General Information of the Compound
Compound ID
CP0115374
Compound Name
1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile
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Structure
Formula
C25H28FN5O2
Molecular Weight
449.53
Canonical SMILES
CC1(CCN(CC1)c1c(cnc2ccc(F)cc12)C(=O)N1CCN(CC1)C(=O)C1CC1)C#N
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InChI
InChI=1S/C25H28FN5O2/c1-25(16-27)6-8-29(9-7-25)22-19-14-18(26)4-5-21(19)28-15-20(22)24(33)31-12-10-30(11-13-31)23(32)17-2-3-17/h4-5,14-15,17H,2-3,6-13H2,1H3
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InChIKey
KTSITCVMAFXAJZ-UHFFFAOYSA-N
Physicochemical Property
logP
3.19838
Rotatable Bonds
3
Heavy Atom Count
33
Polar Areas
80.54
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 142581623
ChEMBL ID
CHEMBL4213542
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03150, Aldehyde dehydrogenase 1A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000207 MIA PaCa-2 Homo sapiens (Human)  1
1
IC50 = 2890 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 33 nM