Cell Line Information

General Information of the Cell Line

Cell Line ID	CL000313
Cell Line Name	SK-MEL-28
Synonyms	SK-Mel-28 SK.MEL.28 SK-MEL 28 SK MEL-28 SK MEL 28 SK Mel 28 SKMel-28 SKMEL-28 SK-MEL28 SK-Mel28 SK Mel28 SKMEL28 SKMel28 SKmel28 SKML-28 SK28 AU-Mel P-36 P36
Category	Cancer cell line
Organism	Homo sapiens (Human)
Cellosaurus ID	CVCL_0526
Tissue Information	Skin
Disease	Cutaneous melanoma (NCIt: C3510)

Map of Molecular Bioactivity Related to the Cell Line

Map of Molecular Bioactivity Related to the Cell Line Cell Line Protein Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Cell Line

Protein ID: PT01381, Serine/threonine-protein kinase B-raf

Protein Info

Compound ID	Compound Name	Compound Formula
CP0888382 Compound Info	N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-2-fluorobenzenesulfonamide Show/Hide	C33H33FN8O3S2	1
1	EC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0498854 Compound Info	D3RKN_118 Show/Hide	C31H29F2N7O3S2	1
1	EC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0851897 Compound Info	N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)benzenesulfonamide Show/Hide	C33H34N8O3S2	1
1	EC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0922376 Compound Info	N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-2,5-difluorobenzenesulfonamide Show/Hide	C33H32F2N8O3S2	1
1	EC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0888381 Compound Info	N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-4-fluorobenzenesulfonamide Show/Hide	C33H33FN8O3S2	1
1	EC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0901666 Compound Info	N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-2,6-difluorobenzenesulfonamide Show/Hide	C33H32F2N8O3S2	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0915386 Compound Info	N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-3-fluorobenzenesulfonamide Show/Hide	C33H33FN8O3S2	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0449553 Compound Info	D3RKN_29 Show/Hide	C31H28F3N7O3S2	2
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
2	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0528280 Compound Info	D3RKN_98 Show/Hide	C33H33ClN8O3S2	1
1	EC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0219526 Compound Info	2,6-difluoro-N-[2-fluoro-5-[5-[2-[(6-morpholin-4-ylpyridin-3-yl)amino]pyrimidin-4-yl]-2-propan-2-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide Show/Hide	C31H28F3N7O3S2	1
1	EC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0941267 Compound Info	2,6-difluoro-N-(3-fluoro-5-(2-isopropyl-5-(2-(6-morpholinopyridin-3-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Show/Hide	C31H28F3N7O3S2	1
1	EC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0511500 Compound Info	D3RKN_117 Show/Hide	C32H32N6O2S2	1
1	EC50 = 52 nM Bioactivity Info	TI LI LO TS
CP0941269 Compound Info	N-(3-(3-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzenesulfonamide Show/Hide	C33H29N7O2S	1
1	EC50 = 99 nM Bioactivity Info	TI LI LO TS
CP0045122 Compound Info	4-({2-[(3-tert-butylphenyl)(methyl)amino]-1H-1,3-benzodiazol-5-yl}oxy)-N-methylpyridine-2-carboxamide Show/Hide	C25H27N5O2	2
1	EC50 = 280 nM Bioactivity Info	TI LI LO TS
2	IC50 = 280 nM Bioactivity Info	TI LI LO TS
CP0915387 Compound Info	2,6-difluoro-N-(3-(2-isopropyl-5-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzamide Show/Hide	C33H30F2N6OS	1
1	EC50 = 580 nM Bioactivity Info	TI LI LO TS
CP0037989 Compound Info	4-(2-(3-isopropylphenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide Show/Hide	C23H22N4O3	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0243398 Compound Info	4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide Show/Hide	C24H24N4O3	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0044688 Compound Info	4-(2-(3-tert-butylphenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide Show/Hide	C24H24N4O2S	1
1	EC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0305871 Compound Info	4-(2-(3-tert-butylphenylamino)benzo[d]thiazol-5-yloxy)picolinamide Show/Hide	C23H22N4O2S	1
1	EC50 = 2900 nM Bioactivity Info	TI LI LO TS
CP0345950 Compound Info	4-(2-(4-isopropylphenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide Show/Hide	C23H22N4O2S	1
1	EC50 = 3200 nM Bioactivity Info	TI LI LO TS
CP0233101 Compound Info	4-(2-(3-isopropylphenylamino)benzo[d]oxazol-5-yloxy)picolinamide Show/Hide	C22H20N4O3	1
1	EC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0469002 Compound Info	D3RKN_120 Show/Hide	C33H34N8O3S2	1
1	EC50 = 4731 nM Bioactivity Info	TI LI LO TS
CP0226906 Compound Info	4-(2-(4-ethylphenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide Show/Hide	C22H20N4O3	1
1	EC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0050214 Compound Info	4-(2-(4-bromophenylamino)benzo[d]oxazol-5-yloxy)-N-methylpicolinamide Show/Hide	C20H15BrN4O3	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0243392 Compound Info	4-(2-(4-bromophenylamino)benzo[d]thiazol-5-yloxy)-N-(2-morpholinoethyl)picolinamide Show/Hide	C25H24BrN5O3S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0314155 Compound Info	4-(2-(4-bromophenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide Show/Hide	C20H15BrN4O2S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0921107 Compound Info	2,6-difluoro-N-(3-(3-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide hydrochloride Show/Hide	C34H28ClF2N7O	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0126581 Compound Info	4-[2-(3-tert-butylanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide Show/Hide	C25H25N5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0205293 Compound Info	4-[2-(3-tert-butylanilino)quinolin-6-yl]oxy-N-methylpyridine-2-carboxamide Show/Hide	C26H26N4O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0291996 Compound Info	4-[2-(3-tert-butylanilino)quinoxalin-6-yl]oxy-N-methylpyridine-2-carboxamide Show/Hide	C25H25N5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0397181 Compound Info	4-[2-(3-chloroanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide Show/Hide	C21H16ClN5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0399191 Compound Info	N-methyl-4-[2-(4-pyridin-3-ylanilino)quinazolin-6-yl]oxypyridine-2-carboxamide Show/Hide	C26H20N6O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0399192 Compound Info	4-[2-(2-bromoanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide Show/Hide	C21H16BrN5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0400767 Compound Info	4-(2-anilinoquinazolin-6-yl)oxy-N-methylpyridine-2-carboxamide Show/Hide	C21H17N5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0400768 Compound Info	N-methyl-4-[2-[3-(trifluoromethyl)anilino]quinazolin-6-yl]oxypyridine-2-carboxamide Show/Hide	C22H16F3N5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0400769 Compound Info	N-methyl-4-[2-[3-(trifluoromethoxy)anilino]quinazolin-6-yl]oxypyridine-2-carboxamide Show/Hide	C22H16F3N5O3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0400770 Compound Info	4-[2-(4-bromoanilino)quinazolin-6-yl]oxy-N-(2-hydroxyethyl)pyridine-2-carboxamide Show/Hide	C22H18BrN5O3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0400771 Compound Info	N-methyl-4-[2-(2-phenoxyanilino)quinazolin-6-yl]oxypyridine-2-carboxamide Show/Hide	C27H21N5O3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0400772 Compound Info	N-methyl-4-[2-(4-phenoxyanilino)quinazolin-6-yl]oxypyridine-2-carboxamide Show/Hide	C27H21N5O3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0403551 Compound Info	N-methyl-4-[2-(4-propan-2-ylanilino)quinazolin-6-yl]oxypyridine-2-carboxamide Show/Hide	C24H23N5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0417156 Compound Info	4-[2-(4-fluoroanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide Show/Hide	C21H16FN5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0417157 Compound Info	4-[2-(4-methoxyanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide Show/Hide	C22H19N5O3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0476527 Compound Info	N-methyl-4-[2-(3-propan-2-ylanilino)quinazolin-6-yl]oxypyridine-2-carboxamide Show/Hide	C24H23N5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0476528 Compound Info	N-methyl-4-[2-[4-(trifluoromethoxy)anilino]quinazolin-6-yl]oxypyridine-2-carboxamide Show/Hide	C22H16F3N5O3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0476529 Compound Info	N-methyl-4-[2-[4-(trifluoromethyl)anilino]quinazolin-6-yl]oxypyridine-2-carboxamide Show/Hide	C22H16F3N5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0496390 Compound Info	4-[2-(4-bromoanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide Show/Hide	C21H16BrN5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0497201 Compound Info	4-[2-(3-bromoanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide Show/Hide	C21H16BrN5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0503030 Compound Info	4-[2-(4-bromoanilino)quinazolin-6-yl]oxy-N-(2-piperidin-1-ylethyl)pyridine-2-carboxamide Show/Hide	C27H27BrN6O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0504128 Compound Info	4-[2-(2-ethylanilino)quinazolin-6-yl]oxy-N-methylpyridine-2-carboxamide Show/Hide	C23H21N5O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0915388 Compound Info	1-(2,6-difluorophenyl)-3-(3-(3-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)urea Show/Hide	C34H28F2N8O	1
1	EC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0941268 Compound Info	1-(4-(5-(4-(2-ethyl-4-(3-(phenylsulfonylmethyl)phenyl)thiazol-5-yl)pyrimidin-2-ylamino)pyridin-2-yl)piperazin-1-yl)ethanone Show/Hide	C33H33N7O3S2	1
1	EC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0922748 Compound Info	N-(2,6-difluorophenyl)-3-(3-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)benzamide hydrochloride Show/Hide	C34H28ClF2N7O	1
1	EC50 > 2200 nM Bioactivity Info	TI LI LO TS
CP0095082 Compound Info	DABRAFENIB Show/Hide	C23H20F3N5O2S2	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0731367 Compound Info	2,6-difluoro-N-(3-(2-isopropyl-5-(2-(2-(methylsulfonyl)ethylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Show/Hide	C25H25F2N5O4S3	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0720646 Compound Info	N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)phenyl)-2,5-difluorobenzenesulfonamide Show/Hide	C23H21F2N5O2S2	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0850844 Compound Info	2,6-difluoro-N-(2-fluoro-3-(2-isopropyl-5-(2-(2-(methylsulfonyl)ethylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Show/Hide	C25H24F3N5O4S3	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0884731 Compound Info	N-(5-(2-tert-butyl-5-(2-(2-(methylsulfonyl)ethylamino)pyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide Show/Hide	C26H26F3N5O4S3	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0732540 Compound Info	2-(4-(4-(3-(3-fluorophenylsulfonamido)phenyl)-2-isopropylthiazol-5-yl)pyrimidin-2-ylamino)acetamide Show/Hide	C24H23FN6O3S2	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0850483 Compound Info	N-(3-(5-(2-(cyclopropylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-3-fluorobenzenesulfonamide Show/Hide	C25H24FN5O2S2	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0386018 Compound Info	N-(5-tert-butyl-2-fluorophenyl)-1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxybenzimidazol-2-amine Show/Hide	C27H24F4N6O	1
1	IC50 = 42 nM Bioactivity Info	TI LI LO TS
CP0058906 Compound Info	N-[4-[2-(3-tert-butylanilino)-1-methylbenzimidazol-5-yl]oxypyridin-2-yl]acetamide Show/Hide	C25H27N5O2	1
1	IC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0680666 Compound Info	2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(2-(methylsulfonyl)ethylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Show/Hide	C25H24F3N5O4S3	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0691759 Compound Info	N-(3-(5-(2-(3-(dimethylamino)propylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-3-fluorobenzenesulfonamide Show/Hide	C27H31FN6O2S2	1
1	IC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0691688 Compound Info	N-(3-(5-(2-aminopyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-2,6-difluorobenzenesulfonamide Show/Hide	C22H19F2N5O2S2	1
1	IC50 = 78 nM Bioactivity Info	TI LI LO TS
CP0153437 Compound Info	N-(3-tert-butylphenyl)-1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxybenzimidazol-2-amine Show/Hide	C27H25F3N6O	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0382080 Compound Info	N-(4-tert-butylphenyl)-1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxybenzimidazol-2-amine Show/Hide	C27H25F3N6O	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0036068 Compound Info	1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine Show/Hide	C24H16F6N6O	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0431882 Compound Info	N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxybenzimidazol-2-amine Show/Hide	C24H15F7N6O	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0659583 Compound Info	5-(2-(1H-imidazol-2-yl)pyridin-4-yloxy)-N-(3-tert-butylphenyl)-1-methyl-1H-benzo[d]imidazol-2-amine Show/Hide	C26H26N6O	1
1	IC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0376223 Compound Info	N-(3-tert-butylphenyl)-1-methyl-5-[2-(5-phenyl-1H-imidazol-2-yl)pyridin-4-yl]oxybenzimidazol-2-amine Show/Hide	C32H30N6O	1
1	IC50 = 480 nM Bioactivity Info	TI LI LO TS
CP0447902 Compound Info	N-[2-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-5-[2-(5-methyl-1H-imidazol-2-yl)pyridin-4-yl]oxybenzimidazol-2-amine Show/Hide	C24H18F4N6O	1
1	IC50 = 620 nM Bioactivity Info	TI LI LO TS
CP0431881 Compound Info	1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[3-(trifluoromethyl)phenyl]benzimidazol-2-amine Show/Hide	C24H16F6N6O	1
1	IC50 = 780 nM Bioactivity Info	TI LI LO TS
CP0886005 Compound Info	N-(5-(5-(2-aminopyrimidin-4-yl)-2-isopropylthiazol-4-yl)-2-fluorophenyl)-3-fluorobenzenesulfonamide Show/Hide	C22H19F2N5O2S2	1
1	IC50 = 2555 nM Bioactivity Info	TI LI LO TS

Cell Viability or Cytotoxicity Assay

Compound ID	Compound Name	Compound Formula
CP0003433 Compound Info	(Arylindolyl)maleimide deriv. 27 Show/Hide	C21H16N4O2	2
1	GI50 = 3050 nM	TI LI LO TS
2	LC50 > 100000 nM	TI LI LO TS
CP0006369 Compound Info	6-[3-[4-[1-(5-cyanopentyl)indol-3-yl]-1-hydroxy-2,5-dioxopyrrol-3-yl]indol-1-yl]hexanenitrile Show/Hide	C32H31N5O3	1
1	GI50 = 6070 nM	TI LI LO TS
CP0007711 Compound Info	(E)-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]-N'-propylprop-2-enehydrazide;2,2,2-trifluoroacetic acid Show/Hide	C26H31F3N4O3	1
1	LC50 = 893 nM	TI LI LO TS
CP0064592 Compound Info	[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate Show/Hide	C47H51NO14	1
1	GI50 = 400 nM	TI LI LO TS
CP0086475 Compound Info	2-[(4-methoxyphenyl)-diphenylmethyl]sulfanylethanamine Show/Hide	C22H23NOS	1
1	GI50 = 640 nM	TI LI LO TS
CP0095082 Compound Info	DABRAFENIB Show/Hide	C23H20F3N5O2S2	2
1	IC50 = 3 nM	TI LI LO TS
2	IC50 = 43 nM	TI LI LO TS
CP0113988 Compound Info	CEP-32496 Show/Hide	C24H22F3N5O5	1
1	EC50 = 454 nM	TI LI LO TS
CP0160473 Compound Info	2-(4-(2-(1H-pyrazol-3-ylamino)-1H-benzo[d]imidazol-1-yl)-6-methyl-1,3,5-triazin-2-ylamino)acetonitrile Show/Hide	C16H14N10	1
1	IC50 = 470 nM	TI LI LO TS
CP0383276 Compound Info	N-(4-methoxyphenyl)-N,2,6-trimethylfuro[2,3-d]pyrimidin-4-amine Show/Hide	C16H17N3O2	1
1	GI50 = 37.7 nM	TI LI LO TS
CP0449553 Compound Info	D3RKN_29 Show/Hide	C31H28F3N7O3S2	2
1	EC50 = 8 nM	TI LI LO TS
2	IC50 = 48 nM	TI LI LO TS
CP0634648 Compound Info	N-((R)-Cyclopropyl(pyridin-2-yl)methyl)-3-(4-((endo)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1H-indazole-5-carboxamide Show/Hide	C30H31N5O2	1
1	GI50 = 210 nM	TI LI LO TS
CP0680666 Compound Info	2,6-difluoro-N-(2-fluoro-5-(2-isopropyl-5-(2-(2-(methylsulfonyl)ethylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Show/Hide	C25H24F3N5O4S3	1
1	IC50 = 266 nM	TI LI LO TS
CP0691688 Compound Info	N-(3-(5-(2-aminopyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-2,6-difluorobenzenesulfonamide Show/Hide	C22H19F2N5O2S2	1
1	IC50 = 641 nM	TI LI LO TS
CP0691759 Compound Info	N-(3-(5-(2-(3-(dimethylamino)propylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-3-fluorobenzenesulfonamide Show/Hide	C27H31FN6O2S2	1
1	IC50 = 1292 nM	TI LI LO TS
CP0720646 Compound Info	N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)phenyl)-2,5-difluorobenzenesulfonamide Show/Hide	C23H21F2N5O2S2	1
1	IC50 = 69 nM	TI LI LO TS
CP0731367 Compound Info	2,6-difluoro-N-(3-(2-isopropyl-5-(2-(2-(methylsulfonyl)ethylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzenesulfonamide Show/Hide	C25H25F2N5O4S3	1
1	IC50 = 10 nM	TI LI LO TS
CP0850483 Compound Info	N-(3-(5-(2-(cyclopropylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-3-fluorobenzenesulfonamide Show/Hide	C25H24FN5O2S2	1
1	IC50 = 671 nM	TI LI LO TS
CP0851897 Compound Info	N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)benzenesulfonamide Show/Hide	C33H34N8O3S2	1
1	EC50 = 24 nM	TI LI LO TS
CP0884731 Compound Info	N-(5-(2-tert-butyl-5-(2-(2-(methylsulfonyl)ethylamino)pyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide Show/Hide	C26H26F3N5O4S3	1
1	IC50 = 87 nM	TI LI LO TS
CP0886005 Compound Info	N-(5-(5-(2-aminopyrimidin-4-yl)-2-isopropylthiazol-4-yl)-2-fluorophenyl)-3-fluorobenzenesulfonamide Show/Hide	C22H19F2N5O2S2	1
1	IC50 = 15716 nM	TI LI LO TS
CP0888382 Compound Info	N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-2-fluorobenzenesulfonamide Show/Hide	C33H33FN8O3S2	1
1	EC50 = 4 nM	TI LI LO TS
CP0897293 Compound Info	1-(7-Benzyl-2-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline hydrochloride Show/Hide	C24H25ClN4O	1
1	GI50 = 368 nM	TI LI LO TS
CP0906523 Compound Info	7-Benzyl-N-(4-methoxyphenyl)-N,2,5-trimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine hydrochloride Show/Hide	C23H25ClN4O	1
1	GI50 = 48.7 nM	TI LI LO TS
CP0911977 Compound Info	N-(4-Methoxyphenyl)-N,2-dimethyl-6,7-dihydro-5H-cyclopenta-[d]pyrimidin-4-aminium Chloride Show/Hide	C16H20ClN3O	1
1	GI50 < 10 nM	TI LI LO TS
CP0915387 Compound Info	2,6-difluoro-N-(3-(2-isopropyl-5-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)thiazol-4-yl)phenyl)benzamide Show/Hide	C33H30F2N6OS	1
1	EC50 = 2753 nM	TI LI LO TS
CP0921107 Compound Info	2,6-difluoro-N-(3-(3-(2-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide hydrochloride Show/Hide	C34H28ClF2N7O	1
1	EC50 = 5316 nM	TI LI LO TS
CP0922376 Compound Info	N-(3-(5-(2-(6-(4-acetylpiperazin-1-yl)pyridin-3-ylamino)pyrimidin-4-yl)-2-isopropylthiazol-4-yl)phenyl)-2,5-difluorobenzenesulfonamide Show/Hide	C33H32F2N8O3S2	1
1	EC50 = 8 nM	TI LI LO TS
CP0941268 Compound Info	1-(4-(5-(4-(2-ethyl-4-(3-(phenylsulfonylmethyl)phenyl)thiazol-5-yl)pyrimidin-2-ylamino)pyridin-2-yl)piperazin-1-yl)ethanone Show/Hide	C33H33N7O3S2	1
1	EC50 = 11091 nM	TI LI LO TS

Protein family and CMB statistics Related to the Cell Line

Cell Lines Derived from the same Tissue Source (Skin)

Cell Line Name		Organism	Disease
A-375	Cell Line Info	Homo sapiens (Human)	Amelanotic melanoma
A375-P	Cell Line Info	Homo sapiens (Human)	Amelanotic melanoma
A375-SM	Cell Line Info	Homo sapiens (Human)	Amelanotic melanoma
EBC-1	Cell Line Info	Homo sapiens (Human)	Lung squamous cell carcinoma
WM115	Cell Line Info	Homo sapiens (Human)	Melanoma
WM266-4	Cell Line Info	Homo sapiens (Human)	Melanoma
G-361	Cell Line Info	Homo sapiens (Human)	Melanoma
UACC-62	Cell Line Info	Homo sapiens (Human)	Melanoma
SK-MEL-2	Cell Line Info	Homo sapiens (Human)	Melanoma
Mt2-4	Cell Line Info	Homo sapiens (Human)	Mitochondrial diabetes
NMIi005-A	Cell Line Info	Homo sapiens (Human)	Schizophrenia
A-431	Cell Line Info	Homo sapiens (Human)	Skin squamous cell carcinoma
FF	Cell Line Info	Mesocricetus auratus (Golden hamster)	Hamster melanoma
B16-F10	Cell Line Info	Mus musculus (Mouse)	Mouse melanoma
B16	Cell Line Info	Mus musculus (Mouse)	Mouse melanoma
B16-BL6	Cell Line Info	Mus musculus (Mouse)	Mouse melanoma
B16-F1	Cell Line Info	Mus musculus (Mouse)	Mouse melanoma
B16-F0	Cell Line Info	Mus musculus (Mouse)	Mouse melanoma
HaCaT	Cell Line Info	Homo sapiens (Human)	-
HFF	Cell Line Info	Homo sapiens (Human)	-
S12 [Human keratinocyte]	Cell Line Info	Homo sapiens (Human)	-
Malme-3	Cell Line Info	Homo sapiens (Human)	-
BJ [Human fibroblast]	Cell Line Info	Homo sapiens (Human)	-
HMEC-1	Cell Line Info	Homo sapiens (Human)	-
297L1	Cell Line Info	Homo sapiens (Human)	-
HaCaT-ARE-Luc	Cell Line Info	Homo sapiens (Human)	-
Melan-a	Cell Line Info	Mus musculus (Mouse)	-
JB6 Cl 41-5a	Cell Line Info	Mus musculus (Mouse)	-

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han