General Information of the Protein
Protein ID
PT00337
Protein Name
L-lactate dehydrogenase
Gene Name
HEL-S-133P
Sequence
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Uniprot ID
V9HWB9
Subcellular Location
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000569 , A-673
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0362432
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H26N4O4S2
  1
1
IC50 = 517 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0098250
 Compound Info 
2-[5-cyclopropyl-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C29H24N4O4S2
  1
1
IC50 = 983 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0213712
 Compound Info 
GNE-140 (6)
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C25H23ClN2O3S2
  1
1
IC50 = 1440 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547940
 Compound Info 
2-[5-cyclopropyl-3-(3-phenylphenyl)-4-(4-sulfamoylphenoxy)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H22N4O5S2
  1
1
IC50 = 1920 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0361785
 Compound Info 
2-[5-(cyclopropylmethyl)-3-phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C24H22N4O4S2
  1
1
IC50 = 3370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0361784
 Compound Info 
2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-(trifluoromethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H19F3N4O4S2
  1
1
IC50 = 4350 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0506646
 Compound Info 
2-[5-amino-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C26H21N5O4S2
  1
1
IC50 = 9450 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0558594
 Compound Info 
2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C26H20N4O4S2
  1
1
IC50 = 9880 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0109412
 Compound Info 
3-[[3-(cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino]-5-(3,5-difluorophenoxy)benzoic acid
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C31H25F2N5O7S
  1
1
IC50 = 14500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0414075
 Compound Info 
2-[5-cyclopropyl-3-phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C23H20N4O4S2
  1
1
IC50 = 14700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0414073
 Compound Info 
2-[3-phenyl-5-pyridin-3-yl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C25H19N5O4S2
  1
1
IC50 = 16500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0506645
 Compound Info 
2-[3-(3-phenylphenyl)-4-(4-sulfamoylanilino)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C25H19N5O4S2
  1
1
IC50 = 19900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0098303
 Compound Info 
2-[3-phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C20H16N4O4S2
  1
1
IC50 = 25200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0458622
 Compound Info 
2-[3-phenyl-4-(4-sulfamoylanilino)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C19H15N5O4S2
  1
1
IC50 = 26800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0537212
 Compound Info 
2-[3-oxo-5-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid
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C26H20N4O5S2
  1
1
IC50 = 26800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0560331
 Compound Info 
2-[5-[3-(2-fluorophenyl)phenyl]-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid
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C26H19FN4O5S2
  1
1
IC50 = 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0537207
 Compound Info 
2-[3-(3,4-difluorophenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C20H14F2N4O4S2
  1
1
IC50 = 30800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0108302
 Compound Info 
2-[5-(3,4-difluorophenyl)-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid
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C20H14F2N4O5S2
  1
1
IC50 > 57000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0309124
 Compound Info 
2-[3-phenyl-5-pyridin-4-yl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C25H19N5O4S2
  1
1
IC50 > 57000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0402827
 Compound Info 
LDHA Inhibitor, 33
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C25H27N3O6S
  1
1
IC50 > 57000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0546842
 Compound Info 
2-[5-(3-bromophenyl)-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid
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C20H15BrN4O5S2
  1
1
IC50 > 57000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000207 , MIA PaCa-2
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
100% Identity
Protein ID Protein Name Protein Organism
PT02629 L-lactate dehydrogenase A chain Homo sapiens, Human
 Protein Info