General Information of the Cell Line
Cell Line ID
CL000782
Cell Line Name
297L1
Synonyms
NHDF-iPS
Category
Induced pluripotent stem cell
Organism
Homo sapiens (Human)
Tissue Information
Skin
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00967, Glucocorticoid receptor
Compound ID Compound Name Compound Formula
CP0353545
(+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbaldehyde O-ethyl oxime
   Show/Hide
C24H29N3O2
 1
1
IC50 = 3.4 nM
   TI
   LI
   LO
   TS
CP0056751
(+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbaldehyde O-tert-butyl oxime
   Show/Hide
C26H33N3O2
 1
1
IC50 = 3.8 nM
   TI
   LI
   LO
   TS
CP0049750
(+/-)-(3R,4S)-7-fluoro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C21H23FN2O
 1
1
IC50 = 4.1 nM
   TI
   LI
   LO
   TS
CP0056753
(+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbaldehyde O-methyl oxime
   Show/Hide
C23H27N3O2
 1
1
IC50 = 4.2 nM
   TI
   LI
   LO
   TS
CP0371255
(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-cyanophenylcarbamate
   Show/Hide
C28H23ClF2N4O2
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0206803
(4Z)-4-ethoxyimino-5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-1,3-dihydroquinolin-3-ol
   Show/Hide
C22H23F2N3O2
 1
1
IC50 = 5.2 nM
   TI
   LI
   LO
   TS
CP0049753
(+/-)-(3R,4S)-5-fluoro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C21H23FN2O
 1
1
IC50 = 7.1 nM
   TI
   LI
   LO
   TS
CP0181072
(+/-)-(3R,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C21H23ClN2O
 1
1
IC50 = 7.8 nM
   TI
   LI
   LO
   TS
CP0353546
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,5,8-pentamethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C22H26N2O
 1
1
IC50 = 9.3 nM
   TI
   LI
   LO
   TS
CP0052526
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C20H20F2N2O
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0242004
5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-isopropyl oxime
   Show/Hide
C23H25F2N3O
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0298248
(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-chloro-4-methoxyphenylcarbamate
   Show/Hide
C28H25Cl2F2N3O3
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0160743
5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-tert-butyl oxime
   Show/Hide
C24H27F2N3O
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0353543
(+/-)-(3R,4S)-5-chloro-8-fluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C20H20ClFN2O
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0353544
(+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbaldehyde O-phenyl oxime
   Show/Hide
C29H31N3O2
 1
1
IC50 = 14.4 nM
   TI
   LI
   LO
   TS
CP0113425
(+/-)-(3R,4S)-8-chloro-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C20H19ClF2N2O
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0113426
(+/-)-3-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-5-yl)acrylonitrile
   Show/Hide
C24H25N3O
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0288207
(+/-)-(3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbonitrile
   Show/Hide
C22H23N3O
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0272638
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-cyanophenylcarbamate
   Show/Hide
C28H24F2N4O2
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0333656
methyl 4-[[(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-3,4-dihydro-1H-quinolin-3-yl]oxycarbonylamino]benzoate
   Show/Hide
C29H27F2N3O4
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0218142
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl isopropylcarbamate
   Show/Hide
C24H26ClF2N3O2
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0281237
(4Z)-5,7-difluoro-4-methoxyimino-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-1,3-dihydroquinolin-3-ol
   Show/Hide
C21H21F2N3O2
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0287158
(+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C20H19F3N2O
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0206805
6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one O-tert-butyl oxime
   Show/Hide
C23H24ClF2N3O
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0353542
(+/-)-(3R,4S)-7,8-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C20H20F2N2O
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0257888
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-acetylphenylcarbamate
   Show/Hide
C29H27F2N3O3
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0422817
6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-3-hydroxy-2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one O-methyl oxime
   Show/Hide
C20H18ClF2N3O2
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0047174
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
   Show/Hide
C21H28O5
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0297515
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl cyclohexylcarbamate
   Show/Hide
C27H30ClF2N3O2
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0052482
(+/-)-(3R,4S)-7-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C21H23ClN2O
 1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
CP0321172
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-chlorophenylcarbamate
   Show/Hide
C27H24ClF2N3O2
 1
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
CP0225062
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-acetylphenylcarbamate
   Show/Hide
C29H27F2N3O3
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0329293
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-chloro-4-methoxyphenylcarbamate
   Show/Hide
C28H26ClF2N3O3
 1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0321171
(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl phenylcarbamate
   Show/Hide
C27H24ClF2N3O2
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0294135
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-cyanophenylcarbamate
   Show/Hide
C28H24F2N4O2
 1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
CP0225061
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-(dimethylamino)phenylcarbamate
   Show/Hide
C29H30F2N4O2
 1
1
IC50 = 39 nM
   TI
   LI
   LO
   TS
CP0091080
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl benzylcarbamate
   Show/Hide
C28H26ClF2N3O2
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0460331
5,7-difluoro-6-(1H-indol-7-yl)-2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one O-tert-butyl oxime
   Show/Hide
C23H25F2N3O
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0333655
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl benzo[d][1,3]dioxol-5-ylcarbamate
   Show/Hide
C28H25F2N3O4
 1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
CP0298247
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl methylcarbamate
   Show/Hide
C22H22ClF2N3O2
 1
1
IC50 = 52 nM
   TI
   LI
   LO
   TS
CP0206806
5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-1-hydroxy-2-methylpropan-2-yl oxime
   Show/Hide
C24H27F2N3O2
 1
1
IC50 = 65 nM
   TI
   LI
   LO
   TS
CP0181071
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-7-vinyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C23H26N2O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0218632
(+/-)-(3R,4S)-5,7-dichloro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C20H20Cl2N2O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0261459
(+/-)-(3R,4S)-5-ethyl-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C23H28N2O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0287369
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,7,8-pentamethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C22H26N2O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0288262
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C22H23F3N2O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0292204
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-5-vinyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C23H26N2O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0295461
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C21H24N2O
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0776055
(+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbaldehyde oxime
   Show/Hide
C22H25N3O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0783981
(+/-)-4-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-5-yl)but-3-en-2-one
   Show/Hide
C25H28N2O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0281951
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl phenylcarbamate
   Show/Hide
C27H25F2N3O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0329292
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl methyl(phenyl)carbamate
   Show/Hide
C28H27F2N3O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0333652
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl methylcarbamate
   Show/Hide
C22H23F2N3O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Skin)
Cell Line Name Organism Disease
A-375 Homo sapiens (Human) Amelanotic melanoma
A375-P Homo sapiens (Human) Amelanotic melanoma
A375-SM Homo sapiens (Human) Amelanotic melanoma
SK-MEL-28 Homo sapiens (Human) Cutaneous melanoma
EBC-1 Homo sapiens (Human) Lung squamous cell carcinoma
WM115 Homo sapiens (Human) Melanoma
WM266-4 Homo sapiens (Human) Melanoma
G-361 Homo sapiens (Human) Melanoma
UACC-62 Homo sapiens (Human) Melanoma
SK-MEL-2 Homo sapiens (Human) Melanoma
Mt2-4 Homo sapiens (Human) Mitochondrial diabetes
NMIi005-A Homo sapiens (Human) Schizophrenia
A-431 Homo sapiens (Human) Skin squamous cell carcinoma
FF Mesocricetus auratus (Golden hamster) Hamster melanoma
B16-F10 Mus musculus (Mouse) Mouse melanoma
B16 Mus musculus (Mouse) Mouse melanoma
B16-BL6 Mus musculus (Mouse) Mouse melanoma
B16-F1 Mus musculus (Mouse) Mouse melanoma
B16-F0 Mus musculus (Mouse) Mouse melanoma
HaCaT Homo sapiens (Human) -
HFF Homo sapiens (Human) -
S12 [Human keratinocyte] Homo sapiens (Human) -
Malme-3 Homo sapiens (Human) -
BJ [Human fibroblast] Homo sapiens (Human) -
HMEC-1 Homo sapiens (Human) -
HaCaT-ARE-Luc Homo sapiens (Human) -
Melan-a Mus musculus (Mouse) -
JB6 Cl 41-5a Mus musculus (Mouse) -