| Compound ID |
Compound Name |
Compound Formula |
|
CP0194557
|
pyridylpurine aminoisoquinoline, 1
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|
C26H19ClN8
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0116137
|
4-[2-amino-4-methyl-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C33H28N6O3
|
1
|
| 1 |
EC50 = 190 nM
|
|
|
|
CP0261167
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2,2-dimethylpropane-1-sulfonamide
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|
C21H21F2N7O2S
|
1
|
| 1 |
EC50 = 202 nM
|
|
|
|
CP0237053
|
US9216981, 4
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|
C20H13F2N7O2S2
|
1
|
| 1 |
EC50 = 402 nM
|
|
|
|
CP0095082
|
DABRAFENIB
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|
C23H20F3N5O2S2
|
1
|
| 1 |
EC50 = 529 nM
|
|
|
|
CP0240291
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2,2,2-trifluoroethanesulfonamide
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|
C18H12F5N7O2S
|
1
|
| 1 |
EC50 = 713 nM
|
|
|
|
CP0096017
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]butane-2-sulfonamide
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|
C20H19F2N7O2S
|
1
|
| 1 |
EC50 = 778 nM
|
|
|
|
CP0198701
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1,3-thiazole-2-sulfonamide
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|
C19H12F2N8O2S2
|
1
|
| 1 |
EC50 = 783 nM
|
|
|
|
CP0090716
|
US9216981, 30
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|
C21H14F2N8O2S
|
1
|
| 1 |
EC50 = 786 nM
|
|
|
|
CP0112871
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1H-pyrazole-4-sulfonamide
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|
C19H13F2N9O2S
|
1
|
| 1 |
EC50 = 807 nM
|
|
|
|
CP0240290
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2-fluorobenzenesulfonamide
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|
C22H14F3N7O2S
|
1
|
| 1 |
EC50 = 873 nM
|
|
|
|
CP0265728
|
US9216981, 5
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|
C19H17F2N7O2S
|
1
|
| 1 |
EC50 = 936 nM
|
|
|
|
CP0112627
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]piperidine-1-sulfonamide
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|
C21H20F2N8O2S
|
1
|
| 1 |
EC50 = 1220 nM
|
|
|
|
CP0108608
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-2-methylpropane-1-sulfonamide
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|
C20H19F2N7O2S
|
1
|
| 1 |
EC50 = 1450 nM
|
|
|
|
CP0096018
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]oxolane-3-sulfonamide
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|
C20H17F2N7O3S
|
1
|
| 1 |
EC50 = 1480 nM
|
|
|
|
CP0174503
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-fluorobenzenesulfonamide
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|
C22H14F3N7O2S
|
1
|
| 1 |
EC50 = 1510 nM
|
|
|
|
CP0129307
|
US9216981, 1
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|
C19H17F2N7O2S
|
1
|
| 1 |
EC50 = 1540 nM
|
|
|
|
CP0215627
|
6-[2-[3-(dimethylsulfamoylamino)-2,6-difluoroanilino]pyridin-3-yl]-7H-purine
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|
C18H16F2N8O2S
|
1
|
| 1 |
EC50 = 1780 nM
|
|
|
|
CP0376263
|
6-[2-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluoroanilino]pyridin-3-yl]-7H-purine
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|
C19H18F2N8O2S
|
1
|
| 1 |
EC50 = 1780 nM
|
|
|
|
CP0237056
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclobutanesulfonamide
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|
C20H17F2N7O2S
|
1
|
| 1 |
EC50 = 1790 nM
|
|
|
|
CP0090745
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]cyclopentanesulfonamide
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|
C21H19F2N7O2S
|
1
|
| 1 |
EC50 = 1800 nM
|
|
|
|
CP0098453
|
US9216981, 19
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|
C19H15F2N7O2S
|
1
|
| 1 |
EC50 = 2070 nM
|
|
|
|
CP0211509
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyrrolidine-1-sulfonamide
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|
C20H18F2N8O2S
|
1
|
| 1 |
EC50 = 2070 nM
|
|
|
|
CP0536419
|
1-cyclopropyl-N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]methanesulfonamide
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|
C20H17F2N7O2S
|
1
|
| 1 |
EC50 = 2140 nM
|
|
|
|
CP0325790
|
US9216981, 43
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|
C20H15F2N9O2S
|
1
|
| 1 |
EC50 = 2220 nM
|
|
|
|
CP0006321
|
PLX-4032
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|
C23H18ClF2N3O3S
|
1
|
| 1 |
EC50 = 2290 nM
|
|
|
|
CP0218262
|
US9216981, 35
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|
C22H15F2N7O2S
|
1
|
| 1 |
EC50 = 2290 nM
|
|
|
|
CP0121975
|
US9216981, 21
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|
C20H18F2N8O3S
|
1
|
| 1 |
EC50 = 3580 nM
|
|
|
|
CP0261168
|
US9216981, 11
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|
C22H21F2N7O2S
|
1
|
| 1 |
EC50 = 4370 nM
|
|
|
|
CP0090744
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-1-phenylmethanesulfonamide
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|
C23H17F2N7O2S
|
1
|
| 1 |
EC50 = 5080 nM
|
|
|
|
CP0134021
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-4-fluorobenzenesulfonamide
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|
C22H14F3N7O2S
|
1
|
| 1 |
EC50 = 5650 nM
|
|
|
|
CP0134022
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]methanesulfonamide
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|
C17H13F2N7O2S
|
1
|
| 1 |
EC50 = 6690 nM
|
|
|
|
CP0259109
|
(3R)-N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]-3-hydroxypyrrolidine-1-sulfonamide
Show/Hide
|
C20H18F2N8O3S
|
1
|
| 1 |
EC50 = 7190 nM
|
|
|
|
CP0090717
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyridine-2-sulfonamide
Show/Hide
|
C21H14F2N8O2S
|
1
|
| 1 |
EC50 = 7940 nM
|
|
|
|
CP0098452
|
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pentane-2-sulfonamide
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|
C21H21F2N7O2S
|
1
|
| 1 |
EC50 = 8090 nM
|
|
|
|
CP0112625
|
6-[2-[3-(diethylsulfamoylamino)-2,6-difluoroanilino]pyridin-3-yl]-7H-purine
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|
C20H20F2N8O2S
|
1
|
| 1 |
EC50 = 9910 nM
|
|
|
