General Information of the Cell Line
Cell Line ID
CL000430
Cell Line Name
H4-II-E-C3
Synonyms
H4IIEC3
H4-IIE-C3
H4-II-EC3
H-II-E-C3
Category
Cancer cell line
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_0285
Tissue Information
Liver
Disease
Rat hepatocellular carcinoma (NCIt: C60416)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00967, Glucocorticoid receptor
 Protein Info 
Compound ID Compound Name Compound Formula
CP0047174
 Compound Info 
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
   Show/Hide
C21H28O5
  1
1
EC50 = 26 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0052526
 Compound Info 
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
   Show/Hide
C20H20F2N2O
  1
1
EC50 = 98 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0225062
 Compound Info 
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-acetylphenylcarbamate
   Show/Hide
C29H27F2N3O3
  1
1
EC50 = 182 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0333652
 Compound Info 
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl methylcarbamate
   Show/Hide
C22H23F2N3O2
  1
1
EC50 = 199 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0333656
 Compound Info 
methyl 4-[[(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-3,4-dihydro-1H-quinolin-3-yl]oxycarbonylamino]benzoate
   Show/Hide
C29H27F2N3O4
  1
1
EC50 = 267 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0371255
 Compound Info 
(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-cyanophenylcarbamate
   Show/Hide
C28H23ClF2N4O2
  1
1
EC50 = 272 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0298248
 Compound Info 
(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-chloro-4-methoxyphenylcarbamate
   Show/Hide
C28H25Cl2F2N3O3
  1
1
EC50 = 283 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0294135
 Compound Info 
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-cyanophenylcarbamate
   Show/Hide
C28H24F2N4O2
  1
1
EC50 = 287 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0257888
 Compound Info 
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-acetylphenylcarbamate
   Show/Hide
C29H27F2N3O3
  1
1
EC50 = 333 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0218142
 Compound Info 
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl isopropylcarbamate
   Show/Hide
C24H26ClF2N3O2
  1
1
EC50 = 361 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0225061
 Compound Info 
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-(dimethylamino)phenylcarbamate
   Show/Hide
C29H30F2N4O2
  1
1
EC50 = 361 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0321171
 Compound Info 
(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl phenylcarbamate
   Show/Hide
C27H24ClF2N3O2
  1
1
EC50 = 379 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0297515
 Compound Info 
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl cyclohexylcarbamate
   Show/Hide
C27H30ClF2N3O2
  1
1
EC50 = 435 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0091080
 Compound Info 
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl benzylcarbamate
   Show/Hide
C28H26ClF2N3O2
  1
1
EC50 = 454 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0298247
 Compound Info 
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl methylcarbamate
   Show/Hide
C22H22ClF2N3O2
  1
1
EC50 = 463 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0329293
 Compound Info 
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-chloro-4-methoxyphenylcarbamate
   Show/Hide
C28H26ClF2N3O3
  1
1
EC50 = 687 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0333655
 Compound Info 
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl benzo[d][1,3]dioxol-5-ylcarbamate
   Show/Hide
C28H25F2N3O4
  1
1
EC50 = 874 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT00870, Glucocorticoid receptor
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0036197
 Compound Info 
2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
   Show/Hide
 C20H22N8O5  1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0434007
 Compound Info 
6-Amino-2-[6-amino-2-(4-carboxy-4-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-hexanoylamino]-hexanoic acid
   Show/Hide
 C32H46N12O7  1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0544025
 Compound Info 
6-Amino-2-(4-carboxy-4-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-hexanoic acid
   Show/Hide
 C26H34N10O6  1
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Liver)
Cell Line Name Organism Disease
Huh-7
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
HLF
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-7-Lunet
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-7.5
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-5-2
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
PLC/PRF/5
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Hep 3B2.1-7
 Cell Line Info 
Homo sapiens (Human) Childhood hepatocellular carcinoma
VACO 241
 Cell Line Info 
Homo sapiens (Human) Colon carcinoma
LM
 Cell Line Info 
Homo sapiens (Human) Extrarenal rhabdoid tumor of the liver
GTL-16
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
MKN45
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
NCI-N87
 Cell Line Info 
Homo sapiens (Human) Gastric tubular adenocarcinoma
Hep-G2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2/C3A
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
CellSensor ARE-bla Hep G2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2 VA-13
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepDES19
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
DPX2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2/2.2.15
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepAD38
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepG2-Lucia AhR
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepG2-hNTCP
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HCCC-9810
 Cell Line Info 
Homo sapiens (Human) Intrahepatic cholangiocarcinoma
SU.86.86
 Cell Line Info 
Homo sapiens (Human) Pancreatic adenocarcinoma
Capan-1
 Cell Line Info 
Homo sapiens (Human) Pancreatic ductal adenocarcinoma
Hepa-1c1c7
 Cell Line Info 
Mus musculus (Mouse) Hepatocellular carcinoma of the mouse
H5
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H4-II-E
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
McA-RH7777
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H2.35
 Cell Line Info 
Mus musculus (Mouse) -