General Information of the Cell Line
Cell Line ID
CL000150
Cell Line Name
HaCaT
Synonyms
HaCAT
HACAT
Hacat
Category
Spontaneously immortalized cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0038
Tissue Information
Skin
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00922, Epidermal growth factor receptor
 Protein Info 
Compound ID Compound Name Compound Formula
CP0293062
 Compound Info 
N-[1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methylbenzimidazol-2-yl]-2-methylpyridine-4-carboxamide
   Show/Hide
C27H34N6O2
  1
1
IC50 = 68 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0145964
 Compound Info 
N-[1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methylbenzimidazol-2-yl]-2-(trifluoromethyl)pyridine-4-carboxamide
   Show/Hide
C27H31F3N6O2
  1
1
IC50 = 72 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0033646
 Compound Info 
AZD-9291
   Show/Hide
C28H33N7O2
  1
1
IC50 = 73.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0240838
 Compound Info 
N-[7-chloro-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]benzimidazol-2-yl]-2-methylpyridine-4-carboxamide
   Show/Hide
C26H31ClN6O2
  1
1
IC50 = 160.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0316934
 Compound Info 
N-[7-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
   Show/Hide
C25H25F3N4O2
  1
1
IC50 = 249.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0065286
 Compound Info 
AVL-301
   Show/Hide
C27H28F3N7O3
  1
1
IC50 = 262.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0217163
 Compound Info 
N-[1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methylbenzimidazol-2-yl]-3-(trifluoromethyl)benzamide
   Show/Hide
C28H32F3N5O2
  1
1
IC50 = 351 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0419521
 Compound Info 
N-[5-methyl-1-(1-prop-2-enoylazepan-3-yl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
   Show/Hide
C25H25F3N4O2
  1
1
IC50 = 4330 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0385108
 Compound Info 
N-[5-methyl-1-[3-[methyl(prop-2-enoyl)amino]phenyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
   Show/Hide
C26H21F3N4O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0396216
 Compound Info 
N-[5-methyl-1-[3-(prop-2-enoylamino)phenyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
   Show/Hide
C25H19F3N4O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0428083
 Compound Info 
N-[5-methyl-1-[3-(prop-2-enoylamino)propyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
   Show/Hide
C22H21F3N4O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0442242
 Compound Info 
N-[5-methyl-1-(1-prop-2-enoylpiperidin-3-yl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
   Show/Hide
C24H23F3N4O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01503, Signal transducer and activator of transcription 3
 Protein Info 
Protein ID: PT01221, TGF-beta receptor type-1
 Protein Info 
Protein ID: PT02378, Vitamin D3 receptor
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0030899
 Compound Info 
1-[(2-chlorophenyl)-diphenylmethyl]imidazole
   Show/Hide
 C22H17ClN2  1
1
LD50 = 40000 nM
   TI
   LI
   LO
   TS
CP0072935
 Compound Info 
1,8-dihydroxy-9(10H)-anthracenone
   Show/Hide
 C14H10O3  1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0102514
 Compound Info 
1,8-dihydroxy-9,10-dihydroanthracene-9,10-dione
   Show/Hide
 C14H8O4  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0246047
 Compound Info 
10-Ethylsulfanyl-1,8-dihydroxy-10H-anthracen-9-one
   Show/Hide
 C16H14O3S  1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0274224
 Compound Info 
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole
   Show/Hide
 C22H17ClN2  1
1
EC50 = 40000 nM
   TI
   LI
   LO
   TS
CP0303955
 Compound Info 
TACALCITOL
   Show/Hide
 C27H44O3  1
1
IC50 = 2070 nM
   TI
   LI
   LO
   TS
CP0374657
 Compound Info 
1,3,8-Trihydroxy-6-methyl-4,5-bis-(3-methyl-but-2-enyl)-10H-anthracen-9-one
   Show/Hide
 C25H28O4  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0374658
 Compound Info 
1,8-Dihydroxy-2-methyl-10H-anthracen-9-one
   Show/Hide
 C15H12O3  1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0383299
 Compound Info 
1,3,8-Trihydroxy-6-methyl-10H-anthracen-9-one
   Show/Hide
 C15H12O4  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0395258
 Compound Info 
4,5-Dihydroxy-10H-anthracen-9-one
   Show/Hide
 C14H10O3  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0404664
 Compound Info 
1,8-Dichloro-10H-anthracen-9-one
   Show/Hide
 C14H8Cl2O  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0410332
 Compound Info 
2-(1H-benzimidazol-2-ylmethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole
   Show/Hide
 C16H11ClN4O  1
1
IC50 = 9500 nM
   TI
   LI
   LO
   TS
CP0417344
 Compound Info 
5-tosyl-5H-dibenzo[b,d]azepin-7(6H)-one
   Show/Hide
 C21H17NO3S  1
1
EC50 = 8400 nM
   TI
   LI
   LO
   TS
CP0420806
 Compound Info 
(5Z)-3-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-5-[(3,4-dimethoxyphenyl)methylidene]imidazolidine-2,4-dione
   Show/Hide
 C26H30Cl2N4O4  1
1
IC50 = 296440 nM
   TI
   LI
   LO
   TS
CP0448374
 Compound Info 
1-Amino-10H-anthracen-9-one
   Show/Hide
 C14H11NO  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0448703
 Compound Info 
Acetic acid 1,8-diacetoxy-9,10-dihydro-anthracen-9-yl ester
   Show/Hide
 C20H18O6  1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0454837
 Compound Info 
2-(1H-benzimidazol-2-ylmethyl)-5-(phenoxymethyl)-1,3,4-oxadiazole
   Show/Hide
 C17H14N4O2  1
1
IC50 = 61000 nM
   TI
   LI
   LO
   TS
CP0454844
 Compound Info 
2-(1H-benzimidazol-2-ylmethyl)-5-(2,3-dimethoxyphenyl)-1,3,4-oxadiazole
   Show/Hide
 C18H16N4O3  1
1
IC50 = 55300 nM
   TI
   LI
   LO
   TS
CP0457265
 Compound Info 
1-(2-Acetyl-benzyloxy)-8-hydroxy-10H-anthracen-9-one
   Show/Hide
 C23H18O4  1
1
IC50 = 3700 nM
   TI
   LI
   LO
   TS
CP0457274
 Compound Info 
1,8-dihydroxy-3-methyl-9(10H)-anthracenone
   Show/Hide
 C15H12O3  1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0458905
 Compound Info 
4,5-Dihydroxy-10-oxo-9,10-dihydro-anthracene-2-carboxylic acid methyl ester
   Show/Hide
 C16H12O5  1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0461070
 Compound Info 
1,8,9-Trimethoxy-9,10-dihydro-anthracene
   Show/Hide
 C17H18O3  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0461083
 Compound Info 
10-Bromo-1,8-dihydroxy-10H-anthracen-9-one
   Show/Hide
 C14H9BrO3  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0463223
 Compound Info 
4,5-Dihydroxy-10-oxo-9,10-dihydro-anthracene-9-carbaldehyde
   Show/Hide
 C15H10O4  1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0478559
 Compound Info 
2-[(6-chloro-1H-benzimidazol-2-yl)methyl]-5-(2-chlorophenyl)-1,3,4-oxadiazole
   Show/Hide
 C16H10Cl2N4O  1
1
IC50 = 19500 nM
   TI
   LI
   LO
   TS
CP0479899
 Compound Info 
2-(1H-benzimidazol-2-ylmethyl)-5-(2-methylphenyl)-1,3,4-oxadiazole
   Show/Hide
 C17H14N4O  1
1
IC50 = 64700 nM
   TI
   LI
   LO
   TS
CP0479900
 Compound Info 
2-[(6-chloro-1H-benzimidazol-2-yl)methyl]-5-(4-chlorophenyl)-1,3,4-oxadiazole
   Show/Hide
 C16H10Cl2N4O  1
1
IC50 = 24400 nM
   TI
   LI
   LO
   TS
CP0482788
 Compound Info 
9,10-Dihydro-anthracene
   Show/Hide
 C14H12  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0486103
 Compound Info 
9(10H)-anthracenone
   Show/Hide
 C14H10O  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0486112
 Compound Info 
1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracene-2-carbonitrile
   Show/Hide
 C15H9NO3  1
1
IC50 = 4200 nM
   TI
   LI
   LO
   TS
CP0496303
 Compound Info 
10-Dimethylaminomethylene-1,8-dihydroxy-10H-anthracen-9-one
   Show/Hide
 C17H15NO3  1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0501013
 Compound Info 
1,5-Dihydroxy-10H-anthracen-9-one
   Show/Hide
 C14H10O3  1
1
IC50 = 4300 nM
   TI
   LI
   LO
   TS
CP0501015
 Compound Info 
10-Acetyl-1,8-dihydroxy-10H-anthracen-9-one
   Show/Hide
 C16H12O4  1
1
IC50 = 2600 nM
   TI
   LI
   LO
   TS
CP0511043
 Compound Info 
1,2-Dihydroxy-10H-anthracen-9-one
   Show/Hide
 C14H10O3  1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0517811
 Compound Info 
2-(1H-benzimidazol-2-ylmethyl)-5-(2-chlorophenyl)-1,3,4-oxadiazole
   Show/Hide
 C16H11ClN4O  1
1
IC50 = 25300 nM
   TI
   LI
   LO
   TS
CP0525459
 Compound Info 
2-[[5-[3-[4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl]pentan-3-yl]-1-methylpyrrole-2-carbonyl]amino]acetic acid
   Show/Hide
 C26H38N2O5  1
1
IC50 = 9810 nM
   TI
   LI
   LO
   TS
CP0529139
 Compound Info 
10,10-Dibenzyl-1,8-dihydroxy-10H-anthracen-9-one
   Show/Hide
 C28H22O3  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0535241
 Compound Info 
1,8,10-Trihydroxy-10H-anthracen-9-one
   Show/Hide
 C14H10O4  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0535518
 Compound Info 
4,5-Dihydroxy-10-oxo-9,10-dihydro-anthracene-2-carboxylic acid
   Show/Hide
 C15H10O5  1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0639868
 Compound Info 
(Z)-3-((4-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N-ethyl-2-oxoindoline-6-carboxamide
   Show/Hide
 C27H28N4O2  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0643877
 Compound Info 
(Z)-N-ethyl-3-((4-((ethylamino)methyl)phenylamino)(phenyl)methylene)-N-methyl-2-oxoindoline-6-carboxamide
   Show/Hide
 C28H30N4O2  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Skin)
Cell Line Name Organism Disease
A-375
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
A375-P
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
A375-SM
 Cell Line Info 
Homo sapiens (Human) Amelanotic melanoma
SK-MEL-28
 Cell Line Info 
Homo sapiens (Human) Cutaneous melanoma
EBC-1
 Cell Line Info 
Homo sapiens (Human) Lung squamous cell carcinoma
WM115
 Cell Line Info 
Homo sapiens (Human) Melanoma
WM266-4
 Cell Line Info 
Homo sapiens (Human) Melanoma
G-361
 Cell Line Info 
Homo sapiens (Human) Melanoma
UACC-62
 Cell Line Info 
Homo sapiens (Human) Melanoma
SK-MEL-2
 Cell Line Info 
Homo sapiens (Human) Melanoma
Mt2-4
 Cell Line Info 
Homo sapiens (Human) Mitochondrial diabetes
NMIi005-A
 Cell Line Info 
Homo sapiens (Human) Schizophrenia
A-431
 Cell Line Info 
Homo sapiens (Human) Skin squamous cell carcinoma
FF
 Cell Line Info 
Mesocricetus auratus (Golden hamster) Hamster melanoma
B16-F10
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-BL6
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F1
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
B16-F0
 Cell Line Info 
Mus musculus (Mouse) Mouse melanoma
HFF
 Cell Line Info 
Homo sapiens (Human) -
S12 [Human keratinocyte]
 Cell Line Info 
Homo sapiens (Human) -
Malme-3
 Cell Line Info 
Homo sapiens (Human) -
BJ [Human fibroblast]
 Cell Line Info 
Homo sapiens (Human) -
HMEC-1
 Cell Line Info 
Homo sapiens (Human) -
297L1
 Cell Line Info 
Homo sapiens (Human) -
HaCaT-ARE-Luc
 Cell Line Info 
Homo sapiens (Human) -
Melan-a
 Cell Line Info 
Mus musculus (Mouse) -
JB6 Cl 41-5a
 Cell Line Info 
Mus musculus (Mouse) -