| Compound ID |
Compound Name |
Compound Formula |
|
CP0554850
|
2-[5-(cyclopropylmethyl)-3-[3-(3,3-dimethylbut-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H28F2N4O4S2
|
1
|
| 1 |
IC50 = 141 nM
|
|
|
|
CP0484665
|
2-(5-(cyclopropylmethyl)-3- (3-((2,5-dimethylthiophen-3- yl)ethynyl)phenyl)-4-(3-fluoro- 4-sulfamoylbenzyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
Show/Hide
|
C32H27FN4O4S3
|
1
|
| 1 |
IC50 = 161 nM
|
|
|
|
CP0365471
|
2-(5-(2-cyclopropylethyl)-3- (3-((2,5-dimethylthiophen-3- yl)ethynyl)phenyl)-4-(3-fluoro- 4-sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C33H29FN4O4S3
|
1
|
| 1 |
IC50 = 162 nM
|
|
|
|
CP0484666
|
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H27FN4O4S3
|
1
|
| 1 |
IC50 = 174 nM
|
|
|
|
CP0547640
|
2-[3-[3-[2-(5-chlorothiophen-2-yl)ethynyl]phenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H22ClFN4O4S3
|
1
|
| 1 |
IC50 = 218 nM
|
|
|
|
CP0537718
|
2-[5-(cyclopropylmethyl)-3-[3-(3-cyclopropylprop-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H26F2N4O4S2
|
1
|
| 1 |
IC50 = 234 nM
|
|
|
|
CP0258269
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-methylbut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C29H26F2N4O4S2
|
1
|
| 1 |
IC50 = 284 nM
|
|
|
|
CP0317515
|
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(4- methylpent-1-yn-1- yl)phenyl)-4-(3- fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
Show/Hide
|
C30H28F2N4O4S2
|
1
|
| 1 |
IC50 = 284 nM
|
|
|
|
CP0537723
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-propan-2-ylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C33H29FN4O4S3
|
1
|
| 1 |
IC50 = 296 nM
|
|
|
|
CP0258271
|
2-[3-[3-(2-cyclopentylethynyl)phenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H29FN4O4S2
|
1
|
| 1 |
IC50 = 298 nM
|
|
|
|
CP0484667
|
2-(5-(2-cyclopropylethyl)- 4-(3-fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-4- yl)ethynyl)phenyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C31H26FN5O4S3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0362417
|
2-[3-[3-[(E)-2-cyclopropylethenyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C29H26F2N4O4S2
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0484664
|
2-(3-(3-((5-cyclobutylthiophen- 2-yl)ethynyl)phenyl)- 5-(cyclopropylmethyl)-4- (3-fluoro-4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C34H29FN4O4S3
|
1
|
| 1 |
IC50 = 333 nM
|
|
|
|
CP0362416
|
2-[5-(cyclopropylmethyl)-3-[3-[2-[5-(difluoromethyl)thiophen-2-yl]ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H23F3N4O4S3
|
1
|
| 1 |
IC50 = 345 nM
|
|
|
|
CP0538514
|
2-[5-(cyclopropylmethyl)-3-[3-[2-(3,5-dimethylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H27FN4O4S3
|
1
|
| 1 |
IC50 = 345 nM
|
|
|
|
CP0539178
|
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[3-(1-methylcyclopropyl)prop-1-ynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H31FN4O4S2
|
1
|
| 1 |
IC50 = 346 nM
|
|
|
|
CP0354428
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[(E)-2-(5-methylthiophen-2-yl)ethenyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H27FN4O4S3
|
1
|
| 1 |
IC50 = 357 nM
|
|
|
|
CP0539167
|
2-[5-(cyclopropylmethyl)-3-[3-[(E)-3,3-dimethylbut-1-enyl]-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H30F2N4O4S2
|
1
|
| 1 |
IC50 = 361 nM
|
|
|
|
CP0538516
|
2-(5-(2-cyclopropylethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylthiazol-2- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
Show/Hide
|
C31H26FN5O4S3
|
1
|
| 1 |
IC50 = 364 nM
|
|
|
|
CP0543634
|
2-[3-[3-[2-(2-cyclopropylcyclopropyl)ethynyl]phenyl]-5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C33H31FN4O4S2
|
1
|
| 1 |
IC50 = 364 nM
|
|
|
|
CP0258249
|
2-[3-[3-[(E)-2-cyclopentylethenyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H30F2N4O4S2
|
1
|
| 1 |
IC50 = 371 nM
|
|
|
|
CP0366919
|
2-[3-[3-(2-cyclobutylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H26F2N4O4S2
|
1
|
| 1 |
IC50 = 378 nM
|
|
|
|
CP0354427
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(3-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O4S3
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0364209
|
2-[5-(2-cyclopropylethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H26F2N4O4S3
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0364192
|
2-[5-(cyclopropylmethyl)-3-[3-[2-(5-cyclopropylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C33H27FN4O4S3
|
1
|
| 1 |
IC50 = 403 nM
|
|
|
|
CP0538515
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[(E)-prop-1-enyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H24F2N4O4S2
|
1
|
| 1 |
IC50 = 405 nM
|
|
|
|
CP0556265
|
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-hex-1-ynylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H28F2N4O4S2
|
1
|
| 1 |
IC50 = 405 nM
|
|
|
|
CP0258268
|
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(pent-1- yn-1-yl)phenyl)-4-(3- fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
Show/Hide
|
C29H26F2N4O4S2
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0537720
|
2-[5-(2-cyclopropylethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H26F2N4O4S3
|
1
|
| 1 |
IC50 = 434 nM
|
|
|
|
CP0538518
|
2-(5-(2-cyclopropylethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-5- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
Show/Hide
|
C31H26FN5O4S3
|
1
|
| 1 |
IC50 = 434 nM
|
|
|
|
CP0547641
|
2-(5-(2-cyclopropylethyl)- 3-(3-((5-cyclopropylthiophen- 2-yl)ethynyl)phenyl)-4-(3- fluoro-4-sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole- 4-carboxylic acid
Show/Hide
|
C34H29FN4O4S3
|
1
|
| 1 |
IC50 = 434 nM
|
|
|
|
CP0362435
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-(2-thiophen-2-ylethynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H22F2N4O4S3
|
1
|
| 1 |
IC50 = 438 nM
|
|
|
|
CP0253018
|
2-[3-[3-(3-cyclopentyl-3-fluoroprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H29F3N4O4S2
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0362432
|
2-[5-(cyclopropylmethyl)-3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H26N4O4S2
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0364193
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylfuran-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O5S2
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0258248
|
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-phenylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24F2N4O4S2
|
1
|
| 1 |
IC50 = 465 nM
|
|
|
|
CP0258272
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-[5-(trifluoromethyl)thiophen-2-yl]ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H22F4N4O4S3
|
1
|
| 1 |
IC50 = 485 nM
|
|
|
|
CP0538517
|
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-(2-spiro[2.2]pentan-2-ylethynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H29FN4O4S2
|
1
|
| 1 |
IC50 = 485 nM
|
|
|
|
CP0258266
|
2-[3-[3-(3-cyclopentylprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H30F2N4O4S2
|
1
|
| 1 |
IC50 = 487 nM
|
|
|
|
CP0514956
|
2-[3-(3-but-1-ynyl-4-fluorophenyl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C28H24F2N4O4S2
|
1
|
| 1 |
IC50 = 487 nM
|
|
|
|
CP0514745
|
2-(5-(cyclopropylmethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylthiophen-3- yl)ethynyl)phenyl)-1H-pyrazol-1- yl)thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O4S3
|
1
|
| 1 |
IC50 = 494 nM
|
|
|
|
CP0258267
|
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-prop-1-ynylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H22F2N4O4S2
|
1
|
| 1 |
IC50 = 505 nM
|
|
|
|
CP0362527
|
2-[3-[3-(2-cyclopentylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H28F2N4O4S2
|
1
|
| 1 |
IC50 = 509 nM
|
|
|
|
CP0514955
|
2-(3-([1,1''-biphenyl]- 3-yl)-5-(2- cyclopropylethyl)-4- (4-sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid (M + H)+ = 585
Show/Hide
|
C31H28N4O4S2
|
1
|
| 1 |
IC50 = 509 nM
|
|
|
|
CP0539857
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methyl-1,3-oxazol-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24FN5O5S2
|
1
|
| 1 |
IC50 = 525 nM
|
|
|
|
CP0487438
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methyl-1,3-thiazol-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24FN5O4S3
|
1
|
| 1 |
IC50 = 527 nM
|
|
|
|
CP0543608
|
2-[3-[3-[2-(5-tert-butylthiophen-2-yl)ethynyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C34H30F2N4O4S3
|
1
|
| 1 |
IC50 = 529 nM
|
|
|
|
CP0362415
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methylfuran-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H24F2N4O5S2
|
1
|
| 1 |
IC50 = 544 nM
|
|
|
|
CP0362419
|
2-(5-(2-cyclopropylethyl)-4- (3-fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylfuran-2- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C32H27FN4O5S2
|
1
|
| 1 |
IC50 = 547 nM
|
|
|
|
CP0552995
|
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(p- tolyloxy)phenyl)-4- (3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
Show/Hide
|
C31H26F2N4O5S2
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0317925
|
2-(3-(3-((5-cyclobutylthiophen- 2-yl)ethynyl)phenyl)- 5-(2-cyclopropylethyl)- 4-(3-fluoro-4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C35H31FN4O4S3
|
1
|
| 1 |
IC50 = 572 nM
|
|
|
|
CP0565301
|
US11247971, Cmpd ID 340
Show/Hide
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C31H27FN4O5S2
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0317514
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-phenylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H25FN4O4S2
|
1
|
| 1 |
IC50 = 613 nM
|
|
|
|
CP0354426
|
2-[3-[3-(3-cyclopropylbut-1-ynyl)phenyl]-5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H31FN4O4S2
|
1
|
| 1 |
IC50 = 685 nM
|
|
|
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CP0539180
|
2-[3-[3-(2-cyclopropylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C29H24F2N4O4S2
|
1
|
| 1 |
IC50 = 695 nM
|
|
|
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CP0253023
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-prop-1-ynylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H23FN4O4S2
|
1
|
| 1 |
IC50 = 713 nM
|
|
|
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CP0364208
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-(3,3,3-trifluoroprop-1-en-2-yl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H22F4N4O4S2
|
1
|
| 1 |
IC50 = 713 nM
|
|
|
|
CP0539166
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(2-methyl-1,3-thiazol-5-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24FN5O4S3
|
1
|
| 1 |
IC50 = 713 nM
|
|
|
|
CP0573588
|
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-((3- fluorobenzyl)oxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
Show/Hide
|
C31H25F3N4O5S2
|
1
|
| 1 |
IC50 = 730 nM
|
|
|
|
CP0265966
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O4S3
|
1
|
| 1 |
IC50 = 760 nM
|
|
|
|
CP0362434
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-methoxyprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C28H24F2N4O5S2
|
1
|
| 1 |
IC50 = 769 nM
|
|
|
|
CP0317516
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-fluorobut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C28H23F3N4O4S2
|
1
|
| 1 |
IC50 = 800 nM
|
|
|
|
CP0362528
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2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H25FN4O4S2
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1
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| 1 |
IC50 = 835 nM
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CP0253022
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H24F2N4O4S3
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1
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| 1 |
IC50 = 873 nM
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CP0549707
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2-[5-(cyclopropylmethyl)-3-(3-ethynyl-4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C26H20F2N4O4S2
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1
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| 1 |
IC50 = 902 nM
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CP0552591
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-(oxolan-2-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H28F2N4O5S2
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1
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| 1 |
IC50 = 933 nM
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CP0365470
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2-[5-(cyclopropylmethyl)-3-[3-(3,3-difluoroprop-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H20F4N4O4S2
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1
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| 1 |
IC50 = 937 nM
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CP0549705
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(2-methyl-1,3-thiazol-5-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H23F2N5O4S3
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1
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| 1 |
IC50 = 937 nM
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CP0362412
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-(oxetan-3-yl)but-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H28F2N4O5S2
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1
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| 1 |
IC50 = 1052 nM
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CP0253020
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-fluoro-3-(oxolan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H27F3N4O5S2
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1
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| 1 |
IC50 = 1056 nM
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CP0253021
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-pyrrolidin-1-ylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H29F2N5O4S2
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1
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| 1 |
IC50 = 1086 nM
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CP0537995
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US11247971, Cmpd ID 400
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C28H24F4N4O5S2
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1
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| 1 |
IC50 = 1100 nM
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CP0546393
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2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-((5- (trifluoromethyl)furan- 2- yl)methoxy)phenyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; MS (ES) 694.9 (M + H)+,
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C30H23F5N4O6S2
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1
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| 1 |
IC50 = 1100 nM
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CP0557973
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2-(5-(cyclopropylmethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-4- yl)ethynyl)phenyl)-1H-pyrazol-1- yl)thiazole-4-carboxylic acid
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C30H24FN5O4S3
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1
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| 1 |
IC50 = 1174 nM
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CP0514743
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(oxolan-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H26F2N4O5S2
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1
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| 1 |
IC50 = 1268 nM
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CP0362413
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-fluoro-3-(oxetan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H25F3N4O5S2
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1
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| 1 |
IC50 = 1324 nM
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CP0514744
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methyl-1,3-thiazol-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H23F2N5O4S3
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1
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| 1 |
IC50 = 1324 nM
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CP0258245
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2-(3-([1,1'-biphenyl]- 3-yl)-5-((2,2- difluorocyclopropyl) methyl)-4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C30H24F2N4O4S2
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1
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| 1 |
IC50 = 1423 nM
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CP0317517
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(3-methylimidazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H24F2N6O4S2
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1
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| 1 |
IC50 = 1597 nM
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CP0362531
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(1-methylpyrazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H24F2N6O4S2
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1
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| 1 |
IC50 = 1603 nM
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CP0258246
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2-(3-([1,1'-biphenyl]- difluorocyclopropyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C29H22F2N4O4S2
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1
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| 1 |
IC50 = 1861 nM
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CP0258273
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2-[5-(2-cyclopropylethyl)-3-[3-(3,3-dicyclopropylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C34H33FN4O4S2
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1
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| 1 |
IC50 = 1864 nM
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CP0363019
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2-(3-(3- cydopropoxy-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C27H24F2N4O5S2
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1
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| 1 |
IC50 = 1900 nM
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CP0253019
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2-[3-[3-(3-cyclopentyl-3-hydroxyprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H30F2N4O5S2
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1
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| 1 |
IC50 = 1931 nM
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CP0552564
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2-[3-(3-benzamido-4-fluorophenyl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H25F2N5O5S2
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1
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| 1 |
IC50 = 2300 nM
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CP0558851
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(4-hydroxybut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H24F2N4O5S2
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1
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| 1 |
IC50 = 2475 nM
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CP0537993
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2-(5- (cyclopropylmethyl)- 3-(3- (phenylamino)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;
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C30H27N5O4S2
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1
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| 1 |
IC50 = 3100 nM
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CP0553356
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2-[3-[3-(2-cyanoethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H19F2N5O4S2
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1
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| 1 |
IC50 = 4010 nM
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CP0258247
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2-[5-(cyclopropylmethyl)-4-[(2-fluoro-4-sulfamoylphenyl)methyl]-3-(3-phenylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H25FN4O4S2
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1
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| 1 |
IC50 = 4465 nM
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CP0567918
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2-(3-(3- (benzylcarbamoyl)-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid: MS (ES) 664.0 (M + H)+,
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C32H27F2N5O5S2
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1
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| 1 |
IC50 = 4700 nM
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CP0539856
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-hydroxy-3-(oxolan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H28F2N4O6S2
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1
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| 1 |
IC50 = 5937 nM
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CP0569833
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2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-morpholin-4-ylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H28FN5O5S2
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1
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| 1 |
IC50 = 9400 nM
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CP0144065
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2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-(2,2,2-trifluoroethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H21F3N4O4S2
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1
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| 1 |
IC50 = 9719 nM
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CP0258270
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(2-piperidin-4-ylethynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H29F2N5O4S2
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1
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| 1 |
IC50 = 12241 nM
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CP0362529
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-hydroxy-3-(oxetan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H26F2N4O6S2
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1
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| 1 |
IC50 = 12241 nM
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CP0144066
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-morpholin-4-ylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H29F2N5O5S2
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1
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| 1 |
IC50 = 15349 nM
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CP0544219
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2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- (pyrrolidine-1- carbonyl)phenyl)-4- (3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C29H27F2N5O5S2
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1
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| 1 |
IC50 = 16600 nM
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CP0487439
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2-[5-(2-cyclopropylethyl)-3-[3-(3-cyclopropyl-3-methylbut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C33H33FN4O4S2
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1
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| 1 |
IC50 = 18264 nM
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CP0364189
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2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H23F3N4O4S2
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1
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| 1 |
IC50 = 20186 nM
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CP0362414
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2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-(3,3,3-trifluoroprop-1-ynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H19F5N4O4S2
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1
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| 1 |
IC50 > 30000 nM
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