General Information of the Cell Line
Cell Line ID
CL000542
Cell Line Name
Malme-3
Synonyms
MALME-3
Category
Finite cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1437
Tissue Information
Skin
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01381, Serine/threonine-protein kinase B-raf
 Protein Info 
Compound ID Compound Name Compound Formula
CP0114052
 Compound Info 
2,6-difluoro-N-(2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H19F2N5O3S
  1
1
IC50 = 17 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0104718
 Compound Info 
2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C17H17F2N5O4S
  1
1
IC50 = 19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0416095
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-(2-pyridin-3-ylpyrazolo[1,5-a]pyrimidin-6-yl)benzamide
   Show/Hide
C21H18F2N6O3S
  1
1
IC50 = 27 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420829
 Compound Info 
2,6-difluoro-N-[2-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C20H19F2N7O3S
  1
1
IC50 = 48 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0385592
 Compound Info 
2,6-difluoro-N-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18F3N5O3S
  1
1
IC50 = 54 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0423927
 Compound Info 
2,6-difluoro-N-[2-(3-fluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C22H18F3N5O3S
  1
1
IC50 = 60 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0134382
 Compound Info 
2,6-difluoro-N-(2-methoxypyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C17H17F2N5O4S
  1
1
IC50 = 68 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0432348
 Compound Info 
2,6-difluoro-N-[2-(2-methoxyethoxy)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C19H21F2N5O5S
  1
1
IC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0410192
 Compound Info 
N-(2-ethoxypyrazolo[1,5-a]pyrimidin-6-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C18H19F2N5O4S
  1
1
IC50 = 205 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420824
 Compound Info 
N-(2-ethylpyrazolo[1,5-a]pyrimidin-6-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C18H19F2N5O3S
  1
1
IC50 = 228 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0524800
 Compound Info 
2,6-difluoro-N-(2-methylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C17H17F2N5O3S
  1
1
IC50 = 248 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420825
 Compound Info 
N-(2-cyclopropylpyrazolo[1,5-a]pyrimidin-6-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C19H19F2N5O3S
  1
1
IC50 = 299 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420828
 Compound Info 
2,6-difluoro-N-(2-morpholin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C20H22F2N6O4S
  1
1
IC50 = 315 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0410276
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-[2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]benzamide
   Show/Hide
C17H14F5N5O3S
  1
1
IC50 = 374 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0524806
 Compound Info 
2,6-difluoro-N-[2-(methylamino)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C17H18F2N6O3S
  1
1
IC50 = 382 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420827
 Compound Info 
2,6-difluoro-N-[2-(propan-2-ylamino)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
   Show/Hide
C19H22F2N6O3S
  1
1
IC50 = 395 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0470544
 Compound Info 
N-(2-cyclopentylpyrazolo[1,5-a]pyrimidin-6-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
   Show/Hide
C21H23F2N5O3S
  1
1
IC50 = 448 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0435994
 Compound Info 
2,6-difluoro-N-(2-propan-2-yloxypyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide
   Show/Hide
C19H21F2N5O4S
  1
1
IC50 = 449 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0392016
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-pyrazolo[1,5-a]pyrimidin-6-ylbenzamide
   Show/Hide
C16H15F2N5O3S
  1
1
IC50 = 488 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0517475
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-(2-pyrrolidin-1-ylpyrazolo[1,5-a]pyrimidin-6-yl)benzamide
   Show/Hide
C20H22F2N6O3S
  1
1
IC50 = 664 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0213065
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-quinolin-3-ylbenzamide
   Show/Hide
C19H17F2N3O3S
  1
1
IC50 = 1381 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0450680
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-(1H-pyrrolo[3,2-b]pyridin-6-yl)benzamide
   Show/Hide
C17H16F2N4O3S
  1
1
IC50 = 1513 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0438366
 Compound Info 
2,6-difluoro-3-(propylsulfonylamino)-N-pyridin-3-ylbenzamide
   Show/Hide
C15H15F2N3O3S
  1
1
IC50 = 6730 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Skin)
Cell Line Name Organism Disease
A-375
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
A375-P
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
A375-SM
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
SK-MEL-28
 Cell Line Info 
Homo sapiens (Human) Cutaneous melanoma
EBC-1
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
WM115
 Cell Line Info 
Homo sapiens (Human) Melanoma
WM266-4
 Cell Line Info 
Homo sapiens (Human) Melanoma
G-361
 Cell Line Info 
Homo sapiens (Human) Melanoma
UACC-62
 Cell Line Info 
Homo sapiens (Human) Melanoma
SK-MEL-2
 Cell Line Info 
Homo sapiens (Human) Melanoma
Mt2-4
 Cell Line Info 
Homo sapiens (Human) Mitochondrial diabetes
NMIi005-A
 Cell Line Info 
Homo sapiens (Human) Schizophrenia
A-431
 Cell Line Info 
Homo sapiens (Human) Skin squamous cell carcinoma
FF
 Cell Line Info 
Mesocricetus auratus (Golden hamster) Hamster melanoma
B16-F10
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-BL6
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F1
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F0
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
HaCaT
 Cell Line Info 
Homo sapiens (Human) -
HFF
 Cell Line Info 
Homo sapiens (Human) -
S12 [Human keratinocyte]
 Cell Line Info 
Homo sapiens (Human) -
BJ [Human fibroblast]
 Cell Line Info 
Homo sapiens (Human) -
HMEC-1
 Cell Line Info 
Homo sapiens (Human) -
297L1
 Cell Line Info 
Homo sapiens (Human) -
HaCaT-ARE-Luc
 Cell Line Info 
Homo sapiens (Human) -
Melan-a
 Cell Line Info 
Mus musculus (Mouse) -
JB6 Cl 41-5a
 Cell Line Info 
Mus musculus (Mouse) -