Protein Information

General Information of the Protein

Protein ID	PT03150
Protein Name	Aldehyde dehydrogenase 1A1
Secondarily Protein Name	3-deoxyglucosone dehydrogenase ALDH-E1 ALHDII Aldehyde dehydrogenase family 1 member A1 Aldehyde dehydrogenase cytosolic Retinal dehydrogenase 1
Gene Name	ALDH1A1
Secondarily Gene Name	ALDC ALDH1 PUMB1
Sequence	MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Oxidoreductase
Function	Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:19296407, PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:26373694, PubMed:25450233). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:19296407, PubMed:12941160, PubMed:15623782). Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). Show/Hide
Uniprot ID	Primary ID: P00352 Secondarily ID: O00768 Q5SYR1 Show/Hide
Ensembl ID	ENSG00000165092
HGNC ID	HGNC:402
Subcellular Location	Cytoplasm Cytosol Cell projection Axon

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000207 , MIA PaCa-2

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0115366 Compound Info	1-[6,7-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C27H27F2N5O3S	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0538681 Compound Info	1-[6-(4-methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C25H27N5O3S2	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0429561 Compound Info	2-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]-2-methylpropanenitrile Show/Hide	C25H25FN4O3S	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0115367 Compound Info	1-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopentane-1-carbonitrile Show/Hide	C27H27FN4O3S	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0097088 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C27H28FN5O3S	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0547344 Compound Info	4-[4-[4-(1-cyanocyclopropyl)phenyl]-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-sulfonamide Show/Hide	C26H26FN5O3S	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0148548 Compound Info	2-[4-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]phenyl]-2-methylpropanenitrile Show/Hide	C28H27FN4O2	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0412840 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-(2-fluorophenyl)piperidine-4-carbonitrile Show/Hide	C27H27F2N5O3S	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0545254 Compound Info	1-[6-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C28H31N5O4S	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0558114 Compound Info	1-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclobutane-1-carbonitrile Show/Hide	C26H25FN4O3S	1
1	IC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0148549 Compound Info	[4-[4-(4-tert-butylphenyl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C28H30FN3O2	1
1	IC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0364636 Compound Info	4-[4-(4-cyano-4-phenylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide Show/Hide	C29H31FN6O2	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0538683 Compound Info	4-[4-(4-cyano-4-phenylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-sulfonamide Show/Hide	C28H31FN6O3S	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0410945 Compound Info	1-[4-[6-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C26H26N4O4S	1
1	IC50 = 42 nM Bioactivity Info	TI LI LO TS
CP0237548 Compound Info	1-[7-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C28H31N5O4S	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0115365 Compound Info	1-[6,8-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C27H27F2N5O3S	1
1	IC50 = 47 nM Bioactivity Info	TI LI LO TS
CP0199187 Compound Info	1-[4-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C28H25FN4O2	1
1	IC50 = 47 nM Bioactivity Info	TI LI LO TS
CP0429560 Compound Info	1-[6-chloro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C27H28ClN5O3S	1
1	IC50 = 48 nM Bioactivity Info	TI LI LO TS
CP0402443 Compound Info	1-[4-[6-chloro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C25H23ClN4O3S	1
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
CP0563625 Compound Info	1-[4-[6-chloro-3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C28H25ClN4O2	1
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
CP0532797 Compound Info	4-[4-[4-(1-cyanocyclopropyl)phenyl]-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide Show/Hide	C27H26FN5O2	1
1	IC50 = 54 nM Bioactivity Info	TI LI LO TS
CP0364635 Compound Info	1-[4-[6,7-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C25H22F2N4O3S	1
1	IC50 = 55 nM Bioactivity Info	TI LI LO TS
CP0429562 Compound Info	[4-(4-tert-butylphenyl)-6-fluoroquinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone Show/Hide	C25H28FN3O3S	1
1	IC50 = 62 nM Bioactivity Info	TI LI LO TS
CP0097086 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C30H30FN5O2	1
1	IC50 = 63 nM Bioactivity Info	TI LI LO TS
CP0577971 Compound Info	1-[6-chloro-3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C30H30ClN5O2	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0148547 Compound Info	1-[6-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[3,2-b]pyridin-7-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C28H29N5O2S	1
1	IC50 = 71 nM Bioactivity Info	TI LI LO TS
CP0240915 Compound Info	1-[4-[7-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C26H26N4O4S	1
1	IC50 = 74 nM Bioactivity Info	TI LI LO TS
CP0097087 Compound Info	1-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C25H23FN4O3S	1
1	IC50 = 77 nM Bioactivity Info	TI LI LO TS
CP0240920 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-(4-fluorophenyl)piperidine-4-carbonitrile Show/Hide	C27H27F2N5O3S	1
1	IC50 = 87 nM Bioactivity Info	TI LI LO TS
CP0415885 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbaldehyde Show/Hide	C27H29FN4O4S	1
1	IC50 = 94 nM Bioactivity Info	TI LI LO TS
CP0566844 Compound Info	2-[3-fluoro-4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]-2-methylpropanenitrile Show/Hide	C25H24F2N4O3S	1
1	IC50 = 96 nM Bioactivity Info	TI LI LO TS
CP0364612 Compound Info	1-[1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidin-4-yl]ethanone Show/Hide	C28H31FN4O4S	1
1	IC50 = 106 nM Bioactivity Info	TI LI LO TS
CP0538680 Compound Info	1-[4-[6,8-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C25H22F2N4O3S	1
1	IC50 = 111 nM Bioactivity Info	TI LI LO TS
CP0415886 Compound Info	cyclopropyl-[4-[4-(4,4-dimethylcyclohexen-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H30FN3O2	1
1	IC50 = 112 nM Bioactivity Info	TI LI LO TS
CP0115370 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-ethylpiperidine-4-carbonitrile Show/Hide	C26H30FN5O2	1
1	IC50 = 153 nM Bioactivity Info	TI LI LO TS
CP0564008 Compound Info	4-ethyl-1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C23H28FN5O3S	1
1	IC50 = 206 nM Bioactivity Info	TI LI LO TS
CP0148546 Compound Info	1-[4-[6-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[3,2-b]pyridin-7-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C26H24N4O2S	1
1	IC50 = 319 nM Bioactivity Info	TI LI LO TS
CP0547300 Compound Info	4-(4-chlorophenyl)-1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C27H27ClFN5O3S	1
1	IC50 = 346 nM Bioactivity Info	TI LI LO TS
CP0410940 Compound Info	1'-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]spiro[1H-indene-3,4'-piperidine]-2-one Show/Hide	C28H29FN4O4S	1
1	IC50 = 472 nM Bioactivity Info	TI LI LO TS
CP0429565 Compound Info	4-[4-(4-cyano-4-methylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-sulfonamide Show/Hide	C23H29FN6O3S	1
1	IC50 = 477 nM Bioactivity Info	TI LI LO TS
CP0402765 Compound Info	1-[3-fluoro-4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C25H22F2N4O3S	1
1	IC50 = 486 nM Bioactivity Info	TI LI LO TS
CP0063241 Compound Info	1-[4-[6-(4-methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C23H22N4O3S2	1
1	IC50 = 507 nM Bioactivity Info	TI LI LO TS
CP0415887 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-(cyclopropylmethyl)piperidine-4-carbonitrile Show/Hide	C28H32FN5O2	1
1	IC50 = 572 nM Bioactivity Info	TI LI LO TS
CP0477990 Compound Info	[4-(4,4-dimethylcyclohexen-1-yl)-6-fluoroquinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone Show/Hide	C23H28FN3O3S	1
1	IC50 = 873 nM Bioactivity Info	TI LI LO TS
CP0353601 Compound Info	2-[(2-butan-2-yl-3-oxo-2H-imidazo[1,2-c]quinazolin-5-yl)sulfanyl]-N-(2-methylphenyl)butanamide Show/Hide	C25H28N4O2S	1
1	IC50 = 1010 nM Bioactivity Info	TI LI LO TS
CP0148552 Compound Info	1-[6-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[3,2-b]pyridin-7-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H27N5O2S	1
1	IC50 = 1050 nM Bioactivity Info	TI LI LO TS
CP0364614 Compound Info	[4-[4-(8-azaspiro[4.5]decan-8-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C27H33FN4O2	1
1	IC50 = 1110 nM Bioactivity Info	TI LI LO TS
CP0240923 Compound Info	4-methyl-1-[6-(4-methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]piperidine-4-carbonitrile Show/Hide	C20H25N5O3S2	1
1	IC50 = 1210 nM Bioactivity Info	TI LI LO TS
CP0542698 Compound Info	1-[3-(4-ethylsulfonylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H28FN5O3S	1
1	IC50 = 1410 nM Bioactivity Info	TI LI LO TS
CP0353681 Compound Info	4-[4-(4-cyano-4-methylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide Show/Hide	C24H29FN6O2	1
1	IC50 = 1450 nM Bioactivity Info	TI LI LO TS
CP0115372 Compound Info	1-[6-fluoro-3-[4-(2-methylpropanoyl)piperazine-1-carbonyl]quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C25H30FN5O2	1
1	IC50 = 1480 nM Bioactivity Info	TI LI LO TS
CP0429564 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperidine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C26H29FN4O2	1
1	IC50 = 1570 nM Bioactivity Info	TI LI LO TS
CP0199186 Compound Info	[4-(4-ethenylsulfonylpiperazin-1-yl)-6-fluoroquinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone Show/Hide	C21H26FN5O5S2	1
1	IC50 = 1590 nM Bioactivity Info	TI LI LO TS
CP0477993 Compound Info	[4-[6-chloro-4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C25H29ClN4O4	1
1	IC50 = 1970 nM Bioactivity Info	TI LI LO TS
CP0564009 Compound Info	1-[6-fluoro-3-[(3S)-3-methyl-4-methylsulfonylpiperazine-1-carbonyl]quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H28FN5O3S	1
1	IC50 = 1980 nM Bioactivity Info	TI LI LO TS
CP0115368 Compound Info	1'-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]spiro[3H-indene-2,4'-piperidine]-1-one Show/Hide	C28H29FN4O4S	1
1	IC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0532831 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,7-dimethoxyquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C27H34N4O6	1
1	IC50 = 2220 nM Bioactivity Info	TI LI LO TS
CP0410944 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methylquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H32N4O4	1
1	IC50 = 2270 nM Bioactivity Info	TI LI LO TS
CP0240926 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C25H29FN4O4	1
1	IC50 = 2420 nM Bioactivity Info	TI LI LO TS
CP0240925 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-7-methoxyquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H32N4O5	1
1	IC50 = 2430 nM Bioactivity Info	TI LI LO TS
CP0148554 Compound Info	1-[5-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[2,3-b]pyridin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H27N5O2S	1
1	IC50 = 2450 nM Bioactivity Info	TI LI LO TS
CP0240544 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,7-difluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C25H28F2N4O4	1
1	IC50 = 2460 nM Bioactivity Info	TI LI LO TS
CP0574142 Compound Info	cyclopropyl-[4-[4-(4,4-dimethylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C25H31FN4O2	1
1	IC50 = 2570 nM Bioactivity Info	TI LI LO TS
CP0148556 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperidine-1-carbonyl)quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H27FN4O3S	1
1	IC50 = 2800 nM Bioactivity Info	TI LI LO TS
CP0240924 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,8-difluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C25H28F2N4O4	1
1	IC50 = 2880 nM Bioactivity Info	TI LI LO TS
CP0115374 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C25H28FN5O2	1
1	IC50 = 2890 nM Bioactivity Info	TI LI LO TS
CP0415889 Compound Info	4-methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)thieno[2,3-b]pyridin-4-yl]piperidine-4-carbonitrile Show/Hide	C20H25N5O3S2	1
1	IC50 = 2950 nM Bioactivity Info	TI LI LO TS
CP0364479 Compound Info	[4-[4-(3-azaspiro[5.5]undecan-3-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C28H35FN4O2	1
1	IC50 = 3120 nM Bioactivity Info	TI LI LO TS
CP0148558 Compound Info	8-[6-methoxy-3-(4-methoxyphenyl)sulfonylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C24H26N2O6S	1
1	IC50 = 3430 nM Bioactivity Info	TI LI LO TS
CP0353683 Compound Info	cyclopropyl-[4-[6-fluoro-4-(1-oxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H31FN4O3	1
1	IC50 = 3550 nM Bioactivity Info	TI LI LO TS
CP0542699 Compound Info	1-[6-fluoro-3-(4-propanoylpiperazine-1-carbonyl)quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C24H28FN5O2	1
1	IC50 = 3890 nM Bioactivity Info	TI LI LO TS
CP0574143 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-fluoro-8-methylquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H31FN4O4	1
1	IC50 = 3930 nM Bioactivity Info	TI LI LO TS
CP0148401 Compound Info	[4-[4-(6-azaspiro[2.5]octan-6-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C25H29FN4O2	1
1	IC50 = 4040 nM Bioactivity Info	TI LI LO TS
CP0429569 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methoxyquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H32N4O5	1
1	IC50 = 4090 nM Bioactivity Info	TI LI LO TS
CP0063244 Compound Info	[6-fluoro-4-[4-(hydroxymethyl)-4-phenylpiperidin-1-yl]quinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone Show/Hide	C27H31FN4O4S	1
1	IC50 = 4110 nM Bioactivity Info	TI LI LO TS
CP0364613 Compound Info	4-benzyl-1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C28H30FN5O3S	1
1	IC50 = 4510 nM Bioactivity Info	TI LI LO TS
CP0346518 Compound Info	cyclopropyl-[4-[4-(4,4-diethylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C27H35FN4O2	1
1	IC50 = 4570 nM Bioactivity Info	TI LI LO TS
CP0364611 Compound Info	1'-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]spiro[2H-indene-3,4'-piperidine]-1-one Show/Hide	C28H29FN4O4S	1
1	IC50 = 4680 nM Bioactivity Info	TI LI LO TS
CP0082269 Compound Info	1-benzyl-2,3-dihydro-1H-indole-2,3-dione Show/Hide	C15H11NO2	1
1	IC50 = 4870 nM Bioactivity Info	TI LI LO TS
CP0415818 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C22H26FN5O3S	1
1	IC50 = 5080 nM Bioactivity Info	TI LI LO TS
CP0364478 Compound Info	4-methyl-1-[1-methyl-5-(4-methylsulfonylpiperazine-1-carbonyl)pyrazolo[3,4-b]pyridin-4-yl]piperidine-4-carbonitrile Show/Hide	C20H27N7O3S	1
1	IC50 = 5230 nM Bioactivity Info	TI LI LO TS
CP0410942 Compound Info	1-[6-fluoro-3-[(3R)-3-methyl-4-methylsulfonylpiperazine-1-carbonyl]quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H28FN5O3S	1
1	IC50 = 5380 nM Bioactivity Info	TI LI LO TS
CP0115371 Compound Info	4-methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]piperidine-4-carbonitrile Show/Hide	C20H26N6O3S	1
1	IC50 = 5440 nM Bioactivity Info	TI LI LO TS
CP0098099 Compound Info	[4-[4-(2-azaspiro[4.5]decan-2-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C27H33FN4O2	1
1	IC50 = 5610 nM Bioactivity Info	TI LI LO TS
CP0532830 Compound Info	1-[3-(4-cyclopropylsulfonylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C24H28FN5O3S	1
1	IC50 = 6340 nM Bioactivity Info	TI LI LO TS
CP0364515 Compound Info	8-[[4-(cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione Show/Hide	C21H32N6O3	1
1	IC50 = 6790 nM Bioactivity Info	TI LI LO TS
CP0115369 Compound Info	[6-fluoro-4-(4-hydroxy-4-phenylpiperidin-1-yl)quinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone Show/Hide	C26H29FN4O4S	1
1	IC50 = 7420 nM Bioactivity Info	TI LI LO TS
CP0575827 Compound Info	[4-[4-[(3aS,7aR)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C26H31FN4O2	1
1	IC50 = 9220 nM Bioactivity Info	TI LI LO TS
CP0545238 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C25H30N4O4	1
1	IC50 = 9760 nM Bioactivity Info	TI LI LO TS
CP0563618 Compound Info	1-[3-(4-acetylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H26FN5O2	1
1	IC50 = 11380 nM Bioactivity Info	TI LI LO TS
CP0575825 Compound Info	[4-[4-(azepan-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C24H29FN4O2	1
1	IC50 = 11600 nM Bioactivity Info	TI LI LO TS
CP0410943 Compound Info	[4-[4-[(1R,5S)-3-azabicyclo[3.2.1]octan-3-yl]-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C25H29FN4O2	1
1	IC50 = 11700 nM Bioactivity Info	TI LI LO TS
CP0098097 Compound Info	[4-[4-(2-azaspiro[3.5]nonan-2-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C26H31FN4O2	1
1	IC50 = 11800 nM Bioactivity Info	TI LI LO TS
CP0063251 Compound Info	cyclopropyl-[4-[[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methoxyquinolin-3-yl]methyl]piperazin-1-yl]methanone Show/Hide	C26H34N4O4	1
1	IC50 = 12400 nM Bioactivity Info	TI LI LO TS
CP0148551 Compound Info	cyclopropyl-[4-[6-fluoro-4-(4-phenylpiperidin-1-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C29H31FN4O2	1
1	IC50 = 13600 nM Bioactivity Info	TI LI LO TS
CP0542697 Compound Info	4-methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidine-4-carbonitrile Show/Hide	C19H25N7O3S	1
1	IC50 = 15600 nM Bioactivity Info	TI LI LO TS
CP0410941 Compound Info	[4-[4-(4-benzylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C30H33FN4O2	1
1	IC50 = 17300 nM Bioactivity Info	TI LI LO TS
CP0429563 Compound Info	4-benzyl-1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C31H32FN5O2	1
1	IC50 = 22600 nM Bioactivity Info	TI LI LO TS
CP0093742 Compound Info	ethyl 2-[[4-oxo-3-(3-pyrrolidin-1-ylpropyl)-[1]benzothiolo[3,2-d]pyrimidin-2-yl]sulfanyl]acetate Show/Hide	C21H25N3O3S2	1
1	IC50 > 57000 nM Bioactivity Info	TI LI LO TS
CP0115373 Compound Info	1-[4-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]piperazin-1-yl]ethanone Show/Hide	C24H28FN5O3	1
1	IC50 > 57000 nM Bioactivity Info	TI LI LO TS
CP0148400 Compound Info	cyclopropyl-[4-[4-(4,4-difluoropiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C23H25F3N4O2	1
1	IC50 > 57000 nM Bioactivity Info	TI LI LO TS
CP0199189 Compound Info	1-[3-(3,3-dimethyl-4-methylsulfonylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C24H30FN5O3S	1
1	IC50 > 57000 nM Bioactivity Info	TI LI LO TS
CP0237549 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-methoxyquinolin-4-yl]piperidin-4-one Show/Hide	C24H28N4O4	1
1	IC50 > 57000 nM Bioactivity Info	TI LI LO TS
CP0353677 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C21H24FN5O3S	1
1	IC50 > 57000 nM Bioactivity Info	TI LI LO TS
CP0477991 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C24H26FN5O2	1
1	IC50 > 57000 nM Bioactivity Info	TI LI LO TS
CP0477992 Compound Info	cyclopropyl-[4-[6-fluoro-4-(4-fluoropiperidin-1-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C23H26F2N4O2	1
1	IC50 > 57000 nM Bioactivity Info	TI LI LO TS
CP0563619 Compound Info	cyclopropyl-[4-[6-fluoro-4-(4-methylsulfonylpiperazin-1-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C23H28FN5O4S	1
1	IC50 > 57000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000849 , OV-90

Cell Line Info

Cell Line ID: CL000848 , SKOV3/TR

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0240915 Compound Info	1-[4-[7-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C26H26N4O4S	1
1	IC50 = 5 nM
CP0148548 Compound Info	2-[4-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]phenyl]-2-methylpropanenitrile Show/Hide	C28H27FN4O2	1
1	IC50 = 6 nM
CP0199187 Compound Info	1-[4-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C28H25FN4O2	1
1	IC50 = 6 nM
CP0364636 Compound Info	4-[4-(4-cyano-4-phenylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide Show/Hide	C29H31FN6O2	1
1	IC50 = 6 nM
CP0547344 Compound Info	4-[4-[4-(1-cyanocyclopropyl)phenyl]-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-sulfonamide Show/Hide	C26H26FN5O3S	1
1	IC50 = 6 nM
CP0097087 Compound Info	1-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C25H23FN4O3S	4
1	IC50 = 7 nM
2	IC50 = 48.5 nM
3	Ki = 7.2 nM
4	Ki = 23.3 nM
CP0097088 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C27H28FN5O3S	4
1	IC50 = 7 nM
2	IC50 = 19.6 nM
3	Ki = 5.5 nM
4	Ki = 26.1 nM
CP0402443 Compound Info	1-[4-[6-chloro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C25H23ClN4O3S	1
1	IC50 = 7 nM
CP0410945 Compound Info	1-[4-[6-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C26H26N4O4S	1
1	IC50 = 7 nM
CP0412840 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-(2-fluorophenyl)piperidine-4-carbonitrile Show/Hide	C27H27F2N5O3S	1
1	IC50 = 7 nM
CP0558114 Compound Info	1-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclobutane-1-carbonitrile Show/Hide	C26H25FN4O3S	1
1	IC50 = 7 nM
CP0097086 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C30H30FN5O2	1
1	IC50 = 8 nM
CP0364635 Compound Info	1-[4-[6,7-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C25H22F2N4O3S	1
1	IC50 = 8 nM
CP0532797 Compound Info	4-[4-[4-(1-cyanocyclopropyl)phenyl]-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide Show/Hide	C27H26FN5O2	1
1	IC50 = 8 nM
CP0429561 Compound Info	2-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]-2-methylpropanenitrile Show/Hide	C25H25FN4O3S	1
1	IC50 = 9 nM
CP0538680 Compound Info	1-[4-[6,8-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C25H22F2N4O3S	1
1	IC50 = 9 nM
CP0566844 Compound Info	2-[3-fluoro-4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]-2-methylpropanenitrile Show/Hide	C25H24F2N4O3S	1
1	IC50 = 9 nM
CP0082269 Compound Info	1-benzyl-2,3-dihydro-1H-indole-2,3-dione Show/Hide	C15H11NO2	2
1	IC50 = 10 nM
2	IC50 = 20 nM
CP0415885 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbaldehyde Show/Hide	C27H29FN4O4S	1
1	IC50 = 10 nM
CP0538681 Compound Info	1-[6-(4-methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C25H27N5O3S2	1
1	IC50 = 10 nM
CP0115365 Compound Info	1-[6,8-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C27H27F2N5O3S	1
1	IC50 = 11 nM
CP0240920 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-(4-fluorophenyl)piperidine-4-carbonitrile Show/Hide	C27H27F2N5O3S	1
1	IC50 = 11 nM
CP0364612 Compound Info	1-[1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidin-4-yl]ethanone Show/Hide	C28H31FN4O4S	1
1	IC50 = 11 nM
CP0115366 Compound Info	1-[6,7-difluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C27H27F2N5O3S	1
1	IC50 = 12 nM
CP0148547 Compound Info	1-[6-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[3,2-b]pyridin-7-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C28H29N5O2S	1
1	IC50 = 12 nM
CP0429562 Compound Info	[4-(4-tert-butylphenyl)-6-fluoroquinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone Show/Hide	C25H28FN3O3S	1
1	IC50 = 12 nM
CP0545254 Compound Info	1-[6-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C28H31N5O4S	1
1	IC50 = 12 nM
CP0564008 Compound Info	4-ethyl-1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C23H28FN5O3S	1
1	IC50 = 12 nM
CP0415886 Compound Info	cyclopropyl-[4-[4-(4,4-dimethylcyclohexen-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H30FN3O2	1
1	IC50 = 13 nM
CP0415887 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-(cyclopropylmethyl)piperidine-4-carbonitrile Show/Hide	C28H32FN5O2	1
1	IC50 = 13 nM
CP0477993 Compound Info	[4-[6-chloro-4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C25H29ClN4O4	1
1	IC50 = 13 nM
CP0563625 Compound Info	1-[4-[6-chloro-3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C28H25ClN4O2	1
1	IC50 = 13 nM
CP0115367 Compound Info	1-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopentane-1-carbonitrile Show/Hide	C27H27FN4O3S	1
1	IC50 = 14 nM
CP0148549 Compound Info	[4-[4-(4-tert-butylphenyl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C28H30FN3O2	1
1	IC50 = 14 nM
CP0237548 Compound Info	1-[7-methoxy-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C28H31N5O4S	1
1	IC50 = 14 nM
CP0538683 Compound Info	4-[4-(4-cyano-4-phenylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-sulfonamide Show/Hide	C28H31FN6O3S	1
1	IC50 = 14 nM
CP0577971 Compound Info	1-[6-chloro-3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C30H30ClN5O2	1
1	IC50 = 14 nM
CP0115370 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-ethylpiperidine-4-carbonitrile Show/Hide	C26H30FN5O2	1
1	IC50 = 15 nM
CP0429560 Compound Info	1-[6-chloro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-phenylpiperidine-4-carbonitrile Show/Hide	C27H28ClN5O3S	1
1	IC50 = 15 nM
CP0402765 Compound Info	1-[3-fluoro-4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C25H22F2N4O3S	1
1	IC50 = 16 nM
CP0148546 Compound Info	1-[4-[6-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[3,2-b]pyridin-7-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C26H24N4O2S	1
1	IC50 = 17 nM
CP0148552 Compound Info	1-[6-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[3,2-b]pyridin-7-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H27N5O2S	1
1	IC50 = 17 nM
CP0148558 Compound Info	8-[6-methoxy-3-(4-methoxyphenyl)sulfonylquinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane Show/Hide	C24H26N2O6S	2
1	IC50 = 17 nM
2	IC50 = 50 nM
CP0410940 Compound Info	1'-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]spiro[1H-indene-3,4'-piperidine]-2-one Show/Hide	C28H29FN4O4S	1
1	IC50 = 18 nM
CP0240926 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C25H29FN4O4	1
1	IC50 = 19 nM
CP0364479 Compound Info	[4-[4-(3-azaspiro[5.5]undecan-3-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C28H35FN4O2	1
1	IC50 = 19 nM
CP0429569 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methoxyquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H32N4O5	1
1	IC50 = 19 nM
CP0063241 Compound Info	1-[4-[6-(4-methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]phenyl]cyclopropane-1-carbonitrile Show/Hide	C23H22N4O3S2	1
1	IC50 = 20 nM
CP0093742 Compound Info	ethyl 2-[[4-oxo-3-(3-pyrrolidin-1-ylpropyl)-[1]benzothiolo[3,2-d]pyrimidin-2-yl]sulfanyl]acetate Show/Hide	C21H25N3O3S2	4
1	IC50 = 20 nM
2	IC50 = 4600 nM
3	IC50 = 6890 nM
4	Ki = 230 nM
CP0240925 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-7-methoxyquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H32N4O5	1
1	IC50 = 21 nM
CP0477990 Compound Info	[4-(4,4-dimethylcyclohexen-1-yl)-6-fluoroquinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone Show/Hide	C23H28FN3O3S	1
1	IC50 = 21 nM
CP0574143 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-fluoro-8-methylquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H31FN4O4	1
1	IC50 = 22 nM
CP0240924 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,8-difluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C25H28F2N4O4	1
1	IC50 = 23 nM
CP0547300 Compound Info	4-(4-chlorophenyl)-1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C27H27ClFN5O3S	1
1	IC50 = 23 nM
CP0353681 Compound Info	4-[4-(4-cyano-4-methylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-carboxamide Show/Hide	C24H29FN6O2	1
1	IC50 = 24 nM
CP0429565 Compound Info	4-[4-(4-cyano-4-methylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]-N,N-dimethylpiperazine-1-sulfonamide Show/Hide	C23H29FN6O3S	1
1	IC50 = 25 nM
CP0115372 Compound Info	1-[6-fluoro-3-[4-(2-methylpropanoyl)piperazine-1-carbonyl]quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C25H30FN5O2	1
1	IC50 = 27 nM
CP0063251 Compound Info	cyclopropyl-[4-[[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methoxyquinolin-3-yl]methyl]piperazin-1-yl]methanone Show/Hide	C26H34N4O4	1
1	IC50 = 28 nM
CP0364614 Compound Info	[4-[4-(8-azaspiro[4.5]decan-8-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C27H33FN4O2	1
1	IC50 = 28 nM
CP0240923 Compound Info	4-methyl-1-[6-(4-methylsulfonylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yl]piperidine-4-carbonitrile Show/Hide	C20H25N5O3S2	1
1	IC50 = 32 nM
CP0115374 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C25H28FN5O2	1
1	IC50 = 33 nM
CP0098099 Compound Info	[4-[4-(2-azaspiro[4.5]decan-2-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C27H33FN4O2	1
1	IC50 = 35 nM
CP0410944 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-methylquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H32N4O4	1
1	IC50 = 35 nM
CP0532831 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,7-dimethoxyquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C27H34N4O6	1
1	IC50 = 35 nM
CP0199186 Compound Info	[4-(4-ethenylsulfonylpiperazin-1-yl)-6-fluoroquinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone Show/Hide	C21H26FN5O5S2	1
1	IC50 = 38 nM
CP0364515 Compound Info	8-[[4-(cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione Show/Hide	C21H32N6O3	1
1	IC50 = 41 nM
CP0353683 Compound Info	cyclopropyl-[4-[6-fluoro-4-(1-oxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C26H31FN4O3	1
1	IC50 = 43 nM
CP0575827 Compound Info	[4-[4-[(3aS,7aR)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C26H31FN4O2	1
1	IC50 = 45 nM
CP0574142 Compound Info	cyclopropyl-[4-[4-(4,4-dimethylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C25H31FN4O2	1
1	IC50 = 46 nM
CP0115368 Compound Info	1'-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]spiro[3H-indene-2,4'-piperidine]-1-one Show/Hide	C28H29FN4O4S	1
1	IC50 = 47 nM
CP0240544 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6,7-difluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C25H28F2N4O4	1
1	IC50 = 50 nM
CP0214017 Compound Info	CHEBI:86194 Show/Hide	C11H15NO	3
1	IC50 = 57 nM
2	IC50 = 480 nM
3	IC50 = 520 nM
CP0415889 Compound Info	4-methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)thieno[2,3-b]pyridin-4-yl]piperidine-4-carbonitrile Show/Hide	C20H25N5O3S2	1
1	IC50 = 60 nM
CP0364611 Compound Info	1'-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]spiro[2H-indene-3,4'-piperidine]-1-one Show/Hide	C28H29FN4O4S	1
1	IC50 = 61 nM
CP0148554 Compound Info	1-[5-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]thieno[2,3-b]pyridin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H27N5O2S	1
1	IC50 = 64 nM
CP0148401 Compound Info	[4-[4-(6-azaspiro[2.5]octan-6-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C25H29FN4O2	1
1	IC50 = 67 nM
CP0545238 Compound Info	cyclopropyl-[4-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C25H30N4O4	1
1	IC50 = 68 nM
CP0063244 Compound Info	[6-fluoro-4-[4-(hydroxymethyl)-4-phenylpiperidin-1-yl]quinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone Show/Hide	C27H31FN4O4S	1
1	IC50 = 80 nM
CP0346518 Compound Info	cyclopropyl-[4-[4-(4,4-diethylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C27H35FN4O2	1
1	IC50 = 86 nM
CP0564009 Compound Info	1-[6-fluoro-3-[(3S)-3-methyl-4-methylsulfonylpiperazine-1-carbonyl]quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H28FN5O3S	1
1	IC50 = 86 nM
CP0364478 Compound Info	4-methyl-1-[1-methyl-5-(4-methylsulfonylpiperazine-1-carbonyl)pyrazolo[3,4-b]pyridin-4-yl]piperidine-4-carbonitrile Show/Hide	C20H27N7O3S	1
1	IC50 = 87 nM
CP0429564 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperidine-1-carbonyl]-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C26H29FN4O2	1
1	IC50 = 89 nM
CP0415818 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C22H26FN5O3S	1
1	IC50 = 94 nM
CP0098097 Compound Info	[4-[4-(2-azaspiro[3.5]nonan-2-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C26H31FN4O2	1
1	IC50 = 113 nM
CP0353601 Compound Info	2-[(2-butan-2-yl-3-oxo-2H-imidazo[1,2-c]quinazolin-5-yl)sulfanyl]-N-(2-methylphenyl)butanamide Show/Hide	C25H28N4O2S	2
1	IC50 = 119 nM
2	IC50 = 390 nM
CP0542698 Compound Info	1-[3-(4-ethylsulfonylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H28FN5O3S	1
1	IC50 = 122 nM
CP0542699 Compound Info	1-[6-fluoro-3-(4-propanoylpiperazine-1-carbonyl)quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C24H28FN5O2	1
1	IC50 = 122 nM
CP0148556 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperidine-1-carbonyl)quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H27FN4O3S	1
1	IC50 = 127 nM
CP0115371 Compound Info	4-methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]piperidine-4-carbonitrile Show/Hide	C20H26N6O3S	1
1	IC50 = 193 nM
CP0575825 Compound Info	[4-[4-(azepan-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C24H29FN4O2	1
1	IC50 = 194 nM
CP0115369 Compound Info	[6-fluoro-4-(4-hydroxy-4-phenylpiperidin-1-yl)quinolin-3-yl]-(4-methylsulfonylpiperazin-1-yl)methanone Show/Hide	C26H29FN4O4S	1
1	IC50 = 199 nM
CP0410943 Compound Info	[4-[4-[(1R,5S)-3-azabicyclo[3.2.1]octan-3-yl]-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C25H29FN4O2	1
1	IC50 = 211 nM
CP0542697 Compound Info	4-methyl-1-[5-(4-methylsulfonylpiperazine-1-carbonyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidine-4-carbonitrile Show/Hide	C19H25N7O3S	1
1	IC50 = 251 nM
CP0563618 Compound Info	1-[3-(4-acetylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H26FN5O2	1
1	IC50 = 343 nM
CP0532830 Compound Info	1-[3-(4-cyclopropylsulfonylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C24H28FN5O3S	1
1	IC50 = 371 nM
CP0410942 Compound Info	1-[6-fluoro-3-[(3R)-3-methyl-4-methylsulfonylpiperazine-1-carbonyl]quinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C23H28FN5O3S	1
1	IC50 = 388 nM
CP0364613 Compound Info	4-benzyl-1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C28H30FN5O3S	1
1	IC50 = 574 nM
CP0148551 Compound Info	cyclopropyl-[4-[6-fluoro-4-(4-phenylpiperidin-1-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C29H31FN4O2	1
1	IC50 = 597 nM
CP0429563 Compound Info	4-benzyl-1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C31H32FN5O2	1
1	IC50 = 767 nM
CP0563619 Compound Info	cyclopropyl-[4-[6-fluoro-4-(4-methylsulfonylpiperazin-1-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C23H28FN5O4S	1
1	IC50 = 1400 nM
CP0477992 Compound Info	cyclopropyl-[4-[6-fluoro-4-(4-fluoropiperidin-1-yl)quinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C23H26F2N4O2	1
1	IC50 = 1900 nM
CP0148400 Compound Info	cyclopropyl-[4-[4-(4,4-difluoropiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]methanone Show/Hide	C23H25F3N4O2	1
1	IC50 = 2330 nM
CP0410941 Compound Info	[4-[4-(4-benzylpiperidin-1-yl)-6-fluoroquinoline-3-carbonyl]piperazin-1-yl]-cyclopropylmethanone Show/Hide	C30H33FN4O2	1
1	IC50 = 2510 nM
CP0199189 Compound Info	1-[3-(3,3-dimethyl-4-methylsulfonylpiperazine-1-carbonyl)-6-fluoroquinolin-4-yl]-4-methylpiperidine-4-carbonitrile Show/Hide	C24H30FN5O3S	1
1	IC50 = 4490 nM
CP0353677 Compound Info	1-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C21H24FN5O3S	1
1	IC50 = 4830 nM
CP0477991 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]piperidine-4-carbonitrile Show/Hide	C24H26FN5O2	1
1	IC50 = 23380 nM
CP0237549 Compound Info	1-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-methoxyquinolin-4-yl]piperidin-4-one Show/Hide	C24H28N4O4	1
1	IC50 = 26410 nM
CP0115373 Compound Info	1-[4-[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-6-fluoroquinolin-4-yl]piperazin-1-yl]ethanone Show/Hide	C24H28FN5O3	1
1	IC50 > 57000 nM

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Prof. Feng ZHU

Prof. Leo, Lianyi Han