General Information of the Cell Line
Cell Line ID
CL000207
Cell Line Name
MIA PaCa-2
Synonyms
MIA-PaCa-2
MIA-PACA-2
MIA-Pa-Ca-2
MIA Paca2
MIA PaCa2
MiaPaCa-2
MIAPACA-2
MiaPaca.2
MiaPaCa2
Miapaca2
MIAPaCa2
MIAPACA2
Mia PACA 2
MIAPaCa-2
PaCa2
MiaPaCa
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0428
Tissue Information
Pancreas
Disease
Pancreatic ductal adenocarcinoma (NCIt: C9120)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT03150, Aldehyde dehydrogenase 1A1
 Protein Info 
Compound ID Compound Name Compound Formula
CP0115366
 Compound Info 
1-[6,7-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C27H27F2N5O3S
  1
1
IC50 = 22 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0538681
 Compound Info 
1-[6-(4-methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C25H27N5O3S2
  1
1
IC50 = 22 nM
 Bioactivity Info 
   TI
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   LO
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CP0429561
 Compound Info 
2-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]-2-methylpropanenitrile
   Show/Hide
C25H25FN4O3S
  1
1
IC50 = 24 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0115367
 Compound Info 
1-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopentane-1-carbonitrile
   Show/Hide
C27H27FN4O3S
  1
1
IC50 = 28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0097088
 Compound Info 
1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C27H28FN5O3S
  1
1
IC50 = 30 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547344
 Compound Info 
4-[4-[4-(1-cyanocyclopropyl)phenyl]-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-sulfonamide
   Show/Hide
C26H26FN5O3S
  1
1
IC50 = 31 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0148548
 Compound Info 
2-[4-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]phenyl]-2-methylpropanenitrile
   Show/Hide
C28H27FN4O2
  1
1
IC50 = 32 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0412840
 Compound Info 
1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-(2-fluorophenyl)piperidine-4-carbonitrile
   Show/Hide
C27H27F2N5O3S
  1
1
IC50 = 32 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545254
 Compound Info 
1-[6-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C28H31N5O4S
  1
1
IC50 = 32 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0558114
 Compound Info 
1-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclobutane-1-carbonitrile
   Show/Hide
C26H25FN4O3S
  1
1
IC50 = 33 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0148549
 Compound Info 
[4-[4-(4-tert-butylphenyl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone
   Show/Hide
C28H30FN3O2
  1
1
IC50 = 39 nM
 Bioactivity Info 
   TI
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   LO
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CP0364636
 Compound Info 
4-[4-(4-cyano-4-phenylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide
   Show/Hide
C29H31FN6O2
  1
1
IC50 = 40 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0538683
 Compound Info 
4-[4-(4-cyano-4-phenylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-sulfonamide
   Show/Hide
C28H31FN6O3S
  1
1
IC50 = 40 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0410945
 Compound Info 
1-[4-[6-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile
   Show/Hide
C26H26N4O4S
  1
1
IC50 = 42 nM
 Bioactivity Info 
   TI
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CP0237548
 Compound Info 
1-[7-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C28H31N5O4S
  1
1
IC50 = 45 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0115365
 Compound Info 
1-[6,8-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C27H27F2N5O3S
  1
1
IC50 = 47 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0199187
 Compound Info 
1-[4-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]phenyl]cyclopropane-1-carbonitrile
   Show/Hide
C28H25FN4O2
  1
1
IC50 = 47 nM
 Bioactivity Info 
   TI
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CP0429560
 Compound Info 
1-[6-chloro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C27H28ClN5O3S
  1
1
IC50 = 48 nM
 Bioactivity Info 
   TI
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CP0402443
 Compound Info 
1-[4-[6-chloro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile
   Show/Hide
C25H23ClN4O3S
  1
1
IC50 = 53 nM
 Bioactivity Info 
   TI
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   LO
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CP0563625
 Compound Info 
1-[4-[6-chloro-3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile
   Show/Hide
C28H25ClN4O2
  1
1
IC50 = 53 nM
 Bioactivity Info 
   TI
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CP0532797
 Compound Info 
4-[4-[4-(1-cyanocyclopropyl)phenyl]-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide
   Show/Hide
C27H26FN5O2
  1
1
IC50 = 54 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0364635
 Compound Info 
1-[4-[6,7-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile
   Show/Hide
C25H22F2N4O3S
  1
1
IC50 = 55 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0429562
 Compound Info 
[4-(4-tert-butylphenyl)-6-fluoroquinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone
   Show/Hide
C25H28FN3O3S
  1
1
IC50 = 62 nM
 Bioactivity Info 
   TI
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   LO
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CP0097086
 Compound Info 
1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C30H30FN5O2
  1
1
IC50 = 63 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0577971
 Compound Info 
1-[6-chloro-3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C30H30ClN5O2
  1
1
IC50 = 65 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0148547
 Compound Info 
1-[6-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[3,2-b]pyridin-7-yl]-4-phenylpiperidine-4-carbonitrile
   Show/Hide
C28H29N5O2S
  1
1
IC50 = 71 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0240915
 Compound Info 
1-[4-[7-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile
   Show/Hide
C26H26N4O4S
  1
1
IC50 = 74 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0097087
 Compound Info 
1-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile
   Show/Hide
C25H23FN4O3S
  1
1
IC50 = 77 nM
 Bioactivity Info 
   TI
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   LO
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CP0240920
 Compound Info 
1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-(4-fluorophenyl)piperidine-4-carbonitrile
   Show/Hide
C27H27F2N5O3S
  1
1
IC50 = 87 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0415885
 Compound Info 
1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbaldehyde
   Show/Hide
C27H29FN4O4S
  1
1
IC50 = 94 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0566844
 Compound Info 
2-[3-fluoro-4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]-2-methylpropanenitrile
   Show/Hide
C25H24F2N4O3S
  1
1
IC50 = 96 nM
 Bioactivity Info 
   TI
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   LO
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CP0364612
 Compound Info 
1-[1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidin-4-yl]ethanone
   Show/Hide
C28H31FN4O4S
  1
1
IC50 = 106 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0538680
 Compound Info 
1-[4-[6,8-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile
   Show/Hide
C25H22F2N4O3S
  1
1
IC50 = 111 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0415886
 Compound Info 
cyclopropyl-[4-[4-(4,4-dimethylcyclohexen-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C26H30FN3O2
  1
1
IC50 = 112 nM
 Bioactivity Info 
   TI
   LI
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CP0115370
 Compound Info 
1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-ethylpiperidine-4-carbonitrile
   Show/Hide
C26H30FN5O2
  1
1
IC50 = 153 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0564008
 Compound Info 
4-ethyl-1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile
   Show/Hide
C23H28FN5O3S
  1
1
IC50 = 206 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0148546
 Compound Info 
1-[4-[6-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[3,2-b]pyridin-7-yl]phenyl]cyclopropane-1-carbonitrile
   Show/Hide
C26H24N4O2S
  1
1
IC50 = 319 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547300
 Compound Info 
4-(4-chlorophenyl)-1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile
   Show/Hide
C27H27ClFN5O3S
  1
1
IC50 = 346 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0410940
 Compound Info 
1'-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]spiro[1H-indene-3,4'-piperidine]-2-one
   Show/Hide
C28H29FN4O4S
  1
1
IC50 = 472 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0429565
 Compound Info 
4-[4-(4-cyano-4-methylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-sulfonamide
   Show/Hide
C23H29FN6O3S
  1
1
IC50 = 477 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0402765
 Compound Info 
1-[3-fluoro-4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile
   Show/Hide
C25H22F2N4O3S
  1
1
IC50 = 486 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0063241
 Compound Info 
1-[4-[6-(4-methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]phenyl]cyclopropane-1-carbonitrile
   Show/Hide
C23H22N4O3S2
  1
1
IC50 = 507 nM
 Bioactivity Info 
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CP0415887
 Compound Info 
1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-(cyclopropylmethyl)piperidine-4-carbonitrile
   Show/Hide
C28H32FN5O2
  1
1
IC50 = 572 nM
 Bioactivity Info 
   TI
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CP0477990
 Compound Info 
[4-(4,4-dimethylcyclohexen-1-yl)-6-fluoroquinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone
   Show/Hide
C23H28FN3O3S
  1
1
IC50 = 873 nM
 Bioactivity Info 
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CP0353601
 Compound Info 
2-[(2-butan-2-yl-3-oxo-2H-imidazo[1,2-c]quinazolin-5-yl)sulfanyl]-N-(2-methylphenyl)butanamide
   Show/Hide
C25H28N4O2S
  1
1
IC50 = 1010 nM
 Bioactivity Info 
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CP0148552
 Compound Info 
1-[6-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[3,2-b]pyridin-7-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C23H27N5O2S
  1
1
IC50 = 1050 nM
 Bioactivity Info 
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CP0364614
 Compound Info 
[4-[4-(8-azaspiro[4.5]decan-8-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone
   Show/Hide
C27H33FN4O2
  1
1
IC50 = 1110 nM
 Bioactivity Info 
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CP0240923
 Compound Info 
4-methyl-1-[6-(4-methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]piperidine-4-carbonitrile
   Show/Hide
C20H25N5O3S2
  1
1
IC50 = 1210 nM
 Bioactivity Info 
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CP0542698
 Compound Info 
1-[3-(4-ethylsulfonylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C23H28FN5O3S
  1
1
IC50 = 1410 nM
 Bioactivity Info 
   TI
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CP0353681
 Compound Info 
4-[4-(4-cyano-4-methylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide
   Show/Hide
C24H29FN6O2
  1
1
IC50 = 1450 nM
 Bioactivity Info 
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CP0115372
 Compound Info 
1-[6-fluoro-3-[4-(2-methylpropanoyl)piperazine-1-carbonyl]quinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C25H30FN5O2
  1
1
IC50 = 1480 nM
 Bioactivity Info 
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CP0429564
 Compound Info 
1-[3-[4-(cyclopropanecarbonyl)piperidine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C26H29FN4O2
  1
1
IC50 = 1570 nM
 Bioactivity Info 
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CP0199186
 Compound Info 
[4-(4-ethenylsulfonylpiperazin-1-yl)-6-fluoroquinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone
   Show/Hide
C21H26FN5O5S2
  1
1
IC50 = 1590 nM
 Bioactivity Info 
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CP0477993
 Compound Info 
[4-[6-chloro-4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone
   Show/Hide
C25H29ClN4O4
  1
1
IC50 = 1970 nM
 Bioactivity Info 
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CP0564009
 Compound Info 
1-[6-fluoro-3-[(3S)-3-methyl-4-methylsulfonylpiperazine-1-carbonyl]quinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C23H28FN5O3S
  1
1
IC50 = 1980 nM
 Bioactivity Info 
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CP0115368
 Compound Info 
1'-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]spiro[3H-indene-2,4'-piperidine]-1-one
   Show/Hide
C28H29FN4O4S
  1
1
IC50 = 2200 nM
 Bioactivity Info 
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CP0532831
 Compound Info 
cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,7-dimethoxyquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C27H34N4O6
  1
1
IC50 = 2220 nM
 Bioactivity Info 
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CP0410944
 Compound Info 
cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methylquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C26H32N4O4
  1
1
IC50 = 2270 nM
 Bioactivity Info 
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CP0240926
 Compound Info 
cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C25H29FN4O4
  1
1
IC50 = 2420 nM
 Bioactivity Info 
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CP0240925
 Compound Info 
cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-7-methoxyquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C26H32N4O5
  1
1
IC50 = 2430 nM
 Bioactivity Info 
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CP0148554
 Compound Info 
1-[5-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[2,3-b]pyridin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C23H27N5O2S
  1
1
IC50 = 2450 nM
 Bioactivity Info 
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CP0240544
 Compound Info 
cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,7-difluoroquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C25H28F2N4O4
  1
1
IC50 = 2460 nM
 Bioactivity Info 
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CP0574142
 Compound Info 
cyclopropyl-[4-[4-(4,4-dimethylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C25H31FN4O2
  1
1
IC50 = 2570 nM
 Bioactivity Info 
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CP0148556
 Compound Info 
1-[6-fluoro-3-(4-methylsulfonylpiperidine-1-carbonyl)quinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C23H27FN4O3S
  1
1
IC50 = 2800 nM
 Bioactivity Info 
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CP0240924
 Compound Info 
cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,8-difluoroquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C25H28F2N4O4
  1
1
IC50 = 2880 nM
 Bioactivity Info 
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CP0115374
 Compound Info 
1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C25H28FN5O2
  1
1
IC50 = 2890 nM
 Bioactivity Info 
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CP0415889
 Compound Info 
4-methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)thieno[2,3-b]pyridin-4-yl]piperidine-4-carbonitrile
   Show/Hide
C20H25N5O3S2
  1
1
IC50 = 2950 nM
 Bioactivity Info 
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CP0364479
 Compound Info 
[4-[4-(3-azaspiro[5.5]undecan-3-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone
   Show/Hide
C28H35FN4O2
  1
1
IC50 = 3120 nM
 Bioactivity Info 
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CP0148558
 Compound Info 
8-[6-methoxy-3-(4-methoxyphenyl)sulfonylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
   Show/Hide
C24H26N2O6S
  1
1
IC50 = 3430 nM
 Bioactivity Info 
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CP0353683
 Compound Info 
cyclopropyl-[4-[6-fluoro-4-(1-oxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C26H31FN4O3
  1
1
IC50 = 3550 nM
 Bioactivity Info 
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CP0542699
 Compound Info 
1-[6-fluoro-3-(4-propanoylpiperazine-1-carbonyl)quinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C24H28FN5O2
  1
1
IC50 = 3890 nM
 Bioactivity Info 
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CP0574143
 Compound Info 
cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-fluoro-8-methylquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C26H31FN4O4
  1
1
IC50 = 3930 nM
 Bioactivity Info 
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CP0148401
 Compound Info 
[4-[4-(6-azaspiro[2.5]octan-6-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone
   Show/Hide
C25H29FN4O2
  1
1
IC50 = 4040 nM
 Bioactivity Info 
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CP0429569
 Compound Info 
cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methoxyquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C26H32N4O5
  1
1
IC50 = 4090 nM
 Bioactivity Info 
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CP0063244
 Compound Info 
[6-fluoro-4-[4-(hydroxymethyl)-4-phenylpiperidin-1-yl]quinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone
   Show/Hide
C27H31FN4O4S
  1
1
IC50 = 4110 nM
 Bioactivity Info 
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CP0364613
 Compound Info 
4-benzyl-1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile
   Show/Hide
C28H30FN5O3S
  1
1
IC50 = 4510 nM
 Bioactivity Info 
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CP0346518
 Compound Info 
cyclopropyl-[4-[4-(4,4-diethylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C27H35FN4O2
  1
1
IC50 = 4570 nM
 Bioactivity Info 
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CP0364611
 Compound Info 
1'-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]spiro[2H-indene-3,4'-piperidine]-1-one
   Show/Hide
C28H29FN4O4S
  1
1
IC50 = 4680 nM
 Bioactivity Info 
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CP0082269
 Compound Info 
1-benzyl-2,3-dihydro-1H-indole-2,3-dione
   Show/Hide
C15H11NO2
  1
1
IC50 = 4870 nM
 Bioactivity Info 
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CP0415818
 Compound Info 
1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C22H26FN5O3S
  1
1
IC50 = 5080 nM
 Bioactivity Info 
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CP0364478
 Compound Info 
4-methyl-1-[1-methyl-5-(4-methylsulfonylpiperazine-1-carbonyl)pyrazolo[3,4-b]pyridin-4-yl]piperidine-4-carbonitrile
   Show/Hide
C20H27N7O3S
  1
1
IC50 = 5230 nM
 Bioactivity Info 
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CP0410942
 Compound Info 
1-[6-fluoro-3-[(3R)-3-methyl-4-methylsulfonylpiperazine-1-carbonyl]quinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C23H28FN5O3S
  1
1
IC50 = 5380 nM
 Bioactivity Info 
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CP0115371
 Compound Info 
4-methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]piperidine-4-carbonitrile
   Show/Hide
C20H26N6O3S
  1
1
IC50 = 5440 nM
 Bioactivity Info 
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CP0098099
 Compound Info 
[4-[4-(2-azaspiro[4.5]decan-2-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone
   Show/Hide
C27H33FN4O2
  1
1
IC50 = 5610 nM
 Bioactivity Info 
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CP0532830
 Compound Info 
1-[3-(4-cyclopropylsulfonylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C24H28FN5O3S
  1
1
IC50 = 6340 nM
 Bioactivity Info 
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CP0364515
 Compound Info 
8-[[4-(cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione
   Show/Hide
C21H32N6O3
  1
1
IC50 = 6790 nM
 Bioactivity Info 
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CP0115369
 Compound Info 
[6-fluoro-4-(4-hydroxy-4-phenylpiperidin-1-yl)quinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone
   Show/Hide
C26H29FN4O4S
  1
1
IC50 = 7420 nM
 Bioactivity Info 
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CP0575827
 Compound Info 
[4-[4-[(3aS,7aR)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone
   Show/Hide
C26H31FN4O2
  1
1
IC50 = 9220 nM
 Bioactivity Info 
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CP0545238
 Compound Info 
cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C25H30N4O4
  1
1
IC50 = 9760 nM
 Bioactivity Info 
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CP0563618
 Compound Info 
1-[3-(4-acetylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C23H26FN5O2
  1
1
IC50 = 11380 nM
 Bioactivity Info 
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CP0575825
 Compound Info 
[4-[4-(azepan-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone
   Show/Hide
C24H29FN4O2
  1
1
IC50 = 11600 nM
 Bioactivity Info 
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CP0410943
 Compound Info 
[4-[4-[(1R,5S)-3-azabicyclo[3.2.1]octan-3-yl]-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone
   Show/Hide
C25H29FN4O2
  1
1
IC50 = 11700 nM
 Bioactivity Info 
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CP0098097
 Compound Info 
[4-[4-(2-azaspiro[3.5]nonan-2-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone
   Show/Hide
C26H31FN4O2
  1
1
IC50 = 11800 nM
 Bioactivity Info 
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CP0063251
 Compound Info 
cyclopropyl-[4-[[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methoxyquinolin-3-yl]methyl]piperazin-1-yl]methanone
   Show/Hide
C26H34N4O4
  1
1
IC50 = 12400 nM
 Bioactivity Info 
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CP0148551
 Compound Info 
cyclopropyl-[4-[6-fluoro-4-(4-phenylpiperidin-1-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C29H31FN4O2
  1
1
IC50 = 13600 nM
 Bioactivity Info 
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CP0542697
 Compound Info 
4-methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidine-4-carbonitrile
   Show/Hide
C19H25N7O3S
  1
1
IC50 = 15600 nM
 Bioactivity Info 
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CP0410941
 Compound Info 
[4-[4-(4-benzylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone
   Show/Hide
C30H33FN4O2
  1
1
IC50 = 17300 nM
 Bioactivity Info 
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CP0429563
 Compound Info 
4-benzyl-1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]piperidine-4-carbonitrile
   Show/Hide
C31H32FN5O2
  1
1
IC50 = 22600 nM
 Bioactivity Info 
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CP0093742
 Compound Info 
ethyl 2-[[4-oxo-3-(3-pyrrolidin-1-ylpropyl)-[1]benzothiolo[3,2-d]pyrimidin-2-yl]sulfanyl]acetate
   Show/Hide
C21H25N3O3S2
  1
1
IC50 > 57000 nM
 Bioactivity Info 
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CP0115373
 Compound Info 
1-[4-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]piperazin-1-yl]ethanone
   Show/Hide
C24H28FN5O3
  1
1
IC50 > 57000 nM
 Bioactivity Info 
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CP0148400
 Compound Info 
cyclopropyl-[4-[4-(4,4-difluoropiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C23H25F3N4O2
  1
1
IC50 > 57000 nM
 Bioactivity Info 
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CP0199189
 Compound Info 
1-[3-(3,3-dimethyl-4-methylsulfonylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile
   Show/Hide
C24H30FN5O3S
  1
1
IC50 > 57000 nM
 Bioactivity Info 
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CP0237549
 Compound Info 
1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-methoxyquinolin-4-yl]piperidin-4-one
   Show/Hide
C24H28N4O4
  1
1
IC50 > 57000 nM
 Bioactivity Info 
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CP0353677
 Compound Info 
1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile
   Show/Hide
C21H24FN5O3S
  1
1
IC50 > 57000 nM
 Bioactivity Info 
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CP0477991
 Compound Info 
1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]piperidine-4-carbonitrile
   Show/Hide
C24H26FN5O2
  1
1
IC50 > 57000 nM
 Bioactivity Info 
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CP0477992
 Compound Info 
cyclopropyl-[4-[6-fluoro-4-(4-fluoropiperidin-1-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C23H26F2N4O2
  1
1
IC50 > 57000 nM
 Bioactivity Info 
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CP0563619
 Compound Info 
cyclopropyl-[4-[6-fluoro-4-(4-methylsulfonylpiperazin-1-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone
   Show/Hide
C23H28FN5O4S
  1
1
IC50 > 57000 nM
 Bioactivity Info 
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Protein ID: PT00922, Epidermal growth factor receptor
 Protein Info 
Protein ID: PT00947, Geranylgeranyl pyrophosphate synthase
 Protein Info 
Protein ID: PT03462, GTPase KRas
 Protein Info 
Protein ID: PT01104, Insulin-like growth factor 1 receptor
 Protein Info 
Protein ID: PT00337, L-lactate dehydrogenase
 Protein Info 
Protein ID: PT02629, L-lactate dehydrogenase A chain
 Protein Info 
Protein ID: PT03776, Lysine-specific demethylase 2B
 Protein Info 
Protein ID: PT01092, Platelet-derived growth factor receptor alpha
 Protein Info 
Protein ID: PT01381, Serine/threonine-protein kinase B-raf
 Protein Info 
Protein ID: PT01252, Serine/threonine-protein kinase PLK1
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0004106
 Compound Info 
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one
   Show/Hide
 C28H26N4O3  1
1
IC50 = 370 nM
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CP0016361
 Compound Info 
N-(2-chlorophenyl)-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amine
   Show/Hide
 C20H13ClN6  1
1
EC50 = 300 nM
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CP0036258
 Compound Info 
5-(2,6-difluoroanilino)-N-methylbenzo[c][2,6]naphthyridine-7-carboxamide
   Show/Hide
 C20H14F2N4O  1
1
EC50 = 360 nM
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CP0051754
 Compound Info 
3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl]pyridin-3-yl}oxy)propyl]-1H-indole
   Show/Hide
 C23H22N4O  1
1
IC50 = 12000 nM
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CP0057282
 Compound Info 
N-[4-[(6-oxo-5H-benzo[c][1,8]naphthyridin-1-yl)amino]phenyl]benzamide
   Show/Hide
 C25H18N4O2  1
1
IC50 = 329 nM
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CP0060146
 Compound Info 
5-(2-fluoroanilino)-N-methylbenzo[c][2,6]naphthyridine-7-carboxamide
   Show/Hide
 C20H15FN4O  1
1
EC50 = 1050 nM
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CP0076082
 Compound Info 
N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
   Show/Hide
 C22H18N4O2S3  1
1
EC50 = 1900 nM
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CP0083291
 Compound Info 
N-(2,6-difluorophenyl)-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amine
   Show/Hide
 C20H12F2N6  1
1
EC50 = 830 nM
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CP0098250
 Compound Info 
2-[5-cyclopropyl-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C29H24N4O4S2  1
1
IC50 = 8000 nM
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CP0098303
 Compound Info 
2-[3-phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C20H16N4O4S2  1
1
IC50 > 57000 nM
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CP0099138
 Compound Info 
(2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine
   Show/Hide
 C25H22N4O  1
1
IC50 = 590 nM
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CP0109097
 Compound Info 
1-[(6-aminopyridin-3-yl)methyl]-3-[4-(benzenesulfonyl)phenyl]urea
   Show/Hide
 C19H18N4O3S  1
1
IC50 > 1000 nM
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CP0152940
 Compound Info 
2-[5-chloro-2-cyclopropyl-3-(5-methoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-7-methylindol-1-yl]-N-(1-prop-2-enoylazetidin-3-yl)acetamide
   Show/Hide
 C31H33ClN4O4  1
1
IC50 = 67 nM
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CP0204622
 Compound Info 
5-(2,6-difluoroanilino)benzo[c][2,6]naphthyridine-7-carboxamide
   Show/Hide
 C19H12F2N4O  1
1
EC50 = 440 nM
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CP0210095
 Compound Info 
5-(2-chloroanilino)-N-(2-methylpropyl)benzo[c][2,6]naphthyridine-7-carboxamide
   Show/Hide
 C23H21ClN4O  1
1
EC50 = 8900 nM
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CP0210320
 Compound Info 
N-[2-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amine
   Show/Hide
 C26H24FN7O  1
1
EC50 = 530 nM
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CP0213712
 Compound Info 
GNE-140 (6)
   Show/Hide
 C25H23ClN2O3S2  1
1
IC50 = 1240 nM
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CP0241639
 Compound Info 
N-[2-chloro-4-(4-methylpiperazin-1-yl)phenyl]-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amine
   Show/Hide
 C25H23ClN8  1
1
EC50 = 1500 nM
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CP0248934
 Compound Info 
3-benzyl-8-chloro-2H-pyrazino[1,2-a]indol-1-one
   Show/Hide
 C18H13ClN2O  1
1
IC50 = 1800 nM
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CP0253022
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C31H24F2N4O4S3  1
1
IC50 = 257 nM
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CP0317517
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(3-methylimidazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C30H24F2N6O4S2  1
1
IC50 = 1387 nM
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CP0354427
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(3-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C31H25FN4O4S3  1
1
IC50 = 452 nM
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CP0354428
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[(E)-2-(5-methylthiophen-2-yl)ethenyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C31H27FN4O4S3  1
1
IC50 = 471 nM
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CP0361785
 Compound Info 
2-[5-(cyclopropylmethyl)-3-phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C24H22N4O4S2  1
1
IC50 > 20000 nM
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CP0361808
 Compound Info 
(NE)-N-[(2E,6E)-2-[(2-bromo-4,5-dimethoxyphenyl)methylidene]-4-methyl-6-[(3,5,6-trimethylpyrazin-2-yl)methylidene]cyclohexylidene]hydroxylamine
   Show/Hide
 C24H28BrN3O3  1
1
IC50 = 90 nM
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CP0361809
 Compound Info 
(NE)-N-[(3E,5E)-3-[(2-bromo-4,5-dimethoxyphenyl)methylidene]-1-propan-2-yl-5-[(3,5,6-trimethylpyrazin-2-yl)methylidene]piperidin-4-ylidene]hydroxylamine
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 C25H31BrN4O3  1
1
IC50 = 30 nM
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CP0362432
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C30H26N4O4S2  1
1
IC50 = 3960 nM
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CP0362531
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(1-methylpyrazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C30H24F2N6O4S2  1
1
IC50 = 619 nM
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CP0365470
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-(3,3-difluoroprop-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C27H20F4N4O4S2  1
1
IC50 = 1327 nM
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CP0396392
 Compound Info 
1-[2-[4-[1-adamantyl(phenyl)methyl]phenyl]ethyl]-4-methylpiperazine
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 C30H40N2  1
1
GI50 = 7.5 nM
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CP0407300
 Compound Info 
(3E,5E)-3-[(2-bromo-4,5-dimethoxyphenyl)methylidene]-1-methyl-5-[(3,5,6-trimethylpyrazin-2-yl)methylidene]piperidin-4-one
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 C23H26BrN3O3  1
1
IC50 = 1800 nM
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CP0415673
 Compound Info 
5-chloro-N-(1-hydroxy-3-phenylpropan-2-yl)-1H-indole-2-carboxamide
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 C18H17ClN2O2  1
1
IC50 = 2600 nM
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CP0471780
 Compound Info 
6,7-dimethoxy-2-pentyl-3,4-dihydro-1H-isoquinoline
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 C16H25NO2  1
1
EC50 > 100000 nM
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CP0500230
 Compound Info 
1-[[4-[1-adamantyl(phenyl)methyl]phenyl]methyl]-4-methylpiperazine
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 C29H38N2  1
1
GI50 = 3.61 nM
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CP0506645
 Compound Info 
2-[3-(3-phenylphenyl)-4-(4-sulfamoylanilino)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C25H19N5O4S2  1
1
IC50 > 57000 nM
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CP0512132
 Compound Info 
8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[4,3-d]pyrimidin-2-one
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 C30H30F2N6O3  1
1
IC50 = 1500 nM
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CP0514743
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(oxolan-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C30H26F2N4O5S2  1
1
IC50 = 1224 nM
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CP0514745
 Compound Info 
2-(5-(cyclopropylmethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylthiophen-3- yl)ethynyl)phenyl)-1H-pyrazol-1- yl)thiazole-4-carboxylic acid
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 C31H25FN4O4S3  1
1
IC50 = 332 nM
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CP0514956
 Compound Info 
2-[3-(3-but-1-ynyl-4-fluorophenyl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C28H24F2N4O4S2  1
1
IC50 = 662 nM
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CP0536452
 Compound Info 
1,5-bis[(1S)-5-hydroxy-1-methyl-1,2-dihydrobenzo[e]indol-3-yl]pentane-1,5-dione
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 C31H30N2O4  1
1
IC50 > 10000 nM
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CP0537207
 Compound Info 
2-[3-(3,4-difluorophenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C20H14F2N4O4S2  1
1
IC50 > 57000 nM
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CP0537720
 Compound Info 
2-[5-(2-cyclopropylethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C32H26F2N4O4S3  1
1
IC50 = 223 nM
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CP0539166
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(2-methyl-1,3-thiazol-5-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C30H24FN5O4S3  1
1
IC50 = 641 nM
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CP0541521
 Compound Info 
5-(4-chlorophenyl)-2-phenyl-[1,3]thiazolo[3,2-b][1,2,4]triazole
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 C16H10ClN3S  1
1
IC50 = 6500 nM
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CP0541522
 Compound Info 
5-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3]thiazolo[3,2-b][1,2,4]triazole
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 C19H16ClN3O3S  1
1
IC50 = 3900 nM
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CP0547940
 Compound Info 
2-[5-cyclopropyl-3-(3-phenylphenyl)-4-(4-sulfamoylphenoxy)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C28H22N4O5S2  1
1
IC50 = 28300 nM
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CP0549705
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(2-methyl-1,3-thiazol-5-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C30H23F2N5O4S3  1
1
IC50 = 488 nM
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CP0558747
 Compound Info 
2-(4-methoxyphenyl)-5-phenyl-[1,3]thiazolo[3,2-b][1,2,4]triazole
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 C17H13N3OS  1
1
IC50 = 4900 nM
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CP0558851
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(4-hydroxybut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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 C28H24F2N4O5S2  1
1
IC50 = 1327 nM
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CP0639837
 Compound Info 
8-[2-methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide
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 C23H28N8O2  1
1
IC50 = 44 nM
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CP0807912
 Compound Info 
((2S,3S)-2-{(R)-4-[4-((R)-2,3-dihydroxy-propoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-N-(2-fluoro-4-iodo-phenyl)-3-phenylbutyramide
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 C28H27FIN3O6  1
1
IC50 = 1250 nM
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Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Pancreas)
Cell Line Name Organism Disease
PSN1
 Cell Line Info 
Homo sapiens (Human) Pancreatic adenocarcinoma
DAN-G
 Cell Line Info 
Homo sapiens (Human) Pancreatic adenocarcinoma
PANC-1
 Cell Line Info 
Homo sapiens (Human) Pancreatic ductal adenocarcinoma
MiaPaCa(BCRP)
 Cell Line Info 
Homo sapiens (Human) Pancreatic ductal adenocarcinoma
BxPC-3
 Cell Line Info 
Homo sapiens (Human) Pancreatic ductal adenocarcinoma
Beta-TC-3
 Cell Line Info 
Mus musculus (Mouse) Mouse insulinoma
MIN6
 Cell Line Info 
Mus musculus (Mouse) Mouse insulinoma
Beta-TC-6
 Cell Line Info 
Mus musculus (Mouse) Mouse insulinoma
Panc02
 Cell Line Info 
Mus musculus (Mouse) Mouse pancreatic ductal adenocarcinoma
AR42J
 Cell Line Info 
Rattus norvegicus (Rat) Rat digestive system neoplasms
INS-1
 Cell Line Info 
Rattus norvegicus (Rat) Rat insulinoma
INS-1 832/13
 Cell Line Info 
Rattus norvegicus (Rat) Rat insulinoma
INS-1E
 Cell Line Info 
Rattus norvegicus (Rat) Rat insulinoma