| Compound ID |
Compound Name |
Compound Formula |
|
CP0554850
|
2-[5-(cyclopropylmethyl)-3-[3-(3,3-dimethylbut-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H28F2N4O4S2
|
1
|
| 1 |
IC50 = 137 nM
|
|
|
|
CP0258249
|
2-[3-[3-[(E)-2-cyclopentylethenyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H30F2N4O4S2
|
1
|
| 1 |
IC50 = 149 nM
|
|
|
|
CP0484666
|
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H27FN4O4S3
|
1
|
| 1 |
IC50 = 172 nM
|
|
|
|
CP0365471
|
2-(5-(2-cyclopropylethyl)-3- (3-((2,5-dimethylthiophen-3- yl)ethynyl)phenyl)-4-(3-fluoro- 4-sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C33H29FN4O4S3
|
1
|
| 1 |
IC50 = 188 nM
|
|
|
|
CP0364209
|
2-[5-(2-cyclopropylethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H26F2N4O4S3
|
1
|
| 1 |
IC50 = 197 nM
|
|
|
|
CP0537723
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-propan-2-ylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C33H29FN4O4S3
|
1
|
| 1 |
IC50 = 203 nM
|
|
|
|
CP0484665
|
2-(5-(cyclopropylmethyl)-3- (3-((2,5-dimethylthiophen-3- yl)ethynyl)phenyl)-4-(3-fluoro- 4-sulfamoylbenzyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
Show/Hide
|
C32H27FN4O4S3
|
1
|
| 1 |
IC50 = 218 nM
|
|
|
|
CP0538514
|
2-[5-(cyclopropylmethyl)-3-[3-[2-(3,5-dimethylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H27FN4O4S3
|
1
|
| 1 |
IC50 = 218 nM
|
|
|
|
CP0362417
|
2-[3-[3-[(E)-2-cyclopropylethenyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C29H26F2N4O4S2
|
1
|
| 1 |
IC50 = 231 nM
|
|
|
|
CP0484667
|
2-(5-(2-cyclopropylethyl)- 4-(3-fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-4- yl)ethynyl)phenyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C31H26FN5O4S3
|
1
|
| 1 |
IC50 = 253 nM
|
|
|
|
CP0537720
|
2-[5-(2-cyclopropylethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H26F2N4O4S3
|
1
|
| 1 |
IC50 = 254 nM
|
|
|
|
CP0539167
|
2-[5-(cyclopropylmethyl)-3-[3-[(E)-3,3-dimethylbut-1-enyl]-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H30F2N4O4S2
|
1
|
| 1 |
IC50 = 255 nM
|
|
|
|
CP0537718
|
2-[5-(cyclopropylmethyl)-3-[3-(3-cyclopropylprop-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H26F2N4O4S2
|
1
|
| 1 |
IC50 = 259 nM
|
|
|
|
CP0258271
|
2-[3-[3-(2-cyclopentylethynyl)phenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H29FN4O4S2
|
1
|
| 1 |
IC50 = 281 nM
|
|
|
|
CP0362416
|
2-[5-(cyclopropylmethyl)-3-[3-[2-[5-(difluoromethyl)thiophen-2-yl]ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H23F3N4O4S3
|
1
|
| 1 |
IC50 = 286 nM
|
|
|
|
CP0556265
|
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-hex-1-ynylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H28F2N4O4S2
|
1
|
| 1 |
IC50 = 298 nM
|
|
|
|
CP0362435
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-(2-thiophen-2-ylethynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H22F2N4O4S3
|
1
|
| 1 |
IC50 = 307 nM
|
|
|
|
CP0538515
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[(E)-prop-1-enyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H24F2N4O4S2
|
1
|
| 1 |
IC50 = 321 nM
|
|
|
|
CP0354428
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[(E)-2-(5-methylthiophen-2-yl)ethenyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H27FN4O4S3
|
1
|
| 1 |
IC50 = 331 nM
|
|
|
|
CP0362527
|
2-[3-[3-(2-cyclopentylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H28F2N4O4S2
|
1
|
| 1 |
IC50 = 333 nM
|
|
|
|
CP0538518
|
2-(5-(2-cyclopropylethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-5- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
Show/Hide
|
C31H26FN5O4S3
|
1
|
| 1 |
IC50 = 334 nM
|
|
|
|
CP0258272
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-[5-(trifluoromethyl)thiophen-2-yl]ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H22F4N4O4S3
|
1
|
| 1 |
IC50 = 337 nM
|
|
|
|
CP0258268
|
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(pent-1- yn-1-yl)phenyl)-4-(3- fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
Show/Hide
|
C29H26F2N4O4S2
|
1
|
| 1 |
IC50 = 361 nM
|
|
|
|
CP0265966
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O4S3
|
1
|
| 1 |
IC50 = 367 nM
|
|
|
|
CP0317925
|
2-(3-(3-((5-cyclobutylthiophen- 2-yl)ethynyl)phenyl)- 5-(2-cyclopropylethyl)- 4-(3-fluoro-4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C35H31FN4O4S3
|
1
|
| 1 |
IC50 = 379 nM
|
|
|
|
CP0547641
|
2-(5-(2-cyclopropylethyl)- 3-(3-((5-cyclopropylthiophen- 2-yl)ethynyl)phenyl)-4-(3- fluoro-4-sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole- 4-carboxylic acid
Show/Hide
|
C34H29FN4O4S3
|
1
|
| 1 |
IC50 = 387 nM
|
|
|
|
CP0253022
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H24F2N4O4S3
|
1
|
| 1 |
IC50 = 403 nM
|
|
|
|
CP0547640
|
2-[3-[3-[2-(5-chlorothiophen-2-yl)ethynyl]phenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H22ClFN4O4S3
|
1
|
| 1 |
IC50 = 408 nM
|
|
|
|
CP0539178
|
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[3-(1-methylcyclopropyl)prop-1-ynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H31FN4O4S2
|
1
|
| 1 |
IC50 = 409 nM
|
|
|
|
CP0354427
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(3-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O4S3
|
1
|
| 1 |
IC50 = 417 nM
|
|
|
|
CP0362419
|
2-(5-(2-cyclopropylethyl)-4- (3-fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylfuran-2- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C32H27FN4O5S2
|
1
|
| 1 |
IC50 = 417 nM
|
|
|
|
CP0538516
|
2-(5-(2-cyclopropylethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylthiazol-2- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
Show/Hide
|
C31H26FN5O4S3
|
1
|
| 1 |
IC50 = 417 nM
|
|
|
|
CP0258266
|
2-[3-[3-(3-cyclopentylprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H30F2N4O4S2
|
1
|
| 1 |
IC50 = 424 nM
|
|
|
|
CP0366919
|
2-[3-[3-(2-cyclobutylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H26F2N4O4S2
|
1
|
| 1 |
IC50 = 428 nM
|
|
|
|
CP0364193
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylfuran-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O5S2
|
1
|
| 1 |
IC50 = 432 nM
|
|
|
|
CP0364192
|
2-[5-(cyclopropylmethyl)-3-[3-[2-(5-cyclopropylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C33H27FN4O4S3
|
1
|
| 1 |
IC50 = 434 nM
|
|
|
|
CP0258267
|
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-prop-1-ynylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H22F2N4O4S2
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0539857
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methyl-1,3-oxazol-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24FN5O5S2
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0253018
|
2-[3-[3-(3-cyclopentyl-3-fluoroprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H29F3N4O4S2
|
1
|
| 1 |
IC50 = 454 nM
|
|
|
|
CP0538517
|
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-(2-spiro[2.2]pentan-2-ylethynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H29FN4O4S2
|
1
|
| 1 |
IC50 = 459 nM
|
|
|
|
CP0514956
|
2-[3-(3-but-1-ynyl-4-fluorophenyl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C28H24F2N4O4S2
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0258269
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-methylbut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C29H26F2N4O4S2
|
1
|
| 1 |
IC50 = 487 nM
|
|
|
|
CP0317515
|
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(4- methylpent-1-yn-1- yl)phenyl)-4-(3- fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
Show/Hide
|
C30H28F2N4O4S2
|
1
|
| 1 |
IC50 = 487 nM
|
|
|
|
CP0487438
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methyl-1,3-thiazol-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24FN5O4S3
|
1
|
| 1 |
IC50 = 487 nM
|
|
|
|
CP0484664
|
2-(3-(3-((5-cyclobutylthiophen- 2-yl)ethynyl)phenyl)- 5-(cyclopropylmethyl)-4- (3-fluoro-4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C34H29FN4O4S3
|
1
|
| 1 |
IC50 = 491 nM
|
|
|
|
CP0543608
|
2-[3-[3-[2-(5-tert-butylthiophen-2-yl)ethynyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C34H30F2N4O4S3
|
1
|
| 1 |
IC50 = 507 nM
|
|
|
|
CP0543634
|
2-[3-[3-[2-(2-cyclopropylcyclopropyl)ethynyl]phenyl]-5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C33H31FN4O4S2
|
1
|
| 1 |
IC50 = 515 nM
|
|
|
|
CP0253023
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-prop-1-ynylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H23FN4O4S2
|
1
|
| 1 |
IC50 = 525 nM
|
|
|
|
CP0362434
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-methoxyprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C28H24F2N4O5S2
|
1
|
| 1 |
IC50 = 525 nM
|
|
|
|
CP0362415
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methylfuran-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H24F2N4O5S2
|
1
|
| 1 |
IC50 = 547 nM
|
|
|
|
CP0539180
|
2-[3-[3-(2-cyclopropylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C29H24F2N4O4S2
|
1
|
| 1 |
IC50 = 554 nM
|
|
|
|
CP0258248
|
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-phenylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24F2N4O4S2
|
1
|
| 1 |
IC50 = 585 nM
|
|
|
|
CP0362432
|
2-[5-(cyclopropylmethyl)-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H26N4O4S2
|
1
|
| 1 |
IC50 = 636 nM
|
|
|
|
CP0514745
|
2-(5-(cyclopropylmethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylthiophen-3- yl)ethynyl)phenyl)-1H-pyrazol-1- yl)thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O4S3
|
1
|
| 1 |
IC50 = 657 nM
|
|
|
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CP0549707
|
2-[5-(cyclopropylmethyl)-3-(3-ethynyl-4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C26H20F2N4O4S2
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
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CP0573588
|
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-((3- fluorobenzyl)oxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
Show/Hide
|
C31H25F3N4O5S2
|
1
|
| 1 |
IC50 = 670 nM
|
|
|
|
CP0565301
|
US11247971, Cmpd ID 340
Show/Hide
|
C31H27FN4O5S2
|
1
|
| 1 |
IC50 = 690 nM
|
|
|
|
CP0569169
|
US11247971, Cmpd ID 336
Show/Hide
|
C29H29FN4O5S2
|
1
|
| 1 |
IC50 = 710 nM
|
|
|
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CP0539166
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(2-methyl-1,3-thiazol-5-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24FN5O4S3
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
|
CP0365470
|
2-[5-(cyclopropylmethyl)-3-[3-(3,3-difluoroprop-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H20F4N4O4S2
|
1
|
| 1 |
IC50 = 741 nM
|
|
|
|
CP0514955
|
2-(3-([1,1''-biphenyl]- 3-yl)-5-(2- cyclopropylethyl)-4- (4-sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid (M + H)+ = 585
Show/Hide
|
C31H28N4O4S2
|
1
|
| 1 |
IC50 = 804 nM
|
|
|
|
CP0317516
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-fluorobut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C28H23F3N4O4S2
|
1
|
| 1 |
IC50 = 822 nM
|
|
|
|
CP0514743
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(oxolan-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C30H26F2N4O5S2
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1
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| 1 |
IC50 = 831 nM
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CP0253020
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-fluoro-3-(oxolan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C31H27F3N4O5S2
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1
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| 1 |
IC50 = 867 nM
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CP0317514
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2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-phenylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H25FN4O4S2
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1
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| 1 |
IC50 = 867 nM
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CP0549705
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(2-methyl-1,3-thiazol-5-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C30H23F2N5O4S3
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1
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| 1 |
IC50 = 867 nM
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CP0552995
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2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(p- tolyloxy)phenyl)-4- (3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
Show/Hide
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C31H26F2N4O5S2
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1
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| 1 |
IC50 = 870 nM
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CP0362412
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-(oxetan-3-yl)but-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C31H28F2N4O5S2
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1
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| 1 |
IC50 = 898 nM
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CP0552591
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-(oxolan-2-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C31H28F2N4O5S2
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1
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| 1 |
IC50 = 937 nM
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CP0573589
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2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(3- fluorophenoxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; ;
Show/Hide
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C30H23F3N4O5S2
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1
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| 1 |
IC50 = 970 nM
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CP0364208
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2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-(3,3,3-trifluoroprop-1-en-2-yl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C27H22F4N4O4S2
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1
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| 1 |
IC50 = 972 nM
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CP0546393
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2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-((5- (trifluoromethyl)furan- 2- yl)methoxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; MS (ES) 694.9 (M + H)+,
Show/Hide
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C30H23F5N4O6S2
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1
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| 1 |
IC50 = 1000 nM
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CP0253021
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-pyrrolidin-1-ylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C31H29F2N5O4S2
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1
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| 1 |
IC50 = 1007 nM
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CP0354426
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2-[3-[3-(3-cyclopropylbut-1-ynyl)phenyl]-5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C32H31FN4O4S2
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1
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| 1 |
IC50 = 1027 nM
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CP0362413
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-fluoro-3-(oxetan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C30H25F3N4O5S2
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1
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| 1 |
IC50 = 1047 nM
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CP0317517
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(3-methylimidazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C30H24F2N6O4S2
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1
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| 1 |
IC50 = 1066 nM
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CP0544216
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2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-[4-(trifluoromethyl)phenoxy]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C31H23F5N4O5S2
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1
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| 1 |
IC50 = 1100 nM
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CP0362531
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(1-methylpyrazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C30H24F2N6O4S2
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1
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| 1 |
IC50 = 1141 nM
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CP0557973
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2-(5-(cyclopropylmethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-4- yl)ethynyl)phenyl)-1H-pyrazol-1- yl)thiazole-4-carboxylic acid
Show/Hide
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C30H24FN5O4S3
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1
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| 1 |
IC50 = 1180 nM
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CP0258273
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2-[5-(2-cyclopropylethyl)-3-[3-(3,3-dicyclopropylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C34H33FN4O4S2
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1
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| 1 |
IC50 = 1219 nM
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CP0362528
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2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C30H25FN4O4S2
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1
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| 1 |
IC50 = 1224 nM
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CP0537995
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US11247971, Cmpd ID 400
Show/Hide
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C28H24F4N4O5S2
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1
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| 1 |
IC50 = 1400 nM
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CP0253019
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2-[3-[3-(3-cyclopentyl-3-hydroxyprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C32H30F2N4O5S2
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1
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| 1 |
IC50 = 1479 nM
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CP0514744
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methyl-1,3-thiazol-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C30H23F2N5O4S3
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1
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| 1 |
IC50 = 1603 nM
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CP0558851
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(4-hydroxybut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C28H24F2N4O5S2
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1
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| 1 |
IC50 = 1659 nM
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CP0546394
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2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- phenoxyphenyl)-4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
Show/Hide
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C30H25FN4O5S2
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1
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| 1 |
IC50 = 1700 nM
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CP0550352
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(4-fluorophenoxy)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C30H23F3N4O5S2
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1
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| 1 |
IC50 = 1700 nM
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CP0258245
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2-(3-([1,1'-biphenyl]- 3-yl)-5-((2,2- difluorocyclopropyl) methyl)-4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
Show/Hide
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C30H24F2N4O4S2
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1
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| 1 |
IC50 = 1721 nM
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CP0363019
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2-(3-(3- cydopropoxy-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
Show/Hide
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C27H24F2N4O5S2
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1
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| 1 |
IC50 = 2100 nM
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CP0571620
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US11247971, Cmpd ID 392
Show/Hide
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C30H29F4N5O4S2
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1
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| 1 |
IC50 = 2400 nM
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CP0559585
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2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- ((tetrahydrofuran-2- yl)methoxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
Show/Hide
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C29H28F2N4O6S2
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1
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| 1 |
IC50 = 2900 nM
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CP0571580
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2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- ((tetrahydrofuran-3- yl)methoxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
Show/Hide
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C29H28F2N4O6S2
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1
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| 1 |
IC50 = 3000 nM
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CP0537994
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(morpholine-4-carbonyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C29H27F2N5O6S2
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1
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| 1 |
IC50 = 3200 nM
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CP0363020
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2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-((4- fluorobenzyl)oxy)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
Show/Hide
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C31H26F2N4O5S2
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1
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| 1 |
IC50 = 3300 nM
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CP0539856
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-hydroxy-3-(oxolan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C31H28F2N4O6S2
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1
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| 1 |
IC50 = 3871 nM
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CP0563537
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US11247971, Cmpd ID 395
Show/Hide
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C28H26F3N5O4S2
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1
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| 1 |
IC50 = 4200 nM
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CP0553356
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2-[3-[3-(2-cyanoethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C27H19F2N5O4S2
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1
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| 1 |
IC50 = 4401 nM
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CP0258246
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2-(3-([1,1'-biphenyl]- difluorocyclopropyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
Show/Hide
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C29H22F2N4O4S2
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1
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| 1 |
IC50 = 4760 nM
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CP0362529
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-hydroxy-3-(oxetan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C30H26F2N4O6S2
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1
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| 1 |
IC50 = 4873 nM
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CP0552564
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2-[3-(3-benzamido-4-fluorophenyl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C31H25F2N5O5S2
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1
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| 1 |
IC50 = 5000 nM
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CP0487439
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2-[5-(2-cyclopropylethyl)-3-[3-(3-cyclopropyl-3-methylbut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C33H33FN4O4S2
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1
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| 1 |
IC50 = 5144 nM
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CP0569954
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2-(3-(3-((3- methoxybenzyl)oxy)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; MS (ES) 576.9 (M + H)+
Show/Hide
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C28H24N4O6S2
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1
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| 1 |
IC50 = 5400 nM
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CP0571579
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US11247971, Cmpd ID 278
Show/Hide
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C25H23FN4O5S2
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1
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| 1 |
IC50 = 5700 nM
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CP0550353
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2-(5-(cyclopropylmethyl)- 3-(4-fluoro-3-(2- oxopyrrolidin-1-yl) phenyl)-4-(3-fluoro-4- sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
Show/Hide
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C28H25F2N5O5S2
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1
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| 1 |
IC50 = 6000 nM
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CP0568593
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2-[3-[3-[(3-fluorophenyl)methoxy]phenyl]-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C27H21FN4O5S2
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1
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| 1 |
IC50 = 6100 nM
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CP0258247
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2-[5-(cyclopropylmethyl)-4-[(2-fluoro-4-sulfamoylphenyl)methyl]-3-(3-phenylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C30H25FN4O4S2
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1
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| 1 |
IC50 = 6456 nM
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CP0537993
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2-(5- (cyclopropylmethyl)- 3-(3- (phenylamino)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
Show/Hide
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C30H27N5O4S2
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1
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| 1 |
IC50 = 6700 nM
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CP0544217
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US11247971, Cmpd ID 396
Show/Hide
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C30H29F4N5O4S2
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1
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| 1 |
IC50 = 6900 nM
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CP0570021
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2-[3-[3-[(4-methylphenyl)methoxy]phenyl]-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C28H24N4O5S2
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1
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| 1 |
IC50 = 7500 nM
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CP0552530
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2-[3-[3-(cyclopentylmethoxy)phenyl]-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C26H26N4O5S2
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1
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| 1 |
IC50 = 7700 nM
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CP0571621
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US11247971, Cmpd ID 397
Show/Hide
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C29H28F3N5O4S2
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1
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| 1 |
IC50 = 8600 nM
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CP0571619
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US11247971, Cmpd ID 394
Show/Hide
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C29H28F3N5O4S2
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1
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| 1 |
IC50 = 8700 nM
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CP0258270
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(2-piperidin-4-ylethynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C31H29F2N5O4S2
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1
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| 1 |
IC50 = 8910 nM
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CP0567918
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2-(3-(3- (benzylcarbamoyl)-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid: MS (ES) 664.0 (M + H)+,
Show/Hide
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C32H27F2N5O5S2
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1
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| 1 |
IC50 = 9100 nM
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CP0558023
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2-(3-(3- phenoxyphenyl)-4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; MS (ES) 532.9(M + H)+
Show/Hide
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C26H20N4O5S2
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1
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| 1 |
IC50 = 9400 nM
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CP0546395
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2-(3-(3-(tert- butylcarbamoyl)-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4-carboxylic acid
Show/Hide
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C29H29F2N5O5S2
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1
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| 1 |
IC50 = 11700 nM
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CP0364189
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2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C30H23F3N4O4S2
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1
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| 1 |
IC50 = 12791 nM
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CP0144066
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-morpholin-4-ylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C31H29F2N5O5S2
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1
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| 1 |
IC50 = 18852 nM
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CP0578589
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2-(5- (cyclopropylmethyl)- 3-(3-(3- fluorophenoxy)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
Show/Hide
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C30H25FN4O5S2
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1
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| 1 |
IC50 = 19000 nM
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CP0144065
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2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-(2,2,2-trifluoroethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C28H21F3N4O4S2
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1
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| 1 |
IC50 = 19400 nM
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CP0544219
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2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- (pyrrolidine-1- carbonyl)phenyl)-4- (3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
Show/Hide
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C29H27F2N5O5S2
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1
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| 1 |
IC50 = 19900 nM
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CP0569833
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2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-morpholin-4-ylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C28H28FN5O5S2
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1
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| 1 |
IC50 = 23400 nM
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CP0570022
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(2-propan-2-yl-2,6-diazaspiro[3.3]heptan-6-yl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C32H34F2N6O4S2
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1
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| 1 |
IC50 = 24100 nM
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CP0362414
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2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-(3,3,3-trifluoroprop-1-ynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C27H19F5N4O4S2
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1
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| 1 |
IC50 > 30000 nM
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CP0552994
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2-(3-(3-(pyridin-3- ylmethoxy)phenyl)-4- (4-sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
Show/Hide
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C26H21N5O5S2
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1
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| 1 |
IC50 > 57000 nM
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CP0559582
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2-[3-(3-methoxyphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
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C21H18N4O5S2
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1
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| 1 |
IC50 > 57000 nM
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CP0569558
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2-(3-(3-(pyridin-2- ylmethoxy)phenyl)-4- (4-sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
Show/Hide
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C26H21N5O5S2
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1
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| 1 |
IC50 > 57000 nM
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