General Information of the Protein
Protein ID
PT02629
Protein Name
L-lactate dehydrogenase A chain
Secondarily
Protein Name
Cell proliferation-inducing gene 19 protein
LDH muscle subunit
Renal carcinoma antigen NY-REN-59
Gene Name
LDHA
Secondarily
Gene Name
PIG19
Sequence
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
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Uniprot ID
Primary ID:
P00338

Secondarily ID:
B4DKQ2
B7Z5E3
D3DQY3
F8W819
Q53G53
Q6IBM7
Q6ZNV1
Q9UDE8
Q9UDE9
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Ensembl ID
ENSG00000134333
HGNC ID
HGNC:6535
Subcellular Location
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000569 , A-673
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0554850
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-(3,3-dimethylbut-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H28F2N4O4S2
  1
1
IC50 = 141 nM
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CP0484665
 Compound Info 
2-(5-(cyclopropylmethyl)-3- (3-((2,5-dimethylthiophen-3- yl)ethynyl)phenyl)-4-(3-fluoro- 4-sulfamoylbenzyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
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C32H27FN4O4S3
  1
1
IC50 = 161 nM
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CP0365471
 Compound Info 
2-(5-(2-cyclopropylethyl)-3- (3-((2,5-dimethylthiophen-3- yl)ethynyl)phenyl)-4-(3-fluoro- 4-sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
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C33H29FN4O4S3
  1
1
IC50 = 162 nM
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CP0484666
 Compound Info 
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H27FN4O4S3
  1
1
IC50 = 174 nM
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CP0547640
 Compound Info 
2-[3-[3-[2-(5-chlorothiophen-2-yl)ethynyl]phenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H22ClFN4O4S3
  1
1
IC50 = 218 nM
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CP0537718
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-(3-cyclopropylprop-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H26F2N4O4S2
  1
1
IC50 = 234 nM
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CP0258269
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-methylbut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C29H26F2N4O4S2
  1
1
IC50 = 284 nM
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CP0317515
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(4- methylpent-1-yn-1- yl)phenyl)-4-(3- fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C30H28F2N4O4S2
  1
1
IC50 = 284 nM
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CP0537723
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-propan-2-ylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C33H29FN4O4S3
  1
1
IC50 = 296 nM
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CP0258271
 Compound Info 
2-[3-[3-(2-cyclopentylethynyl)phenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H29FN4O4S2
  1
1
IC50 = 298 nM
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CP0484667
 Compound Info 
2-(5-(2-cyclopropylethyl)- 4-(3-fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-4- yl)ethynyl)phenyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
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C31H26FN5O4S3
  1
1
IC50 = 300 nM
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CP0362417
 Compound Info 
2-[3-[3-[(E)-2-cyclopropylethenyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C29H26F2N4O4S2
  1
1
IC50 = 320 nM
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CP0484664
 Compound Info 
2-(3-(3-((5-cyclobutylthiophen- 2-yl)ethynyl)phenyl)- 5-(cyclopropylmethyl)-4- (3-fluoro-4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid
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C34H29FN4O4S3
  1
1
IC50 = 333 nM
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CP0362416
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-[2-[5-(difluoromethyl)thiophen-2-yl]ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H23F3N4O4S3
  1
1
IC50 = 345 nM
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CP0538514
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-[2-(3,5-dimethylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H27FN4O4S3
  1
1
IC50 = 345 nM
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CP0539178
 Compound Info 
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[3-(1-methylcyclopropyl)prop-1-ynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H31FN4O4S2
  1
1
IC50 = 346 nM
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CP0354428
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[(E)-2-(5-methylthiophen-2-yl)ethenyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H27FN4O4S3
  1
1
IC50 = 357 nM
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CP0539167
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-[(E)-3,3-dimethylbut-1-enyl]-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H30F2N4O4S2
  1
1
IC50 = 361 nM
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CP0538516
 Compound Info 
2-(5-(2-cyclopropylethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylthiazol-2- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
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C31H26FN5O4S3
  1
1
IC50 = 364 nM
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CP0543634
 Compound Info 
2-[3-[3-[2-(2-cyclopropylcyclopropyl)ethynyl]phenyl]-5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C33H31FN4O4S2
  1
1
IC50 = 364 nM
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CP0258249
 Compound Info 
2-[3-[3-[(E)-2-cyclopentylethenyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H30F2N4O4S2
  1
1
IC50 = 371 nM
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CP0366919
 Compound Info 
2-[3-[3-(2-cyclobutylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H26F2N4O4S2
  1
1
IC50 = 378 nM
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CP0354427
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(3-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H25FN4O4S3
  1
1
IC50 = 390 nM
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CP0364209
 Compound Info 
2-[5-(2-cyclopropylethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H26F2N4O4S3
  1
1
IC50 = 390 nM
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CP0364192
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-[2-(5-cyclopropylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C33H27FN4O4S3
  1
1
IC50 = 403 nM
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CP0538515
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[(E)-prop-1-enyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H24F2N4O4S2
  1
1
IC50 = 405 nM
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CP0556265
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-hex-1-ynylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H28F2N4O4S2
  1
1
IC50 = 405 nM
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CP0258268
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(pent-1- yn-1-yl)phenyl)-4-(3- fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C29H26F2N4O4S2
  1
1
IC50 = 420 nM
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CP0537720
 Compound Info 
2-[5-(2-cyclopropylethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H26F2N4O4S3
  1
1
IC50 = 434 nM
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CP0538518
 Compound Info 
2-(5-(2-cyclopropylethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-5- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
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C31H26FN5O4S3
  1
1
IC50 = 434 nM
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CP0547641
 Compound Info 
2-(5-(2-cyclopropylethyl)- 3-(3-((5-cyclopropylthiophen- 2-yl)ethynyl)phenyl)-4-(3- fluoro-4-sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole- 4-carboxylic acid
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C34H29FN4O4S3
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1
IC50 = 434 nM
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CP0362435
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-(2-thiophen-2-ylethynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H22F2N4O4S3
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1
IC50 = 438 nM
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CP0253018
 Compound Info 
2-[3-[3-(3-cyclopentyl-3-fluoroprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H29F3N4O4S2
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1
IC50 = 450 nM
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CP0362432
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H26N4O4S2
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1
IC50 = 450 nM
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CP0364193
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylfuran-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H25FN4O5S2
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1
IC50 = 450 nM
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CP0258248
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-phenylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H24F2N4O4S2
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1
IC50 = 465 nM
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CP0258272
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-[5-(trifluoromethyl)thiophen-2-yl]ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H22F4N4O4S3
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1
IC50 = 485 nM
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CP0538517
 Compound Info 
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-(2-spiro[2.2]pentan-2-ylethynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H29FN4O4S2
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1
IC50 = 485 nM
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CP0258266
 Compound Info 
2-[3-[3-(3-cyclopentylprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H30F2N4O4S2
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1
IC50 = 487 nM
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CP0514956
 Compound Info 
2-[3-(3-but-1-ynyl-4-fluorophenyl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H24F2N4O4S2
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1
IC50 = 487 nM
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CP0514745
 Compound Info 
2-(5-(cyclopropylmethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylthiophen-3- yl)ethynyl)phenyl)-1H-pyrazol-1- yl)thiazole-4-carboxylic acid
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C31H25FN4O4S3
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1
IC50 = 494 nM
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CP0258267
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-prop-1-ynylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H22F2N4O4S2
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1
IC50 = 505 nM
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CP0362527
 Compound Info 
2-[3-[3-(2-cyclopentylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H28F2N4O4S2
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1
IC50 = 509 nM
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CP0514955
 Compound Info 
2-(3-([1,1''-biphenyl]- 3-yl)-5-(2- cyclopropylethyl)-4- (4-sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid (M + H)+ = 585
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C31H28N4O4S2
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1
IC50 = 509 nM
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CP0539857
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methyl-1,3-oxazol-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H24FN5O5S2
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1
IC50 = 525 nM
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CP0487438
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methyl-1,3-thiazol-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H24FN5O4S3
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1
IC50 = 527 nM
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CP0543608
 Compound Info 
2-[3-[3-[2-(5-tert-butylthiophen-2-yl)ethynyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C34H30F2N4O4S3
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1
IC50 = 529 nM
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CP0362415
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methylfuran-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H24F2N4O5S2
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1
IC50 = 544 nM
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CP0362419
 Compound Info 
2-(5-(2-cyclopropylethyl)-4- (3-fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylfuran-2- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4- carboxylic acid
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C32H27FN4O5S2
  1
1
IC50 = 547 nM
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CP0552995
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(p- tolyloxy)phenyl)-4- (3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C31H26F2N4O5S2
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1
IC50 = 550 nM
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CP0317925
 Compound Info 
2-(3-(3-((5-cyclobutylthiophen- 2-yl)ethynyl)phenyl)- 5-(2-cyclopropylethyl)- 4-(3-fluoro-4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid
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C35H31FN4O4S3
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1
IC50 = 572 nM
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CP0565301
 Compound Info 
US11247971, Cmpd ID 340
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C31H27FN4O5S2
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1
IC50 = 590 nM
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CP0317514
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-phenylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H25FN4O4S2
  1
1
IC50 = 613 nM
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CP0354426
 Compound Info 
2-[3-[3-(3-cyclopropylbut-1-ynyl)phenyl]-5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H31FN4O4S2
  1
1
IC50 = 685 nM
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CP0539180
 Compound Info 
2-[3-[3-(2-cyclopropylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C29H24F2N4O4S2
  1
1
IC50 = 695 nM
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CP0253023
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-prop-1-ynylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H23FN4O4S2
  1
1
IC50 = 713 nM
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CP0364208
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-(3,3,3-trifluoroprop-1-en-2-yl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H22F4N4O4S2
  1
1
IC50 = 713 nM
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CP0539166
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(2-methyl-1,3-thiazol-5-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H24FN5O4S3
  1
1
IC50 = 713 nM
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CP0573588
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-((3- fluorobenzyl)oxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C31H25F3N4O5S2
  1
1
IC50 = 730 nM
 Bioactivity Info 
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CP0265966
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H25FN4O4S3
  1
1
IC50 = 760 nM
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CP0362434
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-methoxyprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H24F2N4O5S2
  1
1
IC50 = 769 nM
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CP0317516
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-fluorobut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H23F3N4O4S2
  1
1
IC50 = 800 nM
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CP0362528
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H25FN4O4S2
  1
1
IC50 = 835 nM
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CP0253022
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H24F2N4O4S3
  1
1
IC50 = 873 nM
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CP0549707
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(3-ethynyl-4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C26H20F2N4O4S2
  1
1
IC50 = 902 nM
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CP0552591
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-(oxolan-2-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H28F2N4O5S2
  1
1
IC50 = 933 nM
 Bioactivity Info 
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CP0365470
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-(3,3-difluoroprop-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H20F4N4O4S2
  1
1
IC50 = 937 nM
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CP0549705
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(2-methyl-1,3-thiazol-5-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H23F2N5O4S3
  1
1
IC50 = 937 nM
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CP0362412
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-(oxetan-3-yl)but-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H28F2N4O5S2
  1
1
IC50 = 1052 nM
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CP0253020
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-fluoro-3-(oxolan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H27F3N4O5S2
  1
1
IC50 = 1056 nM
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CP0253021
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-pyrrolidin-1-ylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H29F2N5O4S2
  1
1
IC50 = 1086 nM
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CP0537995
 Compound Info 
US11247971, Cmpd ID 400
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C28H24F4N4O5S2
  1
1
IC50 = 1100 nM
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CP0546393
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-((5- (trifluoromethyl)furan- 2- yl)methoxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; MS (ES) 694.9 (M + H)+,
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C30H23F5N4O6S2
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0557973
 Compound Info 
2-(5-(cyclopropylmethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-4- yl)ethynyl)phenyl)-1H-pyrazol-1- yl)thiazole-4-carboxylic acid
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C30H24FN5O4S3
  1
1
IC50 = 1174 nM
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CP0514743
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(oxolan-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H26F2N4O5S2
  1
1
IC50 = 1268 nM
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CP0362413
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-fluoro-3-(oxetan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H25F3N4O5S2
  1
1
IC50 = 1324 nM
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CP0514744
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methyl-1,3-thiazol-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H23F2N5O4S3
  1
1
IC50 = 1324 nM
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CP0258245
 Compound Info 
2-(3-([1,1'-biphenyl]- 3-yl)-5-((2,2- difluorocyclopropyl) methyl)-4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C30H24F2N4O4S2
  1
1
IC50 = 1423 nM
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CP0317517
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(3-methylimidazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H24F2N6O4S2
  1
1
IC50 = 1597 nM
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CP0362531
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(1-methylpyrazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H24F2N6O4S2
  1
1
IC50 = 1603 nM
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CP0258246
 Compound Info 
2-(3-([1,1'-biphenyl]- difluorocyclopropyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C29H22F2N4O4S2
  1
1
IC50 = 1861 nM
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CP0258273
 Compound Info 
2-[5-(2-cyclopropylethyl)-3-[3-(3,3-dicyclopropylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C34H33FN4O4S2
  1
1
IC50 = 1864 nM
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CP0363019
 Compound Info 
2-(3-(3- cydopropoxy-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C27H24F2N4O5S2
  1
1
IC50 = 1900 nM
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CP0253019
 Compound Info 
2-[3-[3-(3-cyclopentyl-3-hydroxyprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H30F2N4O5S2
  1
1
IC50 = 1931 nM
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CP0552564
 Compound Info 
2-[3-(3-benzamido-4-fluorophenyl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H25F2N5O5S2
  1
1
IC50 = 2300 nM
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CP0558851
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(4-hydroxybut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H24F2N4O5S2
  1
1
IC50 = 2475 nM
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CP0537993
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(3- (phenylamino)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C30H27N5O4S2
  1
1
IC50 = 3100 nM
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CP0553356
 Compound Info 
2-[3-[3-(2-cyanoethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H19F2N5O4S2
  1
1
IC50 = 4010 nM
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CP0258247
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(2-fluoro-4-sulfamoylphenyl)methyl]-3-(3-phenylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H25FN4O4S2
  1
1
IC50 = 4465 nM
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CP0567918
 Compound Info 
2-(3-(3- (benzylcarbamoyl)-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid: MS (ES) 664.0 (M + H)+,
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C32H27F2N5O5S2
  1
1
IC50 = 4700 nM
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CP0539856
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-hydroxy-3-(oxolan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H28F2N4O6S2
  1
1
IC50 = 5937 nM
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CP0569833
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-morpholin-4-ylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C28H28FN5O5S2
  1
1
IC50 = 9400 nM
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CP0144065
 Compound Info 
2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-(2,2,2-trifluoroethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C28H21F3N4O4S2
  1
1
IC50 = 9719 nM
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CP0258270
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(2-piperidin-4-ylethynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C31H29F2N5O4S2
  1
1
IC50 = 12241 nM
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CP0362529
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-hydroxy-3-(oxetan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H26F2N4O6S2
  1
1
IC50 = 12241 nM
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CP0144066
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-morpholin-4-ylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C31H29F2N5O5S2
  1
1
IC50 = 15349 nM
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CP0544219
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- (pyrrolidine-1- carbonyl)phenyl)-4- (3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
   Show/Hide
C29H27F2N5O5S2
  1
1
IC50 = 16600 nM
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CP0487439
 Compound Info 
2-[5-(2-cyclopropylethyl)-3-[3-(3-cyclopropyl-3-methylbut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C33H33FN4O4S2
  1
1
IC50 = 18264 nM
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CP0364189
 Compound Info 
2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H23F3N4O4S2
  1
1
IC50 = 20186 nM
 Bioactivity Info 
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CP0362414
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-(3,3,3-trifluoroprop-1-ynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C27H19F5N4O4S2
  1
1
IC50 > 30000 nM
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Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000207 , MIA PaCa-2
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0253020
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-fluoro-3-(oxolan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C31H27F3N4O5S2
  1
1 IC50 = 1 nM
CP0558851
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(4-hydroxybut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H24F2N4O5S2
  1
1 IC50 = 3 nM
CP0539856
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-hydroxy-3-(oxolan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C31H28F2N4O6S2
  1
1 IC50 = 5 nM
CP0537995
 Compound Info 
US11247971, Cmpd ID 400
   Show/Hide
C28H24F4N4O5S2
  1
1 IC50 = 5 nM
CP0559585
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- ((tetrahydrofuran-2- yl)methoxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
   Show/Hide
C29H28F2N4O6S2
  1
1 IC50 = 5 nM
CP0571580
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- ((tetrahydrofuran-3- yl)methoxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
   Show/Hide
C29H28F2N4O6S2
  1
1 IC50 = 5 nM
CP0362529
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-hydroxy-3-(oxetan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H26F2N4O6S2
  1
1 IC50 = 6 nM
CP0546395
 Compound Info 
2-(3-(3-(tert- butylcarbamoyl)-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4-carboxylic acid
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C29H29F2N5O5S2
  1
1 IC50 = 6 nM
CP0253019
 Compound Info 
2-[3-[3-(3-cyclopentyl-3-hydroxyprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C32H30F2N4O5S2
  1
1 IC50 = 7 nM
CP0362413
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-fluoro-3-(oxetan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H25F3N4O5S2
  1
1 IC50 = 7 nM
CP0514743
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(oxolan-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H26F2N4O5S2
  1
1 IC50 = 7 nM
CP0552564
 Compound Info 
2-[3-(3-benzamido-4-fluorophenyl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C31H25F2N5O5S2
  1
1 IC50 = 7 nM
CP0253021
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-pyrrolidin-1-ylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H29F2N5O4S2
  1
1 IC50 = 8 nM
CP0317517
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(3-methylimidazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H24F2N6O4S2
  1
1 IC50 = 8 nM
CP0362434
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-methoxyprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H24F2N4O5S2
  1
1 IC50 = 8 nM
CP0363019
 Compound Info 
2-(3-(3- cydopropoxy-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C27H24F2N4O5S2
  1
1 IC50 = 8 nM
CP0567918
 Compound Info 
2-(3-(3- (benzylcarbamoyl)-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid: MS (ES) 664.0 (M + H)+,
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C32H27F2N5O5S2
  1
1 IC50 = 8 nM
CP0571579
 Compound Info 
US11247971, Cmpd ID 278
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C25H23FN4O5S2
  1
1 IC50 = 8 nM
CP0253023
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-prop-1-ynylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C27H23FN4O4S2
  1
1 IC50 = 9 nM
CP0362531
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(1-methylpyrazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H24F2N6O4S2
  1
1 IC50 = 9 nM
CP0539180
 Compound Info 
2-[3-[3-(2-cyclopropylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C29H24F2N4O4S2
  1
1 IC50 = 9 nM
CP0549707
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(3-ethynyl-4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C26H20F2N4O4S2
  1
1 IC50 = 9 nM
CP0552591
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-(oxolan-2-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C31H28F2N4O5S2
  1
1 IC50 = 9 nM
CP0362412
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-(oxetan-3-yl)but-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H28F2N4O5S2
  1
1 IC50 = 10 nM
CP0258267
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-prop-1-ynylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C27H22F2N4O4S2
  1
1 IC50 = 11 nM
CP0538515
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[(E)-prop-1-enyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H24F2N4O4S2
  1
1 IC50 = 11 nM
CP0539857
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methyl-1,3-oxazol-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H24FN5O5S2
  1
1 IC50 = 12 nM
CP0557973
 Compound Info 
2-(5-(cyclopropylmethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-4- yl)ethynyl)phenyl)-1H-pyrazol-1- yl)thiazole-4-carboxylic acid
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C30H24FN5O4S3
  1
1 IC50 = 13 nM
CP0569169
 Compound Info 
US11247971, Cmpd ID 336
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C29H29FN4O5S2
  1
1 IC50 = 13 nM
CP0317516
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-fluorobut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H23F3N4O4S2
  1
1 IC50 = 14 nM
CP0514956
 Compound Info 
2-[3-(3-but-1-ynyl-4-fluorophenyl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H24F2N4O4S2
  1
1 IC50 = 14 nM
CP0258270
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(2-piperidin-4-ylethynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H29F2N5O4S2
  1
1 IC50 = 15 nM
CP0362417
 Compound Info 
2-[3-[3-[(E)-2-cyclopropylethenyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C29H26F2N4O4S2
  1
1 IC50 = 15 nM
CP0365470
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-(3,3-difluoroprop-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H20F4N4O4S2
  1
1 IC50 = 15 nM
CP0553356
 Compound Info 
2-[3-[3-(2-cyanoethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H19F2N5O4S2
  1
1 IC50 = 15 nM
CP0563537
 Compound Info 
US11247971, Cmpd ID 395
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C28H26F3N5O4S2
  1
1 IC50 = 15 nM
CP0554850
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-(3,3-dimethylbut-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H28F2N4O4S2
  1
1 IC50 = 16 nM
CP0487438
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methyl-1,3-thiazol-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H24FN5O4S3
  1
1 IC50 = 17 nM
CP0558023
 Compound Info 
2-(3-(3- phenoxyphenyl)-4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; MS (ES) 532.9(M + H)+
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C26H20N4O5S2
  1
1 IC50 = 17 nM
CP0571619
 Compound Info 
US11247971, Cmpd ID 394
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C29H28F3N5O4S2
  1
1 IC50 = 17 nM
CP0571621
 Compound Info 
US11247971, Cmpd ID 397
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C29H28F3N5O4S2
  1
1 IC50 = 18 nM
CP0565301
 Compound Info 
US11247971, Cmpd ID 340
   Show/Hide
C31H27FN4O5S2
  2
1 IC50 = 19 nM
2 Kd = 0.016 nM
CP0258269
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-methylbut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C29H26F2N4O4S2
  1
1 IC50 = 21 nM
CP0569954
 Compound Info 
2-(3-(3-((3- methoxybenzyl)oxy)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; MS (ES) 576.9 (M + H)+
   Show/Hide
C28H24N4O6S2
  1
1 IC50 = 21 nM
CP0362527
 Compound Info 
2-[3-[3-(2-cyclopentylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H28F2N4O4S2
  2
1 IC50 = 22 nM
2 Kd = 0.0193 nM
CP0537994
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(morpholine-4-carbonyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C29H27F2N5O6S2
  1
1 IC50 = 22 nM
CP0573588
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-((3- fluorobenzyl)oxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C31H25F3N4O5S2
  2
1 IC50 = 22 nM
2 Kd = 0.91 nM
CP0258248
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-phenylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H24F2N4O4S2
  1
1 IC50 = 23 nM
CP0362528
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H25FN4O4S2
  1
1 IC50 = 23 nM
CP0366919
 Compound Info 
2-[3-[3-(2-cyclobutylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H26F2N4O4S2
  1
1 IC50 = 23 nM
CP0546393
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-((5- (trifluoromethyl)furan- 2- yl)methoxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; MS (ES) 694.9 (M + H)+,
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C30H23F5N4O6S2
  1
1 IC50 = 23 nM
CP0552994
 Compound Info 
2-(3-(3-(pyridin-3- ylmethoxy)phenyl)-4- (4-sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
   Show/Hide
C26H21N5O5S2
  1
1 IC50 = 23 nM
CP0258268
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(pent-1- yn-1-yl)phenyl)-4-(3- fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C29H26F2N4O4S2
  1
1 IC50 = 24 nM
CP0362432
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H26N4O4S2
  2
1 IC50 = 24 nM
2 Kd = 0.11 nM
CP0484667
 Compound Info 
2-(5-(2-cyclopropylethyl)- 4-(3-fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-4- yl)ethynyl)phenyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
   Show/Hide
C31H26FN5O4S3
  1
1 IC50 = 24 nM
CP0538518
 Compound Info 
2-(5-(2-cyclopropylethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-5- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
   Show/Hide
C31H26FN5O4S3
  1
1 IC50 = 24 nM
CP0258245
 Compound Info 
2-(3-([1,1'-biphenyl]- 3-yl)-5-((2,2- difluorocyclopropyl) methyl)-4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C30H24F2N4O4S2
  1
1 IC50 = 25 nM
CP0317514
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-phenylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H25FN4O4S2
  1
1 IC50 = 25 nM
CP0552995
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(p- tolyloxy)phenyl)-4- (3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C31H26F2N4O5S2
  2
1 IC50 = 26 nM
2 Kd = 1.1 nM
CP0568593
 Compound Info 
2-[3-[3-[(3-fluorophenyl)methoxy]phenyl]-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C27H21FN4O5S2
  1
1 IC50 = 26 nM
CP0569833
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-morpholin-4-ylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C28H28FN5O5S2
  2
1 IC50 = 27 nM
2 Kd = 0.44 nM
CP0573589
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(3- fluorophenoxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; ;
   Show/Hide
C30H23F3N4O5S2
  1
1 IC50 = 27 nM
CP0552530
 Compound Info 
2-[3-[3-(cyclopentylmethoxy)phenyl]-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C26H26N4O5S2
  1
1 IC50 = 29 nM
CP0537718
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-(3-cyclopropylprop-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H26F2N4O4S2
  1
1 IC50 = 31 nM
CP0362435
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-(2-thiophen-2-ylethynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H22F2N4O4S3
  1
1 IC50 = 32 nM
CP0253018
 Compound Info 
2-[3-[3-(3-cyclopentyl-3-fluoroprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C32H29F3N4O4S2
  1
1 IC50 = 33 nM
CP0538516
 Compound Info 
2-(5-(2-cyclopropylethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylthiazol-2- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
   Show/Hide
C31H26FN5O4S3
  1
1 IC50 = 33 nM
CP0549705
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(2-methyl-1,3-thiazol-5-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H23F2N5O4S3
  1
1 IC50 = 33 nM
CP0546394
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- phenoxyphenyl)-4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
   Show/Hide
C30H25FN4O5S2
  1
1 IC50 = 34 nM
CP0258246
 Compound Info 
2-(3-([1,1'-biphenyl]- difluorocyclopropyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
   Show/Hide
C29H22F2N4O4S2
  1
1 IC50 = 36 nM
CP0364193
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylfuran-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C31H25FN4O5S2
  1
1 IC50 = 36 nM
CP0514955
 Compound Info 
2-(3-([1,1''-biphenyl]- 3-yl)-5-(2- cyclopropylethyl)-4- (4-sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid (M + H)+ = 585
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C31H28N4O4S2
  1
1 IC50 = 36 nM
CP0570022
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(2-propan-2-yl-2,6-diazaspiro[3.3]heptan-6-yl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C32H34F2N6O4S2
  1
1 IC50 = 37 nM
CP0364208
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-(3,3,3-trifluoroprop-1-en-2-yl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C27H22F4N4O4S2
  1
1 IC50 = 39 nM
CP0570021
 Compound Info 
2-[3-[3-[(4-methylphenyl)methoxy]phenyl]-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C28H24N4O5S2
  1
1 IC50 = 39 nM
CP0265966
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C31H25FN4O4S3
  2
1 IC50 = 40 nM
2 Kd = 0.0634 nM
CP0550352
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(4-fluorophenoxy)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H23F3N4O5S2
  1
1 IC50 = 41 nM
CP0539166
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(2-methyl-1,3-thiazol-5-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H24FN5O4S3
  1
1 IC50 = 43 nM
CP0258271
 Compound Info 
2-[3-[3-(2-cyclopentylethynyl)phenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C31H29FN4O4S2
  1
1 IC50 = 47 nM
CP0362415
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methylfuran-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C31H24F2N4O5S2
  1
1 IC50 = 47 nM
CP0571620
 Compound Info 
US11247971, Cmpd ID 392
   Show/Hide
C30H29F4N5O4S2
  1
1 IC50 = 47 nM
CP0556265
 Compound Info 
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-hex-1-ynylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C30H28F2N4O4S2
  1
1 IC50 = 50 nM
CP0354428
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[(E)-2-(5-methylthiophen-2-yl)ethenyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C31H27FN4O4S3
  1
1 IC50 = 52 nM
CP0362419
 Compound Info 
2-(5-(2-cyclopropylethyl)-4- (3-fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylfuran-2- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4- carboxylic acid
   Show/Hide
C32H27FN4O5S2
  1
1 IC50 = 52 nM
CP0514744
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methyl-1,3-thiazol-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H23F2N5O4S3
  1
1 IC50 = 52 nM
CP0317515
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(4- methylpent-1-yn-1- yl)phenyl)-4-(3- fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C30H28F2N4O4S2
  1
1 IC50 = 54 nM
CP0253022
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H24F2N4O4S3
  2
1 IC50 = 57 nM
2 Kd = 0.0667 nM
CP0539167
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-[(E)-3,3-dimethylbut-1-enyl]-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H30F2N4O4S2
  1
1 IC50 = 59 nM
CP0544217
 Compound Info 
US11247971, Cmpd ID 396
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C30H29F4N5O4S2
  1
1 IC50 = 59 nM
CP0544216
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-[4-(trifluoromethyl)phenoxy]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H23F5N4O5S2
  1
1 IC50 = 71 nM
CP0258249
 Compound Info 
2-[3-[3-[(E)-2-cyclopentylethenyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H30F2N4O4S2
  1
1 IC50 = 74 nM
CP0569558
 Compound Info 
2-(3-(3-(pyridin-2- ylmethoxy)phenyl)-4- (4-sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C26H21N5O5S2
  1
1 IC50 = 77 nM
CP0363020
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-((4- fluorobenzyl)oxy)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C31H26F2N4O5S2
  1
1 IC50 = 84 nM
CP0514745
 Compound Info 
2-(5-(cyclopropylmethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylthiophen-3- yl)ethynyl)phenyl)-1H-pyrazol-1- yl)thiazole-4-carboxylic acid
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C31H25FN4O4S3
  1
1 IC50 = 87 nM
CP0559582
 Compound Info 
2-[3-(3-methoxyphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C21H18N4O5S2
  1
1 IC50 = 90 nM
CP0354427
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(3-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H25FN4O4S3
  1
1 IC50 = 101 nM
CP0144066
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-morpholin-4-ylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H29F2N5O5S2
  1
1 IC50 = 107 nM
CP0550353
 Compound Info 
2-(5-(cyclopropylmethyl)- 3-(4-fluoro-3-(2- oxopyrrolidin-1-yl) phenyl)-4-(3-fluoro-4- sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
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C28H25F2N5O5S2
  1
1 IC50 = 111 nM
CP0484666
 Compound Info 
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H27FN4O4S3
  1
1 IC50 = 117 nM
CP0538517
 Compound Info 
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-(2-spiro[2.2]pentan-2-ylethynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H29FN4O4S2
  1
1 IC50 = 122 nM
CP0538514
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-[2-(3,5-dimethylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H27FN4O4S3
  1
1 IC50 = 137 nM
CP0362416
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-[2-[5-(difluoromethyl)thiophen-2-yl]ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H23F3N4O4S3
  1
1 IC50 = 154 nM
CP0544219
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- (pyrrolidine-1- carbonyl)phenyl)-4- (3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C29H27F2N5O5S2
  1
1 IC50 = 154 nM
CP0537720
 Compound Info 
2-[5-(2-cyclopropylethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H26F2N4O4S3
  1
1 IC50 = 160 nM
CP0547640
 Compound Info 
2-[3-[3-[2-(5-chlorothiophen-2-yl)ethynyl]phenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H22ClFN4O4S3
  1
1 IC50 = 167 nM
CP0484664
 Compound Info 
2-(3-(3-((5-cyclobutylthiophen- 2-yl)ethynyl)phenyl)- 5-(cyclopropylmethyl)-4- (3-fluoro-4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid
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C34H29FN4O4S3
  1
1 IC50 = 169 nM
CP0364192
 Compound Info 
2-[5-(cyclopropylmethyl)-3-[3-[2-(5-cyclopropylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C33H27FN4O4S3
  1
1 IC50 = 201 nM
CP0258266
 Compound Info 
2-[3-[3-(3-cyclopentylprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H30F2N4O4S2
  2
1 IC50 = 202 nM
2 Kd = 0.1235 nM
CP0364209
 Compound Info 
2-[5-(2-cyclopropylethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H26F2N4O4S3
  1
1 IC50 = 202 nM
CP0258247
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(2-fluoro-4-sulfamoylphenyl)methyl]-3-(3-phenylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H25FN4O4S2
  1
1 IC50 = 229 nM
CP0484665
 Compound Info 
2-(5-(cyclopropylmethyl)-3- (3-((2,5-dimethylthiophen-3- yl)ethynyl)phenyl)-4-(3-fluoro- 4-sulfamoylbenzyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
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C32H27FN4O4S3
  1
1 IC50 = 235 nM
CP0144065
 Compound Info 
2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-(2,2,2-trifluoroethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H21F3N4O4S2
  1
1 IC50 = 274 nM
CP0547641
 Compound Info 
2-(5-(2-cyclopropylethyl)- 3-(3-((5-cyclopropylthiophen- 2-yl)ethynyl)phenyl)-4-(3- fluoro-4-sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole- 4-carboxylic acid
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C34H29FN4O4S3
  1
1 IC50 = 306 nM
CP0539178
 Compound Info 
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[3-(1-methylcyclopropyl)prop-1-ynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H31FN4O4S2
  1
1 IC50 = 307 nM
CP0537993
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(3- (phenylamino)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C30H27N5O4S2
  2
1 IC50 = 314 nM
2 Kd = 1.5 nM
CP0750708
 Compound Info 
(S)-3-(3-hydroxy-6-(methoxymethyl)-4-oxo-4H-pyran-2-yl)-3-(1-isobutyl-2-oxo-1,2-dihydroquinolin-3-yl)propanamide
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C23H26N2O6
  2
1 IC50 = 330 nM
2 Kd = 950 nM
CP0537723
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-propan-2-ylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C33H29FN4O4S3
  1
1 IC50 = 385 nM
CP0258272
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-[5-(trifluoromethyl)thiophen-2-yl]ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H22F4N4O4S3
  1
1 IC50 = 434 nM
CP0362414
 Compound Info 
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-(3,3,3-trifluoroprop-1-ynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H19F5N4O4S2
  1
1 IC50 = 450 nM
CP0365471
 Compound Info 
2-(5-(2-cyclopropylethyl)-3- (3-((2,5-dimethylthiophen-3- yl)ethynyl)phenyl)-4-(3-fluoro- 4-sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
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C33H29FN4O4S3
  1
1 IC50 = 487 nM
CP0317925
 Compound Info 
2-(3-(3-((5-cyclobutylthiophen- 2-yl)ethynyl)phenyl)- 5-(2-cyclopropylethyl)- 4-(3-fluoro-4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid
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C35H31FN4O4S3
  1
1 IC50 = 636 nM
CP0543608
 Compound Info 
2-[3-[3-[2-(5-tert-butylthiophen-2-yl)ethynyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C34H30F2N4O4S3
  1
1 IC50 = 713 nM
CP0354426
 Compound Info 
2-[3-[3-(3-cyclopropylbut-1-ynyl)phenyl]-5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H31FN4O4S2
  1
1 IC50 = 874 nM
CP0578589
 Compound Info 
2-(5- (cyclopropylmethyl)- 3-(3-(3- fluorophenoxy)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C30H25FN4O5S2
  1
1 IC50 = 1060 nM
CP0543634
 Compound Info 
2-[3-[3-[2-(2-cyclopropylcyclopropyl)ethynyl]phenyl]-5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C33H31FN4O4S2
  1
1 IC50 = 1174 nM
CP0364189
 Compound Info 
2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H23F3N4O4S2
  1
1 IC50 = 4104 nM
CP0487439
 Compound Info 
2-[5-(2-cyclopropylethyl)-3-[3-(3-cyclopropyl-3-methylbut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C33H33FN4O4S2
  1
1 IC50 = 4540 nM
CP0258273
 Compound Info 
2-[5-(2-cyclopropylethyl)-3-[3-(3,3-dicyclopropylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C34H33FN4O4S2
  1
1 IC50 = 5270 nM
Clinical Information about the Protein
Target 1 ( Lactate dehydrogenase A (LDHA) )
Target Type Literature-reported Target
Target 2 ( LDHA messenger RNA (LDHA mRNA) )
Target Type Successful Target
Similar Protein(s) and Bioactivity Statistics
100% Identity
Protein ID Protein Name Protein Organism
PT00337 L-lactate dehydrogenase Homo sapiens, Human
 Protein Info