General Information of the Cell Line
Cell Line ID
CL000504
Cell Line Name
EBC-1
Synonyms
EBC-1/original
EBC1
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2891
Tissue Information
Skin
Disease
Lung squamous cell carcinoma (NCIt: C3493)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01201, Hepatocyte growth factor receptor
 Protein Info 
Compound ID Compound Name Compound Formula
CP0237108
 Compound Info 
6-[difluoro-[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline
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C18H12F2N8
  1
1
IC50 = 0.43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0197653
 Compound Info 
6-[difluoro-[6-(1-propylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline
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C20H16F2N8
  1
1
IC50 = 0.67 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0046554
 Compound Info 
6-[difluoro-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline
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C20H11F3N6
  1
1
IC50 = 0.85 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0424647
 Compound Info 
6-[difluoro-[6-(furan-2-yl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline
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C18H10F2N6O
  1
1
IC50 = 2.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0197654
 Compound Info 
US9062045, Comparator No. 1 (JNJ-38877605)
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C19H13F2N7
  1
1
IC50 = 5.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01042, Serine/threonine-protein kinase PAK 1
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0019532
 Compound Info 
CS-055
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 C22H19FN4O2  1
1
IC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0143774
 Compound Info 
1-N'-[4-[6-(2,3-dihydroxypropoxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]oxy-3-fluorophenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
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 C27H25F2N5O6  1
1
IC50 = 6.7 nM
   TI
   LI
   LO
   TS
CP0168326
 Compound Info 
1-N'-[3-fluoro-4-[5-methyl-6-(3-morpholin-4-ylpropoxy)pyrrolo[2,1-f][1,2,4]triazin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
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 C31H32F2N6O5  1
1
IC50 = 4.3 nM
   TI
   LI
   LO
   TS
CP0252512
 Compound Info 
1-N'-[3-fluoro-4-[5-methyl-6-(3-methylsulfonylpropoxy)pyrrolo[2,1-f][1,2,4]triazin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
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 C28H27F2N5O6S  1
1
IC50 = 8.6 nM
   TI
   LI
   LO
   TS
CP0444962
 Compound Info 
5-cyclopropyl-N-[(1S)-1-[4-(hydroxycarbamoyl)phenyl]ethyl]-2-(5-phenyl-1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide
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 C25H22N4O3S2  1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0538839
 Compound Info 
6-(1-methylpyrazol-4-yl)-2-[2-[7-(5-sulfanylpentoxy)quinolin-4-yl]oxyethyl]pyridazin-3-one
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 C24H27N5O3S  1
1
IC50 = 640 nM
   TI
   LI
   LO
   TS
CP0566678
 Compound Info 
N-(2-aminophenyl)-4-[2-[3-(1-methylpyrazol-4-yl)-6-oxopyridazin-1-yl]ethoxy]quinoline-7-carboxamide
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 C26H23N7O3  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Skin)
Cell Line Name Organism Disease
A-375
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
A375-P
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
A375-SM
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
SK-MEL-28
 Cell Line Info 
Homo sapiens (Human) Cutaneous melanoma
WM115
 Cell Line Info 
Homo sapiens (Human) Melanoma
WM266-4
 Cell Line Info 
Homo sapiens (Human) Melanoma
G-361
 Cell Line Info 
Homo sapiens (Human) Melanoma
UACC-62
 Cell Line Info 
Homo sapiens (Human) Melanoma
SK-MEL-2
 Cell Line Info 
Homo sapiens (Human) Melanoma
Mt2-4
 Cell Line Info 
Homo sapiens (Human) Mitochondrial diabetes
NMIi005-A
 Cell Line Info 
Homo sapiens (Human) Schizophrenia
A-431
 Cell Line Info 
Homo sapiens (Human) Skin squamous cell carcinoma
FF
 Cell Line Info 
Mesocricetus auratus (Golden hamster) Hamster melanoma
B16-F10
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-BL6
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F1
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F0
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
HaCaT
 Cell Line Info 
Homo sapiens (Human) -
HFF
 Cell Line Info 
Homo sapiens (Human) -
S12 [Human keratinocyte]
 Cell Line Info 
Homo sapiens (Human) -
Malme-3
 Cell Line Info 
Homo sapiens (Human) -
BJ [Human fibroblast]
 Cell Line Info 
Homo sapiens (Human) -
HMEC-1
 Cell Line Info 
Homo sapiens (Human) -
297L1
 Cell Line Info 
Homo sapiens (Human) -
HaCaT-ARE-Luc
 Cell Line Info 
Homo sapiens (Human) -
Melan-a
 Cell Line Info 
Mus musculus (Mouse) -
JB6 Cl 41-5a
 Cell Line Info 
Mus musculus (Mouse) -