 = 230 nM
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CP0828634
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N-(4-{[(2-Methoxyethyl)(methyl)amino]methyl}phenyl)-6-pyridin-4-ylquinazolin-2-amine
Show/Hide
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C24H25N5O
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1
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| 1 |
IC50 = 230 nM
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CP0259109
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(3R)-N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-hydroxypyrrolidine-1-sulfonamide
Show/Hide
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C20H18F2N8O3S
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1
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| 1 |
IC50 = 233 nM
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CP0932402
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(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazol-5-yl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C26H21N5O4
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1
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| 1 |
IC50 = 240 nM
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CP0212890
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6-chloro-2-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide
Show/Hide
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C17H17ClFN5O4S
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1
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| 1 |
IC50 = 240 nM
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CP0134021
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N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-4-fluorobenzenesulfonamide
Show/Hide
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C22H14F3N7O2S
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1
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| 1 |
IC50 = 242 nM
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CP0328703
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3-[[3-(hydroxymethyl)morpholin-4-yl]methyl]-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide
Show/Hide
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C32H33F3N4O5
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1
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| 1 |
IC50 = 254 nM
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CP0461642
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N-(3-bromo-2H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
Show/Hide
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C16H14BrF2N5O3S
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1
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| 1 |
IC50 = 260 nM
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CP0087452
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aminoquinazoline, 18
Show/Hide
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C25H20ClN5
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1
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| 1 |
IC50 = 270 nM
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CP0853261
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rac-(5-(2-(aminomethyl)phenyl)thiophen-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C26H22N4O2S
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1
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| 1 |
IC50 = 270 nM
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CP0508817
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5-amino-4-(4-chloro-3-hydroxyphenyl)-2-(cyclopropylamino)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C16H14ClN5O2S
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1
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| 1 |
IC50 = 271 nM
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CP0066995
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3-(aminomethyl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;dihydrochloride
Show/Hide
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C27H27Cl2F3N4O3
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1
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| 1 |
IC50 = 274 nM
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CP0420835
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1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(3- (2- fluoropropan-2- yl)isoxazol- 5-yl) urea
Show/Hide
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C23H22FN5O5
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1
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| 1 |
IC50 = 276 nM
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CP0691692
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2-Fluoro-N-(2-methoxyethyl)-4-[(6-pyridin-4-ylquinazolin-2-yl)amino]benzamide
Show/Hide
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C23H20FN5O2
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1
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| 1 |
IC50 = 280 nM
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CP0443929
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1-(4-tert- butylphenyl)- 3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
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C27H28N4O4
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1
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| 1 |
IC50 = 290 nM
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CP0069736
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2,6-difluoro-3-(propylsulfonylamino)-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide
Show/Hide
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C17H16F2N4O3S
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1
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| 1 |
IC50 = 290 nM
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CP0503568
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1-(5-tert- butylisoxazol- 3-yl)-3-(3- (7-methoxy- 6-(2- (piperidin-1- yl)ethoxy) quinazolin-4- yloxy)phenyl) urea
Show/Hide
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C30H36N6O5
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1
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| 1 |
IC50 = 293 nM
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CP0121975
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US9216981, 21
Show/Hide
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C20H18F2N8O3S
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1
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| 1 |
IC50 = 293 nM
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CP0420538
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1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3- (3-(1- (trifluoromethyl) cyclobutyl) isoxazol- 5-yl)urea
Show/Hide
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C25H22F3N5O5
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1
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| 1 |
IC50 = 308 nM
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CP0420838
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1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(5- (1- methoxy-2- methylpropan-2- yl)isoxazol-3-yl) urea
Show/Hide
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C25H27N5O6
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1
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| 1 |
IC50 = 324 nM
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CP0524916
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5-amino-4-[3-[[4-(trifluoromethyl)phenyl]carbamoylamino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C21H15F3N6O2S
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1
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| 1 |
IC50 = 327 nM
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CP0666160
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4-[(6-Pyridin-4-ylquinazolin-2-yl)amino]-N-(2-pyrrolidin-1-ylethyl)benzamide
Show/Hide
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C26H26N6O
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1
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| 1 |
IC50 = 330 nM
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CP0390562
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5-amino-4-(2-fluoro-3-hydroxyphenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino]thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C17H18FN5O3S
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1
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| 1 |
IC50 = 332 nM
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CP0863894
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1-(3-(2-Cyanopropan-2-yl)isoxazol-5-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea
Show/Hide
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C24H22N6O5
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1
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| 1 |
IC50 = 332 nM
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CP0443928
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1-(3-tert- butylphenyl)- 3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
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C27H28N4O4
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1
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| 1 |
IC50 = 333 nM
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CP0420834
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1-(3-tert- butyl-1- methyl-1H- pyrazol-5- yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
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C25H28N6O4
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1
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| 1 |
IC50 = 336 nM
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CP0520606
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1-[3-(1,3- difluoro-2- methylpropan- 2- yl)isoxazol-5- yl]-3- [3- (6,7- dimethoxy- quinazolin- 4- yloxy]phenyl) urea
Show/Hide
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C24H23F2N5O5
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1
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| 1 |
IC50 = 339 nM
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CP0385319
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1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(3- isopropyl- isoxazol- 5- yl)urea
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C23H23N5O5
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1
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| 1 |
IC50 = 340 nM
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CP0919038
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)methanone
Show/Hide
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C21H19N5O2
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1
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| 1 |
IC50 = 350 nM
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CP0666158
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N-(2-Methoxyethyl)-2-methyl-4-[(6-pyridin-4-ylquinazolin-2-yl)amino]benzamide
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C24H23N5O2
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1
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| 1 |
IC50 = 350 nM
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CP0691699
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N-(4-{[(2-Methoxyethyl)amino]methyl}phenyl)-6-pyridin-4-ylquinazolin-2-amine
Show/Hide
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C23H23N5O
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1
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| 1 |
IC50 = 350 nM
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CP0495327
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1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(5- isopropyl- isoxazol-3- yl)urea
Show/Hide
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C23H23N5O5
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1
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| 1 |
IC50 = 355 nM
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CP0134019
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N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]oxane-4-sulfonamide
Show/Hide
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C21H19F2N7O3S
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1
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| 1 |
IC50 = 356 nM
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CP0134022
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N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]methanesulfonamide
Show/Hide
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C17H13F2N7O2S
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1
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| 1 |
IC50 = 356 nM
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CP0920882
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rac-(5-(3-(aminomethyl)phenyl)thiophen-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C26H22N4O2S
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1
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| 1 |
IC50 = 390 nM
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CP0829112
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N-{4-[(6-Pyridin-4-ylquinazolin-2-yl)amino]phenyl}-acetamide
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C21H17N5O
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1
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| 1 |
IC50 = 400 nM
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CP0918378
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(3-(thiophen-2-yl)-1H-pyrazol-5-yl)methanone
Show/Hide
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C22H17N5O2S
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1
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| 1 |
IC50 = 410 nM
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CP0666213
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6-Pyridin-4-yl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-quinazolin-2-amine
Show/Hide
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C25H25N5O
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1
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| 1 |
IC50 = 410 nM
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CP0392019
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2,6-difluoro-3-(propylsulfonylamino)-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
Show/Hide
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C16H15F2N5O3S
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1
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| 1 |
IC50 = 430 nM
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CP0828632
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(R)-N-(1-(4-(7-Chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)-phenyl)ethyl)acetamide
Show/Hide
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C23H20ClN5O
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1
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| 1 |
IC50 = 430 nM
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CP0935747
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(4-methoxyphenyl)isoxazol-3-yl)methanone
Show/Hide
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C25H20N4O4
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1
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| 1 |
IC50 = 460 nM
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CP0470527
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1-(3-(6,7- dimethoxy- quinazolin- 4-ylthio)phenyl)- 3-(5-(1- (trifluoromethyl) cyclopropyl) isoxazol-3-yl) urea
Show/Hide
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C24H20F3N5O4S
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1
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| 1 |
IC50 = 469 nM
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CP0432219
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1-(1-benzyl- 3-tert- butyl- 1H-pyrazol- 5-yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
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C31H32N6O4
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1
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| 1 |
IC50 = 480 nM
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CP0121693
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N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-3-(trifluoromethyl)benzamide
Show/Hide
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C26H22F3N3O3
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1
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| 1 |
IC50 = 487 nM
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CP0520607
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1-(3-tert- butyl-1- isopropyl-1H- pyrazol-5-yl)- 3-(3- (6,7- dimethoxy- quinazolin- 4-yloxy) phenyl)urea
Show/Hide
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C27H32N6O4
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1
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| 1 |
IC50 = 505 nM
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CP0457435
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5-amino-2-(cyclopropylamino)-4-[3-[[4-(trifluoromethyl)phenyl]carbamoylamino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C24H20F3N7O2S
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1
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| 1 |
IC50 = 546 nM
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CP0140535
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US10568884, Cpd 28
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C21H27ClFN7O2S
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1
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| 1 |
IC50 = 550 nM
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CP0392515
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6-chloro-2-fluoro-3-(propylsulfonylamino)-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
Show/Hide
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C16H15ClFN5O3S
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1
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| 1 |
IC50 = 560 nM
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CP0691706
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(R)-N-(1-(4-(7-Methyl-6-(pyridin-4-yl)quinazolin-2-ylamino)-phenyl)ethyl)acetamide
Show/Hide
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C24H23N5O
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1
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| 1 |
IC50 = 573 nM
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CP0942047
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(5-(benzo[d][1,3]dioxol-5-yl)isoxazol-3-yl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C25H18N4O5
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1
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| 1 |
IC50 = 600 nM
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CP0112625
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6-[2-[3-(diethylsulfamoylamino)-2,6-difluoroanilino]pyridin-3-yl]-7H-purine
Show/Hide
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C20H20F2N8O2S
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1
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| 1 |
IC50 = 603 nM
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CP0416085
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1-(3-(1,1- difluoroethyl) isoxazol-5- yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
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C22H19F2N5O5
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1
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| 1 |
IC50 = 645 nM
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CP0475364
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1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(5- (1- hydroxy-2- methylpropan-2- yl)isoxazol- 3-yl)urea
Show/Hide
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C24H25N5O6
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1
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| 1 |
IC50 = 649 nM
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CP0463049
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N-[3-(dimethylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-2,6-difluoro-3-(propylsulfonylamino)benzamide
Show/Hide
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C18H20F2N6O3S
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1
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| 1 |
IC50 = 650 nM
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CP0751114
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3-Methoxy-N-(4-(6-(pyridin-4-yl)quinazolin-2-ylamino)-phenyl)propanamide
Show/Hide
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C23H21N5O2
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1
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| 1 |
IC50 = 660 nM
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CP0917533
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rac-(5-(5-fluoro-2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone
Show/Hide
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C24H17FN4O2S
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1
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| 1 |
IC50 = 680 nM
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CP0410193
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1-(3-tert-butyl- 1-isobutyl- 1H-pyrazol- 5-yl)-3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
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C28H34N6O4
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1
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| 1 |
IC50 = 681 nM
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CP0488278
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5-amino-2-(cyclopropylamino)-4-(5-methoxypyridin-3-yl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C16H16N6O2S
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1
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| 1 |
IC50 = 685 nM
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CP0680663
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(R)-N-(1-(4-(6-(Pyridin-4-yl)quinazolin-2-ylamino)phenyl)-ethyl)piperidine-4-carboxamide
Show/Hide
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C27H28N6O
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1
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| 1 |
IC50 = 688 nM
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CP0499363
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1-(4-chloro-3- (trifluoromethyl) phenyl)- 3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
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C24H18ClF3N4O4
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1
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| 1 |
IC50 = 696 nM
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CP0906513
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(4-methyl-2-(pyrazin-2-yl)thiazol-5-yl)methanone
Show/Hide
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C23H18N6O2S
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1
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| 1 |
IC50 = 710 nM
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CP0325790
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US9216981, 43
Show/Hide
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C20H15F2N9O2S
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1
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| 1 |
IC50 = 710 nM
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CP0922329
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-phenylisoxazol-3-yl)methanone
Show/Hide
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C24H18N4O3
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1
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| 1 |
IC50 = 810 nM
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CP0448127
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2,6-difluoro-N-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide
Show/Hide
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C17H17F2N5O3S
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1
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| 1 |
IC50 = 830 nM
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CP0312952
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3-(3-hydroxyazetidin-3-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;dihydrochloride
Show/Hide
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C29H29Cl2F3N4O4
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1
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| 1 |
IC50 = 854 nM
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CP0691680
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N-(2-Methoxyethyl)-N-methyl-N'-(6-pyridin-4-ylquinazolin-2-yl)benzene-1,4-diamine
Show/Hide
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C23H23N5O
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1
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| 1 |
IC50 = 855 nM
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CP0916835
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(5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C22H19N3O2S
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1
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| 1 |
IC50 = 920 nM
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CP0922328
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(3-methoxyphenyl)isoxazol-3-yl)methanone
Show/Hide
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C25H20N4O4
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1
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| 1 |
IC50 = 930 nM
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CP0942972
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(4-methyl-2-(pyridin-3-yl)thiazol-5-yl)methanone
Show/Hide
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C24H19N5O2S
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1
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| 1 |
IC50 = 940 nM
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CP0470533
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(1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(5- phenylisoxazol- 3-yl) urea
Show/Hide
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C26H21N5O5
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1
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| 1 |
IC50 = 956 nM
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CP0742713
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N-(2-Methoxyethyl)-4-{[6-(3-methylpyridin-4-yl)quinazolin-2-yl]amino}benzamide
Show/Hide
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C24H23N5O2
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1
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| 1 |
IC50 = 960 nM
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CP0906514
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(5-(furan-2-yl)isoxazol-3-yl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C22H16N4O4
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1
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| 1 |
IC50 = 970 nM
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CP0731361
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N-[4-(2-Methoxyethoxy)phenyl]-6-pyridin-4-ylquinazolin-2-amine
Show/Hide
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C22H20N4O2
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1
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| 1 |
IC50 = 970 nM
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CP0096019
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N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]piperazine-1-sulfonamide
Show/Hide
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C20H19F2N9O2S
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1
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| 1 |
IC50 = 1000 nM
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CP0372826
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5-amino-2-[(1-hydroxy-2-methylpropan-2-yl)amino]-4-(5-methoxypyridin-3-yl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C17H20N6O3S
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1
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| 1 |
IC50 = 1010 nM
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CP0913141
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-phenyl-1H-pyrrol-2-yl)methanone
Show/Hide
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C25H20N4O2
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1
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| 1 |
IC50 = 1100 nM
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CP0918379
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(3-phenylisoxazol-5-yl)methanone
Show/Hide
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C24H18N4O3
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1
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| 1 |
IC50 = 1100 nM
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CP0436004
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1-(1-tert- butyl-1H- pyrazol-4-yl)-3- (3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
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C24H26N6O4
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1
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| 1 |
IC50 = 1131 nM
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CP0416086
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1-(3- cyclopentyl- isoxazol- 5-yl)- 3-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
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C25H25N5O5
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1
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| 1 |
IC50 = 1134 nM
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CP0919432
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(S)-methyl 1-(4-(1-isopropyl-3-(3-(methylsulfonamido)phenyl)-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate
Show/Hide
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C22H29N7O4S
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1
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| 1 |
IC50 = 1150 nM
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CP0448128
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N-(6-amino-5-bromopyridin-3-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
Show/Hide
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C15H15BrF2N4O3S
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1
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| 1 |
IC50 = 1200 nM
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CP0896606
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(4-methyl-2-phenylthiazol-5-yl)methanone
Show/Hide
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C25H20N4O2S
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1
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| 1 |
IC50 = 1300 nM
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CP0847664
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rac-(5-(3-fluoro-2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone
Show/Hide
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C24H17FN4O2S
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1
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| 1 |
IC50 = 1400 nM
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CP0917534
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rac-(5-(4-fluoro-2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone
Show/Hide
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C24H17FN4O2S
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1
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| 1 |
IC50 = 1400 nM
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CP0242022
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(5-bromofuran-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C19H14BrN3O3
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1
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| 1 |
IC50 = 1400 nM
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CP0367308
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US10568884, Cpd 16
Show/Hide
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C21H27FN8O4S
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1
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| 1 |
IC50 = 1400 nM
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CP0888595
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rac-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-o-tolylthiophen-2-yl)methanone
Show/Hide
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C26H21N3O2S
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1
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| 1 |
IC50 = 1500 nM
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CP0218989
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanone
Show/Hide
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C19H15N3O2S
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1
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| 1 |
IC50 = 1500 nM
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CP0508816
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5-amino-2-[(1-hydroxy-2-methylpropan-2-yl)amino]-4-[3-[[4-(trifluoromethyl)phenyl]carbamoylamino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C25H24F3N7O3S
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1
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| 1 |
IC50 = 1540 nM
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CP0894723
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N,N-Dimethyl-N'-{4-[(6-pyridin-4-ylquinazolin-2-yl)amino]-benzyl}ethane-1,2-diamine
Show/Hide
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C24H26N6
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1
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| 1 |
IC50 = 1600 nM
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CP0451069
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1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(3- (trifluoromethyl) phenyl) urea
Show/Hide
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C24H19F3N4O4
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1
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| 1 |
IC50 = 1664 nM
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CP0845182
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-phenylfuran-2-yl)methanone
Show/Hide
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C25H19N3O3
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1
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| 1 |
IC50 = 1700 nM
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CP0042167
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furan-2-yl-[3-(2-hydroxyphenyl)-5-pyridin-3-yl-3,4-dihydropyrazol-2-yl]methanone
Show/Hide
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C19H15N3O3
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1
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| 1 |
IC50 = 1800 nM
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CP0851561
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N-(2-Methoxyethyl)-4-{[6-(3-methoxypyridin-4-yl)-quinazolin-2-yl]amino}benzamide
Show/Hide
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C24H23N5O3
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1
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| 1 |
IC50 = 1800 nM
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CP0468297
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1-(4- chlorophenyl)-3- (3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl) urea
Show/Hide
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C23H19ClN4O4
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1
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| 1 |
IC50 = 1850 nM
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CP0038139
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(1H-pyrrol-2-yl)methanone
Show/Hide
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C19H16N4O2
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1
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| 1 |
IC50 = 2000 nM
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CP0742714
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4-{[6-(3-Chloropyridin-4-yl)quinazolin-2-yl]amino}-N-(2-methoxyethyl)benzamide
Show/Hide
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C23H20ClN5O2
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1
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| 1 |
IC50 = 2000 nM
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CP0523719
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5-amino-2-(cyclopropylamino)-4-[3-[(4-methylphenyl)carbamoylamino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C24H23N7O2S
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1
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| 1 |
IC50 = 2030 nM
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CP0420837
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1-(3-(6,7- dimethoxy- quinazolin- 4-yloxy)phenyl)- 3- (3- (trifluoromethyl) isoxazol-5- yl)urea
Show/Hide
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C21H16F3N5O5
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1
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| 1 |
IC50 = 2229 nM
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CP0547618
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3-[2-[7-methyl-3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl]ethynyl]-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
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C27H21F3N6
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1
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| 1 |
IC50 = 2300 nM
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CP0845721
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-p-tolylfuran-2-yl)methanone
Show/Hide
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C26H21N3O3
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1
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| 1 |
IC50 = 2400 nM
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CP0488273
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5-amino-2-[[(2R)-1-hydroxypropan-2-yl]amino]-4-(5-methoxypyridin-3-yl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C16H18N6O3S
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1
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| 1 |
IC50 = 2510 nM
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CP0250749
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(7-ethoxybenzofuran-2-yl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C25H21N3O4
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1
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| 1 |
IC50 = 3500 nM
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CP0910287
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(4-methoxyphenyl)furan-2-yl)methanone
Show/Hide
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C26H21N3O4
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1
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| 1 |
IC50 = 3700 nM
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CP0845171
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(4-fluoro-3-(trifluoromethyl)phenyl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C22H15F4N3O2
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1
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| 1 |
IC50 = 3800 nM
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CP0680658
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N-(2-Methoxyethyl)-4-(6-phenylquinazolin-2-ylamino)-benzamide
Show/Hide
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C24H22N4O2
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1
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| 1 |
IC50 = 3800 nM
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CP0419495
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5-amino-4-(3,4-dichlorophenyl)-2-[[(2R)-1-hydroxypropan-2-yl]amino]thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C16H15Cl2N5O2S
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1
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| 1 |
IC50 = 3820 nM
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CP0557674
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5-amino-2-(cyclopropylamino)-4-(3,4-dichlorophenyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C16H13Cl2N5OS
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1
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| 1 |
IC50 = 4740 nM
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CP0742715
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N-(2-Methoxyethyl)-4-(6-(pyrimidin-5-yl)quinazolin-2-ylamino)benzamide
Show/Hide
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C22H20N6O2
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1
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| 1 |
IC50 = 6400 nM
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CP0018477
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4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
Show/Hide
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C21H16ClF3N4O3
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1
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| 1 |
IC50 = 6599 nM
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CP0481880
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5-amino-4-(3,4-dichlorophenyl)-2-[(2R)-1-hydroxypropan-2-yl]oxythieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C16H14Cl2N4O3S
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1
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| 1 |
IC50 = 6880 nM
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CP0751192
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N-(2-Methoxyethyl)-4-[(6-pyridin-3-ylquinazolin-2-yl)-amino]benzamide
Show/Hide
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C23H21N5O2
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1
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| 1 |
IC50 = 7040 nM
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CP0557673
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5-amino-4-(3,4-dichlorophenyl)-2-(2-hydroxyethylamino)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C15H13Cl2N5O2S
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1
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| 1 |
IC50 = 7910 nM
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CP0931477
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2-cyclopropyl-1-(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone
Show/Hide
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C19H19N3O2
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1
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| 1 |
IC50 = 8000 nM
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CP0038137
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(3-(1H-pyrazol-1-yl)phenyl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C24H19N5O2
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1
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| 1 |
IC50 = 8700 nM
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CP0920109
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(3-fluoro-5-(trifluoromethyl)phenyl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C22H15F4N3O2
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1
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| 1 |
IC50 = 9500 nM
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CP0539602
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5-amino-4-(3,4-dichlorophenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino]thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C17H17Cl2N5O2S
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1
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| 1 |
IC50 = 9640 nM
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CP0392489
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5-amino-2-(2-aminoethylamino)-4-(3,4-dichlorophenyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C15H14Cl2N6OS
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1
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| 1 |
IC50 = 9750 nM
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CP0845724
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(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(thiophen-2-yl)pyridin-3-yl)methanone
Show/Hide
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C24H18N4O2S
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1
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| 1 |
IC50 > 10000 nM
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CP0916834
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2-(3-(pyridin-3-yl)-1-(5-(pyridin-3-yl)thiophen-2-ylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)phenol
Show/Hide
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C23H18N4O3S2
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1
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| 1 |
IC50 > 10000 nM
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CP0941504
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(3-(1H-tetrazol-1-yl)phenyl)(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Show/Hide
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C22H17N7O2
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1
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| 1 |
IC50 > 10000 nM
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CP0480261
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1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(3- methoxyphenyl) urea
Show/Hide
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C24H22N4O5
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1
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| 1 |
IC50 = 10000 nM
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CP0018079
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1-propan-2-yl-3-[2-[3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl]ethynyl]pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
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C26H19F3N6
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1
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| 1 |
IC50 > 10000 nM
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CP0114394
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1-ethyl-3-[2-[3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl]ethynyl]pyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
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C25H17F3N6
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1
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| 1 |
IC50 > 10000 nM
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CP0125575
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3-[2-[3-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]isoquinolin-8-yl]ethynyl]-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Show/Hide
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C31H32N8
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1
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| 1 |
IC50 > 10000 nM
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CP0458286
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5-amino-2-(cyclopropylamino)-4-[3-(phenylcarbamoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C23H21N7O2S
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1
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| 1 |
IC50 = 10100 nM
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CP0524918
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5-amino-2-(cyclopropylamino)-4-(3-methoxyphenyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C17H17N5O2S
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1
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| 1 |
IC50 = 11700 nM
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CP0448131
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5-amino-2-(cyclopropylamino)-4-(4-hydroxyphenyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C16H15N5O2S
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1
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| 1 |
IC50 = 13900 nM
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CP0484755
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5-amino-4-(3,4-dichlorophenyl)-2-[(2S)-3-hydroxy-2-methylpropyl]thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C17H16Cl2N4O2S
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1
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| 1 |
IC50 = 14500 nM
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CP0206844
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1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-phenylurea
Show/Hide
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C23H20N4O4
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1
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| 1 |
IC50 > 15000 nM
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CP0870728
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1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-methylisoxazol-3-yl)urea
Show/Hide
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C21H19N5O5
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1
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| 1 |
IC50 > 15000 nM
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CP0882272
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1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(3-phenylisoxazol-5-yl)urea
Show/Hide
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C26H21N5O5
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1
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| 1 |
IC50 > 15000 nM
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CP0751116
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N-(2-Methoxyethyl)-4-{[6-(2-methylpyridin-4-yl)quinazolin-2-yl]amino}benzamide
Show/Hide
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C24H23N5O2
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1
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| 1 |
IC50 > 17000 nM
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CP0403710
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2,5-diamino-4-(3,4-dichlorophenyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C13H9Cl2N5OS
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1
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| 1 |
IC50 = 17600 nM
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CP0354457
|
US10568884, Cpd 27
Show/Hide
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C24H33N7O5S
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1
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| 1 |
IC50 > 20000 nM
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CP0904818
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rac-(5-(3-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(5-(pyridin-2-yl)thiophen-2-yl)methanone
Show/Hide
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C24H18N4O2S
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1
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| 1 |
IC50 > 25000 nM
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CP0691684
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4-{[6-(6-Fluoropyridin-3-yl)quinazolin-2-yl]amino}-N-(2-methoxyethyl)benzamide
Show/Hide
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C23H20FN5O2
|
1
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| 1 |
IC50 > 32000 nM
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CP0828633
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N-(2-Methoxyethyl)-4-{[6-(6-methoxypyridin-3-yl)-quinazolin-2-yl]amino}benzamide
Show/Hide
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C24H23N5O3
|
1
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| 1 |
IC50 > 32000 nM
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CP0523718
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5-amino-4-(3,4-dichlorophenyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
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C13H8Cl2N4OS
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1
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| 1 |
IC50 > 60000 nM
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CP0090744
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N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1-phenylmethanesulfonamide
Show/Hide
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C23H17F2N7O2S
|
1
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| 1 |
IC50 > 1000 nM
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CP0198901
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N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3,5-dimethyl-1H-pyrazole-4-sulfonamide
Show/Hide
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C21H17F2N9O2S
|
1
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| 1 |
IC50 > 1000 nM
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CP0432242
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1-(3-tert- butyl-1- cyclohexyl- 1H-pyrazol- 5-yl)-3- (3-(6,7- dimethoxy- quinazolin- 4-yloxy) phenyl)urea
Show/Hide
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C30H36N6O4
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1
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| 1 |
IC50 > 1667 nM
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CP0262150
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N-(6-aminopyridin-3-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
Show/Hide
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C15H16F2N4O3S
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1
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| 1 |
IC50 > 3000 nM
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CP0372825
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2,6-difluoro-N-(1H-imidazo[4,5-b]pyridin-6-yl)-3-(propylsulfonylamino)benzamide
Show/Hide
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C16H15F2N5O3S
|
1
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| 1 |
IC50 > 3000 nM
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CP0438366
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2,6-difluoro-3-(propylsulfonylamino)-N-pyridin-3-ylbenzamide
Show/Hide
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C15H15F2N3O3S
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1
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| 1 |
IC50 > 3000 nM
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CP0758717
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N-(2-Methoxyethyl)-3-[(6-pyridin-4-ylquinazolin-2-yl)-amino]benzamide
Show/Hide
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C23H21N5O2
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1
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| 1 |
IC50 > 6000 nM
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