N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-2-fluorobenzenesulfonamide

D3RKN_118

N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)benzenesulfonamide

N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-2,5-difluorobenzenesulfonamide

N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-4-fluorobenzenesulfonamide

N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-2,6-difluorobenzenesulfonamide

N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-3-fluorobenzenesulfonamide

D3RKN_29

D3RKN_98

2,6-difluoro-N-[2-fluoro-5-[5-[2-[(6-morpholin-4-ylpyridin-3-yl)amino]pyrimidin-4-yl]-2-propan-2-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide

2,6-difluoro-N-(3-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide

D3RKN_117

N-(3-(3-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzenesulfonamide

4-({2-[(3-tert-butylphenyl)(methyl)amino]-1H-1,3-benzodiazol-5-yl}oxy)-N-methylpyridine-2-carboxamide

2,6-difluoro-N-(3-(2-isopropyl-5-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzamide

4-(2-(3-isopropylphenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide

4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide

4-(2-(3-tert-butylphenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide

4-(2-(3-tert-butylphenylamino)benzo[d]thiazol-5-yloxy)picolinamide

4-(2-(4-isopropylphenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide

4-(2-(3-isopropylphenylamino)benzo[d]oxazol-5-yloxy)picolinamide

D3RKN_120

4-(2-(4-ethylphenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide

4-(2-(4-bromophenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide

4-(2-(4-bromophenylamino)benzo[d]thiazol-5-yloxy)-N-(2-morpholinoethyl)picolinamide

4-(2-(4-bromophenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide

2,6-difluoro-N-(3-(3-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide hydrochloride

4-[2-(3-tert-butylanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide

4-[2-(3-tert-butylanilino)quinolin-6-yl]oxy-N-methylpyridine-2-carboxamide

4-[2-(3-tert-butylanilino)quinoxalin-6-yl]oxy-N-methylpyridine-2-carboxamide

4-[2-(3-chloroanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide

N-methyl-4-[2-(4-pyridin-3-ylanilino)quinazolin-6-yl]oxypyridine-2-carboxamide

4-[2-(2-bromoanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide

4-(2-anilinoquinazolin-6-yl)oxy-N-methylpyridine-2-carboxamide

N-methyl-4-[2-[3-(trifluoromethyl)anilino]quinazolin-6-yl]oxypyridine-2-carboxamide

N-methyl-4-[2-[3-(trifluoromethoxy)anilino]quinazolin-6-yl]oxypyridine-2-carboxamide

4-[2-(4-bromoanilino)quinazolin-6-yl]oxy-N-(2-hydroxyethyl)pyridine-2-carboxamide

N-methyl-4-[2-(2-phenoxyanilino)quinazolin-6-yl]oxypyridine-2-carboxamide

N-methyl-4-[2-(4-phenoxyanilino)quinazolin-6-yl]oxypyridine-2-carboxamide

N-methyl-4-[2-(4-propan-2-ylanilino)quinazolin-6-yl]oxypyridine-2-carboxamide

4-[2-(4-fluoroanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide

4-[2-(4-methoxyanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide

N-methyl-4-[2-(3-propan-2-ylanilino)quinazolin-6-yl]oxypyridine-2-carboxamide

N-methyl-4-[2-[4-(trifluoromethoxy)anilino]quinazolin-6-yl]oxypyridine-2-carboxamide

N-methyl-4-[2-[4-(trifluoromethyl)anilino]quinazolin-6-yl]oxypyridine-2-carboxamide

4-[2-(4-bromoanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide

4-[2-(3-bromoanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide

4-[2-(4-bromoanilino)quinazolin-6-yl]oxy-N-(2-piperidin-1-ylethyl)pyridine-2-carboxamide

4-[2-(2-ethylanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide

1-(2,6-difluorophenyl)-3-(3-(3-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)urea

1-(4-(5-(4-(2-ethyl-4-(3-(phenylsulfonylmethyl)phenyl)thiazol-5-yl)pyrimidin-2-ylamino)pyridin-2-yl)piperazin-1-yl)ethanone

N-(2,6-difluorophenyl)-3-(3-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)benzamide hydrochloride

DABRAFENIB

2,6-difluoro-N-(3-(2-isopropyl-5-(2-(2-(methylsulfonyl)ethylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide

N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)phenyl)-2,5-difluorobenzenesulfonamide

2,6-difluoro-N-(2-fluoro-3-(2-isopropyl-5-(2-(2-(methylsulfonyl)ethylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide

N-(5-(2-tert-butyl-5-(2-(2-(methylsulfonyl)ethylamino)pyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

2-(4-(4-(3-(3-fluorophenylsulfonamido)phenyl)-2-isopropylthiazol-5-yl)pyrimidin-2-ylamino)acetamide

N-(3-(5-(2-(cyclopropylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-3-fluorobenzenesulfonamide

N-(5-tert-butyl-2-fluorophenyl)-1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxybenzimidazol-2-amine

N-[4-[2-(3-tert-butylanilino)-1-methylbenzimidazol-5-yl]oxypyridin-2-yl]acetamide

2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(2-(methylsulfonyl)ethylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide

N-(3-(5-(2-(3-(dimethylamino)propylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-3-fluorobenzenesulfonamide

N-(3-(5-(2-aminopyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-2,6-difluorobenzenesulfonamide

N-(3-tert-butylphenyl)-1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxybenzimidazol-2-amine

N-(4-tert-butylphenyl)-1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxybenzimidazol-2-amine

1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine

N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxybenzimidazol-2-amine

5-(2-(1H-imidazol-2-yl)pyridin-4-yloxy)-N-(3-tert-butylphenyl)-1-methyl-1H-benzo[d]imidazol-2-amine

N-(3-tert-butylphenyl)-1-methyl-5-[2-(5-phenyl-1H-imidazol-2-yl)pyridin-4-yl]oxybenzimidazol-2-amine

N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-5-[2-(5-methyl-1H-imidazol-2-yl)pyridin-4-yl]oxybenzimidazol-2-amine

1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[3-(trifluoromethyl)phenyl]benzimidazol-2-amine

N-(5-(5-(2-aminopyrimidin-4-yl)-2-isopropylthiazol-4-yl)-2-fluorophenyl)-3-fluorobenzenesulfonamide