| Compound ID |
Compound Name |
Compound Formula |
|
CP0402441
|
BMS-200475-01
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|
C12H15N5O3
|
1
|
| 1 |
EC50 = 0.24 nM
|
|
|
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CP0086203
|
ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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|
C21H22BrFN4O3S
|
6
|
| 1 |
EC50 = 1 nM
|
|
|
| 2 |
EC50 = 14.49 nM
|
|
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| 3 |
EC50 = 17.1 nM
|
|
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| 4 |
EC50 = 30.98 nM
|
|
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| 5 |
EC50 = 34.46 nM
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|
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| 6 |
EC50 = 38.36 nM
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CP0544808
|
(5R,11R)-N-(3-cyano-4-fluorophenyl)-11-fluoro-5,13-dimethyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C20H20F2N6O2
|
1
|
| 1 |
EC50 = 1.6 nM
|
|
|
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CP0426056
|
(3S)-4-[[(4R)-4-(2-chloro-4-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
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|
C22H22ClFN4O5S
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
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CP0548515
|
(3S)-4-[[(4S)-4-(4-chloro-3-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
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|
C22H22ClFN4O5S
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
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CP0575520
|
(5R,11R)-N-[4-fluoro-3-(trifluoromethyl)phenyl]-11-(hydroxymethyl)-5,13-dimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C20H21F4N5O4
|
1
|
| 1 |
EC50 = 2.7 nM
|
|
|
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CP0408985
|
ethyl 4-(2,4-dichlorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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|
C21H22Cl2N4O3S
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
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CP0081527
|
(3S)-4-[[(4R)-4-(2-chloro-4-fluorophenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
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|
C21H20ClFN4O5S
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
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CP0472208
|
(2S)-1-[[(4R)-4-(2-chloro-4-fluorophenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-difluoropyrrolidine-2-carboxylic acid
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|
C21H18ClF3N4O4S
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
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CP0540803
|
(3S)-4-[[(4S)-4-(4-bromo-3-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
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|
C22H22BrFN4O5S
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
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CP0571800
|
(6S)-6-methyl-3-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
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|
C24H22F3N5O2
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
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CP0562035
|
(5R,11R)-N-(4-fluoro-3-methylphenyl)-11-(hydroxymethyl)-5,13-dimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C20H24FN5O4
|
1
|
| 1 |
EC50 = 3.4 nM
|
|
|
|
CP0575080
|
(6S)-6-methyl-3-[(4S)-2-oxo-4-phenylpyrrolidin-1-yl]-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
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|
C24H22F3N5O2
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0533808
|
(11R)-N-(3-chloro-4-fluorophenyl)-11-(hydroxymethyl)-13-methyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C18H19ClFN5O4
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0574349
|
(5R,11R)-N-(3-chloro-4-fluorophenyl)-11-(hydroxymethyl)-5,13-dimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C19H21ClFN5O4
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
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CP0575515
|
(5R,11S)-N-(3-chloro-4-fluorophenyl)-11-(hydroxymethyl)-5,13-dimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C19H21ClFN5O4
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
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CP0574789
|
N-(3-chloro-4-fluorophenyl)-11-fluoro-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C18H18ClF2N5O2
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
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CP0576568
|
N-(3-bromo-4-fluorophenyl)-11-fluoro-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C18H18BrF2N5O2
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0513882
|
ethyl 4-(2-chloro-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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|
C21H22ClFN4O3S
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
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CP0426054
|
(3S)-4-[[(4R)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-4-(2,3,4-trifluorophenyl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
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|
C22H21F3N4O5S
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0472207
|
(3S)-4-[[(4S)-5-ethoxycarbonyl-4-(3-fluoro-4-methylphenyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
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|
C23H25FN4O5S
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
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CP0579636
|
(6S)-6-methyl-3-(2-oxo-4-phenylpyrrolidin-1-yl)-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
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|
C24H22F3N5O2
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0571083
|
(5R,11R)-N-(3-cyano-4-fluorophenyl)-11-(2,2-difluoroethoxymethyl)-5,13-dimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C22H23F3N6O4
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
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CP0575310
|
11-fluoro-N-[4-fluoro-3-(trifluoromethyl)phenyl]-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C19H18F5N5O2
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0543411
|
(5R,11R)-4-N-(3-cyano-4-fluorophenyl)-11-N-(2,2-difluoroethyl)-11-N,5,13-trimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4,11-dicarboxamide
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|
C23H24F3N7O4
|
1
|
| 1 |
EC50 = 5.3 nM
|
|
|
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CP0575512
|
(5R)-N-(3-cyano-4-fluorophenyl)-5,13-dimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C19H19FN6O3
|
1
|
| 1 |
EC50 = 5.3 nM
|
|
|
|
CP0541293
|
ethyl 4-(2-bromo-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-(morpholin-4-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate
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|
C23H22BrF3N4O3
|
1
|
| 1 |
EC50 = 6 nM
|
|
|
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CP0543152
|
(5R,11R)-N-(3-cyano-4-fluorophenyl)-11-(fluoromethyl)-5,13-dimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C20H20F2N6O3
|
1
|
| 1 |
EC50 = 6 nM
|
|
|
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CP0488718
|
(5R,11R)-N-(3-cyano-4-fluorophenyl)-11-(hydroxymethyl)-5,13-dimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C20H21FN6O4
|
1
|
| 1 |
EC50 = 7.3 nM
|
|
|
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CP0534843
|
(6S)-3-[(4S)-4-cyano-2-oxopyrrolidin-1-yl]-6-cyclopropyl-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
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|
C21H19F3N6O2
|
1
|
| 1 |
EC50 = 9 nM
|
|
|
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CP0551671
|
N-(3-chloro-4-fluorophenyl)-11-(hydroxymethyl)-13-methyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C18H19ClFN5O4
|
1
|
| 1 |
EC50 = 9 nM
|
|
|
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CP0577673
|
N-(3-cyano-4-fluorophenyl)-11-fluoro-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C19H18F2N6O2
|
1
|
| 1 |
EC50 = 9 nM
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|
|
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CP0541446
|
ethyl 4-(2-bromophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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|
C21H23BrN4O3S
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
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CP0384223
|
(3S)-4-[[(4S)-4-(4-chloro-3-fluorophenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
Show/Hide
|
C21H20ClFN4O5S
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
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CP0439946
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(3S)-4-[[(4S)-4-(4-bromo-3-fluorophenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
Show/Hide
|
C21H20BrFN4O5S
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
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CP0540919
|
(2S)-1-[[(4R)-4-(2-chloro-4-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-difluoropyrrolidine-2-carboxylic acid
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|
C22H20ClF3N4O4S
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
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CP0579907
|
(6S)-6-cyclopropyl-3-[(4R)-4-(1,3-oxazol-2-yl)-2-oxopyrrolidin-1-yl]-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
Show/Hide
|
C23H21F3N6O3
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
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CP0382839
|
(3S)-4-[[(4S)-4-(3,4-difluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
Show/Hide
|
C22H22F2N4O5S
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
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CP0402245
|
(3S)-4-[[(4R)-4-(2,4-difluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
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|
C22H22F2N4O5S
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
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CP0576565
|
N-(3-chloro-4-fluorophenyl)-11-(hydroxymethyl)-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C19H21ClFN5O3
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
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CP0578359
|
N-(3-chloro-4-fluorophenyl)-11,13-dimethyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C19H21ClFN5O2
|
1
|
| 1 |
EC50 = 14 nM
|
|
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CP0579802
|
11-fluoro-N-(4-fluoro-3-methylphenyl)-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C19H21F2N5O2
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
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CP0478560
|
(3S)-4-[[(4S)-5-ethoxycarbonyl-4-(3-fluorophenyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
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|
C22H23FN4O5S
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
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CP0478562
|
(3S)-4-[[(4S)-5-ethoxycarbonyl-4-(4-fluorophenyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
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|
C22H23FN4O5S
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
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CP0576813
|
(6S)-7-N-(4-fluoro-3-methylphenyl)-6-methyl-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
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|
C19H21F4N5O2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
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CP0575514
|
(11S)-N-(3-chloro-4-fluorophenyl)-11-(hydroxymethyl)-13-methyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C18H19ClFN5O4
|
1
|
| 1 |
EC50 = 15 nM
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CP0541447
|
ethyl 4-(2-chlorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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|
C21H23ClN4O3S
|
1
|
| 1 |
EC50 = 16 nM
|
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CP0540804
|
(3S)-4-[[(4S)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-4-(3,4,5-trifluorophenyl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
Show/Hide
|
C22H21F3N4O5S
|
1
|
| 1 |
EC50 = 18 nM
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CP0544568
|
3-(4-cyano-2-oxopyrrolidin-1-yl)-6-cyclopropyl-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
Show/Hide
|
C21H19F3N6O2
|
1
|
| 1 |
EC50 = 18 nM
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CP0575077
|
(6S)-6-cyclopropyl-3-[(4S)-4-(1,3-oxazol-2-yl)-2-oxopyrrolidin-1-yl]-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
Show/Hide
|
C23H21F3N6O3
|
1
|
| 1 |
EC50 = 18 nM
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|
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CP0541445
|
ethyl 4-(2-bromo-4-fluorophenyl)-2-(1-methylimidazol-2-yl)-6-(morpholin-4-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate
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|
C22H25BrFN5O3
|
1
|
| 1 |
EC50 = 20 nM
|
|
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CP0575078
|
(6S)-3-[(4R)-4-cyano-2-oxopyrrolidin-1-yl]-6-cyclopropyl-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
Show/Hide
|
C21H19F3N6O2
|
1
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| 1 |
EC50 = 20 nM
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|
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CP0575513
|
(5R,11S)-N-(3-chloro-4-fluorophenyl)-11-[(dimethylamino)methyl]-5,13-dimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C21H26ClFN6O3
|
1
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| 1 |
EC50 = 21 nM
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|
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CP0439947
|
(2S)-1-[[(4S)-4-(3,4-difluorophenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-difluoropyrrolidine-2-carboxylic acid
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|
C21H18F4N4O4S
|
1
|
| 1 |
EC50 = 22 nM
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|
|
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CP0488547
|
6-cyclopropyl-3-[4-(1,3-oxazol-2-yl)-2-oxopyrrolidin-1-yl]-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
Show/Hide
|
C23H21F3N6O3
|
1
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| 1 |
EC50 = 22 nM
|
|
|
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CP0577619
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(5R,11S)-N-(3-cyano-4-fluorophenyl)-11-fluoro-5,13-dimethyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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|
C20H20F2N6O2
|
1
|
| 1 |
EC50 = 23 nM
|
|
|
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CP0574556
|
5-N-(3-chlorophenyl)-3-N-methyl-3-N-(oxetan-3-yloxy)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-3,5-dicarboxamide
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|
C18H20ClN5O4
|
1
|
| 1 |
EC50 = 24 nM
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|
|
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CP0408999
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ethyl 4-(2,4-difluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C21H22F2N4O3S
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
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CP0280591
|
(6S)-7-N-(3-cyano-4-fluorophenyl)-6-methyl-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
Show/Hide
|
C19H18F4N6O2
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
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CP0548514
|
(3S)-4-[[(4S)-4-(3-fluoro-4-methylphenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
Show/Hide
|
C22H23FN4O5S
|
1
|
| 1 |
EC50 = 28 nM
|
|
|
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CP0355238
|
4-amino-2-methyl-5-sulfamoyl-N-(3,4,5-trifluorophenyl)benzamide
Show/Hide
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C14H12F3N3O3S
|
3
|
| 1 |
EC50 = 28 nM
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|
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| 2 |
EC50 = 39 nM
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|
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| 3 |
EC50 = 60 nM
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CP0969670
|
(S)-N5-(3-chlorophenyl)-N3-methoxy-N3,6-dimethyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-3,5(4H)-dicarboxamide
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C17H20ClN5O3
|
1
|
| 1 |
EC50 = 31 nM
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CP0578358
|
N-(3-chloro-4-fluorophenyl)-11-(2,2-difluoroethoxy)-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
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C20H21ClF3N5O3
|
1
|
| 1 |
EC50 = 32 nM
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|
|
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CP0390106
|
ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3,4-thiadiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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C20H21BrFN5O3S
|
1
|
| 1 |
EC50 = 35 nM
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|
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CP0394533
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ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-pyridin-2-yl-1,4-dihydropyrimidine-5-carboxylate
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C23H24BrFN4O3
|
1
|
| 1 |
EC50 = 42 nM
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|
|
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CP0542647
|
(6S)-5-N-(3,4-difluorophenyl)-6-methyl-3-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-3,5-dicarboxamide
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C18H18F5N5O2
|
1
|
| 1 |
EC50 = 42 nM
|
|
|
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CP0382838
|
(3S)-4-[[(4S)-4-(3,4-difluorophenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
Show/Hide
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C21H20F2N4O5S
|
1
|
| 1 |
EC50 = 46 nM
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|
|
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CP0576831
|
N-(2-bromo-3-fluoropyridin-4-yl)-11-fluoro-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
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C17H17BrF2N6O2
|
1
|
| 1 |
EC50 = 46 nM
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|
|
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CP0274362
|
BAY-414109
Show/Hide
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C18H13ClF3N3O2
|
1
|
| 1 |
EC50 = 48 nM
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|
|
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CP0498378
|
(6S)-5-N-(2,6-difluoropyridin-4-yl)-6-methyl-3-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-3,5-dicarboxamide
Show/Hide
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C17H17F5N6O2
|
1
|
| 1 |
EC50 = 49.8 nM
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|
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CP0576566
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N-(3-chloro-4-fluorophenyl)-4-methyl-3-oxo-4,7,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1,8-diene-12-carboxamide
Show/Hide
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C17H17ClFN5O2
|
1
|
| 1 |
EC50 = 51 nM
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|
|
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CP0568544
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-(4-hydroxyazocan-1-yl)sulfonylbenzamide
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C20H21ClF2N2O4S
|
1
|
| 1 |
EC50 = 52 nM
|
|
|
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CP0546093
|
(6S)-7-N-(3,4-difluorophenyl)-6-methyl-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
Show/Hide
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C18H18F5N5O2
|
1
|
| 1 |
EC50 = 54 nM
|
|
|
|
CP0488717
|
US10189835, Compound 434
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|
C16H18ClN5O3
|
1
|
| 1 |
EC50 = 54 nM
|
|
|
|
CP0576807
|
(5S,11R)-N-(3-chloro-4-fluorophenyl)-11-(hydroxymethyl)-5,13-dimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C19H21ClFN5O4
|
1
|
| 1 |
EC50 = 54 nM
|
|
|
|
CP0551672
|
N-(3-chloro-4-fluorophenyl)-11-methoxy-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C19H21ClFN5O3
|
1
|
| 1 |
EC50 = 55 nM
|
|
|
|
CP0576830
|
N-(3-chloro-4-fluorophenyl)-11,11-difluoro-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C18H17ClF3N5O2
|
1
|
| 1 |
EC50 = 55 nM
|
|
|
|
CP0551825
|
US10189835, Compound 600
Show/Hide
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C18H22ClN5O3
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
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CP0546544
|
N-(3-chloro-4-fluorophenyl)-11-(dimethylamino)-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C20H24ClFN6O2
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0577708
|
N-(3-chloro-4-fluorophenyl)-14-methyl-15-oxo-4,8,9,14-tetrazatricyclo[7.6.0.02,7]pentadeca-1,7-diene-4-carboxamide
Show/Hide
|
C19H21ClFN5O2
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0558260
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-(3-hydroxyazocan-1-yl)sulfonylbenzamide
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C20H21ClF2N2O4S
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0543963
|
N-(3-chlorophenyl)-3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
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C19H17ClN4O
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0579742
|
N-(3-chloro-4-fluorophenyl)-12-(hydroxymethyl)-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C19H21ClFN5O3
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0572189
|
(6S)-5-N-(3-cyano-4-fluorophenyl)-6-methyl-3-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-3,5-dicarboxamide
Show/Hide
|
C19H18F4N6O2
|
1
|
| 1 |
EC50 = 60.2 nM
|
|
|
|
CP0460689
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-[[(6R)-6-hydroxy-1,4-oxazepan-4-yl]sulfonyl]benzamide
Show/Hide
|
C18H17ClF2N2O5S
|
1
|
| 1 |
EC50 = 63 nM
|
|
|
|
CP0571966
|
US10189835, Compound 599
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|
C17H20ClN5O3
|
1
|
| 1 |
EC50 = 63 nM
|
|
|
|
CP0559475
|
US10189835, Compound 561
Show/Hide
|
C17H19ClN4O2
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
|
CP0576315
|
N-(3-chloro-4-fluorophenyl)-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C18H19ClFN5O2
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
|
CP0576316
|
N-(3-chloro-4-fluorophenyl)-11-(difluoromethyl)-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C19H19ClF3N5O2
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
|
CP0510799
|
ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-thiophen-2-yl-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C22H23BrFN3O3S
|
1
|
| 1 |
EC50 = 69 nM
|
|
|
|
CP0408986
|
ethyl 4-(2-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C21H23FN4O3S
|
1
|
| 1 |
EC50 = 74 nM
|
|
|
|
CP0541448
|
ethyl 4-(2-chloro-4-fluorophenyl)-6-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C21H22ClFN4O4S2
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0207268
|
N-(3-chloro-4-fluorophenyl)-3-[(3S,6R)-3,6-dihydroxyazepan-1-yl]sulfonyl-4-fluorobenzamide
Show/Hide
|
C19H19ClF2N2O5S
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0460688
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-[(6-fluoro-1,4-oxazepan-4-yl)sulfonyl]benzamide
Show/Hide
|
C18H16ClF3N2O4S
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0155068
|
(2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic acid
Show/Hide
|
C8H12N5O4P
|
1
|
| 1 |
EC50 = 82.7 nM
|
|
|
|
CP0578028
|
(5S)-7-N-(3-cyano-4-fluorophenyl)-5-methyl-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
Show/Hide
|
C19H18F4N6O2
|
1
|
| 1 |
EC50 = 83.2 nM
|
|
|
|
CP0562033
|
US10189835, Compound 594
Show/Hide
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C17H20ClN5O3
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0571967
|
US10189835, Compound 805
Show/Hide
|
C19H22ClN5O3
|
1
|
| 1 |
EC50 = 97 nM
|
|
|
|
CP0396424
|
methyl (4R)-4-(2-chloro-4-fluorophenyl)-6-methyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C16H13ClFN3O2S
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
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CP0492031
|
ethyl 6-(morpholin-4-ylmethyl)-4-(2-nitrophenyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C21H23N5O5S
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0513832
|
ethyl 4-(2-chloro-4-fluorophenyl)-6-[(1-oxo-1,4-thiazinan-4-yl)methyl]-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C21H22ClFN4O3S2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0460687
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-[(6-hydroxy-6-methyl-1,4-oxazepan-4-yl)sulfonyl]benzamide
Show/Hide
|
C19H19ClF2N2O5S
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0556346
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-[(6-hydroxy-1,4-oxazepan-4-yl)sulfonyl]benzamide
Show/Hide
|
C18H17ClF2N2O5S
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0575519
|
N-(3-chlorophenyl)-3-(oxazinane-2-carbonyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxamide
Show/Hide
|
C18H20ClN5O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0537694
|
N-(3-chloro-4-fluorophenyl)-10-(hydroxymethyl)-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C19H21ClFN5O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0575309
|
N-(3-chloro-4-fluorophenyl)-11-hydroxy-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C18H19ClFN5O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0575749
|
(6R)-6-cyclopropyl-3-[(4S)-4-(1,3-oxazol-2-yl)-2-oxopyrrolidin-1-yl]-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
Show/Hide
|
C23H21F3N6O3
|
1
|
| 1 |
EC50 = 109 nM
|
|
|
|
CP0460686
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-(4-hydroxy-4-methylazepan-1-yl)sulfonylbenzamide
Show/Hide
|
C20H21ClF2N2O4S
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0559371
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-(2-hydroxyazocan-1-yl)sulfonylbenzamide
Show/Hide
|
C20H21ClF2N2O4S
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0564610
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-(3-hydroxy-3-methylazepan-1-yl)sulfonylbenzamide
Show/Hide
|
C20H21ClF2N2O4S
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0574706
|
US10189835, Compound 699
Show/Hide
|
C17H18ClN5O3
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0568545
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-[(6-methoxy-1,4-oxazepan-4-yl)sulfonyl]benzamide
Show/Hide
|
C19H19ClF2N2O5S
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0424358
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-(4-hydroxyazepan-1-yl)sulfonylbenzamide
Show/Hide
|
C19H19ClF2N2O4S
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0532927
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-[3-(1-hydroxyethyl)azepan-1-yl]sulfonylbenzamide
Show/Hide
|
C21H23ClF2N2O4S
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0550707
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-[[(6S)-6-hydroxy-1,4-oxazepan-4-yl]sulfonyl]benzamide
Show/Hide
|
C18H17ClF2N2O5S
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0559370
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-[3-(hydroxymethyl)azepan-1-yl]sulfonylbenzamide
Show/Hide
|
C20H21ClF2N2O4S
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0568543
|
N-(3-chloro-4-fluorophenyl)-3-(3,3-difluoroazepan-1-yl)sulfonyl-4-fluorobenzamide
Show/Hide
|
C19H17ClF4N2O3S
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0549683
|
ethyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C17H15ClFN3O2S
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0576567
|
N-(3-chloro-4-fluorophenyl)-13-methyl-11-(methylamino)-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C19H22ClFN6O2
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0562034
|
US10189835, Compound 796
Show/Hide
|
C17H20ClN5O4
|
1
|
| 1 |
EC50 = 155 nM
|
|
|
|
CP0546545
|
11-amino-N-(3-chloro-4-fluorophenyl)-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C18H20ClFN6O2
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0536584
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-[(6-hydroxy-1,4-thiazepan-4-yl)sulfonyl]benzamide
Show/Hide
|
C18H17ClF2N2O4S2
|
1
|
| 1 |
EC50 = 170 nM
|
|
|
|
CP0550706
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-(3-hydroxyazepan-1-yl)sulfonylbenzamide
Show/Hide
|
C19H19ClF2N2O4S
|
1
|
| 1 |
EC50 = 170 nM
|
|
|
|
CP0576661
|
(6S)-7-N-(2,6-difluoropyridin-4-yl)-6-methyl-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
Show/Hide
|
C17H17F5N6O2
|
1
|
| 1 |
EC50 = 182 nM
|
|
|
|
CP0575544
|
(6S)-7-N-(3-cyano-4-fluorophenyl)-6-methyl-1-N-[(2S)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
Show/Hide
|
C19H18F4N6O2
|
1
|
| 1 |
EC50 = 195 nM
|
|
|
|
CP0557442
|
ethyl 4-(2-chloro-4-fluorophenyl)-6-(2-methoxyethoxymethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C20H21ClFN3O4S
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0534018
|
US10189835, Compound 912
Show/Hide
|
C19H23ClN6O3
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0575518
|
US10189835, Compound 595
Show/Hide
|
C18H22ClN5O3
|
1
|
| 1 |
EC50 = 210 nM
|
|
|
|
CP0577933
|
US10189835, Compound 795
Show/Hide
|
C18H22ClN5O3
|
1
|
| 1 |
EC50 = 210 nM
|
|
|
|
CP0574564
|
(5S,11S)-N-(3-chloro-4-fluorophenyl)-11-(hydroxymethyl)-5,13-dimethyl-14-oxo-12-oxa-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
|
C19H21ClFN5O4
|
1
|
| 1 |
EC50 = 216 nM
|
|
|
|
CP0424359
|
N-(3-chloro-4-fluorophenyl)-4-fluoro-3-[(4-methyl-3-oxo-1,4-diazepan-1-yl)sulfonyl]benzamide
Show/Hide
|
C19H18ClF2N3O4S
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0036865
|
Atripla
Show/Hide
|
C9H14N5O4P
|
1
|
| 1 |
EC50 = 241.5 nM
|
|
|
|
CP0446408
|
methyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C16H13ClFN3O2S
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0513881
|
ethyl 4-(2-chloro-4-fluorophenyl)-2-(1,3-thiazol-2-yl)-6-(thiomorpholin-4-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate
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C21H22ClFN4O2S2
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1
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| 1 |
EC50 = 250 nM
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CP0559474
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ethyl 5-[(3-chlorophenyl)carbamoyl]-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-3-carboxylate
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C16H17ClN4O3
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1
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| 1 |
EC50 = 260 nM
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CP0969379
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N5-(3-chlorophenyl)-N3-methyl-N3-(tetrahydrofuran-3-yloxy)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-3,5(4H)-dicarboxamide
Show/Hide
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C19H22ClN5O4
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1
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| 1 |
EC50 = 300 nM
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CP0579908
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(6R)-3-[(4S)-4-cyano-2-oxopyrrolidin-1-yl]-6-cyclopropyl-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
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C21H19F3N6O2
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1
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| 1 |
EC50 = 312 nM
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CP0944187
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(R)-N5-(3-chlorophenyl)-N3-methoxy-N3,6-dimethyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-3,5(4H)-dicarboxamide
Show/Hide
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C17H20ClN5O3
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1
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| 1 |
EC50 = 330 nM
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CP0966491
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N5-(3-chlorophenyl)-N3-methyl-N3-(tetrahydro-2H-pyran-3-yloxy)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-3,5(4H)-dicarboxamide
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C20H24ClN5O4
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1
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| 1 |
EC50 = 370 nM
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CP0534017
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5-N-(3-chlorophenyl)-3-N-methoxy-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-3,5-dicarboxamide
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C15H16ClN5O3
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1
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| 1 |
EC50 = 400 nM
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CP0577943
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5-N-(3-chlorophenyl)-3-N-ethyl-3-N-methyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-3,5-dicarboxamide
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C17H20ClN5O2
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1
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| 1 |
EC50 = 410 nM
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CP0578325
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(6R)-7-N-(3,4-difluorophenyl)-6-methyl-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
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C18H18F5N5O2
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1
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| 1 |
EC50 = 432 nM
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CP0498377
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1-N-[(2R)-butan-2-yl]-7-N-(3,4,5-trifluorophenyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
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C18H20F3N5O2
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1
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| 1 |
EC50 = 456 nM
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CP0430138
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4-fluoro-3-(4-hydroxypiperidin-1-yl)sulfonyl-N-(3,4,5-trifluorophenyl)benzamide
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C18H16F4N2O4S
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1
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| 1 |
EC50 = 470 nM
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CP0532928
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N-(3-chloro-4-fluorophenyl)-4-fluoro-3-[(6-hydroxy-4-methyl-1,4-diazepan-1-yl)sulfonyl]benzamide
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C19H20ClF2N3O4S
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1
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| 1 |
EC50 = 470 nM
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CP0451286
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ethyl (4R)-4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C21H22BrFN4O3S
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1
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| 1 |
EC50 = 500 nM
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CP0578217
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7-N-(3,4,5-trifluorophenyl)-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
Show/Hide
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C17H15F6N5O2
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1
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| 1 |
EC50 = 511 nM
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CP0577854
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1-N-(3-methyloxetan-3-yl)-7-N-(3,4,5-trifluorophenyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
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C18H18F3N5O3
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1
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| 1 |
EC50 = 735 nM
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CP0417362
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ethyl 4-(2-chloro-4-fluorophenyl)-6-(ethoxymethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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C19H19ClFN3O3S
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1
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| 1 |
EC50 = 800 nM
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CP0542646
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7-N-(3,4-difluorophenyl)-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
Show/Hide
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C17H16F5N5O2
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1
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| 1 |
EC50 = 818 nM
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CP0005169
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CHEBI:63624
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C10H14N2O5
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1
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| 1 |
EC50 = 819.4 nM
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CP0546092
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7-N-(3-cyano-4-fluorophenyl)-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
Show/Hide
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C18H16F4N6O2
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1
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| 1 |
EC50 = 852 nM
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CP0575079
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(6R)-3-[(4R)-4-cyano-2-oxopyrrolidin-1-yl]-6-cyclopropyl-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
Show/Hide
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C21H19F3N6O2
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1
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| 1 |
EC50 = 864 nM
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CP0543904
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(6R)-6-cyclopropyl-3-[(4R)-4-(1,3-oxazol-2-yl)-2-oxopyrrolidin-1-yl]-N-(3,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
Show/Hide
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C23H21F3N6O3
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1
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| 1 |
EC50 = 866 nM
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CP0396470
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ethyl 4-(2-chloro-4-fluorophenyl)-6-[(2-hydroxyethylamino)methyl]-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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C19H20ClFN4O3S
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1
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| 1 |
EC50 = 900 nM
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CP0578324
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7-N-(3,4-difluorophenyl)-3-(trifluoromethyl)-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
Show/Hide
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C18H15F8N5O2
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1
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| 1 |
EC50 = 922 nM
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CP0568996
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7-N-(2,6-difluoropyridin-4-yl)-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
Show/Hide
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C16H15F5N6O2
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1
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| 1 |
EC50 = 947 nM
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CP0571229
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ethyl 4-(2-chloro-4-fluorophenyl)-6-(propoxymethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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C20H21ClFN3O3S
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1
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| 1 |
EC50 = 1200 nM
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CP0577709
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11-acetamido-N-(3-chloro-4-fluorophenyl)-13-methyl-14-oxo-4,8,9,13-tetrazatricyclo[7.5.0.02,7]tetradeca-1,7-diene-4-carboxamide
Show/Hide
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C20H22ClFN6O3
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1
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| 1 |
EC50 = 1200 nM
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CP0576809
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1-methyl-5-N-(3,4,5-trifluorophenyl)-3-N-[(2R)-1,1,1-trifluoropropan-2-yl]-4,6-dihydropyrrolo[3,4-c]pyrazole-3,5-dicarboxamide
Show/Hide
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C17H15F6N5O2
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1
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| 1 |
EC50 = 2790 nM
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CP0410692
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ethyl (4S)-4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C21H22BrFN4O3S
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1
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| 1 |
EC50 = 3100 nM
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CP0545252
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ethyl 4-(2-chloro-4-fluorophenyl)-6-(piperidin-1-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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C22H24ClFN4O2S
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1
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| 1 |
EC50 = 3500 nM
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CP0578218
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3-methyl-7-N-(3,4,5-trifluorophenyl)-1-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1,7-dicarboxamide
Show/Hide
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C18H17F6N5O2
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1
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| 1 |
EC50 = 4082 nM
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CP0541444
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ethyl 4-(2-bromo-4-fluorophenyl)-2-(1-methyl-1,2,4-triazol-3-yl)-6-(morpholin-4-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C21H24BrFN6O3
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1
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| 1 |
EC50 = 4300 nM
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CP0571228
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ethyl 6-(aminomethyl)-4-(2-chloro-4-fluorophenyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
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C17H16ClFN4O2S
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1
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| 1 |
EC50 = 5100 nM
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CP0546091
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4-N-(3,4,5-trifluorophenyl)-8-N-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1,4-benzoxazine-4,8-dicarboxamide
Show/Hide
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C19H15F6N3O3
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1
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| 1 |
EC50 > 10000 nM
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CP0572188
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1-methyl-N-(3,4,5-trifluorophenyl)-3-[[(2R)-1,1,1-trifluoropropan-2-yl]sulfamoyl]-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide
Show/Hide
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C16H15F6N5O3S
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1
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| 1 |
EC50 > 10000 nM
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CP0573599
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2-N-(3,4,5-trifluorophenyl)-4-N-[(2R)-1,1,1-trifluoropropan-2-yl]-1,3-dihydroisoindole-2,4-dicarboxamide
Show/Hide
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C19H15F6N3O2
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1
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| 1 |
EC50 > 10000 nM
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CP0573600
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2-N-(3-cyano-4-fluorophenyl)-1-methyl-4-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyrrole-2,4-dicarboxamide
Show/Hide
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C17H14F4N4O2
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1
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| 1 |
EC50 > 10000 nM
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CP0576811
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7-N-(3,4-difluorophenyl)-3-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-3,7-dicarboxamide
Show/Hide
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C16H15F5N6O2
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1
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| 1 |
EC50 > 10000 nM
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CP0576812
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7-N-(3,4,5-trifluorophenyl)-2-N-[(2R)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-imidazo[1,2-a]pyrazine-2,7-dicarboxamide
Show/Hide
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C17H15F6N5O2
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1
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| 1 |
EC50 > 10000 nM
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CP0394535
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ethyl 4-(2-chloro-4-fluorophenyl)-6-(piperazin-1-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C21H23ClFN5O2S
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1
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| 1 |
EC50 > 16400 nM
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CP0396471
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4-(2-chloro-4-fluorophenyl)-6-methyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxamide
Show/Hide
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C15H12ClFN4OS
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1
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| 1 |
EC50 > 16400 nM
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CP0408983
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ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(tetrazol-1-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C19H21BrFN7O3
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1
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| 1 |
EC50 > 16400 nM
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CP0408984
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ethyl 4-[4-fluoro-2-(4-methoxyphenyl)phenyl]-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C28H29FN4O4S
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1
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| 1 |
EC50 > 16400 nM
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CP0414050
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ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,2,4-triazol-1-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C20H22BrFN6O3
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1
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| 1 |
EC50 > 16400 nM
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CP0446406
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ethyl 4-(2-chloro-4-fluorophenyl)-1-methyl-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-4H-pyrimidine-5-carboxylate
Show/Hide
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C22H24ClFN4O3S
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1
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| 1 |
EC50 > 16400 nM
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CP0482400
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4-(2-chloro-4-fluorophenyl)-6-methyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylic acid
Show/Hide
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C15H11ClFN3O2S
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1
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| 1 |
EC50 > 16400 nM
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CP0510797
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ethyl 4-(2-bromo-4-fluorophenyl)-2-(5-methoxy-1,3-thiazol-2-yl)-6-(morpholin-4-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C22H24BrFN4O4S
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1
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| 1 |
EC50 > 16400 nM
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CP0513880
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ethyl 4-(4-fluoro-2-phenylphenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C27H27FN4O3S
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1
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| 1 |
EC50 > 16400 nM
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CP0529409
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ethyl 4-(2-bromo-4-fluorophenyl)-2-(5-methyltetrazol-2-yl)-6-(morpholin-4-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C20H23BrFN7O3
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1
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| 1 |
EC50 > 16400 nM
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CP0530730
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ethyl 4-(2-chloro-4-fluorophenyl)-6-(hydroxymethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C17H15ClFN3O3S
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1
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| 1 |
EC50 > 16400 nM
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CP0545251
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ethyl 4-[4-fluoro-2-[4-(trifluoromethyl)phenyl]phenyl]-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C28H26F4N4O3S
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1
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| 1 |
EC50 > 16400 nM
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CP0547332
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ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)pyrimidine-5-carboxylate
Show/Hide
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C21H20BrFN4O3S
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1
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| 1 |
EC50 > 16400 nM
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CP0549682
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4-(2-chloro-4-fluorophenyl)-6-methyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carbohydrazide
Show/Hide
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C15H13ClFN5OS
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1
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| 1 |
EC50 > 16400 nM
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CP0550400
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ethyl 4-(2-bromo-4-fluorophenyl)-2-(5-methyl-1,3,4-thiadiazol-2-yl)-6-(morpholin-4-ylmethyl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C21H23BrFN5O3S
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1
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| 1 |
EC50 > 16400 nM
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CP0550772
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propan-2-yl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C18H17ClFN3O2S
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1
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| 1 |
EC50 > 16400 nM
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CP0557443
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ethyl 4-(2-chloro-4-fluorophenyl)-6-(methoxymethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C18H17ClFN3O3S
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1
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| 1 |
EC50 > 16400 nM
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CP0557444
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tert-butyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C19H19ClFN3O2S
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1
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| 1 |
EC50 > 16400 nM
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CP0571230
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4-(2-chloro-4-fluorophenyl)-N,6-dimethyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxamide
Show/Hide
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C16H14ClFN4OS
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1
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| 1 |
EC50 > 16400 nM
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CP0478561
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(3S)-4-[[(4S)-4-(3-chloro-4-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
Show/Hide
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C22H22ClFN4O5S
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1
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| 1 |
EC50 > 1000 nM
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CP0540805
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(3S)-4-[[(4S)-4-(3-bromo-4-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
Show/Hide
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C22H22BrFN4O5S
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1
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| 1 |
EC50 > 1000 nM
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CP0548516
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(3S)-4-[[(4S)-4-(3-cyano-4-fluorophenyl)-5-ethoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
Show/Hide
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C23H22FN5O5S
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1
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| 1 |
EC50 > 1000 nM
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CP0069893
|
Epivir
Show/Hide
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C8H11N3O3S
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2
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| 1 |
IC50 < 100 nM
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| 2 |
IC50 > 100000 nM
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CP0430045
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2-benzylsulfanyl-6-[2-(diethylamino)ethoxy]-3-(thiophen-2-ylmethyl)quinazolin-4-one
Show/Hide
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C26H29N3O2S2
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2
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| 1 |
IC50 = 710 nM
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| 2 |
IC50 = 840 nM
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CP0489736
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2-benzylsulfanyl-6-[2-(dimethylamino)ethoxy]-3-(thiophen-2-ylmethyl)quinazolin-4-one
Show/Hide
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C24H25N3O2S2
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2
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| 1 |
IC50 = 1540 nM
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| 2 |
IC50 = 1900 nM
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CP0552329
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6-[2-(diethylamino)ethoxy]-2-[(2-methoxyphenyl)methylsulfanyl]-3-(thiophen-2-ylmethyl)quinazolin-4-one
Show/Hide
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C27H31N3O3S2
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1
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| 1 |
IC50 = 1930 nM
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CP0489737
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6-fluoro-2-[(2-methoxyphenyl)methylsulfanyl]-3-(thiophen-2-ylmethyl)quinazolin-4-one
Show/Hide
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C21H17FN2O2S2
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1
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| 1 |
IC50 = 2480 nM
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CP0530842
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2-[(2-methoxyphenyl)methylsulfanyl]-3-(thiophen-2-ylmethyl)quinazolin-4-one
Show/Hide
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C21H18N2O2S2
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1
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| 1 |
IC50 = 2810 nM
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CP0446603
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2-[(5-acetyl-2-methoxyphenyl)methylsulfanyl]-3-(thiophen-2-ylmethyl)quinazolin-4-one
Show/Hide
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C23H20N2O3S2
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1
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| 1 |
IC50 = 4070 nM
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