Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US9216981, 21
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 PubChem ID
CID: 57345097
SID: 136366533
Canonical SMILES
Fc1ccc(NS(=O)(=O)N2CCOCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
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Compound Formula C20H18F2N8O3S
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 293 nM
   TI
   LI
   LO
   TS
CL000463 A375-P
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 360 nM
   TI
   LI
   LO
   TS
CL000207 MIA PaCa-2
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 3580 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 62 nM
2 IC50 = 102 nM