Cell Line Information

General Information of the Cell Line

Cell Line ID	CL000413
Cell Line Name	MKN45
Synonyms	MKN-45 MKN 45
Category	Cancer cell line
Organism	Homo sapiens (Human)
Cellosaurus ID	CVCL_0434
Tissue Information	Liver
Disease	Gastric adenocarcinoma (NCIt: C4004)

Map of Molecular Bioactivity Related to the Cell Line

Map of Molecular Bioactivity Related to the Cell Line Cell Line Protein Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Cell Line

Protein ID: PT01201, Hepatocyte growth factor receptor

Protein Info

Compound ID	Compound Name	Compound Formula
CP0046554 Compound Info	6-[difluoro-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline Show/Hide	C20H11F3N6	1
1	IC50 = 0.46 nM Bioactivity Info	TI LI LO TS
CP0207294 Compound Info	N-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-4-morpholin-4-ylbutanamide Show/Hide	C26H24FN7O2S2	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0149774 Compound Info	N-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide Show/Hide	C22H15FN6OS2	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0207300 Compound Info	1-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-3-(2-morpholin-4-ylethyl)urea Show/Hide	C25H23FN8O2S2	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0197654 Compound Info	US9062045, Comparator No. 1 (JNJ-38877605) Show/Hide	C19H13F2N7	1
1	IC50 = 9.5 nM Bioactivity Info	TI LI LO TS
CP0348658 Compound Info	1-[2-(diethylamino)ethyl]-3-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]urea Show/Hide	C25H25FN8OS2	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0501082 Compound Info	6-[5-amino-6-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyrazin-2-yl]-1'-methylspiro[1H-indole-3,4'-piperidine]-2-one Show/Hide	C25H24Cl2FN5O2	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0224714 Compound Info	2-cyclopropyl-N-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]acetamide Show/Hide	C23H17FN6OS2	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0368729 Compound Info	6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-N-(2-morpholin-4-ylethyl)-1,3-benzothiazol-2-amine Show/Hide	C24H22FN7OS2	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0273535 Compound Info	N-ethyl-6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-amine Show/Hide	C20H15FN6S2	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0083616 Compound Info	6-[6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]-1'-methylspiro[1H-indole-3,4'-piperidine]-2-one Show/Hide	C26H25Cl2FN4O2	2
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
2	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0031719 Compound Info	(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine Show/Hide	C21H22Cl2FN5O	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0524911 Compound Info	5-[6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]-1'-methylspiro[1H-indole-3,4'-piperidine]-2-one Show/Hide	C26H25Cl2FN4O2	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0368730 Compound Info	N-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]acetamide Show/Hide	C20H13FN6OS2	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0519765 Compound Info	5-[5-amino-6-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyrazin-2-yl]-1'-methylspiro[1H-indole-3,4'-piperidine]-2-one Show/Hide	C25H24Cl2FN5O2	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0232310 Compound Info	2-morpholin-4-ylethyl N-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]carbamate Show/Hide	C25H22FN7O3S2	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0347347 Compound Info	1-[2-(1-ethylpiperidin-4-yl)ethyl]-3-[6-[(6-thiophen-2-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulfanyl]-1,3-benzothiazol-2-yl]urea Show/Hide	C26H28N8OS3	1
1	IC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0043422 Compound Info	4-[6-amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro-2H-pyridine-1-carboxamide Show/Hide	C21H19Cl2FN4O3	2
1	IC50 = 42 nM Bioactivity Info	TI LI LO TS
2	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0232309 Compound Info	6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-amine Show/Hide	C18H11FN6S2	1
1	IC50 = 43 nM Bioactivity Info	TI LI LO TS
CP0046394 Compound Info	BMS-907351 Show/Hide	C28H24FN3O5	1
1	IC50 = 44.5 nM Bioactivity Info	TI LI LO TS
CP0016487 Compound Info	BMS-777607 Show/Hide	C25H19ClF2N4O4	1
1	IC50 = 46.6 nM Bioactivity Info	TI LI LO TS
CP0362786 Compound Info	5-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-3-fluoroanilino]-3-(4-fluorophenyl)-1,6-naphthyridin-4-ol Show/Hide	C30H21F2N5O4	1
1	IC50 = 59.4 nM Bioactivity Info	TI LI LO TS
CP0060587 Compound Info	8-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluoroanilino]-2-(4-fluorophenyl)-2,7-naphthyridin-1-one Show/Hide	C25H16ClF2N5O2	1
1	IC50 = 69 nM Bioactivity Info	TI LI LO TS
CP0195511 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-2-oxo-3-phenylimidazolidine-1-carboxamide Show/Hide	C27H21FN6O3S	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0576075 Compound Info	5-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-3-fluoroanilino]-3-(4-fluorophenyl)-1-methyl-1,6-naphthyridin-4-one Show/Hide	C31H23F2N5O4	1
1	IC50 = 82.9 nM Bioactivity Info	TI LI LO TS
CP0564580 Compound Info	5-[4-(6,7-dimethoxyquinazolin-4-yl)oxyanilino]-3-(4-fluorophenyl)-1,6-naphthyridin-4-ol Show/Hide	C30H22FN5O4	1
1	IC50 = 86.5 nM Bioactivity Info	TI LI LO TS
CP0538118 Compound Info	8-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluoroanilino]-2-(4-fluorophenyl)-3-methyl-2,7-naphthyridin-1-one Show/Hide	C26H18ClF2N5O2	1
1	IC50 = 89.8 nM Bioactivity Info	TI LI LO TS
CP0311030 Compound Info	1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-b]pyridine Show/Hide	C20H18ClN7O2S2	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0571104 Compound Info	8-[4-(2-amino-3-iodopyridin-4-yl)oxy-3-fluoroanilino]-2-(4-fluorophenyl)-2,7-naphthyridin-1-one Show/Hide	C25H16F2IN5O2	1
1	IC50 = 116.7 nM Bioactivity Info	TI LI LO TS
CP0571105 Compound Info	8-[4-(2-amino-3-iodopyridin-4-yl)oxy-3-fluoroanilino]-2-(4-fluorophenyl)-3-methyl-2,7-naphthyridin-1-one Show/Hide	C26H18F2IN5O2	1
1	IC50 = 117.8 nM Bioactivity Info	TI LI LO TS
CP0571194 Compound Info	5-[3-fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]oxyanilino]-3-(4-fluorophenyl)-1H-1,6-naphthyridin-4-one Show/Hide	C36H32F2N6O4	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0302484 Compound Info	tert-butyl 4-[4-[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpyrrolo[3,2-b]pyridin-6-yl]pyrazol-1-yl]piperidine-1-carboxylate Show/Hide	C25H26ClN7O4S2	1
1	IC50 = 147 nM Bioactivity Info	TI LI LO TS
CP0431829 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-5-(4-fluorophenyl)-1-phenylpyrazole-4-carboxamide Show/Hide	C33H22F2N6O2S	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0049186 Compound Info	4-(6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-1-ylsulfonyl)benzo[c][1,2,5]oxadiazole Show/Hide	C21H19N7O3S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0215201 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-pyridin-3-ylpyrazole-4-carboxamide Show/Hide	C32H22FN7O2S	1
1	IC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0215183 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-5-(3-methoxyphenyl)-1-phenylpyrazole-4-carboxamide Show/Hide	C34H25FN6O3S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0431830 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-thiophen-3-ylpyrazole-4-carboxamide Show/Hide	C31H21FN6O2S2	1
1	IC50 = 340 nM Bioactivity Info	TI LI LO TS
CP0574342 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-5-(2-methoxyphenyl)-1-phenylpyrazole-4-carboxamide Show/Hide	C34H25FN6O3S	1
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0341503 Compound Info	1-(4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-pyrrolo[3,2-b]pyridin-6-yl)piperazin-1-yl)ethanone Show/Hide	C19H18N6O4S	1
1	IC50 = 370 nM Bioactivity Info	TI LI LO TS
CP0313160 Compound Info	5-[4-[6-[3-(diethylamino)propoxy]-7-methoxyquinazolin-4-yl]oxy-3-fluoroanilino]-3-(4-fluorophenyl)-1H-1,6-naphthyridin-4-one Show/Hide	C36H34F2N6O4	1
1	IC50 = 396.8 nM Bioactivity Info	TI LI LO TS
CP0054775 Compound Info	7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-(1-piperidin-4-ylpyrazol-4-yl)furo[3,2-c]pyridin-6-amine Show/Hide	C23H22Cl2FN5O2	1
1	IC50 = 410 nM Bioactivity Info	TI LI LO TS
CP0233799 Compound Info	(4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-pyrrolo[3,2-b]pyridin-6-yl)piperazin-1-yl)(pyridin-3-yl)methanone Show/Hide	C23H19N7O4S	1
1	IC50 = 480 nM Bioactivity Info	TI LI LO TS
CP0049183 Compound Info	1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-pyrrolo[3,2-b]pyridin-6-amine Show/Hide	C12H8ClN5O2S2	1
1	IC50 = 490 nM Bioactivity Info	TI LI LO TS
CP0046759 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamide Show/Hide	C28H18F4N6O2S	2
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
2	IC50 = 6870 nM Bioactivity Info	TI LI LO TS
CP0116040 Compound Info	4-[6-amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro-2H-pyridine-1-sulfonamide Show/Hide	C20H19Cl2FN4O4S	1
1	IC50 = 550 nM Bioactivity Info	TI LI LO TS
CP0116038 Compound Info	7-[1-(2,6-dichloro-3-fluorophenyl)but-3-ynoxy]-3-(1-piperidin-4-ylpyrazol-4-yl)furo[3,2-c]pyridin-6-amine Show/Hide	C25H22Cl2FN5O2	1
1	IC50 = 560 nM Bioactivity Info	TI LI LO TS
CP0683976 Compound Info	rac-7-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)furo[3,2-c]pyridin-6-amine Show/Hide	C23H22Cl2FN5O2	1
1	IC50 = 560 nM Bioactivity Info	TI LI LO TS
CP0302556 Compound Info	1-(4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-pyrrolo[3,2-b]pyridin-6-yl)piperazin-1-yl)-2-(methylamino)ethanone Show/Hide	C20H21N7O4S	1
1	IC50 = 570 nM Bioactivity Info	TI LI LO TS
CP0395262 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-(trifluoromethyl)triazole-4-carboxamide Show/Hide	C27H17F4N7O2S	1
1	IC50 = 670 nM Bioactivity Info	TI LI LO TS
CP0120376 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1,5-diphenylpyrazole-4-carboxamide Show/Hide	C33H23FN6O2S	1
1	IC50 = 740 nM Bioactivity Info	TI LI LO TS
CP0287559 Compound Info	4-(6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-1-ylsulfonyl)benzo[c][1,2,5]oxadiazole Show/Hide	C23H21N7O3S	1
1	IC50 = 820 nM Bioactivity Info	TI LI LO TS
CP0195506 Compound Info	N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamide Show/Hide	C28H20F4N4O4	1
1	IC50 = 1060 nM Bioactivity Info	TI LI LO TS
CP0357140 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-5-(2-fluorophenyl)-1-phenylpyrazole-4-carboxamide Show/Hide	C33H22F2N6O2S	1
1	IC50 = 1090 nM Bioactivity Info	TI LI LO TS
CP0431828 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-pyridin-2-ylpyrazole-4-carboxamide Show/Hide	C32H22FN7O2S	1
1	IC50 = 1230 nM Bioactivity Info	TI LI LO TS
CP0233798 Compound Info	1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-pyrrolo[3,2-b]pyridin-6-amine Show/Hide	C13H9N5O3S	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0049182 Compound Info	1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-6-(piperazin-1-yl)-1H-pyrrolo[3,2-b]pyridine Show/Hide	C16H15ClN6O2S2	1
1	IC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0357138 Compound Info	4-((6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)methyl)benzo[c][1,2,5]oxadiazole Show/Hide	C22H21N7O	1
1	IC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0259814 Compound Info	tert-butyl 4-[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylpyrrolo[3,2-b]pyridin-6-yl]piperazine-1-carboxylate Show/Hide	C21H23ClN6O4S2	1
1	IC50 = 1946 nM Bioactivity Info	TI LI LO TS
CP0357141 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1,3-diphenylpyrazole-4-carboxamide Show/Hide	C33H23FN6O2S	1
1	IC50 = 2070 nM Bioactivity Info	TI LI LO TS
CP0318712 Compound Info	7-[1-(2,6-dichloro-3-fluorophenyl)but-3-enoxy]-3-(1-piperidin-4-ylpyrazol-4-yl)furo[3,2-c]pyridin-6-amine Show/Hide	C25H24Cl2FN5O2	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0271912 Compound Info	7-[1-(2,6-dichloro-3-fluorophenyl)propoxy]-3-(1-piperidin-4-ylpyrazol-4-yl)furo[3,2-c]pyridin-6-amine Show/Hide	C24H24Cl2FN5O2	1
1	IC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0215182 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-2,4-diphenyl-1,3-thiazole-5-carboxamide Show/Hide	C33H22FN5O2S2	1
1	IC50 = 2260 nM Bioactivity Info	TI LI LO TS
CP0413130 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-(trifluoromethyl)imidazole-4-carboxamide Show/Hide	C28H18F4N6O2S	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0303860 Compound Info	tert-butyl 4-[4-[1-(2,1,3-benzoxadiazol-4-ylmethyl)pyrrolo[3,2-b]pyridin-6-yl]pyrazol-1-yl]piperidine-1-carboxylate Show/Hide	C27H29N7O3	1
1	IC50 = 3080 nM Bioactivity Info	TI LI LO TS
CP0296604 Compound Info	1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-pyrrolo[3,2-b]pyridin-6-ol Show/Hide	C12H7ClN4O3S2	1
1	IC50 = 3600 nM Bioactivity Info	TI LI LO TS
CP0413129 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-3-(trifluoromethyl)pyrazole-4-carboxamide Show/Hide	C28H18F4N6O2S	1
1	IC50 = 3770 nM Bioactivity Info	TI LI LO TS
CP0420379 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-(4-fluorophenyl)-5-(trifluoromethyl)pyrazole-4-carboxamide Show/Hide	C28H17F5N6O2S	1
1	IC50 = 4370 nM Bioactivity Info	TI LI LO TS
CP0466686 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1,5-diphenylpyrrole-3-carboxamide Show/Hide	C34H24FN5O2S	1
1	IC50 = 4840 nM Bioactivity Info	TI LI LO TS
CP0556261 Compound Info	7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-(1-piperidin-4-ylpyrazol-4-yl)furo[3,2-c]pyridin-6-amine Show/Hide	C23H22Cl2FN5O2	1
1	IC50 = 7400 nM Bioactivity Info	TI LI LO TS
CP0467003 Compound Info	6-[6-amino-5-[(2,6-dichloro-3-fluorophenyl)methoxy]pyridin-3-yl]-1'-methylspiro[1H-indole-3,4'-piperidine]-2-one Show/Hide	C25H23Cl2FN4O2	1
1	IC50 = 9000 nM Bioactivity Info	TI LI LO TS
CP0043265 Compound Info	7-[(2,6-dichloro-3-fluorophenyl)methoxy]-3-(1-piperidin-4-ylpyrazol-4-yl)furo[3,2-c]pyridin-6-amine Show/Hide	C22H20Cl2FN5O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0525637 Compound Info	5-[6-amino-5-[(2,6-dichloro-3-fluorophenyl)methoxy]pyridin-3-yl]-1'-methylspiro[1H-indole-3,4'-piperidine]-2-one Show/Hide	C25H23Cl2FN4O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0464156 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-5-(4-methoxyphenyl)-1-phenylpyrazole-4-carboxamide Show/Hide	C34H25FN6O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0534770 Compound Info	N-[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-phenyl-5-pyridin-4-ylpyrazole-4-carboxamide Show/Hide	C32H22FN7O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS

Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma

Protein Info

Cell Viability or Cytotoxicity Assay

Compound ID	Compound Name	Compound Formula
CP0092152 Compound Info	2,10-Dihydroxy-6-[(4-cyanobenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C34H27N5O10	1
1	IC50 = 85 nM	TI LI LO TS
CP0095287 Compound Info	[4-(3-chloroanilino)thieno[2,3-d]pyrimidin-6-yl]-(1H-indol-2-yl)methanone Show/Hide	C21H13ClN4OS	1
1	IC50 = 20200 nM	TI LI LO TS
CP0137418 Compound Info	N-[4-[2-(1-ethylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2-oxoimidazolidine-1-carboxamide Show/Hide	C28H22F2N6O3S	1
1	IC50 = 10 nM	TI LI LO TS
CP0143774 Compound Info	1-N'-[4-[6-(2,3-dihydroxypropoxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]oxy-3-fluorophenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Show/Hide	C27H25F2N5O6	1
1	IC50 = 9.7 nM	TI LI LO TS
CP0176598 Compound Info	N-[4-[2-[(2S,3S,5R)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-1,3-dithian-2-yl]phenyl]-N'-hydroxyoctanediamide Show/Hide	C34H52N4O7S2Si	1
1	GI50 = 3801.89 nM	TI LI LO TS
CP0178369 Compound Info	6-(Benzylamino)-2,10-dihydroxy-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C33H28N4O10	1
1	IC50 = 3.4 nM	TI LI LO TS
CP0199012 Compound Info	2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-4-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C33H29N5O11	1
1	IC50 = 0.35 nM	TI LI LO TS
CP0221706 Compound Info	2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-3-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C33H29N5O11	1
1	IC50 = 0.62 nM	TI LI LO TS
CP0232310 Compound Info	2-morpholin-4-ylethyl N-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]carbamate Show/Hide	C25H22FN7O3S2	1
1	IC50 = 95 nM	TI LI LO TS
CP0237965 Compound Info	2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-2-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C33H29N5O11	1
1	IC50 = 1.6 nM	TI LI LO TS
CP0252512 Compound Info	1-N'-[3-fluoro-4-[5-methyl-6-(3-methylsulfonylpropoxy)pyrrolo[2,1-f][1,2,4]triazin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Show/Hide	C28H27F2N5O6S	1
1	IC50 = 8.2 nM	TI LI LO TS
CP0264632 Compound Info	2,10-Dihydroxy-6-[(3-hydroxybenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C33H28N4O11	1
1	IC50 = 4.5 nM	TI LI LO TS
CP0264635 Compound Info	2,10-Dihydroxy-6-[(pyrazin-2-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C31H26N6O10	1
1	IC50 = 2.8 nM	TI LI LO TS
CP0269237 Compound Info	2,10-Dihydroxy-6-[(quinolin-2-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C36H29N5O10	1
1	IC50 = 14 nM	TI LI LO TS
CP0271912 Compound Info	7-[1-(2,6-dichloro-3-fluorophenyl)propoxy]-3-(1-piperidin-4-ylpyrazol-4-yl)furo[3,2-c]pyridin-6-amine Show/Hide	C24H24Cl2FN5O2	1
1	IC50 = 3600 nM	TI LI LO TS
CP0280882 Compound Info	2,10-Dihydroxy-6-[(4-hydroxybenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C33H28N4O11	1
1	IC50 = 3 nM	TI LI LO TS
CP0311569 Compound Info	2,10-Dihydroxy-6-[(quinolin-3-ylmethyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C36H29N5O10	1
1	IC50 = 23 nM	TI LI LO TS
CP0330922 Compound Info	2,10-Dihydroxy-6-{[4-(hydroxymethyl)benzyl]amino}-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C34H30N4O11	1
1	IC50 = 2.7 nM	TI LI LO TS
CP0333355 Compound Info	2,10-Dihydroxy-6-{[3-(hydroxymethyl)benzyl]amino}-13-(beta-Dglucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C34H30N4O11	1
1	IC50 = 11 nM	TI LI LO TS
CP0333357 Compound Info	2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-3-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C33H29N5O11	1
1	IC50 = 2.6 nM	TI LI LO TS
CP0333359 Compound Info	2,10-Dihydroxy-6-[(4-methylbenzyl)amino]-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione Show/Hide	C34H30N4O10	1
1	IC50 = 390 nM	TI LI LO TS
CP0345034 Compound Info	[(2R)-1-(4-tert-butylphenoxy)-3-(2-nitroimidazol-1-yl)propan-2-yl] 4-[(2-hydroxy-5-oxocyclopenta-1,3-dien-1-yl)methylideneamino]benzoate Show/Hide	C29H28N4O7	1
1	LC50 = 74000 nM	TI LI LO TS
CP0392874 Compound Info	1-N'-[3-fluoro-4-[6-[2-hydroxy-3-(4-methylpiperazin-1-yl)propoxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Show/Hide	C32H35F2N7O5	1
1	IC50 = 1.2 nM	TI LI LO TS
CP0451721 Compound Info	(1S,7R,10S,16E,21R)-7-benzyl-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone Show/Hide	C26H34N4O6S2	1
1	GI50 = 64 nM	TI LI LO TS
CP0517983 Compound Info	N-[4-[2-[(2S,3S,5S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-1,3-dithian-2-yl]phenyl]-N'-hydroxyoctanediamide Show/Hide	C34H52N4O7S2Si	1
1	GI50 = 10000 nM	TI LI LO TS
CP0534755 Compound Info	[(1R)-1-[[(2S)-2-(3,4-dihydro-1H-isoquinoline-2-carbonylamino)-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid Show/Hide	C24H32BN3O4	1
1	IC50 = 15.52 nM	TI LI LO TS

Protein family and CMB statistics Related to the Cell Line

Cell Lines Derived from the same Tissue Source (Liver)

Cell Line Name		Organism	Disease
Huh-7	Cell Line Info	Homo sapiens (Human)	Adult hepatocellular carcinoma
HLF	Cell Line Info	Homo sapiens (Human)	Adult hepatocellular carcinoma
Huh-7-Lunet	Cell Line Info	Homo sapiens (Human)	Adult hepatocellular carcinoma
Huh-7.5	Cell Line Info	Homo sapiens (Human)	Adult hepatocellular carcinoma
Huh-5-2	Cell Line Info	Homo sapiens (Human)	Adult hepatocellular carcinoma
PLC/PRF/5	Cell Line Info	Homo sapiens (Human)	Adult hepatocellular carcinoma
Hep 3B2.1-7	Cell Line Info	Homo sapiens (Human)	Childhood hepatocellular carcinoma
VACO 241	Cell Line Info	Homo sapiens (Human)	Colon carcinoma
LM	Cell Line Info	Homo sapiens (Human)	Extrarenal rhabdoid tumor of the liver
GTL-16	Cell Line Info	Homo sapiens (Human)	Gastric adenocarcinoma
NCI-N87	Cell Line Info	Homo sapiens (Human)	Gastric tubular adenocarcinoma
Hep-G2	Cell Line Info	Homo sapiens (Human)	Hepatoblastoma
Hep-G2/C3A	Cell Line Info	Homo sapiens (Human)	Hepatoblastoma
CellSensor ARE-bla Hep G2	Cell Line Info	Homo sapiens (Human)	Hepatoblastoma
Hep-G2 VA-13	Cell Line Info	Homo sapiens (Human)	Hepatoblastoma
HepDES19	Cell Line Info	Homo sapiens (Human)	Hepatoblastoma
DPX2	Cell Line Info	Homo sapiens (Human)	Hepatoblastoma
Hep-G2/2.2.15	Cell Line Info	Homo sapiens (Human)	Hepatoblastoma
HepAD38	Cell Line Info	Homo sapiens (Human)	Hepatoblastoma
HepG2-Lucia AhR	Cell Line Info	Homo sapiens (Human)	Hepatoblastoma
HepG2-hNTCP	Cell Line Info	Homo sapiens (Human)	Hepatoblastoma
HCCC-9810	Cell Line Info	Homo sapiens (Human)	Intrahepatic cholangiocarcinoma
SU.86.86	Cell Line Info	Homo sapiens (Human)	Pancreatic adenocarcinoma
Capan-1	Cell Line Info	Homo sapiens (Human)	Pancreatic ductal adenocarcinoma
Hepa-1c1c7	Cell Line Info	Mus musculus (Mouse)	Hepatocellular carcinoma of the mouse
H5	Cell Line Info	Rattus norvegicus (Rat)	Rat hepatocellular carcinoma
H4-II-E	Cell Line Info	Rattus norvegicus (Rat)	Rat hepatocellular carcinoma
H4-II-E-C3	Cell Line Info	Rattus norvegicus (Rat)	Rat hepatocellular carcinoma
McA-RH7777	Cell Line Info	Rattus norvegicus (Rat)	Rat hepatocellular carcinoma
H2.35	Cell Line Info	Mus musculus (Mouse)	-

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han