Brief Information of the Compound and Protein
Compound Name
 Compound Info 
methyl 4-[[(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-3,4-dihydro-1H-quinolin-3-yl]oxycarbonylamino]benzoate
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 PubChem ID
CID: 53318680
Canonical SMILES
COC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](C)c3c(NC2(C)C)cc(F)c(c3F)-c2cccc3cc[nH]c23)cc1
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Compound Formula C29H27F2N3O4
Compound Structure
Protein Name
 Protein Info 
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
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Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P04150
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000782 297L1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CL000044 CV-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CL000430 H4-II-E-C3
 Cell Line Info 
Rattus norvegicus (Rat)  1
1
EC50 = 267 nM
   TI
   LI
   LO
   TS
CL000063 Hep-G2
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 30 nM