General Information of the Cell Line
Cell Line ID
CL000448
Cell Line Name
BxPC-3
Synonyms
BxPc-3
BXPC-3
Bx-PC3
BXPC3
BxPC3
BxPc3
Biopsy xenograft of Pancreatic Carcinoma line-3
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0186
Tissue Information
Pancreas
Disease
Pancreatic ductal adenocarcinoma (NCIt: C9120)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT04241, Equilibrative nucleoside transporter 1
Compound ID Compound Name Compound Formula
CP0057024
med.21724, Compound Gemcitabine
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C9H11F2N3O4
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0955356
N'-[(1S)-2-[[(1S)-5-amino-1-[[(1S)-1-[(2S)-2-[[(1S)-1-[[(1S)-1-carbamoyl-3-methylsulfanyl-propyl]carbamoyl]-2-methyl-propyl]carbamoyl]pyrrolidine-1-carbonyl]-3-methyl-butyl]carbamoyl]pentyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]butanediamide
   Show/Hide
C51H74F2N12O12S
 1
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
CP0968860
N'-[(1S)-2-[[(1S)-1-[(2S)-2-[[(1S,2R)-1-[[(1S)-1-[[(1S)-5-amino-1-carbamoyl-pentyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]pyrrolidine-1-carbonyl]-2-methyl-propyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]butanediamide
   Show/Hide
C50H72F2N12O13
 1
1
IC50 = 381 nM
   TI
   LI
   LO
   TS
CP0955875
N'-[(1S)-5-amino-1-[[(1S)-1-[(2S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-3-methylsulfanyl-propyl]carbamoyl]-2-methyl-propyl]carbamoyl]pyrrolidine-1-carbonyl]-3-methyl-butyl]carbamoyl]pentyl]-N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]butanediamide
   Show/Hide
C51H74F2N12O12S
 1
1
IC50 = 384 nM
   TI
   LI
   LO
   TS
CP0961945
(2S)-N-[(1S,2R)-1-[[(1S)-1-[[(1S)-5-amino-1-carbamoyl-pentyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-hydroxy-propyl]-1-[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-3-methyl-butanoyl]pyrrolidine-2-carboxamide
   Show/Hide
C37H59N9O7
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0963259
(2S)-N-[(1S)-1-[[(1S)-1-[[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-3-methylsulfanyl-propyl]carbamoyl]-2-methyl-propyl]-1-[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-4-methyl-pentanoyl]pyrrolidine-2-carboxamide
   Show/Hide
C38H61N9O6S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0967034
(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-4-methyl-pentanoyl]-N-[(1R)-1-[[(1S)-1-carbamoyl-3-methylsulfanyl-propyl]carbamoyl]-2-methyl-propyl]pyrrolidine-2-carboxamide
   Show/Hide
C38H61N9O6S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0003145
(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
   Show/Hide
C27H44O3  1
1
IC50 = 21070 nM
   TI
   LI
   LO
   TS
CP0006113
4-[3-[4-(benzenesulfonylmethoxy)-3-methylphenyl]pentan-3-yl]-N-[2-(diethylamino)ethyl]-1-ethylpyrrole-2-carboxamide
   Show/Hide
C32H45N3O4S  1
1
IC50 = 4690 nM
   TI
   LI
   LO
   TS
CP0008907
N-[2-(diethylamino)ethyl]-1-ethyl-5-[3-[3-methyl-4-(methylsulfanylmethoxy)phenyl]pentan-3-yl]pyrrole-2-carboxamide
   Show/Hide
C27H43N3O2S  1
1
IC50 = 5130 nM
   TI
   LI
   LO
   TS
CP0008908
1-ethyl-5-[3-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]pentan-3-yl]-N-[(2S)-1-hydroxypropan-2-yl]pyrrole-2-carboxamide
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C28H44N2O4  1
1
IC50 = 15780 nM
   TI
   LI
   LO
   TS
CP0018072
US10662186, Compound 63
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C27H32F2N8  1
1
IC50 = 36.2 nM
   TI
   LI
   LO
   TS
CP0086325
2-amino-5-(3,4-dimethylphenyl)-5,5-diphenylpentanoic acid
   Show/Hide
C25H27NO2  1
1
GI50 = 44 nM
   TI
   LI
   LO
   TS
CP0086818
ethyl 7-[3-[[3-(trifluoromethyl)benzoyl]amino]phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylate
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C23H17F3N4O3  1
1
IC50 = 3250 nM
   TI
   LI
   LO
   TS
CP0112599
US8569511, 2
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C23H22F2N6O2  1
1
IC50 = 430 nM
   TI
   LI
   LO
   TS
CP0117454
2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)pyrimidin-4-ylamino)-N-methylbenzamide
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C23H25ClN6O3  2
1
IC50 = 1030 nM
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0156010
(2R)-2-amino-3-[(3-ethyl-4-methylphenyl)-diphenylmethyl]sulfanylpropanoic acid
   Show/Hide
C25H27NO2S  1
1
GI50 = 26 nM
   TI
   LI
   LO
   TS
CP0158116
4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl}-amino)-7-[(1E)-4-(4-ethylpiperazin-1-yl)but-1-enyl]quinoline-3-carbonitrile
   Show/Hide
C30H32ClN7S  1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CP0250629
(2R)-2-amino-3-[(3,4-dimethylphenyl)-diphenylmethyl]sulfanylpropanoic acid
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C24H25NO2S  1
1
GI50 = 124 nM
   TI
   LI
   LO
   TS
CP0329823
2-Acetylfuranonaphthoquinone
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C14H8O4  2
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
2
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0397754
2-[[5-chloro-2-[4-(1-morpholin-4-yl-1-oxobutan-2-yl)oxyanilino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
C26H29ClN6O4  1
1
IC50 = 8730 nM
   TI
   LI
   LO
   TS
CP0411565
2-(4-indol-1-ylbutyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline
   Show/Hide
C23H28N2O2  1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0417440
N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine
   Show/Hide
C19H18N4OS  1
1
GI50 = 3 nM
   TI
   LI
   LO
   TS
CP0431822
3-[(Z)-[1-[4-(4-cyclohexylpiperazin-1-yl)butyl]-2H-indol-3-ylidene]amino]-1,1-dimethylthiourea
   Show/Hide
C25H40N6S  1
1
EC50 = 6150 nM
   TI
   LI
   LO
   TS
CP0452777
1-[3-[4-[1-adamantyl(phenyl)methyl]phenyl]propyl]-4-methylpiperazine
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C31H42N2  1
1
GI50 = 3.41 nM
   TI
   LI
   LO
   TS
CP0472068
3-[(Z)-[1-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)butyl]-2H-indol-3-ylidene]amino]-1,1-dimethylthiourea
   Show/Hide
C26H35N5O2S  1
1
EC50 = 2340 nM
   TI
   LI
   LO
   TS
CP0517268
1-[4-[1-adamantyl(phenyl)methyl]phenyl]-4-ethylpiperazine
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C29H38N2  1
1
LC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0519012
2-[[5-chloro-2-[4-(1-morpholin-4-yl-1-oxopropan-2-yl)oxyanilino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
C25H27ClN6O4  1
1
IC50 = 5340 nM
   TI
   LI
   LO
   TS
CP0524983
1-[4-[1-adamantyl(phenyl)methyl]phenyl]-4-benzylpiperazine
   Show/Hide
C34H40N2  1
1
GI50 = 7510 nM
   TI
   LI
   LO
   TS
CP0529687
2-[[5-chloro-2-[4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
C24H25ClN6O4  1
1
IC50 = 5990 nM
   TI
   LI
   LO
   TS
CP0535102
N-[2-[4-[5-[[2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]pentyl]piperidin-1-yl]ethyl]-4,9-dioxobenzo[f][1]benzofuran-2-carboxamide
   Show/Hide
C39H41N5O8  1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0536607
2-[[2-[4-[[ethoxy(morpholin-4-yl)phosphoryl]methyl]anilino]-5-nitropyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
C25H30N7O6P  1
1
IC50 = 1020 nM
   TI
   LI
   LO
   TS
CP0546239
N-[2-[4-[5-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]pentyl]piperidin-1-yl]ethyl]-4,9-dioxobenzo[f][1]benzofuran-2-carboxamide
   Show/Hide
C38H39N5O8  1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0561801
N-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-4,9-dioxobenzo[f][1]benzofuran-2-carboxamide
   Show/Hide
C36H36N4O12  1
1
IC50 = 10100 nM
   TI
   LI
   LO
   TS
CP0561956
2-[[5-chloro-2-[4-[(4-methoxyphenyl)sulfonylamino]-3-methylanilino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
C26H25ClN6O4S  1
1
IC50 = 10600 nM
   TI
   LI
   LO
   TS
CP0564443
2-[[5-chloro-2-[4-[(4-fluorophenyl)sulfonylamino]-3-methoxyanilino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
C25H22ClFN6O4S  1
1
IC50 = 31600 nM
   TI
   LI
   LO
   TS
CP0565884
(2S,4R)-1-[(2S)-2-[[2-[2-[(4,9-dioxobenzo[f][1]benzofuran-2-carbonyl)amino]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
   Show/Hide
C39H41N5O9S  1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0568939
2-[[5-chloro-2-[4-[(4-methoxyphenyl)sulfonylamino]anilino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
C25H23ClN6O4S  1
1
IC50 = 24100 nM
   TI
   LI
   LO
   TS
CP0575085
2-[[5-chloro-2-[4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]-N-cyclopropylbenzamide
   Show/Hide
C26H27ClN6O4  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0575678
2-[[5-chloro-2-[4-[(4-methylphenyl)sulfonylamino]anilino]pyrimidin-4-yl]amino]-N-methylbenzamide
   Show/Hide
C25H23ClN6O3S  1
1
IC50 = 19400 nM
   TI
   LI
   LO
   TS
CP0955356
N'-[(1S)-2-[[(1S)-5-amino-1-[[(1S)-1-[(2S)-2-[[(1S)-1-[[(1S)-1-carbamoyl-3-methylsulfanyl-propyl]carbamoyl]-2-methyl-propyl]carbamoyl]pyrrolidine-1-carbonyl]-3-methyl-butyl]carbamoyl]pentyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]butanediamide
   Show/Hide
C51H74F2N12O12S  1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0963259
(2S)-N-[(1S)-1-[[(1S)-1-[[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-3-methylsulfanyl-propyl]carbamoyl]-2-methyl-propyl]-1-[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-4-methyl-pentanoyl]pyrrolidine-2-carboxamide
   Show/Hide
C38H61N9O6S  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0968860
N'-[(1S)-2-[[(1S)-1-[(2S)-2-[[(1S,2R)-1-[[(1S)-1-[[(1S)-5-amino-1-carbamoyl-pentyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]pyrrolidine-1-carbonyl]-2-methyl-propyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]butanediamide
   Show/Hide
C50H72F2N12O13  1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Pancreas)
Cell Line Name Organism Disease
PSN1 Homo sapiens (Human) Pancreatic adenocarcinoma
DAN-G Homo sapiens (Human) Pancreatic adenocarcinoma
PANC-1 Homo sapiens (Human) Pancreatic ductal adenocarcinoma
MIA PaCa-2 Homo sapiens (Human) Pancreatic ductal adenocarcinoma
MiaPaCa(BCRP) Homo sapiens (Human) Pancreatic ductal adenocarcinoma
Beta-TC-3 Mus musculus (Mouse) Mouse insulinoma
MIN6 Mus musculus (Mouse) Mouse insulinoma
Beta-TC-6 Mus musculus (Mouse) Mouse insulinoma
Panc02 Mus musculus (Mouse) Mouse pancreatic ductal adenocarcinoma
AR42J Rattus norvegicus (Rat) Rat digestive system neoplasms
INS-1 Rattus norvegicus (Rat) Rat insulinoma
INS-1 832/13 Rattus norvegicus (Rat) Rat insulinoma
INS-1E Rattus norvegicus (Rat) Rat insulinoma