General Information of the Cell Line
Cell Line ID
CL000322
Cell Line Name
Huh-7-Lunet
Synonyms
Huh-7 Lunet
Huh-7/Lunet
Huh7-Lunet
Huh7Lunet
Huh7L
Huh-7-Luc-Neo-ET
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_U459
Tissue Information
Liver
Disease
Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00149, Nonstructural protein 5A
 Protein Info 
Compound ID Compound Name Compound Formula
CP0032498
 Compound Info 
CVD-0019437
   Show/Hide
C40H50N8O6
  2
1
EC50 = 0.032 nM
 Bioactivity Info 
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2
EC50 = 0.079 nM
 Bioactivity Info 
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CP0868535
 Compound Info 
methyl N-[(3S,6S,9aR)-3-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-6-yl]carbamate
   Show/Hide
C40H48N8O6
  2
1
EC50 = 0.037 nM
 Bioactivity Info 
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2
EC50 = 0.471 nM
 Bioactivity Info 
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CP0960971
 Compound Info 
methyl N-[(3S,6S,9aS)-3-[5-[4-[4-[2-[(8S)-7-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]-1,4-dioxa-7-azaspiro[4.4]nonan-8-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-6-yl]carbamate
   Show/Hide
C42H50N8O8
  2
1
EC50 = 0.046 nM
 Bioactivity Info 
   TI
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2
EC50 = 8.581 nM
 Bioactivity Info 
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CP0951257
 Compound Info 
methyl N-[(3S,6R,9aR)-3-[5-[4-[4-[2-[(8S)-7-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]-1,4-dioxa-7-azaspiro[4.4]nonan-8-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-6-yl]carbamate
   Show/Hide
C42H50N8O8
  2
1
EC50 = 0.047 nM
 Bioactivity Info 
   TI
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2
EC50 = 0.707 nM
 Bioactivity Info 
   TI
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CP0868534
 Compound Info 
methyl N-[(3S,6R,9aR)-3-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-6-yl]carbamate
   Show/Hide
C40H48N8O6
  2
1
EC50 = 0.059 nM
 Bioactivity Info 
   TI
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2
EC50 = 0.673 nM
 Bioactivity Info 
   TI
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CP0911877
 Compound Info 
methyl N-[(3S,6S,9aR)-3-[5-[4-[4-[2-[(8S)-7-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]-1,4-dioxa-7-azaspiro[4.4]nonan-8-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-6-yl]carbamate
   Show/Hide
C42H50N8O8
  2
1
EC50 = 0.064 nM
 Bioactivity Info 
   TI
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2
EC50 = 1.524 nM
 Bioactivity Info 
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CP0951256
 Compound Info 
methyl N-[(3S,6R,9aS)-3-[5-[4-[4-[2-[(8S)-7-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]-1,4-dioxa-7-azaspiro[4.4]nonan-8-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-6-yl]carbamate
   Show/Hide
C42H50N8O8
  2
1
EC50 = 0.08 nM
 Bioactivity Info 
   TI
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2
EC50 = 14.52 nM
 Bioactivity Info 
   TI
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CP0951258
 Compound Info 
methyl N-[(1S)-1-[(8S)-8-[5-[4-[4-[2-[(3S,6S,9aR)-6-(dimethylamino)-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-3-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-1,4-dioxa-7-azaspiro[4.4]nonane-7-carbonyl]-2-methyl-propyl]carbamate
   Show/Hide
C42H52N8O6
  2
1
EC50 = 0.084 nM
 Bioactivity Info 
   TI
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2
EC50 = 7.707 nM
 Bioactivity Info 
   TI
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CP0868724
 Compound Info 
US9427428, 14::US9433609, 14
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C48H46N8O6
  1
1
EC50 = 0.093 nM
 Bioactivity Info 
   TI
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CP0868533
 Compound Info 
methyl N-[(3S,6S,9aS)-3-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-6-yl]carbamate
   Show/Hide
C40H48N8O6
  2
1
EC50 = 0.109 nM
 Bioactivity Info 
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2
EC50 = 17.44 nM
 Bioactivity Info 
   TI
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CP0967154
 Compound Info 
methyl N-[(3S,6R,9aS)-3-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-6-yl]carbamate
   Show/Hide
C40H48N8O6
  2
1
EC50 = 0.133 nM
 Bioactivity Info 
   TI
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2
EC50 = 12.48 nM
 Bioactivity Info 
   TI
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CP0943048
 Compound Info 
methyl N-[(1S)-1-[(8S)-8-[5-[4-[4-[2-[(3S,6S,9aS)-6-(dimethylamino)-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-3-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-1,4-dioxa-7-azaspiro[4.4]nonane-7-carbonyl]-2-methyl-propyl]carbamate
   Show/Hide
C42H52N8O6
  2
1
EC50 = 0.209 nM
 Bioactivity Info 
   TI
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2
EC50 = 32.16 nM
 Bioactivity Info 
   TI
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CP0953793
 Compound Info 
methyl N-[(1S)-1-[(8S)-8-[5-[4-[4-[2-[(3S,6R,9aS)-6-(dimethylamino)-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-3-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-1,4-dioxa-7-azaspiro[4.4]nonane-7-carbonyl]-2-methyl-propyl]carbamate
   Show/Hide
C42H52N8O6
  2
1
EC50 = 0.217 nM
 Bioactivity Info 
   TI
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2
EC50 = 119.15 nM
 Bioactivity Info 
   TI
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CP0903192
 Compound Info 
US9427428, 12::US9433609, 12
   Show/Hide
C46H54N8O8
  1
1
EC50 = 0.275 nM
 Bioactivity Info 
   TI
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CP0953457
 Compound Info 
methyl N-[(1S)-1-[(8S)-8-[5-[4-[4-[2-[(3S,6R,9aR)-6-(dimethylamino)-5-oxo-1,2,3,6,7,8,9,9a-octahydropyrrolo[1,2-a]azepin-3-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-1,4-dioxa-7-azaspiro[4.4]nonane-7-carbonyl]-2-methyl-propyl]carbamate
   Show/Hide
C42H52N8O6
  2
1
EC50 = 0.298 nM
 Bioactivity Info 
   TI
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2
EC50 = 10.63 nM
 Bioactivity Info 
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CP0923330
 Compound Info 
US9427428, 6::US9433609, 6
   Show/Hide
C40H46N8O8
  1
1
EC50 = 1.013 nM
 Bioactivity Info 
   TI
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CP0969801
 Compound Info 
US9427428, 6::US9433609, 6
   Show/Hide
C40H46N8O8
  1
1
EC50 = 1.013 nM
 Bioactivity Info 
   TI
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CP0960189
 Compound Info 
US9427428, 10
   Show/Hide
C42H50N8O8
  1
1
EC50 = 1.032 nM
 Bioactivity Info 
   TI
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CP0909845
 Compound Info 
US9427428, 15
   Show/Hide
C46H54N8O6
  1
1
EC50 = 1.192 nM
 Bioactivity Info 
   TI
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CP0959532
 Compound Info 
US9427428, 7::US9433609, 7
   Show/Hide
C44H54N8O6
  1
1
EC50 = 3.411 nM
 Bioactivity Info 
   TI
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CP0926760
 Compound Info 
US9427428, 19
   Show/Hide
C44H54N8O6
  1
1
EC50 = 5.186 nM
 Bioactivity Info 
   TI
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CP0957624
 Compound Info 
US9433609, 19
   Show/Hide
C44H54N8O6
  1
1
EC50 = 5.186 nM
 Bioactivity Info 
   TI
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CP0923329
 Compound Info 
US9427428, 5::US9433609, 5
   Show/Hide
C42H46N8O6
  1
1
EC50 = 10.85 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0969930
 Compound Info 
US9433609, 21
   Show/Hide
C43H52N8O7
  1
1
EC50 = 275 nM
 Bioactivity Info 
   TI
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   TS
CP0865738
 Compound Info 
US9427428, 20
   Show/Hide
C43H52N8O7
  1
1
EC50 = 336 nM
 Bioactivity Info 
   TI
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CP0913788
 Compound Info 
US9433609, 20
   Show/Hide
C43H52N8O7
  1
1
EC50 = 336 nM
 Bioactivity Info 
   TI
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Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Liver)
Cell Line Name Organism Disease
Huh-7
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
HLF
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-7.5
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Huh-5-2
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
PLC/PRF/5
 Cell Line Info 
Homo sapiens (Human) Adult hepatocellular carcinoma
Hep 3B2.1-7
 Cell Line Info 
Homo sapiens (Human) Childhood hepatocellular carcinoma
VACO 241
 Cell Line Info 
Homo sapiens (Human) Colon carcinoma
LM
 Cell Line Info 
Homo sapiens (Human) Extrarenal rhabdoid tumor of the liver
GTL-16
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
MKN45
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
NCI-N87
 Cell Line Info 
Homo sapiens (Human) Gastric tubular adenocarcinoma
Hep-G2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2/C3A
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
CellSensor ARE-bla Hep G2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2 VA-13
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepDES19
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
DPX2
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
Hep-G2/2.2.15
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepAD38
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepG2-Lucia AhR
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HepG2-hNTCP
 Cell Line Info 
Homo sapiens (Human) Hepatoblastoma
HCCC-9810
 Cell Line Info 
Homo sapiens (Human) Intrahepatic cholangiocarcinoma
SU.86.86
 Cell Line Info 
Homo sapiens (Human) Pancreatic adenocarcinoma
Capan-1
 Cell Line Info 
Homo sapiens (Human) Pancreatic ductal adenocarcinoma
Hepa-1c1c7
 Cell Line Info 
Mus musculus (Mouse) Hepatocellular carcinoma of the mouse
H5
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H4-II-E
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H4-II-E-C3
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
McA-RH7777
 Cell Line Info 
Rattus norvegicus (Rat) Rat hepatocellular carcinoma
H2.35
 Cell Line Info 
Mus musculus (Mouse) -