General Information of the Cell Line
Cell Line ID
CL000569
Cell Line Name
A-673
Synonyms
A673
RMS 1598
RMS1598
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0080
Disease
Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00337, L-lactate dehydrogenase
 Protein Info 
Compound ID Compound Name Compound Formula
CP0362432
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H26N4O4S2
  1
1
IC50 = 517 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0098250
 Compound Info 
2-[5-cyclopropyl-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C29H24N4O4S2
  1
1
IC50 = 983 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0213712
 Compound Info 
GNE-140 (6)
   Show/Hide
C25H23ClN2O3S2
  1
1
IC50 = 1440 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547940
 Compound Info 
2-[5-cyclopropyl-3-(3-phenylphenyl)-4-(4-sulfamoylphenoxy)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C28H22N4O5S2
  1
1
IC50 = 1920 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0361785
 Compound Info 
2-[5-(cyclopropylmethyl)-3-phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C24H22N4O4S2
  1
1
IC50 = 3370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0361784
 Compound Info 
2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-(trifluoromethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C27H19F3N4O4S2
  1
1
IC50 = 4350 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0506646
 Compound Info 
2-[5-amino-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C26H21N5O4S2
  1
1
IC50 = 9450 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0558594
 Compound Info 
2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C26H20N4O4S2
  1
1
IC50 = 9880 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0109412
 Compound Info 
3-[[3-(cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino]-5-(3,5-difluorophenoxy)benzoic acid
   Show/Hide
C31H25F2N5O7S
  1
1
IC50 = 14500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0414075
 Compound Info 
2-[5-cyclopropyl-3-phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C23H20N4O4S2
  1
1
IC50 = 14700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0414073
 Compound Info 
2-[3-phenyl-5-pyridin-3-yl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C25H19N5O4S2
  1
1
IC50 = 16500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0506645
 Compound Info 
2-[3-(3-phenylphenyl)-4-(4-sulfamoylanilino)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C25H19N5O4S2
  1
1
IC50 = 19900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0098303
 Compound Info 
2-[3-phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C20H16N4O4S2
  1
1
IC50 = 25200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0458622
 Compound Info 
2-[3-phenyl-4-(4-sulfamoylanilino)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C19H15N5O4S2
  1
1
IC50 = 26800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0537212
 Compound Info 
2-[3-oxo-5-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C26H20N4O5S2
  1
1
IC50 = 26800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0560331
 Compound Info 
2-[5-[3-(2-fluorophenyl)phenyl]-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C26H19FN4O5S2
  1
1
IC50 = 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0537207
 Compound Info 
2-[3-(3,4-difluorophenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C20H14F2N4O4S2
  1
1
IC50 = 30800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0108302
 Compound Info 
2-[5-(3,4-difluorophenyl)-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C20H14F2N4O5S2
  1
1
IC50 > 57000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0309124
 Compound Info 
2-[3-phenyl-5-pyridin-4-yl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C25H19N5O4S2
  1
1
IC50 > 57000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0402827
 Compound Info 
LDHA Inhibitor, 33
   Show/Hide
C25H27N3O6S
  1
1
IC50 > 57000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0546842
 Compound Info 
2-[5-(3-bromophenyl)-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C20H15BrN4O5S2
  1
1
IC50 > 57000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT02629, L-lactate dehydrogenase A chain
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0109412
 Compound Info 
3-[[3-(cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino]-5-(3,5-difluorophenoxy)benzoic acid
   Show/Hide
 C31H25F2N5O7S  1
1
IC50 = 840 nM
   TI
   LI
   LO
   TS
CP0253019
 Compound Info 
2-[3-[3-(3-cyclopentyl-3-hydroxyprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C32H30F2N4O5S2  1
1
IC50 = 2187 nM
   TI
   LI
   LO
   TS
CP0258246
 Compound Info 
2-(3-([1,1'-biphenyl]- difluorocyclopropyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
   Show/Hide
 C29H22F2N4O4S2  1
1
IC50 = 24440 nM
   TI
   LI
   LO
   TS
CP0258266
 Compound Info 
2-[3-[3-(3-cyclopentylprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C32H30F2N4O4S2  1
1
IC50 = 939 nM
   TI
   LI
   LO
   TS
CP0317517
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(3-methylimidazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C30H24F2N6O4S2  1
1
IC50 = 1542 nM
   TI
   LI
   LO
   TS
CP0361784
 Compound Info 
2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-(trifluoromethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C27H19F3N4O4S2  1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0362432
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C30H26N4O4S2  2
1
IC50 = 2230 nM
   TI
   LI
   LO
   TS
2
IC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0363019
 Compound Info 
2-(3-(3- cydopropoxy-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
   Show/Hide
 C27H24F2N4O5S2  1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0414075
 Compound Info 
2-[5-cyclopropyl-3-phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C23H20N4O4S2  1
1
IC50 > 57000 nM
   TI
   LI
   LO
   TS
CP0458622
 Compound Info 
2-[3-phenyl-4-(4-sulfamoylanilino)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C19H15N5O4S2  1
1
IC50 > 57000 nM
   TI
   LI
   LO
   TS
CP0484665
 Compound Info 
2-(5-(cyclopropylmethyl)-3- (3-((2,5-dimethylthiophen-3- yl)ethynyl)phenyl)-4-(3-fluoro- 4-sulfamoylbenzyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
   Show/Hide
 C32H27FN4O4S3  1
1
IC50 = 716 nM
   TI
   LI
   LO
   TS
CP0514955
 Compound Info 
2-(3-([1,1''-biphenyl]- 3-yl)-5-(2- cyclopropylethyl)-4- (4-sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid (M + H)+ = 585
   Show/Hide
 C31H28N4O4S2  1
1
IC50 = 1959 nM
   TI
   LI
   LO
   TS
CP0537995
 Compound Info 
US11247971, Cmpd ID 400
   Show/Hide
 C28H24F4N4O5S2  1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS
CP0539178
 Compound Info 
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[3-(1-methylcyclopropyl)prop-1-ynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C32H31FN4O4S2  1
1
IC50 = 590 nM
   TI
   LI
   LO
   TS
CP0539856
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-hydroxy-3-(oxolan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C31H28F2N4O6S2  1
1
IC50 = 2635 nM
   TI
   LI
   LO
   TS
CP0546842
 Compound Info 
2-[5-(3-bromophenyl)-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C20H15BrN4O5S2  1
1
IC50 > 57000 nM
   TI
   LI
   LO
   TS
CP0547940
 Compound Info 
2-[5-cyclopropyl-3-(3-phenylphenyl)-4-(4-sulfamoylphenoxy)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C28H22N4O5S2  1
1
IC50 = 25800 nM
   TI
   LI
   LO
   TS
CP0558594
 Compound Info 
2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
 C26H20N4O4S2  2
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
2
IC50 > 57000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line